Continuing Medical Education examination Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases Instructions for category 1 Continuing Medical Education credit The American Academy of Allergy, Asthma & Immunology is accredited as a provider of Continuing Medical Education (CME) by the Accreditation Council for Continuing Medical Education. Test ID no.: mai00259 Contact hours: 1.0 Expiration date: June 30, 2014 Category 1 credit can be earned by reading the text material and taking this CME examination online. For complete instructions, visit the Journal’s Web site at www.jacionline.org. The Editors thank the University of South Florida Allergy/Immunology training program for developing this CME examination. The individuals who contributed to its preparation were Neetu Talreja, MD, Salman Aljubran, MD, Gregory M. Cowan, MD, Nauman Salim, MD, Susan Culverhouse, MD, and Roger W. Fox, MD, under the direction of Richard F. Lockey, MD. Learning objectives: ‘‘Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases’’ 1. To identify microRNA (miRNA) proﬁles involved in the pathogenesis of asthma, eosinophilic esophagitis, allergic rhinitis, and atopic dermatitis. 2. To understand the role of miRNAs in regulating eosinophils and their development. 3. To identify perspectives for future investigation and clinical utility of miRNAs. CME items Question 1. Which signal transducer and activator of transcription (STAT) is targeted by miR-146a and suppresses T H 1 responses? A. STAT1 B. STAT3 C. STAT4 D. STAT6 Question 2. Which of the following cytokines is important for the development of eosinophil lineage? A. IL-2 B. IL-13 C. IL-5 D. IL-10 Question 3. miR-223 acts on which of the following receptors to limit eosinophil progenitor proliferation? A. insulin-like growth factor 1 receptor (IGF1R) B. Fcε IgE C. CCR3 D. TGF-b Question 4. Which miRNA family member is associated with allergic asthma, eosinophilic esophagitis, and atopic dermatitis? A. miR-155 B. miR-365 C. let-7c D. miR-187 Question 5. Which mechanism regulates miRNA expression? A. reprogramming B. DNA sequence length changes C. anticipation D. DNA methylation 14 July 2013 J ALLERGY CLIN IMMUNOL

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

Download PDF Report

Upload
trandieu
View
215
Download
0

Embed Size (px)

Citation preview

Continuing Medical Education examination

Diagnostic, functional, and therapeutic roles of microRNAin allergic diseases

Instructions for category 1 Continuing Medical Education credit

The American Academy of Allergy, Asthma & Immunology is accredited as a provider of Continuing Medical Education (CME) bythe Accreditation Council for Continuing Medical Education.

Test ID no.: mai00259Contact hours: 1.0Expiration date: June 30, 2014

Category 1 credit can be earned by reading the text material and taking this CME examination online. For complete instructions, visitthe Journal’s Web site at www.jacionline.org.

The Editors thank the University of South Florida Allergy/Immunology training program for developing this CME examination. Theindividuals who contributed to its preparation were Neetu Talreja, MD, Salman Aljubran,MD, GregoryM. Cowan,MD, Nauman Salim,MD, Susan Culverhouse, MD, and Roger W. Fox, MD, under the direction of Richard F. Lockey, MD.

Learning objectives: ‘‘Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases’’

1. To identify microRNA (miRNA) profiles involved in the pathogenesis of asthma, eosinophilic esophagitis, allergic rhinitis, andatopic dermatitis.

2. To understand the role of miRNAs in regulating eosinophils and their development.3. To identify perspectives for future investigation and clinical utility of miRNAs.

CME items

Question 1. Which signal transducer and activator of transcription(STAT) is targeted by miR-146a and suppresses TH1 responses?

A. STAT1B. STAT3C. STAT4D. STAT6

Question 2. Which of the following cytokines is important for thedevelopment of eosinophil lineage?

A. IL-2B. IL-13C. IL-5D. IL-10

14 July 2013

Question 3. miR-223 acts on which of the following receptors tolimit eosinophil progenitor proliferation?

A. insulin-like growth factor 1 receptor (IGF1R)B. Fcε IgEC. CCR3D. TGF-b

Question 4. Which miRNA family member is associated withallergic asthma, eosinophilic esophagitis, and atopic dermatitis?

A. miR-155B. miR-365C. let-7cD. miR-187

Question 5. Which mechanism regulates miRNA expression?

A. reprogrammingB. DNA sequence length changesC. anticipationD. DNA methylation