Differential Gene Expression between Han Chinese and Japanese

Yuan YuanProf. Shuhua Xu’s group

Population genomic groupPICB

Chinese and Japanese are very similar in phenotype.

Expression variation among Chinese and Japanese individuals

Differentlyexpressed

Illumina's commercial whole genome expression array, Sentrix Human-6 Expression BeadChip version 2 These arrays utilize a bead pool with ~48,000 unique bead types Each with several hundred thousand gene-specific 50mer probes attached.

Genome locations of 768 DE genes

Functional enrichment of 768 DE genes

Identify local (Cis) and distant (Trans) genetic regulators that associate with gene expression difference

Population

Cis: # genes(snps)

Trans: # genes(snps)

CHB 39 (306) 271 (4544)

JPT 68 (648) 92 (1216)

Distribution of cis-associations(SNPs) relative to the transcription start site (TSS)

Genetic contributions to total expression variation for 11 cis-genes

Cis-gene vs GWAS trait

CTSS vs cis-SNPs

Acknowledgment

Dr. Shuhua Xu

Yang ling, Lu dongsheng, Shi meng, Lou haiyi

Jin wenfei, Pankaj

All in population genomics group