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Ibrahim D. Bori, Ph.D.604 West Knox Street, Durham, NC
27701(home) Email: [email protected] Beard Hall, CB#7360,
UNC Eshelman School of Pharmacy, Chapel Hill, NC
27599-7360(work)Phone: 919-956-850 (home) 919-630-6295 (cell)
919-966-13949 (office)
________________________________________________________
A. Professional PreparationNIAID Postdoctoral Research
Associate, Division of Medicinal Chemistry & NaturalProducts,
University of North Carolina Chapel Hill, NC, 2009-Present .
Advisor: Professor K. H. Lee
NSF AGEP Postdoctoral Research Associate, Chemistry department,
University of Michigan Ann Arbor, MI, 2008-2009. Advisor: Professor
Anna K. Mapp
Ph.D., NC State University, Organic Chemistry, June, 2008.
Advisor: Professor Daniel L. Comins.Thesis Title: aProgress toward
the Total Synthesis of 14-Isoazacamptothecin, andSynthesis of
Substituted Quinolinesa.
M.S., NC Central University, Organic Chemistry, May 2003.
Advisors: Wendell W. Wilkerson (Chemistry), andlate Professor
Richard Bukoski (BBRI). Thesis Title: aThe Synthesis and Biological
Evaluation of a Series of N-substituted
8-methoxy-10,11-dihydrodibenzo [b,f]
thiepin -(10-yl)-piperazine Derivatives as Vasodilatorsa.
B.A., University of North Carolina, Greensboro, Biology,
Chemistry minor, December 1984.
B. Appointments2009-present-Postdoctoral Research Associate,
Med. Chem. & Nat. Products Division, UNC Chapel Hill,
NC2008-2009-Postdoctoral Research Associate, Chemistry department,
University of Michigan, Ann Arbor, MI2003-Summer Intern,
GlaxoSmithKline, Research Triangle Park, NC2002-Summer Intern,
GlaxoSmithKline, Research Triangle Park,
NC2002-2008-Research/Teaching Assistant, Chemistry department, NC
State University
, Raleigh, NC2000-2002- Research/Teaching Assistant, Chemistry
department NC Central University, Durham, NC1989-2000-Certifying
Scientist, Laboratory Corporation of America, Research Triangle
Park, NC1990-1994-Research Technician, Med. Chem. & Nat.
Products Division, School of Pharmacy, Department of
Pharmacology, School of Medicine, UNC Chapel Hill, NC
C. Research and Mentoring Experience2009-present- NIAID
Postdoctoral Research Fellow with Professor K.H. Lee, University of
North Carolina- Synthetic modification of bioactive natural
products, and their evaluation for
the dual use as anti-HIV entry andmaturation inhibitors
- Bioactivity-directed fractionation and isolation (BDFI) of
lead compounds frommedicinal plants- Mentoring graduate students
and visiting graduate students from China, Japan,and Taiwan
conducting researchin Professor K.H. Leeas Lab
2008-2009-- NSF AGEP Postdoctoral Research Fellowship with
Professor Anna K. Mapp, Univ. Michigan
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- Synthesis and evaluation of small molecules for their ability
to up-regulate gene specific transcription-Mentored graduate
students and rotation graduate students in Anna Mappas Lab
2002-2008-Ph.D. Thesis Research with Professor Daniel L. Comins,
NC State University- Developed methodologies for the total
asymmetric synthesis f novel of Camptothecin- Developed
methodologies for the synthesis of new quinolines- Developed
methodologies for the expanding the scope of Directed
ortho-metalation (DoM) on quinolines (Tett.Lett., 2005, 46,
6697-6699)
- Developed methodologies for the synthesis of new
2,5-dibromopyridine derivatives-Developed methodologies for the
synthesis of iodoacetamide derivatives that were used as tags for
thedetection of peptides in proteomic research as part of
collaborative efforts between Comins and Muddiman research groups
at NC State (JACS, 2008, 130, 2122-2123)-Mentored new graduate
students in Professor Cominsa Lab-Mentored undergraduate students
conducting research in Professor Comins Lab during NSF REU summer
program-Awarded 2008 Percy Lavon Julian Graduate Award for
Excellence in Teaching
Summer 2002 & 2003- GlaxoSmithKline, Research Triangle Park,
NC (Internship Med
Chem.)
-Synthesis and Structural Activity Relationships (SAR) study on
lead drug candidates for the treatment ofpostmenopausal symptoms
and breast cancer-Scaled-up synthesis of varieties of
pharmaceutical intermediates-Developed methodology for the
synthesis of a series of Phenol Ethers and Tamoxifen analogs using
Solid Phase
2000-2002-M.S. Thesis Research with Professor Wendell Wilkerson
(Chemistry) andlate Professor RichardBukoski (Biomed. &
Biotech. Res. Inst.), NC Central University-Synthesized and
evaluated analogs of known neuroleptics, N-substituted 8-Methox
y-10,11-dihydro dibenzo[b,f]thiepin, for their antihypertensive
potentials-SAR on lead dihydro dibenzo[b,f]
thiepin-(10-yl)-piperazine derivatives
D. Work Experience2002-2008- NC State University, Raleigh, NC
(Research/Teaching Assistant)-Teaching Assistant for General,
Analytical and Organic Chemistry Laboratory Experiments; and
Problem Sessions-Occasionally volunteered to teach undergraduate
Organic Chemistry classes
2000-2002- NC Central University, Durham, NC (Teaching
Assistant)-Organized and taught General Chemistry Laboratory
Experiments
1989-2000- Laboratory Corporation of America, Research Triangle
Park, NC (Certifying Scientist)- Reviewed and certified data from
the analysis of blood and urine samples for the presence of alcohol
and drugs of abuse-Trained and provided guidance for other
scientists regarding procedures, troubleshooting, and practice of
Lab. Corp. Policy compliance- Prepared Litigation Packages and
Quantitation Reports for Lab. Corpas Client
1999-2000-Duke University Medical Center, Durham, NC (Research
Technician)-Gene therapy research on the application of
Adeno-Associated Virus (AAV) for th
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e treatment of glycogen storage disease1990-1994- University of
North Carolina, Chapel Hill, NC (Research Technician)Department of
Medicinal Chemistry & Natural Product, School of Pharmacy,
Department of Pharmacology, School of Medicine-Screened Chinese
medicinal plant extracts, and synthetic compounds againstcancer
cell lines so as to identify Topoisomerase inhibitors that may have
potential use in cancer treatment-Performed cytotoxicity
assays-Tissue culture support and cell line maintenance-Studied
drug resistance in drug treated cancer cells by measuring
p-glycoprotein levels in cells-Isolated and purified RNA, DNA,
proteins, and prepare cDNA libraries-Performed Northern, Southern,
Western blotting and SDS-PAGE electrophoresis-Tissue culture
support and cell line maintenance
E. Awards and Honors2009- Judge undergraduate/graduate
poster/oral presentations for 2009 Annual Biomedical Research
Conference for Minority Students (Phoenix, AZ, November 4-7,
2009)2009- NIH Postdoctoral Research Fellowship, UNC, Chapel Hill,
NC2008- NSF AGEP Postdoctoral Research Fellowship, University of
Michigan, Ann Arbor, MI2008-Percy Lavon Julian Graduate Award for
Excellence in Teaching, NCSU Chemistr
y Department2004-President, North Carolina State Chapter of
NOBCChE2003-3rd Place Business Plan Competition NCSU College of
Management (Team RedX)2002- Department of Chemistry Award for
Academic Excellence, NC Central University, Durham, NC2001- NIH
PURSUE Graduate Fellowship, NC Central University, Durham, NC2000-
JLC BBRI Graduate Research Fellowship, NC Central University,
Durham, NC
F. Professional OrganizationsAmerican Chemical SocietyNational
Organization for the Professional Advancement of Black Chemists and
Chemical Engineers (NOBCChE)
G. Peer-reviewed primary publications:1. Williams, D., Meadows,
C., Bori, I.D., Hawkridge, A.M., Comins, D. L., and Muddiman, D.C.
(2008). Synthesis, Characterization, and Application of
Iodoacetamide Derivatives Utilized for the ALiPHAT Strategy J. Am.
Chem. Soc. 130, 2122-2123.
2. Frahm, J.L., Bori, I.D., Comins, D.L., Hawkridge, A.M., and
Muddiman, D.C. (2007). Achieving Augmented Limits of Detection for
Peptides with Hydrophobic Alkyl Tags Analytical Chemistry 79,
3989-3995.
3. Comins, D.L., Nolan, J.M., Bori, I.D., (2005). Regioselective
lithium-halogenexchange and palladium-catalyzed cross coupling
reactions of 2,4-dihaloquinoline Tet. Lett. 46, 6697-6699
4. Kitanaka, S., Yasuda, I., Kashiwada,Y., Hu, C.Q., Bastow,
K.F., Bori, I.D., and Lee, K.H. (1995). Antitumor Agents,
162.Cell-based assays for identifying novel DNA Topoisomerase
inhibitors: Studies on the constituents of Fatsia Japonica. J. Nat.
Prod. 58, 1647.
5. Bastow, K.F., ltoigawa, M., Furukawa, H., Kashiwada,Y., Bori,
I.D., Ballas, L.M., and Lee,K.H. (1994). Antiploriferative actions
of 7-substituted 1,3-dihydroxy acridones; possible involvement of
DNA Topoisomerase II and Protein Kinase Cas biochemical targets
Bioorg. & Med. Chem. 2, 1403
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6. Bastow, K.F., Tatemastu, H., Bori,I.D., Fukishima,Y., Sun,
L., Goz, B., andLee, K.H. (1993). Induction of reversible
protein-linked DNA breaks in human osteosarcorna cells by novel
cytocidal Colchicine derivatives which inhibit DNA Topoisomerase II
in Vitro: Absence of cross-resistance in colchicine- resistance sub
clone Bioorg. & Med. Chem. Lett. 3, 1045.
7. Bastow, K.F., Bori. I.D., Fukishima,Y., Kashiwada,Y.,
Tanaka,T., Nonaka, G.I., and Lee, K.H. (1993). Inhibition of
DNATopoisornerase by Sanguin H-6, a cytotoxic dimeric ellagitannin
from Sanguisorba Officinalis Planta Medica 59, 240.
8. Kashiwada,Y., Nonaka, G.I., Nishioka, I., Lee, K.J-H., Bori,
I.D, Fukishima,Y., Bastow, K.F., and Lee, K.H. (1993). Tannins as
potent inhibitors of DNA Topoisomerase II in Vitro .J. Pharm. Sci.
82, 487.
H. Professional Presentations:1.D. Keith Williams Jr*., Ibrahim
D. Bori, Pauline Ondachi, Daniel L. Comins & David C. Muddiman
(May 2009). Understanding Hydrophobicity and Limits of Detection
for Biologically Relevant Peptides using the ALiPHAT Method and
ElectrosprayIonization 57th ASMS Conference on Mass Spectrometry,
Philadelphia, PA (Poster).
2. JENNIFER L. FRAHM*, Adam M. Hawkridge, Daniel L. Comins,
Ibrahim D. Bori, & D
avid C. Muddiman (June 2007). Augmented Limits of Detection for
Peptides with Hydrophobic Alkyl Tags (ALiPHAT) 55th ASMS Conference
on Mass Spectrometry, Indianapolis, IN (Poster).
3. Corey W. Meadows*, D. Keith Williams Jr., Ibrahim D. Bori,
David C. Muddiman,Adam M. Hawkridge, & Daniel L. Comins (July
2007) Achieving Augmented Limits of Detection for Peptideswith
Hydrophobic Alkyl Tags., The 6th Annual NC State University
Undergraduate Summer Research Symposium (UGRS REU), Raleigh, NC
(Poster).
4. Ibrahim D. Bori* & Daniel L. Comins (April 2007).
Development of Synthetic Methodologies Toward The Asymmetric
Construction of Camptothecin Analogs 2007 National Conference of
The National Organization of Black Chemists & Chemical Engi
neers (NOBCChE), Orlando, Fl (Oral).
5. Ibrahim D. Bori*, Jason M. Nolan, & Daniel L. Comins
(November 2004). Synthesis of Camptothecin Analogs 2004
Southeastern Regional Meeting of The American Chemical Society
(SERMACS 2004) and the Meeting of the Two-Year College
ChemistryCommittee (2YC3), Research Triangle Park, NC (Oral).
6. Ibrahim D. Bori*, Jason M. Nolan; & Daniel L. Comins
(September 2004). TotalAsymmetric Synthesis of Camptothecin Analogs
& Clinically Useful Compounds 3rd Pfizer Global Research &
Development (PGRD) Annual Symposium Celebrating Diversity in
Organic Chemistry, Groton, CT (Poster).
7. Ibrahim D. Bori*, Jason M. Nolan, & Daniel L. Comins
(June 2004). Synthesis of C-7 Camptothecin Analogs &
Biologically Active Compounds The National GEM Consortium 6th
Annual Future Faculty & Professionals Symposium, Las Vegas, NV
(Poster).
Professional References:
Professor Daniel L. Comins434 Dabney Hall, Department of
Chemistry.NC State University, Raleigh, NC 27695:
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Phone: (919)515-2911 Fax:(919) 515-9371Email:
[email protected]
Professor Wendell WilkersonChemistry DepartmentNorth Carolina
Central University, Durham, NC 27707Phone: (919)-530-5134 Fax:
(919)-530-5135Email: [email protected]
Professor K.H. LeeNatural Products Research LaboratoriesDivision
of Medicinal Chemistry & Natural ProductsUNC Eshelman School of
PharmacyChapel Hill, NC 27599Phone: 919-962-0066 Fax:
919-966-3893Email: [email protected]
