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2005 Medicinal chemistry V 1100 Discovery of Potent and Use-Dependent Sodium Channel Blockers for Treatment of Chronic Pain. — Compounds (I) and (II) show sodium-channel blocking activity. — (LIANG*, J.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 11, 2943-2947; Dep. Med. Chem., Merck Res. Lab., Rahway, NJ 07065, USA; Eng.) — C. Oppel 42- 239

Discovery of Potent and Use-Dependent Sodium Channel Blockers for Treatment of Chronic Pain

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2005

Medicinal chemistryV 1100 Discovery of Potent and Use-Dependent Sodium Channel Blockers for Treatment

of Chronic Pain. — Compounds (I) and (II) show sodium-channel blocking activity. — (LIANG*, J.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 11, 2943-2947; Dep. Med. Chem., Merck Res. Lab., Rahway, NJ 07065, USA; Eng.) — C. Oppel

42- 239