DIT Day 1 FlashCards

Embed Size (px)

Citation preview

  • 7/26/2019 DIT Day 1 FlashCards

    1/314

    What are the four "must

    know" Pharm equations?

  • 7/26/2019 DIT Day 1 FlashCards

    2/314

    1. Volume of Distribution2. Clearance

    3. Loading Dose4. Maintenance Dose

  • 7/26/2019 DIT Day 1 FlashCards

    3/314

    What is the equation for

    Volume of Distribution?

  • 7/26/2019 DIT Day 1 FlashCards

    4/314

    Vd= (amt drug given IV)/

    (drug plasma concentratio

  • 7/26/2019 DIT Day 1 FlashCards

    5/314

    What is the equation for

    Clearance?

  • 7/26/2019 DIT Day 1 FlashCards

    6/314

    Cl= (0.7 x Vd) / t1/2

  • 7/26/2019 DIT Day 1 FlashCards

    7/314

    What is the equation for

    loading dose?

  • 7/26/2019 DIT Day 1 FlashCards

    8/314

    LD= Css x Vd

  • 7/26/2019 DIT Day 1 FlashCards

    9/314

    What is the equation for

    maintenance dose?

  • 7/26/2019 DIT Day 1 FlashCards

    10/314

    MD= Css x Cl

  • 7/26/2019 DIT Day 1 FlashCards

    11/314

    What happens to a basic dr

    if the urine pH is low and le

    than the pKa?

  • 7/26/2019 DIT Day 1 FlashCards

    12/314

    The drug gets trapped in th

    urine.

  • 7/26/2019 DIT Day 1 FlashCards

    13/314

    What happens to an acidi

    drug if the urine pH is hig

    and more than the pKa?

  • 7/26/2019 DIT Day 1 FlashCards

    14/314

    The drug gets trapped in th

    urine.

  • 7/26/2019 DIT Day 1 FlashCards

    15/314

    What effects does the

    sympathetic nervous syste

    have on the heart? The

    parasympathetic nervous

    system effects?

  • 7/26/2019 DIT Day 1 FlashCards

    16/314

    Symp= increased HR &contractility

    Para= decreased HR &contractility (vagus nerve

  • 7/26/2019 DIT Day 1 FlashCards

    17/314

    What effects does the

    sympathetic nervous syste

    have on the eye? The

    parasympathetic nervous

    system effects?

  • 7/26/2019 DIT Day 1 FlashCards

    18/314

    Symp=mydriasis (dilatespupil)

    Para= miosis (constrictspupil)

  • 7/26/2019 DIT Day 1 FlashCards

    19/314

    What effects does the

    sympathetic nervous syste

    have on salivary glands? T

    parasympathetic nervous

    system effects?

  • 7/26/2019 DIT Day 1 FlashCards

    20/314

    Symp= viscous secretion

    Para= watery secretion

  • 7/26/2019 DIT Day 1 FlashCards

    21/314

    What effects does the sympathetinervous system have on bronchio

    smooth muscle? The

    parasympathetic nervous systemeffects?

  • 7/26/2019 DIT Day 1 FlashCards

    22/314

    Symp= relaxation

    Para= constriction

  • 7/26/2019 DIT Day 1 FlashCards

    23/314

    What effects does the

    sympathetic nervous syste

    have on the bladder? The

    parasympathetic nervous

    system effects?

  • 7/26/2019 DIT Day 1 FlashCards

    24/314

    Symp= prevents urinatio

    Para= urination

  • 7/26/2019 DIT Day 1 FlashCards

    25/314

    What effects does the

    sympathetic nervous syste

    have on the male GU? Th

    parasympathetic nervous

    system effects?

  • 7/26/2019 DIT Day 1 FlashCards

    26/314

    Symp= ejaculation

    Para= erection

  • 7/26/2019 DIT Day 1 FlashCards

    27/314

    What effects does the

    sympathetic nervous syste

    have on the GI tract? The

    parasympathetic nervous

    system effects?

  • 7/26/2019 DIT Day 1 FlashCards

    28/314

    Symp= decreased digestio

    smooth mm. relaxation,

    increased sphincter tone &

    decreased secretion

    Para= Opposite of above

  • 7/26/2019 DIT Day 1 FlashCards

    29/314

    What are the sx of excess

    parasympathetic activity

  • 7/26/2019 DIT Day 1 FlashCards

    30/314

    DUMBBELSS: Diarrhea, UrinatioMiosis, Bronchospasm, Bradycard

    Excitation (sk mm. & CNS),Lacrimation, Sweating, Salivation

  • 7/26/2019 DIT Day 1 FlashCards

    31/314

    What drugs can cause exce

    parasympathetic activity

  • 7/26/2019 DIT Day 1 FlashCards

    32/314

    1. Direct muscarinic agonists:

    Bethanechol, Pilocarpine,Carbechol, methacholine

    2. Anti-chonlinesterases:Neo/Pyrido/Physostigmine,

    Edrophonium, Echothiophate

  • 7/26/2019 DIT Day 1 FlashCards

    33/314

    What threeanticholinesterases used t

    treat Alzheimer's disease

  • 7/26/2019 DIT Day 1 FlashCards

    34/314

    DonepezilGalantamine

    Rivastigmine

  • 7/26/2019 DIT Day 1 FlashCards

    35/314

    What causes MyastheniaGravis? Symptoms? How is

    diagnosed?

  • 7/26/2019 DIT Day 1 FlashCards

    36/314

    1. Antibodies to Ach Receptors2. Common sx= ptosis or diplopli

    that worsens throughout the day

    3. Dx with edrphonium. If strengttemporarily increases.

  • 7/26/2019 DIT Day 1 FlashCards

    37/314

    What are 3 asssociatedpathologies for Myasthen

    Gravis?

  • 7/26/2019 DIT Day 1 FlashCards

    38/314

    1. Thymic hyperplasia2. Thymic atrophy

    3. Thymoma

  • 7/26/2019 DIT Day 1 FlashCards

    39/314

    What is Myasthenic crisis

    What is used to treat MG

  • 7/26/2019 DIT Day 1 FlashCards

    40/314

    1. Rapidly progressing weakness-

    respiratory difficulty

    2. Tx: Ach-esterase inhibitors

    (Pyridostigmine), CorticosteroidsThymectomy, Plasmapheresis

  • 7/26/2019 DIT Day 1 FlashCards

    41/314

    What drug regeneratesacetylcholinesterases afte

    organophosphate poisonin

  • 7/26/2019 DIT Day 1 FlashCards

    42/314

    Pralidoxime

  • 7/26/2019 DIT Day 1 FlashCards

    43/314

    What are the symptoms oinhibited parasympatheti

    activity?

  • 7/26/2019 DIT Day 1 FlashCards

    44/314

    Hot as a Hare; Dry as a bone; Reda beet; Blind as a bat; Mad as a

    hatter; Bloated as a toad;

    "The patient gets leaky everywher

  • 7/26/2019 DIT Day 1 FlashCards

    45/314

    What drugs inhibitparasympathetic activity a

    what is their use?

  • 7/26/2019 DIT Day 1 FlashCards

    46/314

    1. Atropine, hmoatropine, tropicamide,

    ipratroprium= eye

    2. Benztropine= CNS for Parkinson's

    3. Scopalomine= CNS motion sickness, end o

    to decrease secretions and control

    nausea/vomiting4. Ipratroprium= Lung for asthma and COPS

    5. Oxybutynin= GU for urge incontinence

  • 7/26/2019 DIT Day 1 FlashCards

    47/314

    What anticholinergics arused in the treatment of ur

    type urinary incontinence

  • 7/26/2019 DIT Day 1 FlashCards

    48/314

    OxybutyninTolterodine

    Darifenacin & SolifenacinTrospium

  • 7/26/2019 DIT Day 1 FlashCards

    49/314

    In what patientpopulations/disease is

    atropine contraindicated

  • 7/26/2019 DIT Day 1 FlashCards

    50/314

    Glaucoma

    BPHGI obstruction

    DementiaInfant with fever

  • 7/26/2019 DIT Day 1 FlashCards

    51/314

    What other medications ha

    anticholinergic side effect

  • 7/26/2019 DIT Day 1 FlashCards

    52/314

    1. 1st generation H1 blockers:

    benadryl, doxylamine (Unisom),chlorpheniramine

    2. Traditional neuroleptics

    3. TCA's

    4. Amantadine

  • 7/26/2019 DIT Day 1 FlashCards

    53/314

    Name 3 direct cholinergi

    agonists.

  • 7/26/2019 DIT Day 1 FlashCards

    54/314

    PilocarpineBethanechol

    Carbechol

  • 7/26/2019 DIT Day 1 FlashCards

    55/314

    Name 7 anti-Ach-esterase

  • 7/26/2019 DIT Day 1 FlashCards

    56/314

    Physostigmine, Neostigmine,

    PyridostigmineEchothiophate

    Edrophonium

    Donepezil & Rivastigmine

    (Alzheimer's)

  • 7/26/2019 DIT Day 1 FlashCards

    57/314

    Name 9 anti-muscarinic

    drugs.

    Oxybutynin

  • 7/26/2019 DIT Day 1 FlashCards

    58/314

    Oxybutynin

    Atropine

    DarifenacinIpratropium

    Tropicamide

    Benztropine

    Scopalomine

    Tolteridine

    Trospium

  • 7/26/2019 DIT Day 1 FlashCards

    59/314

    Name the cholinesterase

    regenerator.

  • 7/26/2019 DIT Day 1 FlashCards

    60/314

    Pralidoxime

  • 7/26/2019 DIT Day 1 FlashCards

    61/314

    A gardener presents withSOB, salivation, miosis an

    diarrhea. What caused thiand what is the MOA?

  • 7/26/2019 DIT Day 1 FlashCards

    62/314

    1. Cause= parathion/

    organophosphate poisoning2. MOA= increased parasympath

    stimulation by inhibiting Ach-

    esterase--> Muscarinic receptor

    stimulation

  • 7/26/2019 DIT Day 1 FlashCards

    63/314

    Atropine is not effective ireversal of organophospha

    poisoning. What drug woubest help this patient?

  • 7/26/2019 DIT Day 1 FlashCards

    64/314

    Parlidoxime (Tupam) to

    regenerate Ach-esterase

  • 7/26/2019 DIT Day 1 FlashCards

    65/314

    What drug would helpimprove FEV1 in a patien

    with COPD?

  • 7/26/2019 DIT Day 1 FlashCards

    66/314

    Ipratropium

    h

  • 7/26/2019 DIT Day 1 FlashCards

    67/314

    A 30yo patient with

    schizophrenia now hasurinary retention due to h

    neuroleptic drug. What dyou treat it with?

  • 7/26/2019 DIT Day 1 FlashCards

    68/314

    Bethanechol

  • 7/26/2019 DIT Day 1 FlashCards

    69/314

    In the dark, both pupils are dilate

    In the light, the control pupil is

    miotic with the pupil given drug X

    remains mydriatic. What type ofdrug is drug X?

  • 7/26/2019 DIT Day 1 FlashCards

    70/314

    Pilocarpine, muscarinicantagonist, anti-cholinerg

    drug or a sympathetic

    agonist.

  • 7/26/2019 DIT Day 1 FlashCards

    71/314

    What toxin stimulates Acrelease from presynaptic

    cholinergic neurons?

    inhibits?

  • 7/26/2019 DIT Day 1 FlashCards

    72/314

    Stimulates= Black widowtoxin

    Inhibits= Botulinum

    Wh t i th l

  • 7/26/2019 DIT Day 1 FlashCards

    73/314

    What is the general

    byproduct of phase Imetabolism and what

    reactions take place durinthis phase?

  • 7/26/2019 DIT Day 1 FlashCards

    74/314

    1. Byproduct- generally yields

    slightly polar water-soluble

    metabolites that may still be activ

    2. Reduction, oxidation & hydrolyreactions (cyto P450)

    Wh t i th l

  • 7/26/2019 DIT Day 1 FlashCards

    75/314

    What is the general

    byproduct of phase IImetabolism and what

    reactions take place durinthis phase?

  • 7/26/2019 DIT Day 1 FlashCards

    76/314

    1. Usually yields very polar inactivemtabolites that are renally excre

    2. acetylation, glucouronidation,

    sulfation (conjugations)

  • 7/26/2019 DIT Day 1 FlashCards

    77/314

    What phase of livermetabolism do geriatric

    patients tend to lose first

  • 7/26/2019 DIT Day 1 FlashCards

    78/314

    Phase I metabolism

  • 7/26/2019 DIT Day 1 FlashCards

    79/314

    What questions are askedduring the 4 clinical phase

    of drug development?

    Phase 1 Is it safe

  • 7/26/2019 DIT Day 1 FlashCards

    80/314

    Phase 1- Is it safe

    Phase 2- Does it workPhase 3- Is it more effectiv

    Phase 4- Long-termmonitoring

  • 7/26/2019 DIT Day 1 FlashCards

    81/314

    Name 5 drugs that inhibiAch-esterase and the clinic

    application for each drug

  • 7/26/2019 DIT Day 1 FlashCards

    82/314

    1. Edrophonium- to dx Myasthenia Gravis

    (tensilon test)2. Neostigmine- post-op ileus reversal & post

    NM blockade reversal, urinary retention

    3. Pyridostigmine- Myasthenia Gravis

    4. Physostigmine- Glaucoma and Atropine O

    5. Echothiophate- Glaucoma

  • 7/26/2019 DIT Day 1 FlashCards

    83/314

    What are the various clinic

    applications of atropine?

    1 Eye= to dilate and cycloplegia

  • 7/26/2019 DIT Day 1 FlashCards

    84/314

    1. Eye= to dilate and cycloplegia

    2. Airway= decrease secretion(anesthesia)

    3. Bladder= decrease bladder

    spasms4. Organophosphate poisoning

  • 7/26/2019 DIT Day 1 FlashCards

    85/314

    What G-protein classes dalpha and beta receptors

    stimulate?

  • 7/26/2019 DIT Day 1 FlashCards

    86/314

    alpha-1= Gq

    alpha-2= Gi

    Beta-1= Gs

    Beta-2= Gs

  • 7/26/2019 DIT Day 1 FlashCards

    87/314

    What G-protein classes tomuscarinic and dopamin

    receptors stimulate?

    M1= Gq

  • 7/26/2019 DIT Day 1 FlashCards

    88/314

    M1= Gq

    M2- GiM3- Gq

    D1- GsD2- Gi

    How many half-lives does i

  • 7/26/2019 DIT Day 1 FlashCards

    89/314

    How many half-lives does i

    take for a drug infused at aconstant rate to reach 94%

    steady state? What variabledetermine the t1/2?

  • 7/26/2019 DIT Day 1 FlashCards

    90/314

    1. 4 half lives

    2. Vd & Clearance

  • 7/26/2019 DIT Day 1 FlashCards

    91/314

    How does Hexamethoniu

    affect BP, CO, Urine outpu

    the eye and GI motility? Ho

    does it affect heart rate?

  • 7/26/2019 DIT Day 1 FlashCards

    92/314

    1. It decreases BP, CO, Urin

    output, GI motility and

    causes mydriasis

    2. It increases Heart Rate

  • 7/26/2019 DIT Day 1 FlashCards

    93/314

    Which receptors are

    stimulated by Clonidine?

  • 7/26/2019 DIT Day 1 FlashCards

    94/314

    alpha-2

  • 7/26/2019 DIT Day 1 FlashCards

    95/314

    Which receptors are

    stimulated by dopamine?

  • 7/26/2019 DIT Day 1 FlashCards

    96/314

    D1=D2

  • 7/26/2019 DIT Day 1 FlashCards

    97/314

    Which receptors arestimulated by

    phenylephrine?

  • 7/26/2019 DIT Day 1 FlashCards

    98/314

    alpha-1 > alpha-2

  • 7/26/2019 DIT Day 1 FlashCards

    99/314

    Which receptors arestimulated by albuterol an

    terbutaline?

  • 7/26/2019 DIT Day 1 FlashCards

    100/314

    Beta-2

  • 7/26/2019 DIT Day 1 FlashCards

    101/314

    Which receptors are

    stimulated by norepi?

  • 7/26/2019 DIT Day 1 FlashCards

    102/314

    alpha-1/alpha-2 > B1

  • 7/26/2019 DIT Day 1 FlashCards

    103/314

    Which receptors are

    stimulated by isoprotereno

  • 7/26/2019 DIT Day 1 FlashCards

    104/314

    Beta-1 = Beta-2

  • 7/26/2019 DIT Day 1 FlashCards

    105/314

    Which receptors are

    stimulated by epinephrine

  • 7/26/2019 DIT Day 1 FlashCards

    106/314

    All alpha and Betas

  • 7/26/2019 DIT Day 1 FlashCards

    107/314

    Which receptors are

    stimulated by dobutamine

  • 7/26/2019 DIT Day 1 FlashCards

    108/314

    Beta-1 > Beta-2

  • 7/26/2019 DIT Day 1 FlashCards

    109/314

    Which sympathomimetic given as a nebulizer for

    asthma?

  • 7/26/2019 DIT Day 1 FlashCards

    110/314

    Albuterol and epi (in extrem

    cases)

  • 7/26/2019 DIT Day 1 FlashCards

    111/314

    Which sympathomimetic the drug of choice for

    anaphylaxis?

  • 7/26/2019 DIT Day 1 FlashCards

    112/314

    Epinephrine

    Which sympathomimetic

  • 7/26/2019 DIT Day 1 FlashCards

    113/314

    Which sympathomimetic

    the most common first lin

    agent for pts in cardiogen

    shock?

  • 7/26/2019 DIT Day 1 FlashCards

    114/314

    Dobutamine

  • 7/26/2019 DIT Day 1 FlashCards

    115/314

    Which sympathomimetic most common first line age

    for pts in septic shock?

  • 7/26/2019 DIT Day 1 FlashCards

    116/314

    NE

  • 7/26/2019 DIT Day 1 FlashCards

    117/314

    Which sympathomimetic

    given subQ for asthma?

  • 7/26/2019 DIT Day 1 FlashCards

    118/314

    Terbutaline

  • 7/26/2019 DIT Day 1 FlashCards

    119/314

    Which sympathomimetic used by ENT to vasoconstr

    nasal vessels?

  • 7/26/2019 DIT Day 1 FlashCards

    120/314

    Cocaine or phenylphrine

  • 7/26/2019 DIT Day 1 FlashCards

    121/314

    Which sympathomimetic

    used to tx ADHD?

  • 7/26/2019 DIT Day 1 FlashCards

    122/314

    Amphetamine

    Which of the following dru

  • 7/26/2019 DIT Day 1 FlashCards

    123/314

    Which of the following dru

    would be most appropriate

    a pt in shock because it

    maintains renal blood flow

  • 7/26/2019 DIT Day 1 FlashCards

    124/314

    Dopamine

  • 7/26/2019 DIT Day 1 FlashCards

    125/314

    Outline the flow of aqueou

    humor.

    Formed in capillary bed of ciliary

    bod > secreted into posterior

  • 7/26/2019 DIT Day 1 FlashCards

    126/314

    body-> secreted into posterior

    chamber-> flows between the ang

    of lens and iris diaphragm->

    anterior chamber-> reabsorbed bcanal of Schlemm

  • 7/26/2019 DIT Day 1 FlashCards

    127/314

    What is the pathogenesis

    glaucoma?

    Blocked canal of Schlemm

  • 7/26/2019 DIT Day 1 FlashCards

    128/314

    aqueous humor notreabsorbed-> increased

    pressure-> atrophy of optnerve

  • 7/26/2019 DIT Day 1 FlashCards

    129/314

    What is Open angle

    glaucoma? Risk factors?

    1. Common, insidious form

  • 7/26/2019 DIT Day 1 FlashCards

    130/314

    ,

    almost always bilateral

    2. Risks- >40yo, black,

    diabetes

  • 7/26/2019 DIT Day 1 FlashCards

    131/314

    What are the sx in the earstage of Open angle

    glaucoma? Late stage?

    Early= asymptomatic

  • 7/26/2019 DIT Day 1 FlashCards

    132/314

    Late= areas ofreduced/absent vision,

    contraction of visual fieldfrom peripheral->centra

  • 7/26/2019 DIT Day 1 FlashCards

    133/314

    What is acute angle-closuglaucoma? Symptoms?

    It's an emergency.

    Sx= abrupt onset of pain, nausea,

  • 7/26/2019 DIT Day 1 FlashCards

    134/314

    colored halos and rainbows arounlight

    Signs= red, teary eye with hazy

    cornea, fixed mid-dilated pupil tha

    film to palpation

  • 7/26/2019 DIT Day 1 FlashCards

    135/314

    How is glaucoma diagnose

    Via tonometry;

  • 7/26/2019 DIT Day 1 FlashCards

    136/314

    y;

    Opthalmoscopy with cuppiof optic disc (cup:disc rati

    >1:2)

    A 60yo male has a hard tim

  • 7/26/2019 DIT Day 1 FlashCards

    137/314

    y

    driving at night because oeye pain with oncoming

    headlights. What is the dx

  • 7/26/2019 DIT Day 1 FlashCards

    138/314

    Cataracts

  • 7/26/2019 DIT Day 1 FlashCards

    139/314

    What drug category ends inane?

  • 7/26/2019 DIT Day 1 FlashCards

    140/314

    Inhaled anesthetics

  • 7/26/2019 DIT Day 1 FlashCards

    141/314

    What drug category ends inazine?

  • 7/26/2019 DIT Day 1 FlashCards

    142/314

    Neuroleptics/ Anti-emetic

  • 7/26/2019 DIT Day 1 FlashCards

    143/314

    What drug category ends inbarbital?

  • 7/26/2019 DIT Day 1 FlashCards

    144/314

    Barbiturates

  • 7/26/2019 DIT Day 1 FlashCards

    145/314

    What drug category ends incillin?

  • 7/26/2019 DIT Day 1 FlashCards

    146/314

    Penicillins

  • 7/26/2019 DIT Day 1 FlashCards

    147/314

    What drug category ends inipramine?

  • 7/26/2019 DIT Day 1 FlashCards

    148/314

    TCA's

  • 7/26/2019 DIT Day 1 FlashCards

    149/314

    What drug category ends iolol?

  • 7/26/2019 DIT Day 1 FlashCards

    150/314

    Beta blockers

  • 7/26/2019 DIT Day 1 FlashCards

    151/314

    What drug category ends inoxin?

  • 7/26/2019 DIT Day 1 FlashCards

    152/314

    Cardiac glycosides (inotropagents)

  • 7/26/2019 DIT Day 1 FlashCards

    153/314

    What drug category ends inpril?

  • 7/26/2019 DIT Day 1 FlashCards

    154/314

    ACE inhibitors

  • 7/26/2019 DIT Day 1 FlashCards

    155/314

    What drug category ends intidine?

  • 7/26/2019 DIT Day 1 FlashCards

    156/314

    H2 antagonists

  • 7/26/2019 DIT Day 1 FlashCards

    157/314

    What drug category ends intropin?

  • 7/26/2019 DIT Day 1 FlashCards

    158/314

    Pituitary hormones

  • 7/26/2019 DIT Day 1 FlashCards

    159/314

    What drug category ends indronate?

  • 7/26/2019 DIT Day 1 FlashCards

    160/314

    Bisphosphonates forosteoporosis

  • 7/26/2019 DIT Day 1 FlashCards

    161/314

    What drug category ends inchol?

  • 7/26/2019 DIT Day 1 FlashCards

    162/314

    Cholinesterase inhibitors

  • 7/26/2019 DIT Day 1 FlashCards

    163/314

    What drug category ends inmustine?

  • 7/26/2019 DIT Day 1 FlashCards

    164/314

    Notrosurea (crosses BBB ttx brain tumors)

  • 7/26/2019 DIT Day 1 FlashCards

    165/314

    What drug category ends instatin?

    d

  • 7/26/2019 DIT Day 1 FlashCards

    166/314

    HMG-CoA reductaseinhibitors

    h d d i

  • 7/26/2019 DIT Day 1 FlashCards

    167/314

    What drug category ends inbendazole?

    i h l i h

  • 7/26/2019 DIT Day 1 FlashCards

    168/314

    Anti-helminths

    h d d i

  • 7/26/2019 DIT Day 1 FlashCards

    169/314

    What drug category ends inazepam?

    B

  • 7/26/2019 DIT Day 1 FlashCards

    170/314

    Benzos

    Wh d d i

  • 7/26/2019 DIT Day 1 FlashCards

    171/314

    What drug category ends inazole?

    A i f l

  • 7/26/2019 DIT Day 1 FlashCards

    172/314

    Anti-fungals

    Wh d d i

  • 7/26/2019 DIT Day 1 FlashCards

    173/314

    What drug category ends incaine?

    L l th ti

  • 7/26/2019 DIT Day 1 FlashCards

    174/314

    Local anesthetics

    Wh t d t d i

  • 7/26/2019 DIT Day 1 FlashCards

    175/314

    What drug category ends incycline?

    A tibi ti ( t i th

  • 7/26/2019 DIT Day 1 FlashCards

    176/314

    Antibiotics (protein syntheinhibitors)

    Wh t d t d i

  • 7/26/2019 DIT Day 1 FlashCards

    177/314

    What drug category ends innavir?

    P t i hibit

  • 7/26/2019 DIT Day 1 FlashCards

    178/314

    Protease inhibitors

    Wh t d t d i

  • 7/26/2019 DIT Day 1 FlashCards

    179/314

    What drug category ends inoperidol?

    H ld l/ l ti

  • 7/26/2019 DIT Day 1 FlashCards

    180/314

    Haldol/neuroleptics

    Wh t d t d i

  • 7/26/2019 DIT Day 1 FlashCards

    181/314

    What drug category ends inphylline?

    Meth l anthines

  • 7/26/2019 DIT Day 1 FlashCards

    182/314

    Methylxanthines

    What drug category ends in

  • 7/26/2019 DIT Day 1 FlashCards

    183/314

    What drug category ends interol?

    Beta 2 agonist

  • 7/26/2019 DIT Day 1 FlashCards

    184/314

    Beta-2 agonist

    What drug category ends in

  • 7/26/2019 DIT Day 1 FlashCards

    185/314

    What drug category ends intriptyline?

    TCA's

  • 7/26/2019 DIT Day 1 FlashCards

    186/314

    TCA s

    What drug category ends in

  • 7/26/2019 DIT Day 1 FlashCards

    187/314

    What drug category ends inzosin?

    Alpha 1 antagonists

  • 7/26/2019 DIT Day 1 FlashCards

    188/314

    Alpha-1 antagonists

    What drug category ends in

  • 7/26/2019 DIT Day 1 FlashCards

    189/314

    What drug category ends insartan?

    Angiotensin II receptor

  • 7/26/2019 DIT Day 1 FlashCards

    190/314

    Angiotensin-II receptorantagonist

    What drug category ends in

  • 7/26/2019 DIT Day 1 FlashCards

    191/314

    What drug category ends instigmine?

    Anti cholinesterase

  • 7/26/2019 DIT Day 1 FlashCards

    192/314

    Anti-cholinesterase

    What drug category ends in

  • 7/26/2019 DIT Day 1 FlashCards

    193/314

    What drug category ends incurium/curonium?

    Non-depolarizing NM

  • 7/26/2019 DIT Day 1 FlashCards

    194/314

    Non-depolarizing NMblockers

    What drug category ends in

  • 7/26/2019 DIT Day 1 FlashCards

    195/314

    What drug category ends inglitazone?

    Diabetes drugs that increa

  • 7/26/2019 DIT Day 1 FlashCards

    196/314

    Diabetes drugs that increatarget cell response to insu

    What drug category ends in

  • 7/26/2019 DIT Day 1 FlashCards

    197/314

    What drug category ends indipine?

    Calcium channel blocker

  • 7/26/2019 DIT Day 1 FlashCards

    198/314

    Calcium channel blocker

    What does the proximal

    radial nerve innervate an

  • 7/26/2019 DIT Day 1 FlashCards

    199/314

    radial nerve innervate anwhat is seen if this nerve i

    damaged?

    1. Triceps and skin of posterior ar

    2. Damage-> cannot extend

  • 7/26/2019 DIT Day 1 FlashCards

    200/314

    2. Damage > cannot extendforearm, lose triceps reflex and w

    drop

    What is innervated by the

    deep branch of the radia

  • 7/26/2019 DIT Day 1 FlashCards

    201/314

    deep branch of the radianerve and what is seen if th

    nerve is damaged?

    1. BEST muscles: Brachioradialis,Extensors of wrist and fingers,

    Supinator and Triceps, abductor

    pollicus longus skin of post forea

  • 7/26/2019 DIT Day 1 FlashCards

    202/314

    pollicus longus, skin of post. forea

    2. loss of brachioradialis reflex, wr

    drop, loss of sensation of posteriorforearm

    What is innervated by the

    superficial branch of the

  • 7/26/2019 DIT Day 1 FlashCards

    203/314

    superficial branch of theradial nerve and what is se

    if this nerve is damaged?

    1. Skin of lateral and

    posterior hand

  • 7/26/2019 DIT Day 1 FlashCards

    204/314

    posterior hand2. loss of sensation of later

    and posterior hand

    What is Saturday Night

  • 7/26/2019 DIT Day 1 FlashCards

    205/314

    What is Saturday NightPalsy?

    Radial nerve compression against spiral groove of the humerus-> we

    wrist and finger extension, weak

    brachioradialis reflex but normal

  • 7/26/2019 DIT Day 1 FlashCards

    206/314

    brachioradialis reflex, but normal

    triceps. From passing out with you

    arms over the back of a chair orbench.

    What is innervated by the

    ulnar nerve and what is se

  • 7/26/2019 DIT Day 1 FlashCards

    207/314

    ulnar nerve and what is se

    if this nerve is damaged?

    1. Flexor carpi ulnaris and the

    medial 1/2 of flexor digitorum

    profundus & lumbricles (PAD/DAdd

  • 7/26/2019 DIT Day 1 FlashCards

    208/314

    p ( /2. CLAW HAND, cannot adduct

    thumb, cannot ab/aduct fingers a

    loss of sensation of medial hand

    What is innervated by the

    median nerve and what i

  • 7/26/2019 DIT Day 1 FlashCards

    209/314

    median nerve and what iseen if this nerve is

    damaged?

    1. Flexor muscles, thumb muscles

    and pronators

    2. Loss of pronation, wrist flexionA O C O A

  • 7/26/2019 DIT Day 1 FlashCards

    210/314

    p ,HAND OF BENEDICTION, APE

    HAND, loss of sensation on latera

    palm and distal first 3.5 digits

    What is carpal tunneld

  • 7/26/2019 DIT Day 1 FlashCards

    211/314

    What is carpal tunnelsyndrome?

    Median nerve entrapment at the

    carpal tunnel (enclosed by inelastfl i l ll d

  • 7/26/2019 DIT Day 1 FlashCards

    212/314

    p yflexor retinaculum ventrally and t

    carpal bones dorsally.

    An elderly woman with chronicosteoarthritis and diffuse pain now

    presents with numbness and tingli

    over the lateral digits of her right

  • 7/26/2019 DIT Day 1 FlashCards

    213/314

    g g

    hand that sometimes radiated up t

    the elbow. Exam reveals wasting othe thenar eminence. What is the d

    Carpal tunnel syndrome

  • 7/26/2019 DIT Day 1 FlashCards

    214/314

    C p y

    What is innervated by the

    musculocutaneous nerve ah i if hi i

  • 7/26/2019 DIT Day 1 FlashCards

    215/314

    what is seen if this nerve i

    damaged?

    1. Biceps, brachialis,

    coracobrachialis and skin of later

    forearm2 W k d f fl i

  • 7/26/2019 DIT Day 1 FlashCards

    216/314

    2. Weak arm and forearm flexion

    and weak supination and loss of

    sensation of the lateral forearm

    What nerve is damaged wh

    a patient presents with clah d? A h d? W i t

  • 7/26/2019 DIT Day 1 FlashCards

    217/314

    p phand? Ape hand? Wrist

    drop? Scapular winging?

    1. Claw hand= ulnar nerve

    2. Ape hand= median nerv

    3. Wrist drop= radial nerve

  • 7/26/2019 DIT Day 1 FlashCards

    218/314

    3 p

    4. Scapular winging= long

    thoracic n. (serratus anteri

    What nerve is damaged when a

    patient presents with the inability

    wipe butt? Loss of forearm

  • 7/26/2019 DIT Day 1 FlashCards

    219/314

    p

    pronation? Cannot ab- or adduct

    fingers? Loss of arm abduction?

    1. Wipe butt= Thoracodors

    nerve (lats dorsi)2 F ti

  • 7/26/2019 DIT Day 1 FlashCards

    220/314

    ( )2. Forearm pronation=

    median nerve

  • 7/26/2019 DIT Day 1 FlashCards

    221/314

    1. Lateral rotation= suprascapula

    nerve

    2. Arm/forearm flexion=

  • 7/26/2019 DIT Day 1 FlashCards

    222/314

    musculocutaneous nerve

    3. Forearm extension= radial ner

    What nerve is damaged when a

    patient presents with trouble

    initiating arm abduction? Inabilitto abduct arm beyond 10 degrees

  • 7/26/2019 DIT Day 1 FlashCards

    223/314

    to abduct arm beyond 10 degrees

    Inability to raise arm above

    horizontal?

    1. Initiate arm abduction= Suprascapul

    nerve (supraspinatus m)

    2. Arm abduction >10 degrees= Axillar

    nerve (deltoid m)

  • 7/26/2019 DIT Day 1 FlashCards

    224/314

    3. Raise arm above horizontal= Long

    thoracic nerve (serratus ant) + spinal

    accessory nerve (trapezius m)

    What nerve runs with theposterior circumflex artery

  • 7/26/2019 DIT Day 1 FlashCards

    225/314

    posterior circumflex artery

    Axillary nerve

  • 7/26/2019 DIT Day 1 FlashCards

    226/314

    y

    What nerve runs with thedeep brachial artery?

  • 7/26/2019 DIT Day 1 FlashCards

    227/314

    deep brachial artery?

    Radial nerve

  • 7/26/2019 DIT Day 1 FlashCards

    228/314

    What nerve runs with thebrachial artery?

  • 7/26/2019 DIT Day 1 FlashCards

    229/314

    brachial artery?

    Median nerve

  • 7/26/2019 DIT Day 1 FlashCards

    230/314

    What nerve runs with the

    posterior interosseous

  • 7/26/2019 DIT Day 1 FlashCards

    231/314

    artery?

    Deep branch of the radianerve

  • 7/26/2019 DIT Day 1 FlashCards

    232/314

    nerve

    What nerve is most at risk

    injury with a fracture to th

  • 7/26/2019 DIT Day 1 FlashCards

    233/314

    shaft of the humerus?

    Radial nerve

  • 7/26/2019 DIT Day 1 FlashCards

    234/314

    What nerve is most at risk

    injury with a fracture to thsurgical neck of the

  • 7/26/2019 DIT Day 1 FlashCards

    235/314

    surgical neck of the

    humerus?

    Axillary artery

  • 7/26/2019 DIT Day 1 FlashCards

    236/314

    What nerve is most at risk

    injury with a fracture to thsupracondyle of the

  • 7/26/2019 DIT Day 1 FlashCards

    237/314

    supracondyle of the

    humerus?

    Median nerve

  • 7/26/2019 DIT Day 1 FlashCards

    238/314

    What nerve is most at risk

    injury with a fracture to thdi l i d l

  • 7/26/2019 DIT Day 1 FlashCards

    239/314

    medial epicondyle?

    Ulnar nerve

  • 7/26/2019 DIT Day 1 FlashCards

    240/314

    What nerve is most at risk

    injury with an anteriorh ld di l i ?

  • 7/26/2019 DIT Day 1 FlashCards

    241/314

    shoulder dislocation?

    Axillary nerve

  • 7/26/2019 DIT Day 1 FlashCards

    242/314

    What nerve is most at risk

    injury with injury to thel l?

  • 7/26/2019 DIT Day 1 FlashCards

    243/314

    carpal tunnel?

    Median nerve

  • 7/26/2019 DIT Day 1 FlashCards

    244/314

    A gymnast sustains an

    anterior shoulder dislocatioWhat nerve is most likely

  • 7/26/2019 DIT Day 1 FlashCards

    245/314

    y

    have been injured?

    Axillary nerve (+ posteriocircumflex artery)

  • 7/26/2019 DIT Day 1 FlashCards

    246/314

    y)

    An adolescent falls while

    skateboarding and injures his elb

    He can't feel the medial part of hipalm Which nerve is damaged an

  • 7/26/2019 DIT Day 1 FlashCards

    247/314

    palm. Which nerve is damaged an

    what is the injury?

    Ulnar nerve and medial

    epicondyle fracture ofh

  • 7/26/2019 DIT Day 1 FlashCards

    248/314

    humerus

    A high-school athlete falls on hisarm during practice. In the ER a

    radiograph shows a mid-shaft breof the humerus. Which nerve and

  • 7/26/2019 DIT Day 1 FlashCards

    249/314

    which artery have the highest risk

    being damaged?

    Radial nerve and deepbrachial artery

  • 7/26/2019 DIT Day 1 FlashCards

    250/314

    y

    What are the 5 classes ofdrugs used to tx glaucoma

  • 7/26/2019 DIT Day 1 FlashCards

    251/314

    g g

    1. alpha agonists (Epi, brimonidine)2. beta-blockers (-olol)

    3. Diuretics (CA inhibitors, mannitol)

    4. Cholinomimetics (pilocarpine,carbachol, physostigimine, echothiopha

  • 7/26/2019 DIT Day 1 FlashCards

    252/314

    , p y g , p

    5. Prostaglandins (latanaprost=

    PFF2alpha)

    How does blood pressure response

    phenylephrine administration cha

    if an alpha-blocker is administeredbefore hand? Why is this different

    h h h h i i

  • 7/26/2019 DIT Day 1 FlashCards

    253/314

    than the change seen when epi is

    used rather than phenylephrine?

    With PE+alpha-agonist, BP is

    suppressed but not reversed

    With Epi+ alpha agonist, there is net decrease in BP because of

  • 7/26/2019 DIT Day 1 FlashCards

    254/314

    net decrease in BP because of

    unopposed beta-2 action

    What are common sideeffects of beta-blockers?

  • 7/26/2019 DIT Day 1 FlashCards

    255/314

    Impotence, asthma

    exacerbation, sedation, slealterations, Bradycardia an

  • 7/26/2019 DIT Day 1 FlashCards

    256/314

    AV block

    Which pt populations shou

    use caution when takingbeta blockers?

  • 7/26/2019 DIT Day 1 FlashCards

    257/314

    beta-blockers?

    1. Diabetics-masks sx of hypoglycemia

    2. Asthmatics- only if non-selective is u

    3. Heart block or on calcium channelblockers

    4 Pt with Pheochromocytoma

  • 7/26/2019 DIT Day 1 FlashCards

    258/314

    4. Pt with Pheochromocytoma

    5. Cocaine abusers

    What are the various clinic

    uses for thesympathomimetic

  • 7/26/2019 DIT Day 1 FlashCards

    259/314

    dopamine?

    Hypovolemic shock andheart failure

  • 7/26/2019 DIT Day 1 FlashCards

    260/314

    What are the various clinic

    uses for thesympathomimetic clonidin

  • 7/26/2019 DIT Day 1 FlashCards

    261/314

    sympathomimetic clonidin

    HTN in renal disease

  • 7/26/2019 DIT Day 1 FlashCards

    262/314

    What are the various clinic

    uses for thesympathomimetic

  • 7/26/2019 DIT Day 1 FlashCards

    263/314

    amphetamine?

    ADD/ADHD, narcolepsy a

    depression (while waiting fSSRI to kick in)

  • 7/26/2019 DIT Day 1 FlashCards

    264/314

    SSRI to kick in)

    What are the various clinic

    uses for thesympathomimetic

  • 7/26/2019 DIT Day 1 FlashCards

    265/314

    terbutaline?

    Tocolysis to prevent

    premature uterinecontractions and subQ in

  • 7/26/2019 DIT Day 1 FlashCards

    266/314

    asthma

    What are the various clinic

    uses for thesympathomimetic

  • 7/26/2019 DIT Day 1 FlashCards

    267/314

    epinephrine?

    Anaphylaxis, use with loca

    anesthetics forvasoconstriction, Open ang

    l

  • 7/26/2019 DIT Day 1 FlashCards

    268/314

    glaucoma

    What pathology is associat

    with the following key wordbilateral hilar

    l h d h

  • 7/26/2019 DIT Day 1 FlashCards

    269/314

    lymphadenopathy?

    Sarcoidosis

  • 7/26/2019 DIT Day 1 FlashCards

    270/314

    What pathologies are

    associated with the followi

    key words: cherry-red spo

    l ?

  • 7/26/2019 DIT Day 1 FlashCards

    271/314

    on macula?

    Tay-Sachs

    Niemann-Pick's

    Central retinal artery

    l i

  • 7/26/2019 DIT Day 1 FlashCards

    272/314

    occlusion

    What pathology is associat

    with the following key

    words:slapped cheeks ras

    hild?

  • 7/26/2019 DIT Day 1 FlashCards

    273/314

    on a child?

    Fifth's disease/ Parvo B-1

  • 7/26/2019 DIT Day 1 FlashCards

    274/314

    What pathology is associat

    with the following key

    words:organism from dog

    t bit ?

  • 7/26/2019 DIT Day 1 FlashCards

    275/314

    cat bite?

    Pasturella multocida

  • 7/26/2019 DIT Day 1 FlashCards

    276/314

    What pathology is associat

    with the following key word

    facial muscle spasm upon

    t i th h k?

  • 7/26/2019 DIT Day 1 FlashCards

    277/314

    tapping the cheek?

    Chvostek's sign for

    hypocalcemia

  • 7/26/2019 DIT Day 1 FlashCards

    278/314

    What pathology is associat

    with the following key wordcough, conjunctivitis, coryz

  • 7/26/2019 DIT Day 1 FlashCards

    279/314

    g , j , y

    Measles

  • 7/26/2019 DIT Day 1 FlashCards

    280/314

    What pathology is associat

    with the following key word

    nephritis, hearing loss,

    cataracts?

  • 7/26/2019 DIT Day 1 FlashCards

    281/314

    cataracts?

    Alport's Syndrome (Type I

    collagen mutation) "Can'see, Can't pee, Can't hear

  • 7/26/2019 DIT Day 1 FlashCards

    282/314

    What primary hormone i

    increased or decreased inCushing's syndrome?

  • 7/26/2019 DIT Day 1 FlashCards

    283/314

    Increased cortisol

  • 7/26/2019 DIT Day 1 FlashCards

    284/314

    What primary hormone i

    increased or decreased inConn's syndrome?

  • 7/26/2019 DIT Day 1 FlashCards

    285/314

    Increased aldosterone

  • 7/26/2019 DIT Day 1 FlashCards

    286/314

    What primary hormone i

    increased or decreased inAddison's disease?

  • 7/26/2019 DIT Day 1 FlashCards

    287/314

    Decreased aldosterone an

    cortisol

  • 7/26/2019 DIT Day 1 FlashCards

    288/314

    What primary hormone i

    increased or decreased inGrave's disease?

  • 7/26/2019 DIT Day 1 FlashCards

    289/314

    Decreased TSH, Increase

    T3/4

  • 7/26/2019 DIT Day 1 FlashCards

    290/314

    What is the function of

    MacConkey's agar?

  • 7/26/2019 DIT Day 1 FlashCards

    291/314

    Selective medium for Gram

    ) and lactose ermenters

  • 7/26/2019 DIT Day 1 FlashCards

    292/314

    Your patient has facialangiofibroma, ash-leaf spots of sk

    depigmentation, hx of seizures an

    MR. What condition does this pt

    have? What neoplasms is this pt a

  • 7/26/2019 DIT Day 1 FlashCards

    293/314

    risk of developing?

    Dx= Tuberous Sclerosis

    Risk= Cardiac

    rhabdomyoma, astrocytom

    and angiomyolipoma

  • 7/26/2019 DIT Day 1 FlashCards

    294/314

    and angiomyolipoma

    What is the cause of

    achalasia? How is it dx?

  • 7/26/2019 DIT Day 1 FlashCards

    295/314

    Loss of myenteric/Auerba

    plexus

    Dx= Barium swallow with

    bird's beak or manometr

  • 7/26/2019 DIT Day 1 FlashCards

    296/314

    bird s beak or manometr

    Compare the leading COD

    ages 15-24 to those in age25-64.

  • 7/26/2019 DIT Day 1 FlashCards

    297/314

    15-24= Injuries, homicide

    suicide, cancer, heart dz

    25-64= Cancer, heart dz

    injuries, suicide, stroke

  • 7/26/2019 DIT Day 1 FlashCards

    298/314

    injuries, suicide, stroke

    In which glomerular disea

    would you expect to see th

    following changes: anti-GM

    Abs on IF?

  • 7/26/2019 DIT Day 1 FlashCards

    299/314

    Abs on IF?

    Goodpasture Syndrome

  • 7/26/2019 DIT Day 1 FlashCards

    300/314

    In which glomerular diseawould you expect to see th

    followingchanges:Kimmelstiel-Wils

  • 7/26/2019 DIT Day 1 FlashCards

    301/314

    lesions on LM?

    Diabetic nephropathy

  • 7/26/2019 DIT Day 1 FlashCards

    302/314

    In which glomerular disea

    would you expect to see th

    following changes: 'spike a

    dome' appearance on EM

  • 7/26/2019 DIT Day 1 FlashCards

    303/314

    pp

    Membranous

    glomerulonephritis

  • 7/26/2019 DIT Day 1 FlashCards

    304/314

    In which glomerular diseawould you expect to see th

    following changes: 'tramtrack' of subendothelial

  • 7/26/2019 DIT Day 1 FlashCards

    305/314

    humps on EM?

    Membranoproliferative

    glomerulonephritis

  • 7/26/2019 DIT Day 1 FlashCards

    306/314

    In which glomerular disea

    would you expect to see th

    following changes:

    subepithelial humps on EM

  • 7/26/2019 DIT Day 1 FlashCards

    307/314

    p p

    Acute post-streptococcal

    glomerulonephritis

  • 7/26/2019 DIT Day 1 FlashCards

    308/314

    What are the clinical uses f

    metronidazole?

  • 7/26/2019 DIT Day 1 FlashCards

    309/314

    "GET GAP on the Metro":

    Giardia

    Enatamoeba

    TrichamonasGardnerella

    Anaerobes

  • 7/26/2019 DIT Day 1 FlashCards

    310/314

    H. Pylori

    What are the two most

    common complications aft

    an MI? What is Dressler'

    Syndrome?

  • 7/26/2019 DIT Day 1 FlashCards

    311/314

    1. Arrhythmia and V-fib (anLV failure)

    2. Dressler's= autoimmundz weeks post-MI that lead

  • 7/26/2019 DIT Day 1 FlashCards

    312/314

    to fibrinous carditis

    What is the WAGR comple

  • 7/26/2019 DIT Day 1 FlashCards

    313/314

    Mnemonic for what is seen witWilm's Tumor (2-4yo)

    Wilm's

    Aniridia

    Genitourinary malformation

  • 7/26/2019 DIT Day 1 FlashCards

    314/314

    Retardation