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Do Now. Complete Part 1 on your worksheets with a partner. A problem for you to solve: Given that you know the axon sends signals electrically, and that the synapse sends signals chemically, how would you change the electrical signal of the axon into a chemical signal at the synapse? - PowerPoint PPT Presentation
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Do Now
• Complete Part 1 on your worksheets with a partner.
• A problem for you to solve:– Given that you know the axon sends signals electrically,
and that the synapse sends signals chemically, how would you change the electrical signal of the axon into a chemical signal at the synapse?
– Brainstorm mechanisms to solve this problem with a partner.
From Electrical Signal to Chemical Signal
Chemical Signal
Electrical Signal
Synaptic Transmission
Electrical Signal
Electrical Signal
Synaptic Transmission
The Stage:
Presynaptic cell Synaptic Cleft Postsynaptic Cell
The Characters:
Voltage-gated Ca2+ channels
Synaptic vesicles
Neurotransmitters (NT)
ReceptorsAction
Potential
Reuptake Transporters
Ca2+ sensitive proteins
How do the characters work together to complete synaptic
transmission?
Complete Part 2 of your worksheets with a partner.
The Play:
1. Action Potential
The Play:
1. Action Potential
Ca2+
2. Voltage-gated Ca2+
channels open. Ca2+ flows into cell
The Play:
1. Action Potential
Ca2+
2. Voltage-gated Ca2+
channels open. Ca2+ flows into cell
3. Ca2+ sensitive proteins fuse synaptic vesicles to
membrane, releasing NTs into synaptic cleft
The Play:
1. Action Potential
Ca2+
2. Voltage-gated Ca2+
channels open. Ca2+ flows into cell
4. NTs bind to postsynaptic receptors.
3. Ca2+ sensitive proteins fuse synaptic vesicles to
membrane, releasing NTs into synaptic cleft
The Play:
1. Action Potential
Ca2+
5. Ion channels open on postsynaptic membrane,
allowing ions to flow into cell.
2. Voltage-gated Ca2+
channels open. Ca2+ flows into cell
4. NTs bind to postsynaptic receptors.
3. Ca2+ sensitive proteins fuse synaptic vesicles to
membrane, releasing NTs into synaptic cleft
The Play:
1. Action Potential
2. Voltage-gated Ca2+
channels open. Ca2+ flows into cell
Ca2+
4. NTs bind to postsynaptic receptors.
5. Ion channels open on postsynaptic membrane,
allowing ions to flow into cell.
6. Excess NTs are degraded by enzymes or pumped
back into presynaptic cell.
3. Ca2+ sensitive proteins fuse synaptic vesicles to
membrane, releasing NTs into synaptic cleft
The Play:
1. Action Potential
2. Voltage-gated Ca2+
channels open. Ca2+ flows into cell
Ca2+
4. NTs bind to postsynaptic receptors.
5. Ion channels open on postsynaptic membrane,
allowing ions to flow into cell.
6. Excess NTs are degraded by enzymes or pumped
back into presynaptic cell.
3. Ca2+ sensitive proteins fuse synaptic vesicles to
membrane, releasing NTs into synaptic cleft
Does it matter which ions flow into the cell?
Sodium (Na+) Calcium (Ca2+) Chloride (Cl-)
Positive Positive Negative
Synaptic Transmission
Ca2+
