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DNA(Deoxyribonucleic Acid)

Genetic material of cells…Genetic material of cells…

• GENES – units of genetic material that GENES – units of genetic material that CODES FOR A SPECIFIC TRAITCODES FOR A SPECIFIC TRAIT

• Called Called NUCLEIC ACIDSNUCLEIC ACIDS

• DNA is made up of repeating molecules DNA is made up of repeating molecules called called NUCLEOTIDESNUCLEOTIDES

DNA NucleotideDNA Nucleotide

OO=P-O O

PhosphatePhosphate GroupGroup

NNitrogenous baseNitrogenous base (A, G, C, or T)(A, G, C, or T)

CH2

O

C1C4

C3 C2

5

SugarSugar(deoxyribose)(deoxyribose)

A HISTORY OF DNAA HISTORY OF DNA

• Discovery of the DNA double helixDNA double helix

A. Frederick Griffith – Discovers that a factor in diseased bacteria can transform harmless bacteria into deadly bacteria (1928)

B. Rosalind Franklin - X-ray photo of DNA.(1952)

C. Watson and Crick - described the DNA molecule from Franklin’s X-ray.(1953)

Watson & Crick proposed…Watson & Crick proposed…

•DNA had specific pairing between the DNA had specific pairing between the nitrogen bases:nitrogen bases:

ADENINEADENINE – – THYMINETHYMINE

CYTOSINECYTOSINE - - GUANINEGUANINE

•DNA was made of DNA was made of 22 long stands of long stands of nucleotides arranged in a specific way nucleotides arranged in a specific way

called the called the “Complementary Rule”“Complementary Rule”

DNA Double HelixDNA Double Helix

NitrogenousNitrogenousBase (A,T,G or C)Base (A,T,G or C)

““Rungs of ladder”Rungs of ladder”

““Legs of ladder”Legs of ladder”

Phosphate &Phosphate &Sugar BackboneSugar Backbone

DNA Double HelixDNA Double Helix

P

P

P

O

O

O

1

23

4

5

5

3

3

5

P

P

PO

O

O

1

2 3

4

5

5

3

5

3

G C

T A

Nitrogenous BasesNitrogenous Bases

• PURINESPURINES

1. Adenine (A)Adenine (A)

2. Guanine (G)Guanine (G)

• PYRIMIDINESPYRIMIDINES

3. Thymine (T)Thymine (T)

4. Cytosine (C)Cytosine (C) T or C

A or G

Chargaff’s RuleChargaff’s Rule

• AdenineAdenine must pair with ThymineThymine

• GuanineGuanine must pair with CytosineCytosine

• Their amounts in a given DNA molecule will be about the sameabout the same.

G CT A

BASE-PAIRINGSBASE-PAIRINGS

CG

H-bonds

T A

Genetic Diversity…Genetic Diversity…• Different Different

arrangements of arrangements of NUCLEOTIDESNUCLEOTIDES in a in a nucleic acid (DNA) nucleic acid (DNA) provides the key to provides the key to DIVERSITYDIVERSITY among among living organisms.living organisms.

The Code of Life…The Code of Life…

• The “code” of the chromosome is the The “code” of the chromosome is the SPECIFIC ORDERSPECIFIC ORDER that bases occur. that bases occur.

A T C G T A T G C G G…A T C G T A T G C G G…

DNA is wrapped tightly around histones and coiled tightly to form

chromosomes

See p. 297

DNA DNA ReplicationReplication• During S Phase of a cells life cycle, DNA During S Phase of a cells life cycle, DNA

is replicated (copied) to prepare for Cell is replicated (copied) to prepare for Cell Division.Division.

• DNA Replication occus in the nucleus of DNA Replication occus in the nucleus of the cell.the cell.

• The DNA molecule produces The DNA molecule produces 2 2 IDENTICALIDENTICAL new complementary strands new complementary strands following the rules of base pairing: following the rules of base pairing:

A-T, G-CA-T, G-C

•Each strand of the Each strand of the original DNA serves as original DNA serves as a template for the new a template for the new strand.strand.

DNA Replication

• Enzyme Helicase breaks the hydrogen bonds connecting the complimentary bases of the original DNA molecule.

• By doing this, Helicase unzips the DNA molecule and allows for new complimentary nucleotides to come and pair up with the original template.

• The enzyme DNA Polymerase binds the new nucleotides to the original strand and proof reads for mistakes in pairing.

(1961)(1961) Watson & Crick proposed… Watson & Crick proposed…

• 3 Nucleotides = a triplet or 3 Nucleotides = a triplet or CODONCODON(which code for a specific AMINO ACID)(which code for a specific AMINO ACID)

See p.303See p.303

• AMINO ACIDSAMINO ACIDS are the building blocks are the building blocks of proteins.of proteins.

DNA DNA TranscriptionTranscription

• DNA can “unzip” DNA can “unzip” itself and itself and RNARNA nucleotides match nucleotides match up to the DNA up to the DNA strand.strand.

DNA DNA TranslationTranslation

• The cell uses The cell uses information from information from “messenger” RNA “messenger” RNA to produce proteinsto produce proteins

We will We will discuss details discuss details

of this on a of this on a later datelater date

AMAZING DNA FACTS…AMAZING DNA FACTS…

• DNA from a single human DNA from a single human cell extends in a single cell extends in a single thread for almost 2 meters thread for almost 2 meters long!!!long!!!

• It contains information It contains information equal to some 600,000 equal to some 600,000 printed pages of 500 words printed pages of 500 words each!!! each!!! (a library of about 1,000 books)(a library of about 1,000 books)