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hematopathologist, experienced hematopathologist, IHCVirtualFlow inventor/developer
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Curriculum Vitae
Hernani DM Cualing, MD
Hernani Del Mundo Cualing MD
Address: 18804 Chaville Rd., Lutz, Florida 33558
Telephone: 813-480-7849 (cell phone and blackberry )
813-909-4866 (fax )
Emails: [email protected]
Consultation Specialty: Hematopathology, Cutaneous Hematopoietic Lesions
Business: IHCFlow, Inc.
Website: WWW.IHCFLOW.com
Trademark: VirtualFlow IHCFlow™ Cytometer
Affiliation: Cutaneous Lymphoma Study Group, principal, USF/ Moffitt Cancer Center
Associate Professor, Department of Pathology and Cell Biology
University of South Florida College of Medicine
University of South Florida
12901 Bruce B. Downs Blvd.
Doctorate Education, Residency, Fellowship:
1970-1974 University of the Philippines
Quezon City, Philippines
B.S. Pre-Medicine
1974-1978 University of the Philippines School of Medicine
Manila, Philippines
M.D.
1987-1990 Resident in Anatomic and Clinical Pathology
Nassau County Medical Center, SUNY at Stony Brook Teaching Hospital
East Meadow, NY
1
1990-1991 Chief Resident in Pathology and Surgical Pathology Fellowship, Nassau
County Medical Center under Dr. Vincent Palladino
SUNY at Stony Brook Teaching Hospital
East Meadow, NY
1991-1992 Hematopathology Fellow of Dr. R. Neiman and A. Orazi
Indiana University Medical Center
Riley Children’s Hospital
Indianapolis, IN
Post Graduate Training:
1978-1979 Rotating Internship- Pediatrics, Surgery, Medicine
Capiz Emmanuel Hospital
Roxas City, Philippines
1979-1980 Preventive Medicine Rural Training
University of Philippines Outreach Program
Dao, Panay Island, Philippines
1980-1982 Resident in General Surgery, University of the Philippines
Cardinal Santos Memorial Hospital
Greenhills, Manila, Philippines
1982-1985 Microbiology and Genetics, Post Doctorate MS Courses
University of Illinois at Chicago
Chicago, Illinois, USA
1985-1987 Research Fellowship in Membrane Tumor Biochemistry
Dana-Farber Cancer Institute under Dr. Emil Frei III Laboratory
Harvard Medical School
Boston,MA
2
Awards and Honors:
1969-1971 Scholastic Delegate to Physics, Chemistry, Biology Interscholastic Competitions
Academic Excellence-Top Academic Rank, Section Class # 1 of 26 classes
Senior High School, Ramon Magsaysay High School,
Manila, Philippines
1976-1977 President of Medical Student Society
University of the Philippines College of Medicine
Manila, Philippines
1989-1990 First Prize Award, Resident Presentation in Pathology,
“Zell Ballen” Patterns in Organ of Zukerkandl
Nassau Society of Pathologist
East Meadow, NY
1990-1991 Chief Resident, Department of Pathology
Nassau County Medical Center, SUNY at Stony Brook Teaching Hospital
East Meadow, NY
1992-1993 Finalist, American Society of Clinical Pathologist
Spring Resident Presentation Competition
Boston, MA
1994-1995 Biomedical Engineering Seed Grant Award-Top Score
1994-1995.1.1.1 I Image Analysis of Lymphomas
University of Cincinnati University- Seed Grant Competition
Cincinnati, Ohio
1997-2000 Biomedical Engineering Grant Award
High “High Order Decision Theoretic Diagnosis of Lymphomas”
Whitaker Foundation ( National )
3
2000-2001 Stratmore’s Who’s Who of North America
2003-2008 Marquis Who’s Who, 58th, 60th, 61st, in North America
2006-2008 Marquis Who’s Who, 6th Edition in Science and Engineering,
Marquis Who’s Who, 9th Edition in Medicine & Health
2003-2004 Awardee- Top Overseas Researcher
University of the Philippines College of Medicine
Medical School Alumni Association
Twenty-Five Year Homecoming Celebration, Manila, Philippines
2006 First Prize Research Presentation by Mentored resident
(Farah Khalil- Bone Marrow Quantitation )
Florida West Coast Assoc. of Pathologists/Pathology Alumni Assoc.
Longboat Key Conference, FL
2004-2005 Best Teacher of the Year Award
Awarded by AP/CP Pathology Residents
Department of Pathology
University of South Florida, Tampa, FL
2004-2007 Consultant: Immunohistochemistry and Histology Instrumentation
Council of Advisors for Health Care
New York, NY
2007-2008 Panelist: Small Business Innovations Research (SBIR/STTIR)
Grant
National Science Foundation
Bethesda, MD
4
2007-2008 Mentor: Mentorship for Young scientist
International Society of Analytical Cytometry
Clinical Cytometry Society
Chicago, IL
2008 Consultant Adviser on Cutaneous Lymphomas
Advisory Board on Health Care
Eisai Corporation, Japan and USA
2007 FIRST Prize Research Retreat “Yoshinori Takahashi, D.
Coppola, N. Matshushita, H. Cualing, M. Sun, Y. Sato, C.
Liang, J. Jung, J, Cheng, J. Mule, WJ Pledger, Hong Gang Wang.
Bif-1 interacts with Beclin 1 through UVRAG and regulates
autophagy and tumorigenesis” 2007 Moffitt Scientific Retreat
publication, Blaise Alfano Conf.Center, Feb 24, 2007
2008 FIRST Prize Awardee Fellow Research Y.Takahashi,
D.Coppola,
N. Matshushita, H. Cualing, M. Sato, C. Liang, J. Mule, WJ
Pledger, Hong Gang Wang. H. Lee Mofttitt Cancer Center
Fellow Research Symphosium- Bif-1 in autophagy and tumorigenesis,
Stabile Bldg.
Basic Science Division, May 19, 2008
Licensures and Certifications:
2002-2010 Florida Medical License # ME 84854, Expiration Jan 31, 2012, Active, Clear
1998 4th International Symposium on Predictive Oncology and Therapy, Nice, France
1996 Lymph Node Pathology: ASCP Winter Seminar Certification, Orlando, FL
1994 T-cell Lymphomas-Comparison of Eastern and Western Experience: Hong Kong
5
1992 Ohio Medical License #35-06-4174, Inactive
1992 Diplomate of American Board of Pathology, Hematology Subspecialty
1992 Indiana University School of Medicine, Hematopathology Fellowship Training
1991 Diplomate of American Board of Pathology, Anatomic and Clinical Pathology
1991 Lymph Node Pathology in the 90s (Bharat Nathwani), Washington DC
1990 New York Medical License #184512, Inactive
1990 Iowa Medical License #27672, Inactive
1991 ACLS(Advanced Cardiac Life Support) Certified, NY
1987 Lymphomas, Diagnosis from both sides of the Atlantic: Karl Lennert, Nassau, NY
1981 ECFMG Certification #322-877-2
1978 National Medical Licensure Certification, Philippines
Academic Appointments and Employment
1990-1991 Chief Resident
Nassau Country Medical Center, SUNY Stony Brook Campus
East Meadow, NY
1992-2001 Assistant Professor, Clinical
Attending Staff of Hospital
Department of Pathology and Laboratory Medicine
University of Cincinnati Medical Center, Cincinnati, Ohio
1994-2002 Course Director
Diagnostic Hematopathology
Year IV Medical Student Elective- UC-150146
University of Cincinnati College of Medicine
1993-1997 Medical Director
Hospital Phlebotomy Service
University of Cincinnati Medical Center
6
1993-2002 Consultant: Hematopathology/Hematology Attending
Adams County Hospital Affiliate, Univ of Cincinnati
Cincinnati, Ohio
2001-2002 Co-Director, Hematopathology Fellowship Program
University of Cincinnati Department of Pathology and Lab Medicine
Cincinnati, Ohio
2002- Associate Professor, Anatomic and Clinical Hematopathology
University of Cincinnati College of Medicine
Cincinnati, Ohio
2002-present Associate Professor, Clinical
University of South Florida, Department of Pathology and Cell Biology
Tampa, Florida
2002-present Associate Member and Attending Staff,
Department of Oncologic Sciences, Division of Hematopathology and Laboratory
Medicine, Moffitt Cancer and Research Institute
Tampa, Florida
Clinical appointments
1987-1991 Resident in Anatomic and Clinical Pathology,
Nassau Country Medical Center, SUNY Stony Brook Campus
East Meadow, NY
1990-1991 Chief Resident
Nassau Country Medical Center, SUNY Stony Brook Campus
East Meadow, NY
7
1991-1992 Clinical Fellow in Hematopathology
Indiana University Medical Center
Riley Children’s Hospital
Indianapolis, IN
1992- 2002 Surgical Pathologist Attending Staff
Department of Pathology and Laboratory Medicine
University of Cincinnati Medical Center and Holmes Hospital
Cincinnati, OH
1993- 2002 Consulting Hematopathology Staff
Department of Pathology, Veterans Administration Medical Center
Cincinnati, OH
1996- 2002 Consulting Hematopathology Staff, Adams County Hospital
Adams County, OH
2000-2002 Medical Director
Flow Cytometry and Immunology Division
Health Alliance of Greater Cincinnati, Inc.
Cincinnati, Ohio
2002-present Hematopathology Attending Staff,
Department of Interdisciplinary Oncology/ Oncologic Sciences
Moffitt Cancer Center and Research Institute
Univ of South Florida College of Medicine Clinics,
Tampa, Florida
Heme Malignancies Pathologist
Lymph Nodes, Extranodal Tissue and Bone Marrow Diagnostic Service
Duties: Signs out Flow cytometry, coagulation molecular testing, peripheral blood, bone
marrow, lymph nodes, spleen, cutaneous lymphomas, GI Renal Lung Brain and other
8
extranodal lymphoma work up biopsy, core biopsy specimens of suspected hematologic
malignancies, Reactive and Non neoplastic Hematopathology
Department Case Load: 3800 bone marrows, about 600 lymph nodes and FNAs, 1800
flow cytometry, 600 molecular and blood studies including CISH, FISH, and 22,000
immunohistochemistry tests per year.
2005-present Expert Consultant on Lymphomas and Cutaneous lymphomas
Contract consultant for lymphomas and leukemias involving lymph nodes and
cutaneous and other extranodal tissues
Quest Diagnostics, Fowler Av., Tampa, Florida
2009-present Expert Consultant on Cutaneous Lymphomas
Dermpath Diagnostics, Ameripath, Tampa, FL
Administrative:
2007 Course Co-Director: First Annual Cutaneous Lymphoma seminar, MCC
Cutaneous Cooperative Group: Dr. Frank Glass and Dr. Lubosh Sokol
University of South Florida, Tampa FL
2008 Course Director, 2nd Annual Cutaneous Lymphoma Seminar
With Patients Participation
Lake Buena Vista Resort,Orlando, Florida ( April 19 and April 20 )
Faculty from Boston, Rhode Is. and Florida : Organized the logistics, topics, scope and
faculty roles plus facilitated the direct participation of three lymphoma patients as
speakers.
2002-2008 Medical Director of Immunohistochemistry/Histology
Division of Pathology, Hematopathology and Laboratory Medicine
Department of Interdisciplinary Oncology,
H. Lee Moffitt Cancer Center and Research Institute,
Tampa, Florida.
9
Role: Guide strategic direction as well as supervise day to day quality assurance issues in
histology and immunohistochemistry, chromogenic and fluorescent in situ hybridization,
and special stains supervising 8 FTE histotechnologists and 2 Lead Techs and 1
supervisor with a total of 22,000 annual antibody and in situ hybridization panels.
:Quality Assurance and CAP survey reporting results
:Signed off on Histo-Immunology procedures
: Monitored technologist CAP inspection preparation
: Introduced panels and monitored the more than 135 monoclonal antibodies used in
Surgical and Hematopathology Divisions
: Performed Quality and Cost Effectiveness evaluations for histology and automated
immunohistochemistry instruments
5 Ventana Nexes and 2 Benchmarks, Leica Instruments
2006-2010 Program Director,
Hematopathology Fellowship Training Program
USF- Moffitt DIO and Department of Oncologic Sciences
University of South Florida
Tampa, Florida
Role: Administrative and Teaching-10 % time allotment
Programmatic direction and maintaining Accreditation in American Council of
Graduate Medical Education ( ACGME Hematopathology Program)
2008- Directed program that obtained the 5 year ACGME Full accreditation
Recruitment of fellows
2007 cycle – evaluated 33 applicants candidates for 1 year or 2 year track
2008 cycle – evaluated 32 applicants candidates
2009 cycle- evaluated 34 applicants
Supervision of Fellows
Immediate Past fellows:
10
Supervised and advised two fellows that graduated 2007 and 2008
Current Fellows:
Supervised and advised two 2-year track fellows
:Directed the fellowship rotation: location, content, and quality
: Program Information Plan- monitored and evaluated the competency-based
training of hematopathology fellows according to ACGME approved PIF
: Assignment of mentors and direction of research projects for fellows;
: Administrative meeting with fellows regularly for assessment and feedback;
: Liason with teaching faculty regarding fellows issues
: Directs 2 Fellowship Coordinators and 1 Secretarial Assistant
: Selection and directions for the teaching faculty - 4 hematopathologists, 1
Molecular Pathologist, 2 Heme Oncologist, 2 Molecular Cytogeneticist, and 1
Pediatric Hematopathologist that are based from MCC, VA Haley Medical
Center and All Children’s Hospital.
2000-2002 Medical Director
Health Alliance of Cincinnati, Immunology
Diagnostic Immunology: Protein Electrophoresis, Serology interpretation,
Flow Cytometry Interpretation of Leukemias and Lymphomas,
Diagnostic Flow Cytometry, Health Alliance of Greater Cincinnati
Diagnostic Immunology, FISH, CISH, Health Alliance of Greater Cincinnati
Cincinnati, Ohio
Role: Oversaw the medical /scientific direction and daily quality issues
Supervised Flow Cytometrist 5-FTE in Flow Cytometry and 6 immunology
FTE technologist in immunology division
Reviews daily results including those with discrepancies and gating issues
Liason with clinicians
1993-1996 Medical Director
11
University of Cincinnati Medical Center Phlebotomy Services
Liason with Clinicians and Nursing Staff regarding Blood Drawing Issues
Cincinnati, Ohio
1992-1999 Surgical Pathology and Hematopathology Sign-out including incorporation of flow
cytometry and gene rearrangement results in reports
University of Cincinnati Department of Pathology
Cincinnati, Ohio
1992-2002 Lymphoma Frozen Tissue Bank Database Director
University of Cincinnati Pathology and Hematopathology
Cincinnati, Ohio
Service:
Committee activities:
1990-2002 Deans Residency Review Committee, Resident Member
Nassau Country Medical Center, East Meadow, NY
1994-2002 Director
Telepathology Link Committee with Adams Country Hospital
Cincinnati, Ohio
1998-2002 Member
Scientific Advisory Committee
Confocal and Image analysis instrumentation
2000-2002 Co-Chair with Paul Hurtubise, PhD
Flow Cytometry and Immunology Methods Committees
Health Alliance of Greater Cincinnati
Cincinnati, Ohio
12
2000-2002 Member
Hematopathology Fellowship committee
ACGME Accredited Fellowship, University of Cincinnati
Cincinnati, Ohio
2001-2002 Member
Health Alliance of Greater Cincinnati Bone marrow CAP compliance
Committee, University of Cincinnati
Cincinnati, Ohio
2000-2002 Hematology Sophomore Teaching Block Course Review Committee,
University of Cincinnati College of Medicine, Cincinnati, Ohio
2004-present Member, Resident Teaching Task Force Committee in Pathology
Moffitt Cancer Center, USF and DIO
Tampa, FL
2005-present Member, Graduate Medical Education Committee,
Moffitt Cancer Center GME
2006-present Pathology Teaching Committee member
Department of Pathology and Cell Biology
University of South Florida, Tampa, Florida
2006-present Graduate Medical Education Committee Member,
University of South Florida College of Medicine
USF, Tampa, Florida
2006-2007 Moffitt Cancer Center Appointment Promotion Tenure Committee Member
Department of Interdisciplinary Oncology, Tampa, Florida
13
2007 Internal Reviewer faculty for USF GME office for Pediatric Pathology
Fellowship ACGME accreditation
2007-2007 Graduate Council- University Wide, University of South Florida, member
Fellowship subcommittee: reviewed many Thesis and PhD dissertations for
Presidential and other Scholastic University Wide awards
2007-2010 Policy Review Team Committee, member, MCC Policy Administration,
Moffitt Cancer Center and Research Institute, Tampa, Florida
2009 Internal Reviewer faculty for USF GME office for DermatoPathology
Fellowship ACGME accreditation
Community Service:
1972-1974 Coordinator- Free Medical Clinic Foundation, Premedical Student Branch,
University of the Philippines Outreach to Indigent Urban localities that
schedules medical doctors, free medicines and patients
1973-1978 Volunteers Association of the Philippines Member
Coordinated Free Cataract Surgery for indigents in Lubang Is. Performed by
the Chiefs of Ophthalmic and Neurosurgery Divisions,
Philippine General Hospital, University of the Philippines.
1973-1978 Trained in Acupuncture Medicine by Chinese Acupuncturist and conducted
Free acupuncture services to indigent rural folks, also provided acupuncture
anaesthesia to the Department of Orthopedic Surgery, University of the
Philippines for senior citizens undergoing Decubitus Ulcer debridgement and
Relief of Post Surgical Ileus
14
1974-1976 Organizer and Founder of Medical Student Annual Musical and Talent
Extravaganza –“Tao Rin Pala”- University of the Philipppines College of
Medicine,Manila, Philippines
1976-1978 Organizer
Medical Student Liason for Disaster Relief Prepareness committee
University of the Philippines Office of the Dean, College of Medicine
1979-1980 Organizer, Herbal Medicine Cooperative Group of Rural “Herbolarios”
Compiled the Dao, Panay Island indigenous Flora with Medicinal Uses and
Converted the extracts to pills and emulsions for free medicines
1988-1990 Resident In Charge of Seminar Projectors and AudioVisual Aids to Speakers,
Nassau County Society of Pathologists, East Meadow, NY
1998-2002 Cutaneous Lymphoma Cooperative Group, CTCL patient education seminars
and journal clubs
2003-2004 Alumni Fund raising committee member to benefit University of Philippines
College of Medicine Library, Manila, Philippines
2005-2007 Southwest Florida Committee member for Alumni Affairs
University of the Philippines College of Medicine, Tampa, Florida
2007 Telepathology -Outreach Tumor Board Hematopathologist, for MCC
Parish Medical Center Leukemia Lymphoma Cases
2009 Cutaneous Lymphoma Foundation Patient Education Series
Cutaneous Lymphoma Overview Speaker- Use of modern modalities in early
CTCL diagnosis Feb 21, 2009, Sheraton Venue, Tampa, FL
15
Professional Association Memberships:
1987- 1991 American Association for Advancement of Science
1987- 1991 Nassau Society of Pathologists, resident member
1991- present Fellow of the College of American Pathologists, sustaining member
1992 – 2002 Cincinnati Society of Pathologists, member
1992- 2002 Society for Hematopathologists,member
1993- 2002 Southwest Oncology Group, member
1993- 2000 Cutaneous Lymphoma Cooperative Group, Univ of Cincinnati
1996- 2000 Ohio State Society of Pathologists
1996- present International Academy of Pathologists-USCAP
1996- 2000 American Society of Clinical Pathologists
1998- 2002 The International Society for Optical Engineering
1999- 2002 International Society of Preventive Oncology
2002 -present Moffitt Cancer Center and Research Inst. In-residence
2002 -present American Society of Hematology
2006-2010 International Society of Analytical Cytology
2010 American Society of Tropical Medicine and Hygiene
Teaching experience:
University Courses/Advisory Role:
1991-1992 Clinical Instructor
Indiana University Medical School
Sophomore Clinical Hematology Laboratory Course
1992- 2002 Course Instructor: Lecturer
Hodgkin and Non Hodgkin Lymphomas
University of Cincinnati College of Medicine
Medical Student Sophomore Pathology Lecture series
16
1992- 2002 Course Instructor: Laboratory Session
Leukemias, Anemias, Lymphomas
University of Cincinnati College of Medicine
Medical Student Sophomore Pathology Lecture series
1994- 2002 Course Director
Medical Student Diagnostic Hematopathology
Year IV – Elective Course , University of Cincinnati
Hematopathology Student Papers/Reports: Andrew Mone, Alena Goldman, Yaron
Goldman and others
1994-1995 Thesis Advisor
Masters in Computer Science
Graduate student-Thia Balachander
“Algorithms in the Image Understanding of Features of Lymphoma Cells”
Master Degree of T. Balachander on Image Analysis of Lymphoma/Leukemia cells
1997-1998 Thesis Co-advisor
PhD in Computer Science
Graduate Student- T Balachander and R. Lotlikar
Image analysis and Neural Network Diagnosis of lymphoma/leukemia Cytologic
Romanosky stained Preps
1997-1998 Project Director for Students in programming an Automatic Image Acquisition using
X,Y,Z moveable microscope stage
Whitaker Foundation funded project with Professor R. Kothari
Lymphoma Diagnosis using Artificial Intelligence
1999 and 2001 Project Director for programmatic activity with MS Engineering Student using Oncor
Image, Seed Funding from Dr. Roger Smith
2000 Diagnostic Hematology Elective Medical Student Mentor – Yaron Goldman
17
2001 Medical Student Adviser- Sukjinder Singh
2001 Diagnostic Hematology Medical Student (Year IV) Electives Mentor-
Andrew Mone
2002 Diagnostic Hematology Medical Student (Year IV) Electives Mentor-
Michael Tuchfarber, Alena Goldman that generated case reports
2003 BMS 6600 Hematology Block Course Faculty,
Lectures and Laboratory Courses
University of South Florida
2006 USF Medical Student Teaching (Year IV )
Preceptorship Interdisciplinary Oncology
College of Medicine Course: BCC8117
Hematopathology preceptorship: Jeremy Bowers , T. Condarco that generated a case
report
University of South Florida
2007 Medical Student Mentor to Michael Fuller and Elizabeth Sundean
Year IV Medical Preceptorship in Pathology; BCC8117
Other Courses and National Symposia:
Regional seminars
Mar 17, 2000 Seminar Series sponsored by Cincinnati Society for Pathologists
“Flow Cytometric Immunophenotyping of Hematologic Disorders”
Cincinnati, Ohio
May 26, 2001 “Cutaneous Lymphoma in a Child-“ invited speaker
18
TriState Midwest Pediatric Pathology Conference
Sponsored by Cincinnati Children’s Hospital
Cincinnati, Ohio
April 28, 2007 Seminar Lecture: “WHO-EORT Classification of Cutaneous Lymphomas”
Co-director of 1st Annual Cutaneous Lymphoma Seminar, Sponsored by USF Health.
Cutaneous Lymphoma Foundation, Moffitt Cancer Center, Tampa, Florida targeted
Florida Dermatologist, Pathologists, Dermatopathologists and Oncologist
Sept 4, 2007 COBRE Research Rounds- Core of Biomedical Research Excellence Invited Speaker on
“Emerging Vision Analysis applicable to Tissue Bioengineering and Research”-
Sponsored by Dept of Dermatology, Boston University: Roger Williams Medical Center
with Dr. Vince Falanga host, Providence, Rhode Island
National seminars
Apr 14, 1994 Course Lecturer: “Lymphomas of the Skin and the Role of the Laboratory”
Sponsored by Abbott Pharmaceutical and Nebraska-Iowa Medical Technologist
Societies, Des Moine, Nebraska
Apr 24, 1995 Course faculty Lecturer:
Hematologic Malignancies-overview
Peripheral Blood in Hematologic Malignancies
Review for Hematology Oncology Fellow Board Examination
Sponsored by Osler Institute Review
Cincinnati, Ohio
April 28, 2007 Co-director of 1st Annual Cutaneous Lymphoma Seminar, Moffitt Cancer Center,
Tampa, Sponsored by Moffitt Cancer Center Foundation and jointly with Cutaneous
Lymphoma Foundation- Update on Skin Lymphomas
19
April 19, 20 2008 Director of 2nd Annual Cutaneous Lymphoma Seminar,
Sponsored by Cutaneous Lymphoma Foundation, USF Health, Moffitt Cancer Institute
and Funded by Eisai Corporation, and other National Pharmaceutical Corporations
Lake Buena Vista Resort, Orlando Florida
This two day seminar included three patients as speakers and Faculty from International
Cutaneous Lymphoma Study Group, Harvard Medical School Faculty and attended
nationally by Dermatologist, Pathologists, Oncologists and some attendees from out of
the country.
International lectures/ Presentations:
1994, Fall “Macrosplenomegaly with hemophagocytosis in AIDS”
Presented in oral platform in XX International Congress of the International Academy
of Pathology, Queen Hospital, Hong Kong
1998 October ” Immunophenotypic Diagnosis of Acute Leukemia Using Decision Tree Analysis”
Presentation in International Academy of Pathology, Nice France,
Serialized in Archives d’Anatomie et de cytologie pathologiques: Clinical and
Experimental Pathology.
1999 (July 8-24) Hematology Course Block Lecturer and Course Director for two weeks
Lectured to 2nd year medical Students for about 30 contact lecture/ laboratory hours on
Leukemias and Lymphomas and Benign Hematology
Distributed a 168 pages course handout and 2 hour block examination
Sponsored by St. Mathews University School of Medicine
Ambergis Cay, Belize
2000 Feb 25 Grand Rounds in Pathology. “REAL Classification of Lymphomas” .
Sponsored by Univ of the Philippines Department of Pathology seminar,
Pedro Gil, Metro Manila, Philippines
20
2001 Jan 15 Invited Course lecturer on “Lymphomas and the role of immunohistochemistry and
Flow Cytometry In diagnosis”
Department of Pathology Seminar Series
University of the Philippines College of Medicine
Metro Manila Philippines
Proceedings in Research Meetings:
1. Bernal SD, Cualing HM, Elias AD. Stability and shedding of small cell carcinoma
membrane antigens: applications to detection of antigens in marrow and serum.
Lung Cancer 1988; 4:79-80.
2. Bosserman L, Tanaka I, Cualing H, Elias A, Skarin,
Dreyfuss A, Bernal S. Serum Radioimmunoassay Detects
SM1 antigen in Lung Cancer patients. Proc Am Soc Clin
Onc 5:174 Mar 1986.
3. Wright J, Cucci C, Flatow J, Rosowski A, Cualing H, Bernal
S and Frei III E. Detection of two active Dihydrofolate Acid
Reductase forms in Squamous cancer of the Head
and Neck cell lines using monoclonal antibodies. Proc of Am
Soc Clin Onc Mar 1987.
4. Wright J, Cucci C, Rosowski A, Cualing H, Bernal S, Koch J,
Waxman D and Frei E. Dihydrofolate Reductase from
Methotrexate Resistant Human Squamous Cell Carcinoma for
Monoclonal Antibody generation. Proc of Am Assoc Cancer
Res 28:1175 1987.
21
5. Yoshinori Takahashi, D. Coppola, N. Matshushita, H. Cualing, M.
Sun, Y. Sato, C. Liang, J. Jung, J, Cheng, J. Mule, WJ Pledger, Hong
Gang Wang. Bif-1 interacts with Beclin 1 through UVRAG and
regulates autophagy and tumorigenesis, 2007 Moffitt Scientific
Retreat publication, Blaise Alfano Conf.Center, Feb 24, 2007-
FIRST Prize awardee presentation
6. Yoshinori Takahashi, D. Coppola, N. Matshushita, H. Cualing, M.
Sato, C. Liang, J. Mule, WJ Pledger, Hong Gang Wang. H. Lee
Mofttitt Cancer Center Fellow Research Symphosium- Bif-1 in
autophagy and tumorigenesis.FIRST Prize awardee presentation
Basic Science Division, May 19, 2008
Other CME Lectures
Aug 1, 1992 “Peripheral T-cell lymphoma presenting as Angiocentric Waldeyer’s Ring Lesions “
Clinico Pathology Conference, Sponsored by Internal Medicine
University of Cincinnati Medical Center, Ohio
Aug 9, 1994 “Lymphocytes and their Markers in the Skin “
Joint Department of Dermatology and Hematology-Oncology Grand Rounds
University of Cincinnati Medical Center, Ohio
Sept 2, 1994 “Understanding the Histologic Classification of Hodgkin’s and Non-Hodgkin’s
Lymphoma” Hematology-Oncology special seminar
University of Cincinnati Medical Center, Ohio
Sept 22, 1995 ”Cytophagic Histiocytic Panniculitis”
Hematology -Oncology Grand Rounds
University of Cincinnati Medical Center, Ohio
22
May 11, 1996 “Sea Blue Histiocytes and Lecithin Cholesterol Acyltransferase Deficiency”
Hematology Oncology Grand Rounds
University of Cincinnati Medical Center, Ohio
Nov 8, 1996 Amyloid and Enlarged Tongue”
Clinical Pathology Conference Sponsored by Internal Medicine
University of Cincinnati Medical Center, Ohio
Jan 6, 1997 “REAL (Lymphoma) Classsification”
Grand Rounds in Pathology
University of Cincinnati Medical Center, Ohio
Dec 12, 1997 “Cat Scratch Disease”
Clinical Pathology Conference Sponsored by Internal Medicine
University of Cincinnati Medical Center, Ohio
Jan 5, 1998 “WHO Classification Hematologic Diseases”
Grand Rounds in Pathology
University of Cincinnati Medical Center, Ohio
June 22,1998 “Extranodal Lymphomas”
Grand Rounds in Pathology
University of Cincinnati Medical Center, Ohio
Jan 11, 1999 “Update of WHO Classification of Lymphoid Neoplasms”
Grand Rounds in Pathology
University of Cincinnati Medical Center, Ohio
June 13, 2000. “Ocular adnexal Lymphoproliferations and Pseudotumors”
Department of Opthalmology Grand Rounds
23
University of Cincinnati Medical Center, Ohio
Aug 11, 2000 “Multiple Myeloma”
Clinico Pathology Conference, Sponsored by Internal Medicine
University of Cincinnati Medical Center, Ohio
Jan 26, 2001 “Mantle cell lymphomas”
Morbidity and Mortality Conference- Sponsored by Hematology Oncology
University of Cincinnati Medical Center, Ohio
April 11, 2001 “Gene Structure and Clonality”
Immunology Rounds Sponsored by Health Alliance of Greater Cincinnati
University of Cincinnati Medical Center, Ohio
April 16, 2001 “Reactive Lymphadenopathies”
Grand Rounds in Pathology
University of Cincinnati Medical Center, Ohio
April 25, 2001 “Immunoproliferative Diseases”
Immunology Rounds Sponsored by Health Alliance of Greater Cincinnati
University of Cincinnati Medical Center, Ohio
Aug 9, 2001 “Cutaneous Lymphoproliferative Diseases”
Dermatology Grand Rounds
University of Cincinnati Medical Center, Ohio
Aug 27, 2001 “Lymphocytes – From Biology to Diseases” ( 2 hours)
Grand Rounds in Pathology
University of Cincinnati Medical Center, Ohio
Sept 21, 2001 “Advances in Image Cytometry in Hematopathology”
24
Moffit Cancer Center and Research Institute Grand Rounds in Pathology
Tampa, Florida
Jan 4, 2002 “Multidimensional diagnosis in Hematopathology”
Grand Rounds in Hematology Oncology
University of Cincinnati Medical Center, Ohio
Feb 4, 2002 “Diagnostic Advances using Image Cytometry”
Grand Rounds in Pathology
University of Cincinnati Medical Center, Ohio
Oct 21, 2002 “Understanding the WHO Classification of Lymphomas”
Moffitt Hematologic Malignancies Series-
Sponsored by Hematologic Malignancies
Moffitt Cancer Center, Tampa, Florida
April 10, 2003 “T-cell Prolymphocytic Leukemia”
Interesting Case Presentation- Tuesday VA Rounds
Hematologic Malignancies
Moffitt Cancer Center, Tampa, Florida
Nov 12, 2003 “Patterns in Benign and Malignant Lymphoproliferations”
Pathology Grand Rounds Series
University of South Florida
Tampa, Florida
Mar 2, 2004 WHO Classification of Lymphomas-B cell Malignancies
Pathology Grand Rounds Series
University of South Florida
Tampa, Florida
25
Apr 7, 2004 WHO Classification of Lymphomas-T cell Malignancies
Pathology Grand Rounds Series
University of South Florida
Tampa, Florida
March 10, 2006 WHO/EORTC Cutaneous Lymphoma- From Biology to Disease-Update
Pathology Grand Rounds Series
University of South Florida
Tampa, Florida
April 14, 2006 Functional microanatomy and Diseases of the Spleen- Biology to Disease Series
Pathology Grand Rounds Series
University of South Florida
Tampa, Florida
Oct 13, 2006 Aggressive cutaneous peripheral T cell lymphomas and CD30 lymphomas
Pathology Grand Rounds Series
University of South Florida
Tampa, Florida
Nov 16, 2007 Update on Cutaneous Lymphomas- What’s New and What is Revised
Pathology Grand Rounds Series
University of South Florida
Tampa, Florida
Nov 20, 2007 B-cell lymphomas- Biology to Disease Series
Pathology Grand Rounds Series
University of South Florida
Tampa, Florida
Nov 30, 2007 T-cell lymphomas- Biology to Disease Series
26
Pathology Grand Rounds Series
University of South Florida
Tampa, Florida
Residency Fellowship Directed Unknown Slides and Diagnostic Workshops
May 19, 2004 Hemepath unknowns slides resident conference-Preceptor
June 16, 2004 Hemepath unknowns slides resident conference-Preceptor
July 21, 2004 Lymphocytes-from Biology to Diseases.
August 18, 2004 Major Patterns of Reactive Lymph node Hyperplasia and Cases
Hemepath unknowns slide resident conference-Preceptor
Sept 1, 2004 Peripheral T cell lymphomas and Cases-Preceptor
Sept 29, 2004 Cutaneous Lymphomas and Cases
Oct 13, 2004 Hematology-Oncology Fellows Teaching Rounds- Immunohistochemistry: Applications
Oct 27, 2004 Pathology of Spleen and Cases
Nov 24, 2004 Pattterns of Lymph node Disorders and Cases
January 18,2005 WHO Classification of Lymphomas- B cell type
January 21, 2005 WHO Classification of Lymphomas- Peripheral T cell Lymphomas
July 19, 2005 Immunohistochemistry: Applications/ Theory/ Techniques in Histology
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December 20, 2005 Hematopathology Resident Lecture Slides Series- Pathology of the Spleen
April 25, 2006 ASH paper Clinical Pathology presentation: New Technology of IHCFlow
May 16, 2006 Lymph node Reaction and Pattern of Benign Lymphadenopathies: Biology to Disease
Slide Series
June 13, 2006 Reactive lymph node- unknown slide workshop with residents and fellows
July 14, 2006 Advanced Immunohistochemistry Resident Lecture with Demos
Nov 21, 2006 Workshop on hematopathology diagnosis-competency based training on Potpourri of
Cases
Dec 20, 2006 Grand Round- B cell lymphomas
March 10, 2007 Teaching Rounds in Pathology- Splenic pathology and benign disorders
April 14, 2007 Grand Rounds- Cutaneous Lymphomas
July 24, 2007 Introduction to Histology and Special Immunostains II- Pathology Lecture
Nov 13, 2007 Lymphocytes from Biology to Disease Series- Reactive Lymph Nodes
Teaching Series
2005-2006 Hematopathology Lecture Series for Residents and Fellows-
Dec, 2005 to May, 2006
2007-2008 Hematopathology Fellow Teaching -Slide Weekly Slide Workshop Series
2007-2009 Hematopathology Fellow Teaching -Slide Weekly Slide Workshop Series
ACGME accredited Hematopathology Fellows 2006-2008 Dorna Rezania MD
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2007-2008 Tina Yu MD
2008-2009 Elizabeth Sagatys MD
2009-current Mojdeh Naghashpour, MD
FELLOW SCHOLARLY ACTIVITY
A. List the articles authored or co-authored by fellows in your program
Name of Fellow, Graduation year ( Current Fellow, clinical)
Author(s) (Fellow Name in bold), Name of article, Name of journal, Volume, pages, month Year
Mojdeh Naghashpour MD,2010
M. Naghashpour, H. Cualing, M. Szabunio, M. Bui, “Hyaline-Vascular Castleman Disease: A Rare Cause of a Solitary Subcutaneous Soft Tissue
Mojdeh Naghashpour MD,2010
M. Naghashpour and H. Cualing “Splenomegaly with Sea-Blue Histiocytosis, Dyslipidemia and Nephropathy in a Patient with Lecithin Cholesterol Acyltransferase (LCAT)
Mojdeh Naghashpour MD,2010
Rebecca L. Olin, Kim E. Nichols, Mojdeh Naghashpour, Mariusz Wasik, Brenda Shelly,Edward A. Stadtmauer, and Dan T. Vogl1 “Successful use of the anti-CD25 antibody daclizumab
Mojdeh Naghashpour MD,2010
Mojdeh Naghashpour and Lynn C. Moscinski, “Lymphoma”, in “Cancer Growth and Progression, 2 nd edition; Volume 2; Mechanisms of Carcinogenesis”, Springer 2009.
Name of Fellow, Graduation year
Author(s) (Fellow Name in bold), Name of article, Name of journal, Volume, pages, month Year
Elizabeth Sagatys MD 2009
Condarco T, Sagatys E, Prakash A, Rezania D, Cualing H. Primary Cutaneous B-Cell Lymphoma in a Child. Fetal and Pediatric Pathology.
Elizabeth Sagatys MD 2009
Sagatys E, Messina J, Rojiani A. 55-Year-Old Man with Paraspinal Mass.Brain Pathology. 18(4):631-5.2008
Elizabeth Sagatys MD 2009
Saeed S, Sagatys E, Wasserman J, Morgan MB. Geriatric Fungal Infections. In: Diagnosis of Aging Skin Diseases, RA Norman (ed). pp 121-47.
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Elizabeth Sagatys MD 2009
Sagatys E, Garrett C, Boulware D, Kelly S, Malafa M, Cheng J, Sebti S, Coppola D. Activation of the Serine/Threonine Protein Kinase Akt
Elizabeth Sagatys MD 2009
Saeed S, Sagatys E, Morgan MB. Acral Keratosis with Eosinophilic Dermal Deposits: A Distinctive Clinicopathologic Entity or Colloid
Yu, I-Ting (Tina), 2008 IT Yu, LC Moscinski, L Sokol, HD Cualing. CD4+CD56+ hematodermic neoplasm clinicopathologic study of eight cases. AJSP (manuscript for
Name of Fellow, Graduation year
Author(s) (Fellow Name in bold), Name of Article, Name of Journal, Volume, pages, Month Year
Dorna Rezania, 2007 Rezania D, Cualing HD, Ayala E. The diagnosis, management, and role of hematopoietic stem cell transplantation in aggressive peripheral T-cell neoplasms. Cancer Control. 2007 Apr; 14 (2).
Dorna Rezania, 2007 Rezania D, Sokol L, Cualing H. Classification and treatment of rare and aggressive types of peripheral T-cell/natural killer-cell lymphomas of the skin. Cancer Control. 2007 Apr; 14 (2).
Dorna Rezania, 2007 Rezania D, Ouban A, Marcet J, Coppola D. CMV colitis mimicking recurrent inflammatory bowel disease: report of three cases. Am Surg. 2007 Jan; 73 (1).Dorna Rezania, 2007 Todd J. Alekshun, MD, Dorna Rezania, MD, Hernani Cualing, MD, Ernesto Ayala, MD, Lubomir Sokol, MD. Skeletal Muscle Peripheral T-Cell Lymphoma, Journal of Clinical Oncology,Jan 20 ;26:501-3,2008
Dorna Rezania, 2007 Tania Condarco, MD, Elizabeth Sagatys, MD, Dorna Rezania, MD, Amy Prakash, MD, Hernani Cualing, MD. Primary Cutaneous B-cell Lymphoma in a Child. Pediatric Dermatology,Fetal and Pediatric Pathology, 2008 Dec 27:206-14
Dorna Rezania, 2007 Erica Smithberger MD, Rezania Dorna MD, Chavan R, Lein MH, Cualing H, Glass F, Messina JL. Primary Cutaneous Angioimmunoblastic T-cell lymphoma Histologically Mimicking an Inflammatory Dermatosis. Submitted Archives of Dermatology
B. List the research presentations by fellows (during the last three years) that resulted from fellow research activity during the program.
Name of Fellow, Graduation year
Presenter(s) (Fellow Name in bold), Topic, Audience (or Name of Meeting), Location, Date
30
Mojdeh Naghashpour, MD
EM Sagatys, D Rezania, M Naghashpour, LF Glass, ME Kadin and HD Cualing “CLA, TRAF1, BCL2, NFKB2, CD56, EMA and Fascin
Mojdeh Naghashpour, MD
Naghashpour M, Sagatys E, Smith R, Cualing H. “AIDS-Associated Hemophagocytic Syndrome: A Study of 100 Autopsy Cases” Oral Platform
Mojdeh Naghashpour, MD
Mojdeh Naghashpour, Adam Bagg. “The complementary role of molecular genetic and conventional cytogenetic detection of diagnostically and
Mojdeh Naghashpour, MD
M. Naghashpour, Ahmed S Bedeir, Jed Di-Paola, Yuan Yao, Roger Day and AR Sepulveda1. (United States and Canadian Academy of Pathology 98th Annual Meeting Stowell-Orbison Poster SessionBoston, Massachusetts Elizabeth Sagatys, MD 2009 CLA, TRAF1, BCL2, NFKB2, CD56, EMA and Fascin Expression in CD30+ Lymphoproliferative Disorders of the Skin EM Sagatys, D Rezania, M Naghashpour, LF Glass, ME Kadin, HD Cualing
United States and Canadian Academy of Pathology 98th Annual Meeting Stowell-Orbison Poster SessionBoston, Massachusetts 2009Elizabeth Sagatys, MD
2009Elizabeth Sagatys MD, Dorna Rezania MD, MD, Marshall Kadin MD, Frank Glass MD, Hernani Cualing MD. CLA and TRAF1 are useful in differentiating lymphomatoid papulosis, cutaneous ALCL, and Systemic ALCL. Am Society of Hematology poster, 2008, San Francisco.
Elizabeth Sagatys, MD 2009
AIDS-Associated Hemophagocytic Syndrome: A Study of 100 Autopsy Cases M Naghashpour, EM Sagatys, R Smith, HD Cualing
United States and Canadian Academy of Pathology 98th Annual Meeting Proffered Paper - Infections Session Boston, Massachusetts, 2009Elizabeth Sagatys, MD
2009Analysis of T-cell Subpopulations in the Lymph Nodes of Patients with Mantle Cell LymphomaEM Sagatys, L Moscinski, S Dessureault, E Sotomayor, H Cualing American
Elizabeth Sagatys, MD 2009
Automated Determination of Bone Marrow CellularityEM Sagatys, H Cualing, L Kang, E Zhong, L Moscinski
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Yu, I-Ting (Tina),2008 IT Yu, D Rezania, LC Moscinski, JD Messina, HD Cualing. Differentiating Cd4+/Cd56+ Hematodermic Neoplasm From Acute Monoblastic Leukemia. United States and Canadian
Name of Fellow, Graduation year
Presenter(s) (Fellow Name in bold), Topic, Audience (or Name of Meeting), Location, Date
Dorna Rezania, 2007 Dorna Rezania, MD, Hernani D. Cualing, MD, Eric Zhong MS, Lihua Li PhD. Conversion of Tissue Chromogenic Staining to Virtual Flow Cytometry by iHCFLOW System, United States and Canadian Academy of Pathology (USCAP), annual meeting, SanDiego, CA, 03/2007
Dorna Rezania, 2007 Ghayouri, M, Rezania, D, I-Ting YU , Moscinski, L, Zhong, E. Cualing, H. Automated grading of the reticulin stain of bone marrows using AUTORETIC algorithm. Accepted for United States and Canadian Academy of Pathology (USCAP), annual meeting, Denver, CO, 03/2008
Dorna Rezania, 2007 I-Ting Yu, MD, Dorna Rezania, MD, Lynn C. Moscinski, MD, Jane D. Messina, MD, Hernani D. Cualing, MD. Differentiating CD4+CD56+ Hematodermic neoplasms from acute monoblastic leukemia. Accepted for United States and Canadian Academy of Pathology (USCAP), annual meeting, Denver CO, 03/2008Dorna Rezania, 2007 Elizabeth Sagatys Dorna Rezania MD, MD, Marshall Kadin MD, Frank Glass MD, Hernani Cualing MD. CLA and TRAF1 are useful in differentiating lymphomatoid papulosis, cutaneous ALCL, and Systemic ALCL. Am Society of Hematology, 2008, San Francisco.
Research Support-Clinical Trials:
Title: A Phase II Trial Using a Universal GM-CSF-Producing and CD40L-Expressing Bystander Cell Line
(GM.CD40L) in the Formulation of Autologous Tumor Cell-Based Vaccines for Patients with Mantle Cell
Lymphoma.
Account : MCC# 13840
Type: Foundation Grant
Dates: 2005-2008
Source: Lymphoma Foundation of America
32
Role in the Study: Hematopathologist-Tissue Quantification of tumor infiltrating lymphocytes in mantle
cell lymphoma.
Title: Bortezomib and Vorinostat Trial in Refractory Mantle Cell Lymphoma
Account #: PI/Dr. Sokol Co Investigator: Hernani Cualing MD
Dates: 2008-2009
Source: H. Lee Moffitt Cancer Center
Role in the Study: Hematopathologist and quantification of target antigen
Title: “Medimmune anti CD2 targeted therapy in T cell lymphoma”
Account #: 14120 PI/Dr. Sokol Co Investigator, Hernani Cualing MD
Dates: 2006-2008
Source: H. Lee Moffitt Cancer Center
Role in the Study: Hematopathologist and quantifying target antigen
Title: “Single Agent Phase II study of Forodesine in the treatment of (CTCL) cutaneous T cell
lymphoma”
Account #: 14120 PI/Dr. Sokol Pathologist, Hernani Cualing MD
Dates: 2006-2008
Source: H. Lee Moffitt Cancer Center
Role in the Study: Hematopathologist and quantifying target antigen
Title: “Cytogenetic Studies in Leukemia Patients”
Account #: 14766 PI/Dr Lynn Moscinski, MD Collaborator/Hernani Cualing MD
Dates: 2007-2008
Source: H. Lee Moffitt Cancer Center
Account# 14794 PI/Lynn Moscinski, MD Collaborator/Hernani Cualing, MD
Date: 2007-2008
Source: H. Lee Moffitt Cancer Center
Title: Leukemia Centralized Reference Laboratories and Tissue Respositories, Ancillary
33
External Grant:
1. Account: RC1 Application PI/George Blanck, Ph.D. Co Investigator/Hernani Cualing, MD
Source: National Institute of Health
Title: “Mouse modeling of a CD30+ lymphoproliferative disorder: Role of IRF-1 defects in ALCLs”
% Effort 10%
Role in Study: Co PI: Hematopathologist comparing human CD30+ lymphomas with mouse CD30+
lymphomas
Date Submitted: June 14 , 2009- Not funded, Resubmission SBIR
2. New Multiinstitutional Grant submitted April 27, 2009: Exploratory/Developmental Research Grant
(R21) via American Recovery & Reinvestment Act of 2009 as RFA to Translational Science and
specific Challenge Topic 15-CA-105, The Biology of Cancer in Adolescents and Young Adults.:
using tissue blocks from SEER tissue banks from Hawaii, Iowa, RI, USC
Samples consist of diagnostic tumors from 527 Hodgkin lymphoma patients in the National
Cancer Institute Surveillance, Epidemiology and End-Results (SEER) program
Residual Tissue Repository (RTR). In Los Angeles, Hawaii and Iowa.
% effort: 3 %
Role: To provide hematopathology support and know-how for automated virtual flow analysis of T cell
subsets immunostains on these blocks.
COMPLETED
Internal Grant:
PI/Dr. R. Kothari Co PI Investigator.Hernani Cualing MD
Dates: 1994-1995
Source: University of Cincinnati/College of Engineering Biomedical Engineering Grant
Title: “Intelligent image analysis of lymphomas using artifical neural networks
% Effort: 10%
Role in the Study: Hematopathologist performing diagnosis and image analysis
Total Amount of Award: $ 24,000
Internal Grant:
34
PI: Director of Project Hernani Cualing MD
Dates: 1998-2000
Source: Dr. R Smith Discretionary Fund, Professor Univ of Cincinnati
Title: Color image segmentation of lymphocytes: Biomedical Engineering Grant
% Effort: 5 %
Role in the Study: Hematopathologist and quantification of target antigen
External Grant:
PI/Dr. R. Kothari Co Investigator.Hernani Cualing MD
Dates: 1997-2000
Source: Whitaker Foundation Biomedical Engineering Grant
Title: Microscopic Diagnosis of Lymphoma and Leukemia
% Effort: 15 %
Role in the Study: Hematopathologist performing diagnosis and image analysis
Total Amount of Award: $120,000
PATENTS and TRADEMARKS
1. USPTO/Virtual flow cytometry on immunostained tissue-Tissue cytometer
2. USPTO/ International PCT :Automated Cytomics: Bone Marrow Cellularity Determination
3. USPTO/ Automated Cytomics: Bone Marrow Reticulin Fibrosis Determination
4. USPTO Registered Trademark: VirtualFlow IHCFLOW® Cytometer
PEER REVIEWED JOURNAL REVIEWER:
Cytometry part B
Communications in Clinical Cytometry
Human Pathology
International Journal of Cancer
Transaction on Knowledge and Data Engineering
Leukemia Lymphoma
Pediatric Hematology
Pediatric Dermatology
Computer Methods and Programs in Biomedicine
35
Peer reviewed publications:
1) Bernal S, Cualing H, Elias A., Schwarting G and McCluer R.
Classification of Small Cell Carcinoma Antigens by their Association
with Subcellular Components. Lung Cancer Journal 4: 99-102 1988.
2) Bernal S, Cualing H., Elias A and Siegel R. Stability and Shedding of
Small Cell Carcinoma Membrane Antigens: Applications to Detection
of Antigens in Marrow and Serum. Lung Cancer Journal. 4: 79-80 1988.
3) Pliskin A, Cualing H, Stenger RJ. Primary Squamous Cell Carcinoma of
the Liver Originating in a Congenital Cyst of the Liver. A Case
Report and Review of Literature. Arch of Path Lab Med. 116:105-107, Jan
1992.
4) Cualing H, Siegel R, Schwarting G, Suchy S, McCluer R and Bernal,S.
Expression of H-like blood group glycolipids in Small Cell Carcinoma of
the Lung. Hybridoma, 12(3):239-247, Jun 1993.*
5) Orazi A, Neiman R, Cualing H, Heerema N, John K. , CD34 Immunostaining of
Bone marrow biopsy specimens is a reliable way to classify the phases of
chronic myeloid leukemia. Am J Clin Pathol, 101(4):426-428, Apr 1994.
6) Kothari R, Cualing H. , Balachander T. Neural Network Analysis of Flow
Cytometric Immunophenotype Data. IEEE Transactions in Biomedical
Engineering, 43(8):803-810,Aug 1996.
36
7) Cualing H, Povoski S, Fenoglio-Preiser C, Yassin R, Bell R. Characterization
of Hematologic malignancies in Syrian Golden Hamsters, Carcinogenesis
17(9):1983-1988,1996.*
8) Balachander T, Kothari R, Cualing H. An empirical comparison of
dimensionality reduction techniques for Pattern Classification. Gerstner W et al
eds. Artificial Neural Networks ICANN ’97, Lausanne, Switzerland. Lecture
Notes in Computer Science1327: 589-594, 1997.
9) Cualing H, Vasireddy R. Adult T-cell leukemia and Cutaneous pathology: An
overview. J Geriat Dermatol 5(8): 377-382, 1997.*
10) Giza E*, Stern P, Cualing H. Aggressive Giant Cell Reparative Granuloma of
the Metacarpal. J Hand Surg AM 22A (4): 732-736, 1997.
11) Massela F, Kowal-Vern A, Shrit A, Wibowo A, Rector J, Cotelingham J, Collier
J, Michael A, Cualing H, Schumacher H. Acute Erythroleukemia. Am J Clin
Pathol 110(5):590-598, Nov 1998.
12) Craig A*, Cualing H, Thomas G, Lamerson C, Smith R. Cytophagic
Histiocytic Panniculitis- a syndrome associated with benign and malignant
panniculitis: Case comparison and review of the literature. J Amer Acad
Dermatol 39(5):721-736, part 1 Nov 1998.*
13) Cualing H, Balachander T, Kothari R. Immunophenotypic diagnosis of acute
leukemia using decision tree analysis. Laboratory Investigation , 79(2): 205-212,
Feb 1999.*
14) Nakanishi K, Cualing H, Husseinzadeh N. Dermatomyositis as a presenting
symptom of ovarian cancer. Obstetrics and Gynecology 94(5): 836-838, part 2
Suppl S Nov 1999.
37
15) Marcelo A, Fontelo P, Farolan M, Cualing H. Effect of Image Compression on
Telepathology: A Randomized Controlled Trial. Arch Pathol Lab Med,
124:1653-1656, Nov 2000.
16) Cualing H, Zellner D, Steele P. Blastic transformation of splenic marginal zone
B-cell lymphoma.. Arch Pathol Lab Medicine. 124(3):748-752 March 2000*
17) Cualing H. Perspectives: Automated Analysis in Flow
Cytometry.Communications in Clin Cytometry, 42:110-113, April 2000.*
18) Cualing H. Wang G, Noffsinger A, Fenoglio-Preiser C. Heterotopic ovarian
splenoma: report of a first case. Arch Pathol Lab Med. 2001 Nov;125(11):1483-
5.
19) Cualing H, Schroder L Perme I. Allergic Granulomatosis secondary to a
Limited Churg-Strauss Lymphadenopathy: Case Report with Histologic and
Immunophenotypic analysis- 125:954-957, 2001 Arch of Pathol Lab Med
July 2001
20) Gebrail F*, Knapp M, Perrotta G, Cualing H. Crystalline Histiocytosis in
Hereditary Cystinosis. 126:1135, Sept 2002, Archives of Pathol Lab Med.
(Direct supervision of medical student elective in Diagnostic Hematopathology)
21) Kulow G, Breneman D, Cualing H, Steele P, Breneman J, Van Horn J, Mutasim
D. The Progression of Cutaneous B-cell Pseudolymphoma (CBPL) to
Cutaneous B-cell lymphoma (CBCL). Vol 6(6), 519-528, Nov 2002, J of
Cutaneous Med and Surg.
38
22) Gebrail F*, Lowy A, Cualing H. Angiolymphoid hyperplasia with eosinophilia:
a pathologic quiz case. Vol 127, 113-114, Jan 2003, Archives of Pathol
Lab Med. (Direct supervision of medical student elective in Diagnostic
Hematopathology)
23) Goldman A*, Bedolla G, Gebrail F, Cualing H, Bronchus-Associated
Lymphoid Tissue Lymphoma (BALT lymphoma). Vol 127, 115-116, Jan 2003,
Archives of Pathol and Lab Med. (Direct supervision of medical student elective
in Diagnostic Hematopathology)
24) Breneman DL, Raju US, Breneman JC, Steele PE, McFadden DW, Cualing HD,
Nussbaum MS, Swerdlow SH.Lymph node grading for staging of mycosis
fungoides may benefit from examination of multiple excised lymph
nodes. J Am Acad Dermatol. 2003 May;48(5):702-6.
25) Goldman A*, Gebrail F, Cualing H, Mott cell Granuloma: a 56 year old
presenting with recurrent neck mass. Vol 127: June 2003 Archives of Pathology
and Lab Medicine. (Direct supervision of medical student elective in
Diagnostic Hematopathology)
26) Colvin JH, Lamerson CL, Cualing H, Mutasim DF. Cutaneous
lymphoplasmacytoid lymphoma (immunocytoma) with Waldenstrom's
macroglobulinemia mimicking rosacea.
J Am Acad Dermatol. 2003 Dec;49(6):1159-62.
27) Breneman DL, Raju US, Breneman JC, Steele PE, McFadden DW, Cualing HD,
Nussbaum MS, Swerdlow SH.Reply to Letters to the Editor: Lymph node
grading for staging of mycosis fungoides may benefit from examination
of multiple excised lymph nodes. J Am Acad Dermatol. 2004 vol51:Sept 2004,
483-484.
39
28) Connie Keehn*, Cualing H., Marginal Zone Lymphoma with a Dual Cutaneous
and Leukemic Presentation and an Aberrant MyeloidMonocytic Phenotype.
Journal of Cutaneous Pathology
Volume 33: 6, 236-241, March 2006.
29) Rezania D*, Cualing H, Ayala E. Diagnosis, Management, And The Role Of
Hematopoietic Stem Cell Transplantation in Aggressive Peripheral T Cell
Neoplasms Cancer Control Journal, vol 14, no.2, p 151, April 2007.
30) Rezania D*, Cualing H. Sokol L. Aggressive Peripheral T cell Neoplasms and
subtypes with high predilection in the Skin. Cancer Control Journal, vol 14, no.2,
p 116, April 2007.
31) Droc C*, Cualing H., Kadin M. The Need for an Improved Classification For
Therapy of CD30 + lymphomas. Cancer Control Journal, vol 14, no.2, p 124,
April 2007.
32) Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C,
Jung JU, Cheng JQ, Mulé JJ, Pledger WJ, Wang HG. Bif-1 interacts with Beclin
1 through UVRAG and regulates autophagy and tumorigenesis. Nature Cell Biol.
2007 Sep 23;
33) Khalil F*, Heekin J, Lili Miles, Cualing H. The rate and morphometric pattern
of bone marrow recovery post-myelosuppressive therapy for acute leukemia: a
quantitative study- Archives of Pathology and Lab Medicine, Vol. 131, No. 8,
pp. 1281–1289, Aug 2007
34) *Cualing HD,Moscinski LC, Zhong E. “Virtual Flow Cytometry” of
Immunostained Lymphocytes on Microscopic Tissue Slides, Clinical Cytometry
part B, Volume 72B, Issue 1 , Pages 63 - 76 Jan 15, 2007.
40
35) Alekshun TJ, Rezania D, Ayala E, Cualing H, Sokol L.Skeletal muscle
peripheral T-cell lymphoma. J Clin Oncol. 2008 Jan 20;26(3):501-3. IF:
13.598 PMID: 18202425
36) J Pidala, Cualing H, Pinilla J. Acute basophilic leukemia arising from chronic
myelogenous leukemia with development of t(7;8)(q34, q13) Cancer Genet
Cytogenet. 2008 Apr 1;182 (1):46-9.
37) Raychaudhuri J, Cualing H, Haider K, Kharfan-Dabaja MA.Granulocytic
sarcoma and chronic lymphocytic leukemia of the gastrointestinal tract after
allogeneic hematopoietic cell transplantation mimicking graft-versus-host
disease. Leuk Lymphoma. 2008 Feb;49(2):350-2. IF: 1.559 PMID: 18231925
38) Calder K, Khalil F, Schlauder S, Cualing H, Morgan M. Immunohistochemical
expression of survivin in cutaneous sebaceous lesions. Am J Dermatopathol.
2008 Dec;30(6):545-548. Pubmedid: 19033926.
39) Condarco T, Sagatys E, Prakash A, Rezania D, Cualing H. Primary cutaneous B-
cell lymphoma in a child. Fetal Pediatr Pathol. 2008 Dec;27(4):206-214.
Pubmedid: 18800263.
40) Bernal S, Speak J, Stahel R, Elias A, Mabry M, Cualing H. Small cell carcinoma
antigens. In: Rosen S, Mulshine J, Cuttita F, Abrams P, eds. Biology in lung
cancer: diagnosis and treatment. New York: Marcel Dekker Inc., 1988:213-35:
Book Chapter
41) Cualing H . Pathology of the Spleen. In Handbook of Hematologic Pathology,
Schumacher H, Stass S. Eds. 53-73, Marcel Dekker, Inc., New York, April
2000.: Book Chapter
41
42) Mojdeh Naghashpour, Hernani Cualing* Splenomegaly with sea-blue
histiocytosis, dyslipidemia, and nephropathy in a patient with lecithin-cholesterol
acyltransferase deficiency: a clinicopathologic correlation, in press 2009
Metabolism Clinical and Experimental
43) Mojdeh Naghashpour, MD, PhD; Hernani D Cualing, MD; Margaret Szabunio,
MD;
Marilyn M Bui, MD, PhD Hyaline-Vascular Castleman Disease: A Rare Cause of Solitary
Subcutaneous Soft Tissue, in press, 2009 The American Journal of Dermatopathology
Manuscript Number: AJD-D-09-00143 *
* senior/corresponding author
Ongoing Research mentorship projects for fellows 2007 as topics in the monthly research and
planning meeting Hematopathology Mentorship:
Rezania D, Belongie I, Messina J, Cualing H, Glass F. Angioimmunoblastic T cell lymphoma
in skin- manuscript submitted for Archives of Dermatology
44) *Elizabeth Sagatys, MD, Lynn Moscinski, MD, Sophie Dessureault, MD,
Eduardo Sotomayor, MD and Hernani Cualing, MD Analysis of T-cell
Subpopulations in the Lymph Nodes of Patients with Mantle Cell Lymphoma.
Submitted to 49th ASH Annual Meeting and Exposition, Atlanta GA, Dec 8-11,
2007.
45) Iriana Belongie, Jane Messina, Frank Glass, Hernani Cualing. An unusual
lymphoma evolving from CD8+ epidermotropic CTCL, 44th
Annual Meeting,October 18-21, 2007 The American Society of
Dermatopathology, Baltimore Maryland USA.
46) *Dorna Rezania, MD, Elizabeth Sagatys, MD, Marshall E. Kadin, MD, Frank
Glass, MD, Hernani Cualing, MD. CLA and TRAF-1 are Useful in
Differentiating Lymphomatoid Papulosis, Cutaneous ALCL and Systemic
42
ALCL, H. Lee Moffitt Cancer Center and Research Institute1, Department of
Pathology, The University of South Florida College of Medicine, Tampa, FL and
Roger Williams Medical Center, Providence RI. Poster to be submitted to
USCAP 2009
47) *Tina Yu, Cualing H, Sagatys E, Rezania D, Moscinski L. Hematodermic tumor
and monocytic sarcoma: Differential immunostaining for USCAP meeting,
presented in March 2008 IAP Denver Meeting.
48) *Sagatys, E., H Cualing , E Zhong and L Moscinski. Automated Determination
of Bone Marrow Cellularity presented in IAP. For submission to Cytometry part
B.
49) *Sagatys E, Cualing H , Rezania D, Naghashpour M, Shaheen G, Moscinski L,
CD71 (Transferrin Receptor) Expression in Precursor and Mature B- and T-cell
lymphomas Recognized by REAL/WHO Classification
50) Cualing H, Sagatys E, Naghashpour M, Smith R. Macrosplenomegaly In AIDS.
Manuscript for Archives of Pathology and Lab Medicine
51) * Yu T, Calder K, Moscinski L, Sokol L, Morgan M, Cualing H. Differential
expression of myelomonocytic Markers in Hematodermic Neoplasm and Acute
Monocytic Leukemia.
52) Niessen Melissa, Blanck George, Cualing Hernani. Thymic dysmorphogenesis
and dysfunction in head trauma patients using molecular and
immunohistochemical markers. Dept of Molecular Medicine Clinical Study.
53) Rezania D, Belongie I, Messina J, Cualing H, Glass F. Angioimmunoblastic T
cell lymphoma in skin- manuscript submitted for Archives of Dermatology
43
44