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Dødelighed ved epilepsi Jakob Christensen, Neurologisk Afdeling, Aarhus Universitetshospital

Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

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Page 1: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Dødelighed ved epilepsi

Jakob Christensen, Neurologisk Afdeling, Aarhus Universitetshospital

Page 2: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Disclosure

Company Name Nature of Affiliation

UCBServing on a scientific advisory board, and honoraria for speaking engagements

EisaiServing on a scientific advisory board, and editorial board, and honoraria for speaking engagements

Novartis PI of clinical trial

Pfizer PI of clinical trial

Non-profit organizationThe Danish Epilepsy Association Novo Nordisk Fonden

Page 3: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Risiko for at dø

http://www.valuewalk.com/2012/01/denmarks-aging-population-is-ticking-time-bomb/death-rate-denmark/

http://www.valuewalk.com/2012/01/denmarks-aging-population-is-ticking-time-bomb/death-rate-denmark/

Page 4: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Dødelighed - alder

Page 5: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Dødelighed efter diagnose

Page 6: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Risko for at dø (%)

Page 7: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Epilepsitype

Page 8: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Dødsårsager

Page 9: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Dødsårsager

Medfødte tilstande

Page 10: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Dødsårsager

Psykiatrisk sygdom

Page 11: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

544307YesYes

19,4469,009NoYes

2,596185YesNo

-1.00400,54211,668NoNo

95% CIRelative

Risiko*

KontrolSelvmordEpilepsiPsykiatri

Epilepsi, psykiatrisk sygdom og selvmord

*Justeret for: civilstand, jobstatus, indkomst, kommune og sygemeldinger

.

11.8 – 16.013.7

12.0 – 12.912.5

1.71 – 2.321.99

Page 12: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Medicin og selvmordstanker

Page 13: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Dødsårsager

SUDEP

Page 14: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

SUDEP

Lancet Neurol. 2011 Sep 19.

0

20

40

60

80

100

120

Dødelighed

Placebo

Medicin

Page 15: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Konklusion - dødelighed

Øget ved epilepsi

Høj hos yngre

Høj kort tid efter diagnose

Speciel risiko ved

Psykiatrisk sygdom

SUDEP

Page 16: Dødelighed ved epilepsi - Epilepsiforeningen · Yes Yes 307 544 Yes No 9,009 19,446 No Yes 185 2,596 No No 11,668 400,542 1.00 - Relative 95% CI Risiko* Psykiatri Epilepsi Selvmord

Tak

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