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20 Thyroid J.C. Watkinson, J.A. Smith CONTENTS Management of the solitary thyroid nodule and the dominant nodule within a multinodular goitre 342 Management of malignant thyroid disease 343 Management of Graves’ thyrotoxicosis 343 Management of benign multinodular thyroid disease 343 Thyroid operations 344 Appraise n 1 Indications for thyroid surgery fall into three categories: n Suspected or proven malignancy n Benign symptomatic goitre n Graves' disease (named after the Irish physician Robert James Graves, who described a case of goitre with exophthalmos in 1835. In Europe the condition is named after Karl von Basedow). n 2 All thyroid surgery carries significant potential morbidity. Carefully investigate patients about to undergo surgery and involve the multidisciplinary team to avoid inappropriate or un- necessary surgery. Thyroid surgery is a significant potential source of litigation. As well as counselling your patient, provide clear documentation, especially with regard to potential damage to the recurrent laryngeal nerve and the parathyroid glands. n 3 Thyroid surgery is increasingly performed in specialist centres by surgeons with a special interest in thyroid disorders. Closely liaise with endocrinologists and oncologists to achieve satisfactory outcomes. Joint or combined clinics are advocated, particularly for patients with complex disease. n 4 It is mandatory to have access to and attend an appropriate multi- disciplinary team meeting (MDT) if you regularly undertake malignant thyroid surgery. Familiarize yourself with local arrangements. n 5 Be willing to work jointly with other surgical specialists, such as cardiothoracic surgeons, when treating retrosternal extensions. n 6 Re-operation in the neck carries significantly increased morbid- ity. As a result, partial or subtotal thyroidectomy is now less frequently performed in favour of either hemi- or total thyroid- ectomy. The aim is to leave behind as little thyroid tissue as possible. n 7 Audit your results personally, locally and nationally. In the UK results are submitted to the British Association of Endocrine and Thyroid Surgeons (BAETS). 1 The Association publishes audit results and guidelines for managing thyroid disease. Familiarize yourself with the website www.baets.org.uk. n 8 Assessment (see Table 20.1). n 9 Investigate: n Biochemical evaluation is mandatory in patients with thyroid disease. Familiarize yourself with and check thyroid func- tion tests (tri-iodothyronine (T3), thyroxine (T4) and thy- roid stimulating hormone: TSH), as well as calcium and albumin assays, prior to considering surgery. Undiagnosed or unrecognized thyrotoxicosis can lead to serious conse- quences during general anaesthesia. Vitamin D levels may be assayed in areas where deficiency is endemic and cor- rected prior to surgery. Thyroid auto-antibodies may also be requested to screen for the presence of Hashimoto's thy- roiditis (first described by Japanese physician Hashimoto Hakaru in Germany in 1912). n Fine needle aspiration cytology (FNAC) is an efficient and cost- effective method of evaluating thyroid nodules. Diagnostic accuracy is dependent on the experience of the operator, TABLE 20.1 Assessment in the clinic Ask yourself: History Examination Is the patient euthyroid? Intolerance to heat and cold, weight loss, altered bowel habit, anxiety/depression Tachycardia, tremor, Graves’ eye signs, skin changes What kind of goitre is this? Physiologic, toxic Diffuse, solitary nodule, multinodular Is a malignant process likely? Neck pain, hoarseness, family history of thyroid cancer, previous exposure to radiation Lymph nodal masses, recurrent laryngeal nerve palsy, fixation, Berry’s sign (loss of carotid pulsation indicating invasion by tumour) Does the patient have obstruction? Dysphagia, shortness of breath, inability to lay flat Stridor, venous engorgement, Pemberton’s sign (Hugh Pemberton, 1946) – facial flushing on raising both arms indicating SVC obstruction Can the goitre be delivered through the neck? Longstanding goitre, significant obstructive symptoms Retrosternal extension 341

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  • n2

    of litigation. As well as counselling your patient, provide clear

    n5 Be willing to work jointly with other surgical specialists, such ascardiothoracic surgeons, when treating retrosternal extensions.

    and Thyroid Surgeons (BAETS). The Association publishes audit

    n8 Assessment (see Table 20.1).n9 Investigate:

    n Biochemical evaluation is mandatory in patients with thyroiddisease. Familiarize yourself with and check thyroid func-tion tests (tri-iodothyronine (T3), thyroxine (T4) and thy-roid stimulating hormone: TSH), as well as calcium andalbumin assays, prior to considering surgery. Undiagnosedor unrecognized thyrotoxicosis can lead to serious conse-quences during general anaesthesia. Vitamin D levels maybe assayed in areas where deficiency is endemic and cor-rected prior to surgery. Thyroid auto-antibodies may alsobe requested to screen for the presence of Hashimoto's thy-roiditis (first described by Japanese physician HashimotoHakaru in Germany in 1912).

    n Fine needle aspiration cytology (FNAC) is an efficient and cost-effective method of evaluating thyroid nodules. Diagnosticaccuracy is dependent on the experience of the operator,

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    by tumour)

    Does thepatient haveobstruction?

    Dysphagia,shortness of breath,inability to lay flat

    Stridor, venousengorgement,Pembertons sign

    through the symptoms

    41results and guidelines for managing thyroid disease. Familiarizeyourself with the website www.baets.org.uk.

    neck?

    3possible.n6 Re-operation in the neck carries significantly increased morbid-ity. As a result, partial or subtotal thyroidectomy is now lessfrequently performed in favour of either hemi- or total thyroid-ectomy. The aim is to leave behind as little thyroid tissue as

    n7 Audit your results personally, locally and nationally. In the UKresults are submitted to the British Association of Endocrine

    1

    (Hugh Pemberton,1946) facial flushingon raising both armsindicating SVCobstruction

    Can the goitrebe delivered

    Longstanding goitre,significant obstructive

    Retrosternal extensiondisciplinary team meeting (MDT) if you regularly undertakemalignant thyroid surgery. Familiarize yourself with localarrangements.documentation, especially with regard to potential damage tothe recurrent laryngeal nerve and the parathyroid glands.

    n3 Thyroid surgery is increasingly performed in specialist centres bysurgeons with a special interest in thyroid disorders. Closely liaisewith endocrinologists and oncologists to achieve satisfactoryoutcomes. Joint or combined clinics are advocated, particularlyfor patients with complex disease.

    n4 It is mandatory to have access to and attend an appropriate multi-Carefully investigate patients about to undergo surgery andinvolve the multidisciplinary team to avoid inappropriate or un-necessary surgery. Thyroid surgery is a significant potential sourcen Benign symptomatic goitren Graves' disease (named after the Irish physician Robert James

    Graves, who described a case of goitre with exophthalmos in1835. InEuropethecondition isnamedafterKarl vonBasedow).

    All thyroid surgery carries significant potential morbidity.20

    ThyroidJ.C.Watkinson, J.A. Smith

    CONTENTS

    Management of the solitary thyroid nodule and the

    dominant nodule within a multinodular goitre 342

    Management of malignant thyroid disease 343

    Management of Graves thyrotoxicosis 343

    Management of benign multinodular thyroid

    disease 343

    Thyroid operations 344

    Appraise

    n1 Indications for thyroid surgery fall into three categories:n Suspected or proven malignancycancer, previousexposure to radiation

    nerve palsy, fixation,Berrys sign (loss ofcarotid pulsationindicating invasionBLE 20.1 Assessment in the clinic

    skurself:

    History Examination

    the patientthyroid?

    Intolerance to heat andcold, weight loss,altered bowel habit,anxiety/depression

    Tachycardia, tremor,Graves eye signs, skinchanges

    hat kind ofitre is this?

    Physiologic, toxic Diffuse, solitarynodule, multinodular

    a malignantocess likely?

    Neck pain, hoarseness,family history of thyroid

    Lymph nodal masses,recurrent laryngeal

  • n10

    n11

    c KEY POINTS Risks of surgery

    may lead to subtle changes in voice (typically loss of high-pitched

    B