contact

Dr. Lucas Onder

titel Dr.

first name Lucas

last name Onder

country Switzerland

e-mail lucas.onder@kssg.ch

2

research profile

academic status Wissenschaftler/in

department Interdisziplinäre Medizinische Dienste

faculty Institut für Immunbiologie

position Senior Scientist/Post-Doc at Institute ofImmunobiology, Medical Research Center,Kantonsspital St. Gallen, Switzerland

fields of research Immunobiology, Developmental Biology, Stromalcell biology;Topics: The function and development of secondarylymphoid organs, The role of tumor suppressivestromal cells in the tumor microenvironment;

3

research profile

former positions 2007-2012 Doctoral Student at Institute ofImmunobiology

2007-2012 Doctoral Student at Federal Institute ofTechnology (ETH) Zurich, Switzerland;

Doctoral Thesis: Dissecting the function of lymphoidorgan stromal cells in vivo

2001-2007 Master studies in Molecular Biology andDevelopmental Biology, University of Innsbruck,Austria;

Diploma Thesis: Genetic interactions of pdx1 andhlxb9 in beta-cell formation and regeneration inzebrafish (supervision: Prof. Dirk Meyer, Institute ofMolecular Biology)

2006 Trainee at Daniel Swarovski Laboratory,Medical University of Innsbruck, Austria;

Topic: The role of Akt and BRAF in oncogenesis(supervision: Prof. Jakob Troppmair)

affiliations Swiss Society for Allergology and Immunology(SSAI/SGAI)

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research profile

awards 2013 Silver Medal of the ETH Zurich for outstandingPhD Thesis

2014 Travel support and Posterprize at ThymozMeeting, Heron Island, Australia

2011 Best oral presentation at World ImmuneRegulation Meeting (WIRM), Davos, Switzerland

5

research profile

additional information Selected Publications:

Onder L et al., Lymphatic Endothelial Cells controlInitiation of Lymph Node Organogenesis, Immunity,2017

Novkovic M and Onder L, et al., Topological Small-World Organization of the Fibroblastic Reticular CellNetwork Determines Lymph Node Functionality, PlosBiology, 2016, PMID: 27415420

Onder L, et al., Alternative NF-κB signalingregulates mTEC differentiation from podoplanin-expressing precursors in the cortico-medullaryjunction, European Journal of Immunology, 2015,PMID: 25973789

Chai Q and Onder L, et al., Maturation of lymphnode fibroblastic reticular cells from myofibroblasticprecursors is critical for antiviral immunity,Immunity, 2013, PMID: 23623380

Onder L, et al., Endothelial cell-specificlymphotoxin-β receptor signaling is critical forlymph node and high endothelial venule formation,The Journal of Experimental Medicine, 2013, PMID:23420877

Onder L, et al., IL-7-producing stromal cells arecritical for lymph node remodelling, Blood, 2012,PMID: 22955921

6

publications

title

journalpaper/review

Cheng H W, Urs M , Lütge M, Engetschwiler C, Onder L, Novkovic M, GilCruz C, Perez Shibayama C, Hehlgans T, Scandella E, Ludewig B.Intestinal fibroblastic reticular cell niches control innate lymphoid cellhomeostasis and function. Nat Commun 2022; 13:2027.

Prados A, Onder L, Cheng H W, Mörbe U, Lütge M, Gil Cruz C, PerezShibayama C, Koliaraki V, Ludewig B, Kollias G. Fibroblastic reticular celllineage convergence in Peyer's patches governs intestinal immunity. NatImmunol 2021; 22:510-519.

Pikor N, Cheng H W, Onder L, Ludewig B. Development andImmunological Function of Lymph Node Stromal Cells. J Immunol 2021;206:257-263.

Acton S E, Onder L, Novkovic M, Martinez V G, Ludewig B.Communication, construction, and fluid control: lymphoid organfibroblastic reticular cell and conduit networks. Trends Immunol 2021;42:782-794.

Ring S, Cupovic J, Onder L, Lütge M, Perez Shibayama C, Gil Cruz C,Scandella E, De Martin A, Mörbe U, Hartmann F, Wenger R, Spiegl M,Besse A, Bonilla W V, Stemeseder F, Schmidt S, Orlinger K K, Krebs P,Ludewig B, Flatz L. Viral vector-mediated reprogramming of thefibroblastic tumor stroma sustains curative melanoma treatment. NatCommun 2021; 12:4734.

Onder L, Cheng H W, Ludewig B. Visualization and functionalcharacterization of lymphoid organ fibroblasts. Immunol Rev 2021;.

Okreglicka K, Iten I, Pohlmeier L, Onder L, Feng Q, Kurrer M, Ludewig B,Nielsen P, Schneider C, Kopf M. PPARγ is essential for the development ofbone marrow erythroblastic island macrophages and splenic red pulpmacrophages. J Exp Med 2021; 218:.

7

publications

title

journalpaper/review

Cupovic J, Ring S, Onder L, Colston J M, Lütge M, Cheng H W, De MartinA, Provine N M, Flatz L, Oxenius A, Scandella E, Krebs P, Engeler D S,Klenerman P, Ludewig B. Adenovirus vector vaccination reprogramspulmonary fibroblastic niches to support protective inflating memory CD8T cells. Nat Immunol 2021; 22:1042-1051.

Choi S Y, Bae H, Jeong S H, Park I, Cho H, Hong S P, Lee D H, Lee C K,Park J S, Suh S H, Choi J, Yang M J, Jang J Y, Onder L, Moon J H, Jeong HS, Adams R H, Kim J M, Ludewig B, Song J H, Lim D S, Koh G Y. YAP/TAZdirect commitment and maturation of lymph node fibroblastic reticularcells. Nat Commun 2020; 11:519.

Pikor N, Morbe U, Lütge M, Gil Cruz C, Perez Shibayama C, Novkovic M,Cheng H W, Nombela-Arrieta C, Nagasawa T, Linterman M A, Onder L,Ludewig B. Remodeling of light and dark zone follicular dendritic cellsgoverns germinal center responses. Nat Immunol 2020; 21:649-659.

Novkovic M, Onder L, Bocharov G, Ludewig B. Topological Structure andRobustness of the Lymph Node Conduit System. Cell Rep 2020;30:893-904.e6.

Perez Shibayama C, Islander U, Lütge M, Cheng H W, Onder L, Ring S, DeMartin A, Novkovic M, Colston J, Gil Cruz C, Ludewig B. Type I interferonsignaling in fibroblastic reticular cells prevents exhaustive activation ofantiviral CD8 T cells. Sci Immunol 2020; 5:.

8

publications

title

journalpaper/review

Cosgrove J, Novkovic M, Albrecht S, Pikor N, Zhou Z, Onder L, Mörbe U,Cupovic J, Miller H, Alden K, Thuery A, O'Toole P, Pinter R, Jarrett S,Taylor E, Venetz D, Heller M, Uguccioni M, Legler D F, Lacey C J,Coatesworth A, Polak W G, Cupedo T, Manoury B, Thelen M, Stein J V,Wolf M, Leake M C, Timmis J, Ludewig B, Coles M C. B cell zone reticularcell microenvironments shape CXCL13 gradient formation. Nat Commun2020; 11:3677.

Cheng H W, Onder L, Novkovic M, Soneson C, Lütge M, Pikor N, ScandellaE, Robinson M D, Miyazaki J I, Tersteegen A, Sorg U, Pfeffer K, Rülicke T,Hehlgans T, Ludewig B. Origin and differentiation trajectories offibroblastic reticular cells in the splenic white pulp. Nat Commun 2019;10:1739.

Camara A, Cordeiro O G, Alloush F, Sponsel J, Chypre M, Onder L, AsanoK, Tanaka M, Yagita H, Ludewig B, Flacher V, Mueller C G. Lymph NodeMesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche.Immunity 2019; 50:1467-1481.e6.

Gil Cruz C, Perez Shibayama C, De Martin A, Ronchi F, Van Der Borght K,Niederer R, Onder L, Lütge M, Novkovic M, Nindl V, Ramos G, Arnoldini M,Slack E M C, Boivin-Jahns V, Jahns R, Wyss M, Mooser C, Lambrecht B N,Maeder M T, Rickli H, Flatz L, Eriksson U, Geuking M B, McCoy K D,Ludewig B. Microbiota-derived peptide mimics drive lethal inflammatorycardiomyopathy. Science 2019; 366:881-886.

Perez Shibayama C, Gil Cruz C, Cheng H W, Onder L, Printz A, Morbe U,Novkovic M, Li C, Lopez-Macias C, Buechler M B, Turley S J, Mack M,Soneson C, Robinson M D, Scandella E, Gommerman J, Ludewig B.Fibroblastic reticular cells initiate immune responses in visceral adiposetissues and secure peritoneal immunity. Sci Immunol 2018; 3:.

9

publications

title

journalpaper/review

Cheng H W, Onder L, Cupovic J, Bösch M, Novkovic M, Pikor N, TarantinoI, Rodriguez R, Schneider T, Jochum W, Brutsche M, Ludewig B. CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth bypromoting local antitumor T-cell responses. J Allergy Clin Immunol 2018;.

Onder L, Ludewig B. A Fresh View on Lymph Node Organogenesis. TrendsImmunol 2018; 39:775-787.

Onder L, Ludewig B. Redefining the Nature of Lymphoid Tissue OrganizerCells: Response to 'Complexity of Lymphoid Tissue Organizers' by Koningand Mebius. Trends Immunol 2018; 39:952-953.

Novkovic M, Onder L, Cheng H W, Bocharov G, Ludewig B. IntegrativeComputational Modeling of the Lymph Node Stromal Cell Landscape.Front Immunol 2018; 9:2428.

Bösch M, Onder L, Cheng H W, Novkovic M, Morbe U, Sopper S, Gastl G,Jochum W, Ruhstaller T, Knauer M, Ludewig B. Interleukin 7-expressingfibroblasts promote breast cancer growth through sustenance of tumorcell stemness. Oncoimmunology 2018; 7:e1414129.

Novkovic M, Onder L, Bocharov G, Ludewig B. Graph Theory-BasedAnalysis of the Lymph Node Fibroblastic Reticular Cell Network. MethodsMol Biol 2017; 1591:43-57.

Onder L, Morbe U, Pikor N, Novkovic M, Cheng H W, Hehlgans T, PfefferK, Becher B, Waisman A, Rülicke T, Gommerman J, Mueller C G, Sawa S,Scandella E, Ludewig B. Lymphatic Endothelial Cells Control Initiation ofLymph Node Organogenesis. Immunity 2017; 47:80-92.e4.

10

publications

title

journalpaper/review

Chung J, Ebens C L, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A,Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran I T, Chai Q, OnderL, Yan M, Reddy P, Blazar B R, Huang A Y, Brennan T V, Bishop D K,Ludewig B, Siebel C W, Radtke F, Luther S A, Maillard I. Fibroblasticniches prime T cell alloimmunity through Delta-like Notch ligands. J ClinInvest 2017; 127:1574-1588.

Pikor N, Cupovic J, Onder L, Gommerman J L, Ludewig B. Stromal CellNiches in the Inflamed Central Nervous System. J Immunol 2017;198:1775-1781.

Novkovic M, Onder L, Cupovic J, Abe J, Bomze D, Cremasco V, ScandellaE, Stein J V, Bocharov G, Turley S J, Ludewig B. Topological Small-WorldOrganization of the Fibroblastic Reticular Cell Network Determines LymphNode Functionality. PLoS Biol 2016; 14:e1002515.

Gil Cruz C, Perez Shibayama C, Onder L, Chai Q, Cupovic J, Cheng H W,Novkovic M, Lang P A, Geuking M B, McCoy K D, Abe S, Cui G, Ikuta K,Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinalinflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol2016; 17:1388-1396.

Cupovic J, Onder L, Gil Cruz C, Weiler E, Caviezel-Firner S, PerezShibayama C, Rülicke T, Bechmann I, Ludewig B. Central Nervous SystemStromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced Neuroinflammation. Immunity 2016; 44:622-33.

Grebennikov D, Van Loon R, Novkovic M, Onder L, Savinkov R, SazonovI, Tretyakova R, J Watson D, Bocharov G. Critical Issues in ModellingLymph Node Physiology. Computation 2016; 5:3.

11

publications

title

journalpaper/review

Savinkov R, Kislitsyn A, Watson D J, Van Loon R, Sazonov I, Novkovic M,Onder L, Bocharov G. Data-driven modelling of the FRC network forstudying the fluid flow in the conduit system. Engineering Applications ofArtificial Intelligence 2016; 62:341-349.

Onder L, Nindl V, Scandella E, Chai Q, Cheng H W, Caviezel-Firner S,Novkovic M, Bomze D, Maier R, Mair F, Ledermann B, Becher B, WaismanA, Ludewig B. Alternative NF-κB signaling regulates mTEC differentiationfrom podoplanin-expressing presursors in the cortico-medullary junction.Eur J Immunol 2015;.

Onder L, Ludewig B. Another TLO in the Wall: Education and Control of TCells in Atherosclerotic Arteries. Immunity 2015; 42:981-3.

Mair F, Joller S, Hoeppli R, Onder L, Hahn M, Ludewig B, Waisman A,Becher B. The NFκB-inducing kinase is essential for the developmentalprogramming of skin-resident and IL-17-producing γδ T cells. Elife 2015;4:.

Kislitsyn A, Savinkov R, Novkovic M, Onder L, Bocharov G. ComputationalApproach to 3D Modeling of the Lymph Node Geometry. Computation2015; 3:222-234.

Fasnacht N, Huang H Y, Koch U, Favre S, Auderset F, Chai Q, Onder L,Kallert S, Pinschewer D D, MacDonald H R, Tacchini-Cottier F, Ludewig B,Luther S A, Radtke F. Specific fibroblastic niches in secondary lymphoidorgans orchestrate distinct Notch-regulated immune responses. J ExpMed 2014; 211:2265-79.

Astarita J L, Cremasco V, Fu J, Darnell M C, Peck J R, Nieves-Bonilla J M,Song K, Kondo Y, Woodruff M C, Gogineni A, Onder L, Ludewig B, WeimerR M, Carroll M C, Mooney D J, Xia L, Turley S J. The CLEC-2-podoplaninaxis controls the contractility of fibroblastic reticular cells and lymph nodemicroarchitecture. Nat Immunol 2014; 16:75-84.

12

publications

title

journalpaper/review

Cremasco V, Woodruff M C, Onder L, Cupovic J, Nieves-Bonilla J M,Schildberg F A, Chang J, Cremasco F, Harvey C J, Wucherpfennig K,Ludewig B, Carroll M C, Turley S J. B cell homeostasis and follicle confinesare governed by fibroblastic reticular cells. Nat Immunol 2014;15:973-81.

Perez Shibayama C, Gil Cruz C, Pastelin-Palacios R, Cervantes-BarraganL, Hisaki E, Chai Q, Onder L, Scandella E, Regen T, Waisman A, Isibasi A,López-Macías C, Ludewig B. IFN-γ-producing CD4+ T cells promotegeneration of protective germinal center-derived IgM+ B cell memoryagainst Salmonella Typhi. J Immunol 2014; 192:5192-200.

Caviezel-Firner S, Engeler D S, Bolinger B, Onder L, Scandella E, Yu M,Kroczek R A, Ludewig B. Systemic minor histocompatibility antigenexpression in blood endothelial cells prevents T cell-mediated vascularimmunopathology. Eur J Immunol 2013; 43:3233-43.

Chai Q, Onder L, Scandella E, Gil Cruz C, Perez Shibayama C, Cupovic J,Danuser R, Sparwasser T, Luther S A, Thiel V, Rülicke T, Stein J V,Hehlgans T, Ludewig B. Maturation of lymph node fibroblastic reticularcells from myofibroblastic precursors is critical for antiviral immunity.Immunity 2013; 38:1013-24.

Onder L, Danuser R, Scandella E, Firner S, Chai Q, Hehlgans T, Stein J V,Ludewig B. Endothelial cell-specific lymphotoxin-β receptor signaling iscritical for lymph node and high endothelial venule formation. J Exp Med2013; 210:465-73.

Iolyeva M, Aebischer D, Proulx S T, Willrodt A H, Ecoiffier T, Häner S,Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O,Chen L, Finke D, Halin C. Interleukin-7 is produced by afferent lymphaticvessels and supports lymphatic drainage. Blood 2013; 122:2271-81.

13

publications

title

journalpaper/review

Onder L, Nindl V, Ludewig B. Tight control - decision-making during Tcell-vascular endothelial cell interaction. Front Immunol 2012; 3:279.

Onder L, Narang P, Scandella E, Chai Q, Iolyeva M, Hoorweg K, Halin C,Richie E, Kaye P, Westermann J, Cupedo T, Coles M, Ludewig B. IL-7-producing stromal cells are critical for lymph node remodeling. Blood2012; 120:4675-83.

Onder L, Scandella E, Chai Q, Mayer C T, Sparwasser T, Thiel V, Rülicke T,Ludewig B. A novel bacterial artificial chromosome-transgenicpodoplanin-cre mouse targets lymphoid organ stromal cells in vivo. FrontImmunol 2011; 2:50.

Kumar V, Scandella E, Danuser R, Onder L, Nitschké M, Fukui Y, Halin C,Ludewig B, Stein J V. Global lymphoid tissue remodeling during a viralinfection is orchestrated by a B cell-lymphotoxin-dependent pathway.Blood 2010; 115:4725-33.

Zinkernagel M S, Bolinger B, Krebs P, Onder L, Miller S, Ludewig B.Immunopathological basis of lymphocytic choriomeningitis virus-inducedchorioretinitis and keratitis. Journal of virology 2009; 83:159-66.

14

projects

title status

Systems biology approach to molecularly characterize the lungcancer microenvironment

completed

Funktionelle Charakterisierung und therapeutische Nutzung desmesenchymalen Tumorstromas

completed

Examining the function of lymphoid organ structure duringantiviral immune responses using microscopic and mesoscopicimaging

completed