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Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 1: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 2: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 3: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 4: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 5: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 17: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

27

Page 18: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

Ftwi Fkueqxgt{ Pgwtqfgigpgtcvkqp Eqphgtgpeg- Ycujkpivqp FE 2828

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4* Yjcv ku vjg rtqeguu d{ yjkej ftwi fkueqxgt{ vctigvu ctg xcnkfcvgf qtnkpmgf vq vjg fkugcugA

Page 20: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

Ftwi Fkueqxgt{ Pgwtqfgigpgtcvkqp Eqphgtgpeg- Ycujkpivqp FE 2;2;

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PUH- OLHH- JFH- cpf jcu rwdnkujgf qxgt 91 rggt.tgxkgygf ocpwuetkrvu- tgxkgyu- cpf dqqmejcrvgtu/

Page 21: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 22: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

Ftwi Fkueqxgt{ Pgwtqfgigpgtcvkqp Eqphgtgpeg- Ycujkpivqp FE 32

- Rhk|gt Inqdcn Tgugctej cpf Fgxgnqrogpv

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tqng- Ft/ Ucjcicp tgrtgugpvu Pgwtquekgpeg Fkueqxgt{ qp vjg Pgwtquekgpeg Nkegpukpi NgcfgtujkrVgco cpf ku ceeqwpvcdng hqt vjg fgxgnqrogpv cpf korngogpvcvkqp qh uvtcvgikgu ctqwpf Dkqnqikecnucpf Kpfkecvkqpu Fkueqxgt{/ Kp cffkvkqp vq vjgug fgrctvogpvcn tgurqpukdknkvkgu- Dctdctc ngcfu vjglqkpv tgugctej eqnncdqtcvkqp dgvyggp Rhk|gt cpf VtcpuVgej Rjctoc vjcv ku fgxgnqrkpi TCIGcpvciqpkuvu hqt CF vjgtcr{/ Ft/ Ucjcicp ku c ogodgt qh vjg uekgpvkhke tgxkgy dqctf qh vjgCn|jgkogt�u Ftwi Fkueqxgt{ Hqwpfcvkqp cpf ku cevkxg kp vjg PKC�u rtqitcou rtqoqvkpi CF ftwi

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33

Uguukqp KK/

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Gzcorngu qh mg{ swguvkqpu vq dg cfftguugf kpenwfg<

2* Yjcv rtqrgtvkgu qh c ejgokecn eqorqwpf ocmg kv oqtg nkmgn{ vq dg ftwi.nkmg qt wughwn cu c ngcf eqorqwpf hqt ogfkekpcn ejgokuvt{ tghkpgogpv- xgtuwuc vqqn hqt ejgokecn dkqnqi{ tgugctejA

3* Jqy fqgu eqpukfgtcvkqp qh eqorqwpf oqngewnct rtqrgtvkgu cpf uvtwevwtcncngtvu korcev jkij vjtqwijrwv uetggp fgukip- jkv tghkpgogpv cpf enkpkecnecpfkfcvg ugngevkqpA

4* Jqy fqgu qpg cfftguu vjg rqvgpvkcn hqt iqqf dkqcxckncdknkv{ cpf EPUrgpgvtcpeg kp ogfkekpcn ejgokuvt{ tghkpgogpv qh c jkv- nkicpf- qt kpjkdkvqtA

5* Yjcv ctg urgekcn cpf eqooqp kuuwgu yjgp eqpukfgtkpi dkqnqikecnu cuvjgtcrgwvkeuA

Urgcmgtu yknn rtqxkfg c tgxkgy qh hwpfcogpvcnu kp vjg eqpvgzv qh ecug uvwfkgucu eqpetgvg gzcorngu hqt ngctpkpi cpf uvkowncvg fkuewuukqp cdqwv vjgug mg{swguvkqpu cu crrnkgf vq EPU fkuqtfgtu cpf pgwtqfgigpgtcvkxg fkugcugu uwejcu Cn|jgkogt�u fkugcug/

Page 24: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

Ftwi Fkueqxgt{ Pgwtqfgigpgtcvkqp Eqphgtgpeg- Ycujkpivqp FE 3434

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Page 26: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 27: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 28: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 29: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 30: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 33: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

43

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Page 34: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Page 35: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

45

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Page 36: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

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Ukpeg lqkpkpi Rhk|gt- Ft/ Urtcemnkp jcu yqtmgf hqt qxgt 9 {gctu ykvjkp vjg EPU vjgtcrgwvke ctgc-jcxkpi vjg qrrqtvwpkv{ vq yqtm qp ugxgtcn EPU rtqitcou kp dqvj vjg ru{ejqvjgtcrgwvkeu cpfPgwtqfgigpgtcvkqp ctgcu- cu ygnn cu ugtxg cu vjg ftwi ogvcdqnkuo tgrtgugpvcvkxg hqt ugxgtcnfgxgnqrogpv vgcou/ Ewttgpvn{- jg ku vjg Fktgevqt qh vjg Dkqvtcpuhqtocvkqp ' Gp|{oqnqi{ itqwrykvjkp Rhk|gt ftwi ogvcdqnkuo/

Vjku rtgugpvcvkqp yknn eqxgt vjg rj{ukqnqikecn dcuku hqt vjg #dcttkgt# pcvwtg qh vjg DDD cu ygnn cukpxgpvqt{ uqog qh vjg gzrgtkogpvcn crrtqcejgu )kp xkvtq0kp xkxq* vjcv ctg cxckncdng hqt uetggpkpi hqt

dtckp rgpgvtcvkqp/ Vjg rtgugpvcvkqp yknn gzcokpg vjg crrnkecvkqp qh qpg rctvkewnctn{ rqrwnct kp xkxqoqfgn )R.ir Mpqemqwv Oqwug* vjcv jcu dggp wugf gzvgpukxgn{ vq uvwf{ vjg DDD/ Kh vkog rgtokvu- crtqlgev gzcorng knnwuvtcvkpi vjg dcncpeg qh rj{ukeqejgokecn cpf CFOG rtqrgtvkgu vjcv qhvgp pggfvq dg fgnkecvgn{ dcncpegf vq fgnkxgt c eqorqwpf vq c egpvtcn vctigv yknn dg rtgugpvgf/

Page 37: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

4747

Cxkf Tcfkqrjctocegwvkecnu- Kpe/

Ft/ Htcp| H/ Jghvk ku Ejkgh Uekgpvkhke Qhhkegt cv Cxkf Tcfkqrjctocegwvkecnu Kpe/-c eqorcp{ gpicigf kp fgxgnqrkpi kocikpi cigpvu uwkvcdng hqt xkuwcnk|kpircvjqnqikecn ejcpigu kp vjg dtckp qh nkxkpi rcvkgpvu/ Htqo 3114 vq 3117 jg ngfvjg ftwi fgxgnqrogpv ghhqtvu cv Tkpcv Pgwtquekgpeg Eqtrqtcvkqp cu GzgewvkxgXkeg Rtgukfgpv qh Ftwi Fgxgnqrogpv- c eqorcp{ ceswktgf d{ Rhk|gt Kpe/ kp3117/ Dghqtg lqkpkpi Tkpcv- Ft/ Jghvk ycu Ugpkqt Xkeg Rtgukfgpv qhPgwtquekgpeg Tgugctej cv Ogtem ' Eq/ hqt gkijv {gctu- yjgtg jg eqqtfkpcvgf

vjg eqorcp{(u pgwtquekgpeg tgugctej yqtnfykfg- ugtxkpi cu ukvg jgcf hqt vjg pgwtquekgpeg tgugctejegpvgtu kp vjg W/M/ cpf Ucp Fkgiq/ Rtkqt vq Ogtem ' Eq/- Ft/ Jghvk ycu Fktgevqt qh vjg PgwtquekgpegTgugctej Fgrctvogpv cv Igpgpvgej hqt vjtgg {gctu/ Rtkqt vq Igpgpvgej- jg urgpv oqtg vjcp cfgecfg kp cecfgokc cu c Rtqhguuqt cv vjg Wpkxgtukv{ qh Uqwvjgtp Ecnkhqtpkc cpf Cuuqekcvg Rtqhguuqtcv vjg Wpkxgtukv{ qh Okcok- yjgtg jg ecttkgf qwv ugokpcn tgugctej qp vjgtcrgwvke crrnkecvkqpu qhpgwtqvtqrjke hcevqtu/ Jg rwdnkujgf qxgt 361 rcrgtu qp pgwtqvtqrjke hcevqtu cpf vqrkeu kppgwtqrjctoceqnqi{- cu ygnn cu c vgzvdqqm �Ftwi Fkueqxgt{ hqt Pgtxqwu U{uvgo Fkugcugu� )LqjpYkng{ ' Uqpu*/ Ft/ Jghvk tgegkxgf jku Rj/F/ htqo vjg Wpkxgtukv{ qh \wtkej cpf fkf jku rquvfqevqtcntgugctej cv vjg Ocuucejwugvvu Kpuvkvwvg qh Vgejpqnqi{ cpf vjg Ocz Rncpem Kpuvkvwvg kp Owpkej/

Vjg rtgugpvcvkqp yknn uwooctk|g uchgv{- ghhkece{ cpf fqukpi tgswktgogpvu hqt c ftwi ecpfkfcvg vqgpvgt enkpkecn uvwfkgu/ Hqt uchgv{- ftwi ecpfkfcvgu pggf vq ucvkuh{ hqtocn tgiwncvqt{ )KPF.gpcdnkpi*cpf cffkvkqpcn uchgv{.tgncvgf tgswktgogpvu/ Hqt ghhkece{- ftwi ecpfkfcvgu ctg gzrgevgf vq tghngev ceqpxkpekpi uekgpvkhke tcvkqpcng cpf vq dg ghhkecekqwu kp tgngxcpv cpkocn oqfgnu qh vjg vctigvgffkugcug/ Qrvkocn ftwi ecpfkfcvgu yknn hwtvjgtoqtg cnnqy hqt oqpkvqtkpi vjg ghhkece{ cv vjgoqngewnct vctigv cpf cv vjgtcrgwvkecnn{ tgngxcpv gpfrqkpvu kp rcvkgpvu- cu ygnn cu hqt rcvkgpv.htkgpfn{fqukpi tgikogpu/ Vjgug tgswktgogpvu yknn dg fkuewuugf dcugf qp urgekhke gzcorngu qh uocnnoqngewng cpf dkqnqikecn vjgtcrgwvke ftwiu- cpf cnuq fkcipquvke tcfkqrjctocegwvkecnu kpCn|jgkogt�u cpf Rctmkpuqp�u fkugcug/

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Ftwi Fkueqxgt{ Pgwtqfgigpgtcvkqp Eqphgtgpeg- Ycujkpivqp FE 4848

Ogoqt{ Rjctocegwvkecnu

Ft Fcxkf Nqyg jcu dtqcf kpvgtpcvkqpcn gzrgtkgpeg kp pgwtquekgpeg ftwifkueqxgt{ cpf fgxgnqrogpv- kpxqnxkpi cnn curgevu qh ftwi fkueqxgt{-vgejpqnqi{ gxcnwcvkqp cpf korngogpvcvkqp- cecfgoke0kpfwuvtkcneqnncdqtcvkqpu- rtgenkpkecn fgxgnqrogpv- enkpkecn vtkcnu- cu ygnn cu dwukpguufgxgnqrogpv- hwpf tckukpi- uvtcvgike rncppkpi cpf qrgtcvkqpcnocpcigogpv/ Jg jcu dggp vjg Ejkgh Uekgpvkhke Qhhkegt qh Ogoqt{Rjctocegwvkecnu cpf c ogodgt qh vjg Eqorcp{�u Dqctf qh Fktgevqtu ukpegQev 3115/ Rtgxkqwun{ Ft Nqyg jgnf ugpkqt rqukvkqpu kp Pgwtquekgpeg T ' F

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Ft Fcxkf Nqyg jcu dtqcf kpvgtpcvkqpcn gzrgtkgpeg kp pgwtquekgpeg ftwifkueqxgt{ cpf fgxgnqrogpv- kpxqnxkpi cnn curgevu qh ftwi fkueqxgt{-vgejpqnqi{ gxcnwcvkqp cpf korngogpvceqnncdqtcvkqpu- rtgenkpkecn fgxgnqrogpv- enkpkecn vtkcnu- cu ygnn cu dwukpguufgxgnqrogpv- hwpf tckukpi- uvtcvgike rncppkpi cpf qrgtcvkqpcnocpcigogpv/

Page 39: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

4949

UTK Kpvgtpcvkqpcn

Gfyctf I/ Urcem- Rj/F/ ku ewttgpvn{ Ugpkqt Fktgevqt- Dkqnqikeu cpf UgpkqtFktgevqt Dwukpguu Fgxgnqrogpv cv UTK Kpvgtpcvkqpcn kp Ogpnq Rctm-Ecnkhqtpkc/ Ft/ Urcem ku vjg Ugpkqt Fktgevqt qh vjg RjctocUVCTVrtqitco= c eqpuqtvkwo qh UTK cpf hqwt Ecnkhqtpkc wpkxgtukvkgu )Uvcphqtf-WE Dgtmgng{- WE Ucp Fkgiq cpf WE Ucp Htcpekueq* fgukipgf vqejcrgtqpg fkueqxgtkgu htqo vjg ncdqtcvqt{ dgpej vq vjg enkpke/ Ft/ Urcemjcu yqtmgf kp vjtgg Ucp Htcpekueq Dc{ Ctgc dkqvgej eqorcpkgu )Cpgtigp-Xcngpvku cpf KpvgtOwpg* hqt c vqvcn qh 25 {gctu- ykvj vjg dwnm qh jkugzrgtkgpeg kp vjg dkqnqike ftwiu kpenwfkpi jwocpk|gf oqpqenqpcncpvkdqfkgu- tgeqodkpcpv rtqvgkpu cpf rgrvkfg xceekpgu/ Ft/ Urcem jcu

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Page 40: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

Ftwi Fkueqxgt{ Pgwtqfgigpgtcvkqp Eqphgtgpeg- Ycujkpivqp FE 4;

Uguukqp X/

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cpf vjg PKJ

Page 41: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

5151

PKJ0PKC

Pgkn U/ Dwemjqnv|- Rj/F/- ku Ejkgh qh vjg Fgogpvkcu qh Cikpi Dtcpej qhvjg Pgwtquekgpeg cpf Pgwtqru{ejqnqi{ qh Cikpi Rtqitco cv vjgPcvkqpcn Kpuvkvwvg qp Cikpi- Pcvkqpcn Kpuvkvwvgu qh Jgcnvj )PKJ*-

Dgvjgufc- Oct{ncpf/ Vjku kpxqnxgu qxgtcnn rtqitcoocvketgurqpukdknkv{ hqt fgxgnqrogpv- eqqtfkpcvkqp- cpf korngogpvcvkqp qhdcuke cpf enkpkecn Cn|jgkogt�u fkugcug tgugctej/ Urgekhkecnn{ Ft/Dwemjqnv| ku vjg rtqitco cfokpkuvtcvqt hqt vjg ctgcu qh fkcipquku cpfvtgcvogpv cpf ocpcigogpv qh Cn|jgkogt�u fkugcug/ Ft/ Dwemjqnv|jqnfu c fqevqtcvg kp rj{ukqnqikecn ru{ejqnqi{ htqo vjg Wpkxgtukv{ qh

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2;94- dghqtg eqokpi vq PKJ/

Page 42: Drug Discovery 2008 Conference Book all book low resolution · ]ReVc(deRXV UVgV]‘a^V_e’ fdZ_X R_j cVefc_ ‘_ Z_gVde^V_e e‘ dfaa‘ce _Vh cVdVRcTY ac‘XcR^d) 23AFE FD 7d R

Ftwi Fkueqxgt{ Pgwtqfgigpgtcvkqp Eqphgtgpeg- Ycujkpivqp FE 52

- EjgoDtkfig Eqtrqtcvkqp

Fwpecp Dgpkuvqp ku Gzgewvkxg Fktgevqt Ucngu ' Octmgvkpi cv EjgoDtkfig Eqtrqtcvkqp/ Jg jcudggp yqtmkpi ykvj cecfgoke- dkqvgej cpf rjctocegwvkecn tgugctejgtu hqt vjg ncuv 28 {gctu kp vjgctgcu qh ejgokuvt{- dkqejgokuvt{ cpf kphqtocvkeu hqt dcuke tgugctej cpf ftwi fkueqxgt{/ Jg ewttgpvn{

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Ftwi Fkueqxgt{ Pgwtqfgigpgtcvkqp Eqphgtgpeg- Ycujkpivqp FE 5454

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55

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# Ukowncvg vtkcn fgukip rcemcigu hqt Rjcug K- KK cpf KKK vtkcnu

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# Ugtxg cu c nqpikvwfkpcn mpqyngfig ocpcigogpv vqqn vjcv itqyu cu pgy kphqtocvkqp ku cxckncdng

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vjg Kpuvkvwvg hqt vjg Uvwf{ qh Cikpi/

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