• Drug oriented, topic specific reference.

• Published by AHFS services.

• It display a summary of all of the primary published literature on drug stability & compatibility.

• The monographs are arranged alphabetically

by nonproprietary name.

• The names of the drugs follow the style of

USAN & the USP Dictionary of Drug

Names.

• Each monograph contain the following

information:

• Products:

– Lists many of the sizes, strengths,

volumes, and forms in which the drug is

supplied.

– Instructions for constitution (when applicable).

– pH of the drug products.

– osmotic value of the drug.

– other miscellaneous product information.

• Administration:

– Routes.

– Rates of infusion (when applicable), and other

related administration details.

• Stability:

– Describes the drug’s stability and storage

requirements according to USP.

– In addition, pH effects, the effects of freezing and

exposure to light, and the sorption and filtration

characteristics of the drug are presented.

• Compatibility Information:– Tabulates the results of published reports from primary

reference sources of compatibility testing of the subject

drug with infusion solutions and other drugs.

– The various citations are listed alphabetically by solution

or drug name; the information is completely cross-

referenced among the monographs .

– Four types of tables are utilized to present the available

information, depending on the kind of test being reported.

• Compatible, if the results of original article indicate one or more of the following criteria were met:

1. Physical or visual compatibility of the combination

was reported (no detection of particulate formation,

ppt., color change or gas evolution).

2. Stability of the components for at least 24 hrs in an

admixture under the specified conditions was reported

(decomposition of 10% or less)3. Stability of the components for the entire test period.

• Incompatible, if the results of original article indicate either or both of the following criteria were met:

1. A physical or visual compatibility was reported (detection of

particulate formation, ppt., color change or gas evolution)

2. Greater than 10% decomposition of one or more components

in 24 hrs or less under the specified condition was reported.

• The compatibility of Injectable solution will be discussed in case of:

1. Dilution of drug (or reconstitution) with infusion solution e.g.

NS, D5W.(Solution Compatibility).

2. Mixing of 2 or more drugs in the

Same IV solution.(additive compatbility).

3. Withdrawing of 2 or more drugs by the

same syringe.(syringe compatbility).

4. Administration of 2 drug solution by Y-site injection.

Solution in which the test was conducted

C: compatibleI: incompatible

Description of theResults of the test

Manufacturerof the drug(m)

Manufacturerof the solution

Conc. ofthe drug(m) Primary reference

Manufacturerof the T. drug

Test drug Manufacturerof the drug(m)

Conc. of the T. drug

Conc. of the Drug(m)

Infusion solutionof the test

Test drugManufacturerof the T. drug

Actual Amountof the T. drug

Manufacturerof the drug(m)

Actual Amountof the drug(m)

Test drugConc. of the T. Drug prior to

mixing at Y-site

Conc. of the Drug(m) prior to mixing at Y-site

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