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Drugs Used in Bleeding Disorders
Bgaus Komang Satriyasa
Abstract
Inadequate blood clotting may bresult from vitamin K de ciency,
geneticallydetermined errors of clotting factor synthesis (eg.
Hemophilia), a veriety ofdrug-induced conditions, ande
thtrombocytopenia. reatment, therefore,involves administration of
vitamin K, preformed clotting factors, orantiplasmin drugs.
hrombocytopenia may be treated by administration ofplatelets.
Learning Task
!-". # $% year olds businesse&ecutive is bought to the
emergency room 'hafter the onset of severe chest pain during a
vigoroustennis game. he has ahistory of poorly controlled mild
hypertension and elevated blood cholesterolbut does not smo e, *+
changes con rm the diagnosis of myocardialinfarction. he descision
is made to attempt to open her occluded artery.
!. +onversion of plasmin is brought about by
a. #minocaproic acidb. Heparinc. epirudind. eteplasee.
/arfarin
'. If a 0ibrinolytic drug is used for treatment of this 1oman2s
acutemyocardinal infarction, the adverse drug e3ect that is most li
ely tooccur isa. #cute renal failureb. 4evelopment of antiplatelet
antibodiesc. *ncephalitis secondary to liver dysfunctiond.
Hemorrhagic stro ee. 5eutropenia
". If this patient undergoes a percutaneoeus coronary procedure
andplacement of a stent in a coronary blood vessel, she may be
givenepti batide anticlotting action isa. #ctivation of
antithrombin IIIb. 6loc ade of posttranslational modi cation of
clotting factors
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c. Inhibition of thrombo&ane productiond. Irreversible
inhibition of platelet #47 receptorse. eversible inhibition of
glycoprotein IIb8iii# *+*7 9
:. he follo1ing changes in plasma concentration of 1arfarin
1ereobserved in a patient 1hen 'other agents, drugs 6 and +, 1ere
given
on a daily basis at constant dosage starting at the times sho1n.
/hichof the follo1ing statements most accurately describes 1hat is
sho1n inthe graph belo1;a. 4rug 6 displaces 1arfarin2 from plasma
proteins< drug + displaces
1arfarin from tissue binding sitesb. 4rug 6 inhibits hepatic
metabolism of 1arfarin< drug + displaces
drug 6 from tissue binding sitesc. 4rug 6 stimulates hepatic
metabolism of 1arfarin< drug + displaces
1arfarin from plasma proteind. 4rug 6 increases renal clearance
of 1arfarin< drug + inhibits hepatic
metabolism of drug 6
