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Benzene &

Derivatives

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Benzene as substituent

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Criteria for aromaticity

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Aromatic?

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Aromatic heterocylic molecule

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A consequence of aromaticity

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TCDD- a contaminant in

manufacture of Agent Orange

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Components of sunscreen

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ElectrophilicAromaticSubstitution

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Electrophilic Aromatic Substitution vs.

Electrophilic Addition

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EAS vs EA

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Mechanism for EAS

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Halogenation

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EAS as seen in biological systems

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Nitration

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Sulfonation

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Friedel-Crafts Acylation

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Friedel-Crafts Alkylation

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Electron Donation

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Electron Withdrawal

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Activating substituents

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Moderately activating substituents

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Mechanism of action of moderately activatingsubstituents

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Moderately deactivating substituents

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o,p directing substituents

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Effect of substituents onacidity