Ebola Virus Disease, West Africa outbreak 2014 An update on cases 21/04/2015 To update slides with...
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Ebola Virus Disease, West Africa outbreak 2014 An update on cases 21/04/2015 To update slides with most recent figures, please follow links and instructions
Ebola Virus Disease, West Africa outbreak 2014 An update on
cases 21/04/2015 To update slides with most recent figures, please
follow links and instructions provided in the notes section of the
relevant slides
Slide 2
Background Ebola Virus Disease First discovered in 1976; two
simultaneous human outbreaks South Sudan Northern Zaire (now
Democratic Republic of the Congo) Latter in village near Ebola
river, from which disease takes its name 1976-2012: Several
outbreaks in African regions
Slide 3
Ebola outbreaks, 1976-2014
Slide 4
How does EVD outbreak 2014 compare with past outbreaks?
www.nytimes.com
Slide 5
EVD Outbreak 2014 Key events Apr 2014Mar 2014Feb 2014Jan 2014
Dec 2013 06-Dec: Death of index case 2 year old, Meliandou village,
Guckdou, Guinea. Followed by deaths of his mother, sister,
grandmother All retrospectively identified 18 Mar: Guinea announces
outbreak 20 Mar: Lab tests confirm Ebola 23 Mar: WHO notified of
outbreak in Guinea 25 Mar: First WHO report released 31 Mar:
Liberia reports confirmed case 01 Apr: MSF warns outbreak
unprecedented
Slide 6
EVD Outbreak 2014 Key events Aug 2014Jul 2014Jun 2014 May 2014
12 May: EVD cases in Guinean capital, Conakry 17 Jun: EVD cases now
in Liberian capital, Monrovia 08 Aug: WHO declares PHEIC 12 Aug:
Deaths >1,000 (WHO) 21 Aug: Two medically evacuated cases in US,
successfully treated with experimental therapy ZMapp 29 Aug:
Senegal reports first EVD case 25 Jul: Nigeria reports first EVD
case
Slide 7
EVD Outbreak 2014 Key events Jan 2015Dec 2014 Nov 2014 Oct 2014
Sept 2014 28 Sept: First EVD case in US 06 Oct: First EVD case in
Europe (nurse in Spain) 08 Oct: Death of first US EVD case 12 Oct:
Nurse tests positive in US (2 o case) 15 Oct: 2 nd nurse tests
positive in US 17 Oct: Outbreak declared over in Senegal 20 Oct:
Outbreak declared over in Nigeria 23 Oct: First EVD case in Mali 12
Nov: Three more cases in Mali; no links to first case 02 Dec:
Outbreak declared over in Spain 29 Dec: First EVD case diagnosed in
UK (Scottish nurse) 18 Jan : Outbreak declared over Mali
Slide 8
Ebola Outbreak 2014 in West Africa Affected countries
Widespread transmission Sierra Leone Liberia Guinea Outbreak
declared over Nigeria Senegal Mali
Slide 9
Number of EVD cases and deaths, 2014/2015 WHO update 15 th
April 2015 *Outbreaks declared over, Senegal (17 Oct) and Nigeria
(20 Oct) Widespread and intense transmission
Slide 10
Cases of EVD by country, 2014/2015 WHO Update 15 April 2015
CountryCases*Deaths* Guinea35482346 Liberia100424486 Sierra
Leone122013857 Mali86 Nigeria208 Senegal10 Spain10 United Kingdom10
United States41 Total2582610704 *Confirmed, probable or suspected
but not repatriations
Slide 11
Geographical distribution of new cases and total cases in
Guinea, Liberia, and Sierra Leone WHO Update 17th April 2015
Slide 12
Days since last confirmed case in Guinea, Liberia and Sierra
Leone, 15 th April 2015 Source: WHO Ebola Situation Report 17 April
2015
Slide 13
Clinically compatible cases Guinea, Liberia and Sierra Leone as
of 12 April 2015 Source: Public Health England, 17 April 2015
Slide 14
Cases in Guinea, Liberia and Sierra Leone, 2014/2015 WHO update
15 April 2015
Slide 15
Number of new confirmed cases per report week, 23 November 2014
12 April 2015 Graphs from Public Health England EVD Epidemiological
Update 12 April 2015
Slide 16
Case fatality rate, EVD outbreak 2014 WHO (10 Dec 2014): Case
fatality rate 71% Sierra Leone*: 74% CFR overall 57% CFR < 21
years 94% CFR >45 years Positive correlation between viral load
and risk of death *Clinical illness and outcomes in patients with
Ebola in Sierra Leone, Schieffelin et al, NEJM, 29 Oct 2014
Slide 17
Clinical illness in first 106 patients with EVD, Sierra Leone,
May-June 2014 (n=106) Schieffelin et al, NEJM, 29 Oct 2014
Slide 18
EVD cases and deaths in healthcare workers WHO Update 15 April
2015 CountryCasesDeaths Guinea187 504 Liberia374 Sierra Leone303
Mali2 Nigeria11 Spain2 United Kingdom*3 United States9 Total918
*All cases infected in Sierra Leone Three cases infected in Sierra
Leone, three in Liberia, two cases in US, one in Guinea
Slide 19
Non-repatriated cases of EVD outside of West Africa, as of 15
April 2015 (n=6) Date of diagnosis Country of diagnosis Country of
infection TypeHCWStatus 30 Sep 2014USALiberiaImportedNoDied 06 Oct
2014Spain Local transmission YesEVD free 11 Oct 2014USA Local
transmission YesEVD free 15 Oct 2014USA Local transmission YesEVD
free 23 Oct 2014USAGuineaImportedYesEVD free 29 Dec 2014UKSierra
LeoneImportedYesEVD free
Slide 20
Medical evacuations and repatriations from West Africa, as of
17 th April 2015 65 individuals evacuated or repatriated (includes
confirmed cases or those with an Ebola exposure) 38 evacuated to
Europe 13 confirmed EVD cases Germany 3 ; Spain 2 France 2; UK 2
Norway 1; Netherlands 1 Italy 1; Switzerland 1 25 tested negative
27 evacuated to US
Slide 21
Countries involved in the management of EVD cases
www.wikipedia.com
Slide 22
Ongoing updates on the EVD situation available at:
http://www.who.int/csr/disease/ebola/situati on-reports/en/