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ECOG-ACRIN Overview. November 2013. Introduction. As the ECOG-ACRIN Cancer Research Group, we: Are a multidisciplinary, membership-based scientific organization - PowerPoint PPT Presentation
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ECOG-ACRIN Overview
November 2013
Organizational Overview as of November 2013
Introduction
As the ECOG-ACRIN Cancer Research Group, we:
• Are a multidisciplinary, membership-based scientific organization
• Design and conduct biomarker-driven translational and clinical research involving adults who have or are at risk of developing cancer
• Seek to achieve patient-centered research breakthroughs in all aspects of cancer care to
• Reduce the burden of cancer
• Improve quality of life and survival in patients with cancer
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Organizational Overview as of November 2013
History and Strengths
The 2012 merger combined the complementary strengths of two highly respected National Cancer Institute-sponsored Cooperative Groups:
• Eastern Cooperative Oncology Group (ECOG) large-scale treatment trials changed the standard of care in numerous cancer types and helped to individualize therapy
• American College of Radiology Imaging Network (ACRIN) trials encompassed the full range of medical imaging research, from pilot studies identifying imaging markers to landmark screening trials
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Organizational Overview as of November 2013
Unique Capacity
Because of our biomarker-driven approach and multidisciplinary membership, we are able to:• Integrate therapeutic and diagnostic imaging
research with the latest bioinformatic technologies• Provide laboratory researchers focused on
genetics, targeted therapy, and biomarkers with access to the best and newest technologies in functional imaging
• Explore integral biomarkers, including markers of prognosis and response
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Organizational Overview as of November 2013
Our Research Spans All Aspects of Cancer Care Through Three Scientific Programs Treatment
Prevention
Early Detection and Diagnosis
Symptom Management
Patient-reported Outcomes
Survivorship
Underserved Populations
Comparative and Cost Effectiveness
Experimental Imaging
Developmental Therapeutics
Laboratory Science and Pathology 5
Organizational Overview as of November 2013
Therapeutic Capabilities
• Scientific committees in 11 tumor types• Phase III, large phase II trials integrating laboratory
and advanced imaging science • Biomarker and imaging-based adaptive designs• Strong integrated laboratory programs
o Solid tumors, myeloma, lymphoma, leukemia, immunology, and cytogenetics
• Integrated clinical laboratory, molecular, and imaging databaseso Imaging Core Laboratory manages 100,000+ case
records consisting of >23 terabytes of data6
Organizational Overview as of November 2013
Imaging Capabilities
• Pilot studies to identify, validate imaging biomarkers
• Surveillance strategies for high-risk populations
• Prevention approaches in landmark screening trials
• Trials evaluating imaging markers to predict and monitor therapy response
• Studies of imaging-directed therapy for improving patient management and associated outcomes
• Comparative-effectiveness research and cost-effectiveness analysis
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Organizational Overview as of November 2013
Member Network of Nearly 650 Institutions Throughout 12 Countries
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Ireland
Peru
Argentina
ChinaIsrael
South Africa
The Netherlands
JapanSouth Korea
Australia
Puerto Rico
Canada
Organizational Overview as of November 2013
Members and Their Expertise
More than 6000 individuals involved:• Physicians, scientists, nurses, pharmacists, research associates,
statisticians, biomedical information technology specialists, and cancer research advocates
Broad experience across disciplines:• Clinical: Medical, surgical, and radiation oncology; hematology;
radiology; nuclear medicine; internal medicine; and preventive medicine
• Translational: Laboratory-based pathology, genetics, molecular biology, and experimental imaging
• Related: Biostatistics, bioinformatics, clinical psychology, behavioral sciences, epidemiology, and health services
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Organizational Overview as of November 2013
ECOG-ACRIN Science by the Numbers
• 3 scientific programs
• 17 scientific committees
• About 90 active clinical trials
• 11 tumor types
• 12 research support committees
• More than 6000 individual members
• Nearly 650 participating institutions
• 12 countries
• 41 international sites
• 8 repositories and core laboratories10
www.ecog-acrin.org
Please direct inquires to [email protected]