JOURANAL OF VIROLOGY

EDITORIAL BOARD

Robert R. Wagner, Editor-in-Chief (1972)University of Virginia School of Medicine, Charlottesville

Lloyd M. Kozloff, Editor (1970) Norman P. Salzman, Elitor (1971)University of Colorado Medical Center, National Institute of Allergy and Infectious Diseases.

Denver Bethesda, Md.

Allan NI. Campbell (1969) ..................... University of Rochester, Rochester, N.Y.John F. Enders (1969).. Children's Medical Center, Boston, Mass.Richard M. Franklin (1970) .. .. Public Health Research Institute of the City of New York, New York, N.Y.Harold S. Ginsberg (1970) ................... University of Pennsylvania School of Medicine, PlhiladelphiaAngus Graham (1969)................... Wistar Institute, Philadelphia, Pa.Maurice Green (1970)................... St. Louis University, St. Louis, MoLeonard Hayflick (1969)................... Wistar Institute, Philadelphia, Pa.Werner Henle (1969)................................ Children's Hospital of Philadelphia, Philadelphia. Pa.John Holland (1970).University of California, IrvineKlaus Hummeler (1970).Children's Hospital of Philadelphia, Philadelphia, Pa.Paul J. Kaesberg (1970)..................... The University of Wisconsin, MadisonAlbert S. Kaplan (1970) ....... ........... Albert Einstein Medical Center, Philadelphia, Pa.Edwin D. Kilbourne (1970)................... Cornell University Medical College, New York, N.Y.Margaret Lieb (1970) ................... University of Southern California School of Medicine. Los AngelesJoseph Meliick (1969)................... Baylor University, Houston, Tex.Councilman Morgan (1970) .Columbia University. New York, N.Y.Kenneth Paigen (1970) ...Roswell Park Memorial Institute, Buffalo. N.Y.Elmer R. Pfefferkorn (1970) Dartmouth Medical School, Hanover. N.H.A. F. Rasmussen (1969) .................... University of California, Los AngelesWaclaw Szybalski (1970) .. ............... The University of Wisconsin, MadisonPeter Vogt (1970) ...University of Colorado Medical Center, DenverJulius Youngner (1970) ................... University of Pittsburgh, P'ittsburgh, Pa.

Robert A. Day, .V4anaging Editor, 4715 Cordell Ave., Bethesda, Md. 20014

EN OFFICIO

S. E. Iuria. Presidtnt (1967-1968) ......... ............. Massachusetts Institute of Technology, CambridgeDennis W\. Watson, Vice-President (1967-1968)....................... University of Minnesota, MinneapolisDonald E. Shay, Secretary..................................... University of Maryland. BaltimoreF. B. Nkoodruff. Treasurer................... Merck & Co.. Inc., Rahway, N.J.

Published bimonthly by the American Society for Microbiologyat Mt. Royal & Guilford Avenues

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Second-class postage paid at Baltimore, Md. Made in the U.S.A.

I

AUTHOR INDEX

Adler, Julius, 591, 599Altenbern, Robert A., 1085Anderson, N. G., 659, 1207Andresen, William F., 1238Anken, Milton, 10, 238, 684, 968Arlinghaus, Ralph B., 1130

Babcock, Virginia I., 996Bailey, Roller B., 996Baird, Judith P., 543Baker, R. S., 1207Balduzzi, P. C., 509Baluda, M. A., 1150, 1217Basilico, Claudio, 120Baylor, Martha Barnes, 543Beard, J. W., 1082Becker, Walter B., 1019Bellett, A. J. D., 245Bello, Leonard J., 843Benyesh-Melnick, M., 241Berezesky, Irene K., 374Bernhard, W., 817Bishop, D. H. L., 771Black, Francis L., 653Black, Paul H., 362Blakeslee, James R., Jr., 1045Boatman, Edwin S., 205Bode, Werner, 948Bodo, G., 466Boezi, J. A., 1274Bose, Henry R., Jr., 1117Brodetsky, Anna M., 1150Brody, Edward N., 76Brooks, Katherine, 283Brown, Arthur, 128Brown, F., 368Bujard, H., 1135Burge, Boyce W., 956Burness, A. T. H., 308Butel, Janet S., 876

Campbell, J. B., 145Carp, Richard I., 912Carter, William B., 1168Cartwright, B., 368Carver, David H., 334, 1089Cary, Sylvia G., 538Chanock, R. M., 659, 1019Chapman, V. A., 193Clark, Alvin J., 283Cline, G. B., 659, 1207Coates, Helen, 659Cohen, Gary H., 500Converse, John L., 1096Cooke, Kenneth O., 317Courington, Doris, 400Craighead, John E., 988Crick, Joan, 368Crittenden, Lyman B., 898Crowell, Richard L., 693Cummings, Donald J., 193

Dees, Jane H., 1019DeLong, S. S., 193de Torres, Ramon A., 10, 684,

738, 968Diamond, Leila, 1109Diehl, Volker, 830Doi, Roy H., 935Donini, P., 717Drake, John W., 260Dubbs, Del R., 10, 238, 684, 738,

968Duc-Nguyen, Huu, 415

Easterbrook, K. B., 643Eckert, Edward A., 920Edelman, Robert, 1139Egbert, Larre N., 610Erikson, E., 523Erikson, R. L., 523Erlandson, Robert A., 996Evans, E. A., Jr., 76, 928Evans, Virginia J., 1238

Fantes, Karl H., 1168Feingold, David S., 1164Felgenhauer, Zoya Z., 1193Fiala, Milan, 489Flanagan, John F., 583Franklin, Richard M., 64, 302,

514, 793, 804Freeman, Aaron E., 362Friedman, Robert M., 374, 1168Friend, Patric L., 50Fugmann, Ruth A., 678Fujinaga, Kei, 576Funk, Clare A., 1186

Gaeta, F. S., 717Gehle, Warren D., 648Ginsberg, Harold S., 747, 843,

851Goepfert, J. M., 701Gomez, Beatriz, 779Grace, James T., Jr., 640, 1045,

1186, 1203Graham, A. F., 36, 665Granados, Robert R., 430Granboulan, N., 1010Graves, 1. L., 1098Graziosi, F., 717Green, Howard, 115Green, Maurice, 576, 723, 980Groupe, Vincent, 1122Groyon, Rose Mary, 1255

Hackett, Adeline J., 1271Hahon, Nicholas, 317Hall, William T., 1238Hamre, Dorothy, 810Hare, J. Donald, 905Harris, W. W., 659

1277

Harter, D. H., 1265Haselkorn, Robert, 344Hausmann, Rudolf, 57, 779Hearn, Henry J., Jr., 453, 460Henderson, William R., 1093Henle, Gertrude, 830Henle, Werner, 1, 830Herold, F., 1028Hessler, Anita Y., 543Hinuma, Yorio, 640, 1045, 1203Hirumi, Hiroyuki, 430Ho, Monto, 883Holt, S. C., 1087Howe, C., 215Hsiung, Pe-Hwa L., 1082Hsu, K. C., 215, 384, 1265Hua, S., 928Hudson, James B., 529Huebner, Robert J., 362Hummeler, Klaus, 152, 830, 1227Hunter, B. I., 841Hunter, Donald H., 538

Iglewski, W. J., 302, 793, 804lino, Tetsuo, 445

James, R., 758Jungwirth, C., 466

Kaplan, M. M., 145Kase, Alice, 494Kates, J. R., 110Ke, Yang H., 883Kenny, George E., 489Kessin, Richard H., 92Kim, K. S., 45Kim, Kenneth S. W., 205Kindig, David A., 810Kit, Saul, 10, 238, 684, 738, 968Kitahara, Tsunehiro, 684Kniazeff, Alexis J., 1255Knudson, A. G., Jr., 1150Konn, Mitsuru, 1045, 1203Koprowski, Hilary, 145, 152,

1227Kozinski, Andrzej W., 758, 1193Kozinski, P. B., 758Kudo, H., 36Kunin, Calvin M., 274

Langlois, A. J., 1082Laver, William G., 723Lawrence, William C., 851Lazarus, Harrison M., 1093Le Buis, J., 817Lee, Lucy F., 1274Lengyel, A., 1101Lennette, Edwin H., 494Levine, A. J., 747Levine, Alvin S., 1117Levitt, Neil H., 693Levy, Hilton B., 1168

AUTHOR INDEX

Lipkind, Mikhail A., 327Lipman, Muriel B., 1037Lockart, Royce Z., Jr., 1158Love, Robert, 626Luftig, Ronald, 344

McAuslan, B. R., 110McCombs, R. M., 241McCrea, J. F., 1037McCutchan, James H., 891McGuire, Janice, 260McIntosh, Kenneth, 1019Mackal, Roy P., 76McSharry, James, 268Maes, R. F., 145Mann, Judith, 810Maramorosch, Karl, 430, 1052Marcus, Philip I., 334, 1089Marin, Guglielmo, 120Marmur, Julius, 86Martignoni, Mauro E., 646Martin, E. M., 97Martinez-Palomo, A., 817, 1010Mathews, Christopher K., 92,

963Mayor, Heather D., 171Melnick, Joseph L., 171, 472,

478, 684, 980Mims, C. A., 1091Mitani, Michiko, 445Mitchell, Herschel K., 610Mondale, L., 193Morgan, C., 215, 384Munz, K., 1028

Naegele, Robert F., 838Nagle, Stanley C., Jr., 1096Nakamura, Reiko M., 448Nayak, D. P., 1217Naylor, H. B., 701Newlin, T. E., 1207Nichol, F. Richard, 450Norrby, E., 1101Nutting, L. A., 650Nyberg, B., 1101

Okazaki, William, 898Oshiro, Lyndon S., 384

Pace, N. R., 771Pagano, Joseph S., 891

Paranchych, William, 529Parks, Wade P., 171, 980Pene, Jacques J., 86Pfau, C. J., 1087Pfetferkorn, E. R., 956Philipson, Lennart, 868Piekarski, Lech J., 10Pienta, Roman J., 1122Pifia, Magdalena, 980Polatnick, Jerome, 1130Prescott, Lawrence M., 1085Probstmeyer, F., 241

Rada, B., 24Rapp, Fred, 838Reamer, Richard H., 898Reimer, C. B., 1207Ris, Hans, 599Roane, Philip R., Jr., 181Rodrigues, Louis, 1089Rodriquez, Jose E., 1Roizman, Bernard, 181, 294Rongey, Robert, 171Rose, H. M., 215, 384, 1265Rosenblum, Edith N., 415

St. Cyr, C. DeVaux, 215Salvi, Maria L., 738Salzman, N. P., 16, 550Sankaran, Saraswathi, 1082Sarid, Sara, 559Schade, Sylvia Z., 591, 599Schieble, Jack H., 494Sebring, E. D., 16, 550Sedwick, W. D., 1224, 1227Seto, Dexter S. Y., 1089Shalitin, Channa, 559, 569Sharp, D. G., 45Shatkin, A. J., 24Shikata, Eishiro, 1052Shipkey, Frederick H., 996Sigel, M. Michael, 678Sinsheimer, Robert L., 135, 711Skaaret, P., 1101Slade, Hutton D., 50Smale, C. J., 368Smith, Joseph M., 1093Smith, Kendall O., 648Sonnabend, J. A., 97Soper, William T., 453, 460

Southam, Chester M., 996Speitel, Thomas, 268Spiegelman, S., 771Sporn, Michael B., 1093Spring, Susan B., 181, 294Steele, Frances M., 653Stone, Howard A., 898Stonier, Tom, 268Strauss, James H., Jr., 711Strohmaier, K., 1074Suriano, Robert, 723

Takahashi, I., 841Talens, Luciano, 1271Ter Meulen, Volker, 1, 626Tershak, Daniel R., 450Todaro, George J., 115Tokunaga, Tohru, 448Tryon, J. L., 650Tsvetkova, Inna V., 327

Vaheri, Antti, 891van Frank, R. M., 1207Veneziani-Brizi, L., 717Villarejo, M., 928Vogt, Peter K., 400, 729

Wainwright, Sally, 1091Wallis, Craig, 472, 478Watanabe, Y., 36, 665Weber, E. M., 650Welker, N. E., 617Wheelock, E. Frederick, 1139Wiktor, T. J., 145, 152, 1224Wilcox, Wesley C., 500Wolford, Ronald, 362Wudarski, Donald J., 1045

Yamagishi, H., 841Yamaguchi, Junji, 640,1045,1203Yarus, Michael J., 135Yehle, Clifford 0., 935Yohn, David S., 1186Youngner, Julius S., 1164

Zebovitz, Eugene, 128Zee, Yuan Chung, 1271Zgorniak-Nowosielska, Izabella,

1227zur Hausen, Harald, 830, 1174

1278 J. VIROL.

SUBJECT INDEX

acridine, sensitivity of bacteriophage T2H in Es-cherichia coli, 543

actinomycin D, effect on interferon action, 1158actinomycin D, effect on ribonucleic acid polymerase

formation, 1130adeno-associated satellite virus, nucleic acid of, 980adeno-associated virus, replication, 648adeno-satellite virus, defective, assay and growth, 171S-adenosylmethionine-cleaving enzyme, in Escherichia

coli, 57adenovirus, attachment and eclipse of, 868adenovirus, defective monkey cell-adapting compo-

nent in, 876adenovirus, enzyme induction bv, 10adenovirus, inhibition by fiber antigen, 747adenovirus, N-terminal amino acids of, 723adenovirus, satellite, assay and growth, 171adenovirus, virus-specific ribonucleic acid, 576adenovirus deoxyribonucleic acid, uncoating of, 851adenovirus infection, effect on host cell proteins, 843adenovirus type 7-simian virus 40 hybrid, role in

transformation, 1109adenovirus type 9 components, soluble, 1101adenovirus type 12, effect on embryonic kidney cells,

1174adenovirus type 12 oncogenesis, resistance to, 1186adenovirus type 12-rat embryo transformation system,

362adenovirus type 12 replication, 817, 1010adenovirus type 12 tumor antigen, antibody to, 678adenoviruses, enhancement of replication, 838Agalla constricta, wound tumor virus in, 1052aggregation, cause of non-neutralizable persistent

virus fraction, 478Agrobacteriun tumefaciens Conn, bacteriophage PB21,

268algae, morphology of virus from, 344amber mutants of bacteriophages T3 and T7, 779amethopterin, inhibition of virus reproduction by,

1150amino acid analysis of adenovirus, 723antibiotics, ferritin-labeled, study of simian virus 40,

384antibody to adenovirus type 12 tumor antigens, 678antigens, soluble, vaccinia-infected mammalian cells,

500antigens of adenovirus type 9, 1101antigens of herpesvirus during replication, 181arbovirus, ribonucleic acid polymerase, 97arbovirus, temperature-sensitive biosynthesis, 128arboviruses, development in human cell cultures, 996attenuated viruses, in vitro properties, 453autoradiography of adenovirus-infected KB cells, 1010avian infectious bronchitis virus, morphogenesis of,

1019avian leukosis-sarcoma viruses, cellular resistance to,

898avian leukosis virus, conversion of chick embryo cells

by, 1082avian myeloblastosis virus, transient inhibition, 11506-azauridine, effect on interferon, 450

Bacillus stearothermophilus, bacteriophage T3 of, 610Bacillus subtilis, bacteriophage functions in, 86Bacillus subtilis, expression of bacteriophage genomes

in, 935bacteriophage, T-even, induced structural defects, 193bacteriophage active against Neisseria meningitidis,

538bacteriophage ca, viral functions in, 717bacteriophage x, infection of Serratia marcescens, 445bacteriophage x, mechanism of attack, 599bacteriophage x, purification and chemistry, 591bacteriophage functions in Bacillus subtilis, 86bacteriophage genomes, expression in Bacillus subtilis,

935bacteriophage gh 1, deoxyribonucleic acid of, 1274bacteriophage-induced enzyme synthesis, control of,

92bacteriophage infection, effect on enzyme synthesis, 57bacteriophage infection of Micrococcus lysodeikticus,

701bacteriophage lambda, proteins of, 928bacteriophage lytic enzyme, properties, 617bacteriophage MS2, ribonucleic acid of, 711bacteriophage PB21, inhibition of tumor induction,

268bacteriophage PBS 1 deoxyribonucleic acid, 841bacteriophage 4X174, infectious process, 135bacteriophage R17, effect on host synthesis of ribo-

somal ribonucleates, 529bacteriophage R17, replicative intermediate ribonu-

cleic acid, 523bacteriophage R17 ribonucleic acid, 793, 804bacteriophage ribonucleic acid, replication of, 64, 514,

523bacteriophage sensitivity, chloramphenicol effect on,

50bacteriophage T2, multitailed, 1087bacteriophage T2H, acridine sensitivity in Escherichia

coli, 543bacteriophage T3, amber mutants of, 779bacteriophage T3, of Bacillus stearothermophilus, 610bacteriophage T4, deoxyribonucleic acid in, 758, 1193bacteriophage T4, dihydrofolate reductaseless, 963bacteriophage T4, effect on Escherichia coli lysis, 948bacteriophage T4, gene transcription by putrescine,

569bacteriophage T4, photodynamic mutants, 260bacteriophage T4, polyamine effect on morphogenesis,

559bacteriophages from Clostridium tetani, 1085bovine papilloma virus, deoxyribonucleic acid of, 1135Burkitt lymphoma cell line, virus particles from, 640,

1045, 1203Burkitt tumor cells, comparative study, 830

calcium phosphate, separation of virus variants, 308canine hepatitis virus, as "helper" in adeno-associated

virus replication, 648carcinogenesis, viral, mechanism, 576cell receptors, distribution during virus-cell union, 274

1279

SUBJECT INDEX

chick embryo cells, conversion by avian leukosis virus,1082

chick fibroblasts, infection by defective Rous sarcomavirus, 400

chloramphenicol, effect on bacteriophage sensitivity,50

chromosomal aberrations in kidney cells, virus-in-duced, 1174

circular deoxyribonucleic acid, 1135classification of viruses, nucleic acid comparisons, 245Clostridium tetani, bacteriophages from, 1085complement-fixing antibody to adenovirus type 12

tumor antigens, 678complement-fixing antigen of adenovirus type 9, 1101coxsackievirus B3, HeLa cell receptors for, 693cycloheximide, inhibition of reovirus ribonucleic acid

synthesis by, 36cytomegalovirus, obtained by glycine extraction or

sonic disruption, 241cytoplasmic fractions, in Semliki Forest virus ribo-

nucleic acid replication, 374

density gradient centrifugation, virus purification by,1207

deoxyribonuclease, interferon effect on induction, 466deoxyribonucleic acid, adenovirus, uncoating of, 851deoxyribonucleic acid, bacteriophage, infection of

Mycobacterium, 448deoxyribonucleic acid, from vaccinia virus, 643deoxyribonucleic acid, in bacteriophage T4, 758deoxyribonucleic acid, of adeno-associated satellite

virus, 980deoxyribonucleic acid, of bacteriophage x, 591deoxyribonucleic acid, of bacteriophage gh 1, 1274deoxyribonucleic acid, of bacteriophage PBS 1, 841deoxyribonucleic acid, of bacteriophage T4, 1193deoxyribonucleic acid, of bovine papilloma virus, 1135deoxyribonucleic acid, of virus from algae, 344deoxyribonucleic acid, replication, function in bac-

teriophage infections, 86deoxyribonucleic acid, replication in vaccinia virus, 16deoxyribonucleic acid, synthesis in simian virus 40, 115deoxyribonucleic acid, TI, properties of, 76deoxyribonucleic acid, viral, relation of protein syn-

thesis to, 110deoxyribonucleic acid synthesis, induction by simian

virus 40, 739deoxyribonucleic acid synthesis, phage-directed, 779diethylaminoethyl-dextran, effect on poliovirus ribo-

nucleic acid, 891dihydrofolate reductaseless mutant of bacteriophage

T4, 963

electron microscopic studies, of parainfluenza virus,215

electron microscopic studies, of rabies virus, 152electron microscopic studies, of rubella virus, 205embryo transformation, by adenovirus type 12, 362encephalomyocarditis virus, effect of polycations on,

988encephalomyocarditis virus, interaction with irradi-

ated cells, 509encephalomyocarditis virus, separation of variants,

308encephalomyocarditis virus-cell union, 274

endotoxin-induced interferons, 883enterovirus, concentration on membrane filters, 472envelope protein of influenza viius, 920enzyme synthesis, bacteriophage-induced, control of,

92enzymes, induction in adenovirus-infected cells, 10equine encephalomyelitis virus, in vitro properties, 453equine encephalomyelitis virus, in vivo properties, 460erythrocytes, agglutination by encephalomyocarditis

virus, 274Escherichia coli, acridine sensitivity of bacteriophage

T2H, 543Escherichia coli, S-adenosylmethionine-cleaving en-

zyme in, 57Escherichia coli, bacteriophage T4-infected, 948Escherichia coli, recombination-deficient, X bacteri-

ophage, 283Escherichia coli, spheroplasts, Ti deoxyribonucleic

acid infection, 76

ferritin-conjugated antibody, differentiation of viralcomponents, 415

ferritin-labeled antibodies, study of simian virus 40,384

fiber antigen, inhibition of adenovirus by, 747fluorescent cell counting, assay for respiratory syncy-

tial virus, 494fluorodeoxyuridine, inhibition of virus reproduction

by, 11505-fluorouracil, effect on interferon, 450foot-and-mouth disease virus-infected cells, 1130formaldehyde, stabilization of herpes simplex virus,

294

gene transcription, in bacteriophage T4, 569genetic cellular resistance to avian leukosis-sarcoma

virus, 898glycine extraction, human cytomegalovirus from, 241glycogen metabolism in HeLa cells, 1098guanidine, effect on glycogen metabolism in HeLa

cells, 1098

heat inactivation, stabilization of poliovirus by, 653HeLa cell receptors, regeneration of, 693HeLa cells, effect of viral infection, 626hemagglutinin of adenovirus type 9, 1101hemagglutinin synthesis, in virus-infected cells, 327herpes simplex virus, effect on thymidine kinase, 238herpes simplex virus, products in infections, 294herpes simplex virus, ribonucleic acid synthesis, 583herpes-type particles in Burkitt lymphoma cell line,

1045herpes-type virus, replication in Burkitt cells, 1203herpesvirus, antigens, 181herpesvirus in tumor cells, 830human cytomegalovirus, obtained by glycine extrac-

tion or sonic disruption, 241

immunofluorescence of Burkitt lymphoma cells, 1045immunofluorescence of visna virus, 1265infection with bacteriophage OX174, 135infective virus substructure, vesicular stomatitis virus,

368infectivity assay for MS2 ribonucleic acid, 711influenza virus, envelope protein of, 920

1280 J. VIROL.

SUBJECT INDEX

influenza virus, large-scale purification, 1207influenza virus, nucleic acid of, 1217insect tissue cell cultures, yellow fever virus in, 1096insect vector, plant-pathogenic virus, 430insect vectors, wound tumor virus in, 1052insects, virus particles in, 1028interferon, effect of azauridine and fluorouracil, 450interferon, effect on deoxyribonuclease induction, 466interferon, induction in L cells, effect on Newcastle

disease virus, 1interferon, interference after removal of, 1158interferon action on ribonucleic acid, 1168interferon production by Salmonella typhimurium

mutants, 1164interferons, in rabbits, 883intrinsic interference, by viruses, 3345-iodo-2'-deoxyuridine-treated vaccinia virus, 1037isopycnic banding of virus particles, 659isopycnic centrifugation, separation of viral inclusion

bodies, 646

kidney cells, virus-induced chromosomal aberrations,1174

L cells, changes of Newcastle disease virus in, 1L cells, reovirus directed ribonucleic acid synthesis in,

24lambda bacteriophage, in recombination-deficient

Escherichia coli, 283lambda bacteriophage, proteins of, 928leukocytes as host for vesicular stomatitis virus, 1139loci controlling resistance to avian leukosis-sarcoma

virus, 898lymphocytic choriomeningitis virus, assay for, 1091lymphocytic choriomeningitis virus, plaquing system

for, 1224lytic enzyme, bacteriophage, properties, 617lytic enzyme in Micrococcus lysodeikticus, 701

magnesium, effect on rhinovirus replication, 489maturation process, T-even bacteriophage, 193membrane filters, enterovirus concentration on, 472L-methylisatin 3-thiosemicarbazone, metabolic re-

moval of sulfur from, 650Micrococcus lysodiekticus, phage infection of, 701monkey cell-adapting component in adenovirus, 876monkey kidney cells, rubella virus infection, 205monocyte as host for vesicular stomatitis virus, 1139morphogenesis of avian infectious bronchitis virus,

1019morphogenesis of type 2 parainfluenza virus, 215morphology of rabies virus, 152motile bacteria, bacteriophage x attack mechanisms,

599multiplicity reactivation of vaccinia virus, 45multitailed T2 bacteriophage, 1087mumps virus, morphogenesis, 415murine C-type virus, 1238mutants, bacteriophage T4, dihydrofolate reductase-

less, 963mutants, Salmonella typhimurium, interferon produc-

tion by, 1164mutants, Sindbis virus, temperature-sensitive, 956mycobacteriophage B1, deoxyribonucleic acid, infec-

tion of Mycobacterihn, 448

Mycobacterium tuberculosis, infection with bacteri-ophage deoxyribonucleic acid, 448

mycoplasmas, assay for, 1227myxovirus neuraminidase, synthesis, 327

Neisseria meningitidis, bacteriophages, 538nervous system, plant virus in vector, 430neuraminidase, myxovirus, synthesis, 327Newcastle disease virus, changes after passage in

tissue culture, 1nitrogen mustard, inactivation of vaccinia virus by, 45nucleic acid, bacteriophage, replication of, 64nucleic acid, synthesis, relation of protein synthesis to,

110nucleic acids, virus, classification of, 245nucleic acid of adeno-associated satellite virus type 4,

980nucleic acid of influenza virus, 1217

parainfluenza virus, type 2, morphogenesis, 215Peregrinus maidis, virus particles in, 1028photodynamic mutants, of bacteriophage T4, 260plant virus, in vector nervous system, 430plaque assay for lymphocytic choriomeningitis virus,

1091plaquing system for ribonucleic acid viruses, 1224poliovirus, effect of 2-thiouracil, 653poliovirus, effect on glycogen metabolism in HeLa

cells, 1098poliovirus ribonucleic acid, infectivity of, 891poliovirus TI, HeLa cell receptors for, 693polyamines, effect on bacteriophage T4 morphogene-

sis, 559polycations, effect on encephalomyocarditis virus in

mice, 988polyions, effect on rabies virus infectivity, 145polymerase, ribonucleic acid, presence in virus-in-

fected cells, 97polyoma virus, infection of hamster embryo cells

with, 905polyoma virus, transformation, effect of protein

synthesis on, 120primary virus-cell interactions, 317protein components of lambda bacteriophages, 928protein of influenza virus envelope, 920protein synthesis, effect on polyoma transformation,

120protein synthesis, in adenovirus-infected cells, 843protein synthesis, in vaccinia virus, 16protein synthesis, relation to viral deoxyribonucleic

acid synthesis, 110proteins, virus structural, time course of synthesis, 500proteins of adenoviruses, 723Pseudomonas putida, bacteriophage of, 1274psoralen, mutant induction in presence, 260puromycin, effect on interferon activity, 1158putrescine, gene transcription in bacteriophage T4 by,

569

Q,3-replicase reaction, 771quantitative measurements of virus particles, 1074

rabies virus, in tissue culture, 152rabies virus, infectivity, effect of polyions on, 145rabies virus, plaquing system for, 1224

VOL. 1) 1967 1281

SUBJECT INDEX

radiation effects, on viral infection, 509reovirus, inhibition of ribonucleic acid synthesis in, 36reovirus-directed ribonucleic acid synthesis, 24reovirus ribonucleic acid, properties, 302reovirus ribonucleic acid, structural units of, 665replication, herpesvirus antigens during, 181replication, of bacteriophage ribonucleic acid, 514, 523replication, of reticuloendotheliosis virus, 1117respiratory syncytial virus, fluorescent cell counting

assay, 494respiratory syncytial virus, isolation, 659respiratory virus, new, 810reticuloendotheliosis virus, replication, 1117rhinovirus, magnesium effect on growth, 489ribonucleic acid, bacteriophage, replication of, 64,

514, 523ribonucleic acid, messenger, vaccinia virus, 550ribonucleic acid, of bacteriophage MS2, 711ribonucleic acid, poliovirus, infectivity of, 891ribonucleic acid, renaturation of, 793, 804ribonucleic acid, reovirus, properties, 302ribonucleic acid, reovirus, structural units of, 665ribonucleic acid, replication in Semliki Forest virus,

cytoplasmic fractions, 374ribonucleic acid, Semliki Forest virus, 1168ribonucleic acid, virus-specific synthesis, 583ribonucleic acid polymerase, presence in virus-in-

fected cells, 97ribonucleic acid polymerase formation, effect of

actinomycin D on, 1130ribonucleic acid replication, 771ribonucleic acid synthesis, reovirus, inhibition of, 36ribonucleic acid synthesis, reovirus-directed, 24ribonucleic acid virus from respiratory tract, 810ribonucleic acid viruses, localization of, 1271ribonucleic acid viruses, plaquing system for, 1224ribosomal ribonucleates, effect of bacteriophage R17

on, 529Rous sarcoma cells, nonproducing state of, 729Rous sarcoma virus, defective, infection of chick

fibroblasts, 400Rous sarcoma virus in Japanese quail, 1122rubella virus, electron microscopy of, 205rubella virus replication in mouse brains, 1089

Salmonella typhimurium mutants, interferon produc-tion by, 1164

satellite virus, defective, assay and growth, 171Semliki Forest virus, cytoplasmic fractions in ribo-

nucleic acid replication, 374Semliki Forest virus, in HEp-2 cell cultures, 996Semliki Forest virus, ribonucleic acid, 1168Semliki Forest virus, ribonucleic acid polymerase, 97Serratia marcescens, infection by bacteriophage x, 445sex-related resistance to adenovirus-12 oncogenesis,

1186simian adenovirus SV15, effect on human adeno-

viruses, 830simian virus 40, deoxyribonucleic acid synthesis in, 115simian virus 40, effect on cellular deoxyribonucleic

acid synthesis, 739simian virus 40, effect on thymidine kinase production,

912simian virus 40, study with ferritin-labeled antibiotics,

384

simian virus 40, transformation of, 115simian virus 40-induced hamster tumors, 1093simian virus 40-induced tumor antigen, 684simian virus 40-resistant hamster cells, transformation,

1109simian virus 40-transformed mouse kidney cells, 968Sindbis virus, temperature-sensitive mutants, 956sonic disruption, human cytomegalovirus from, 241spheroplasts, Escherichia coli, Ti deoxyribonucleic

acid infection, 76sporulation of bacteriophage-infected cells, 935strand length of vaccinia virus deoxyribonucleic acid,

1037streptococci, group A, bacteriophage resistance in, 50sulfur, metabolic removal from 1-methylisatin 3-thio-

semicarbazone, 650synchronized cells, vaccinia infection of, 1255

T antigen from simian virus 40-induced tumors, 1093T-even bacteriophage, induced structural defects, 193TI deoxyribonucleic acid, properties of, 76T2 bacteriophage, multitailed, 1087T3 infection, in Escherichia coli, enzyme production,

57temperature-sensitive mutants of phage a, 717temperature-sensitive Sindbis virus mutants, 956temperature-sensitive Venezuelan equine encephalitis

virus, 128thermophilic bacteriophage lytic enzyme, 617thiopyronin, mutant induction in presence, 2602-thiouracil, effect on poliovirus, 653thymidine kinase, herpes simplex virus effect on, 238thymidine kinase, induction in adenovirus-infected

cells, 10thymidine kinase from normal and infected cells, 912tissue cultures, separation of mycoplasmas from, 1227transformation, effect of protein synthesis on, 120transformation of simian virus 40-resistant hamster

cells, 1109transmission of Rous sarcoma virus, 729transplant antigen production by polyoma strains, 905tumor antigen, antibody to, 678tumor antigen, simian virus 40-induced, 684tumor cell lines, polyoma virus-induced, 905tumor cells, comparative study, 830tumor induction, inhibition by PB21, bacteriophage,

268tumor response to adenovirus-12 in hamsters, 1186tumors, T antigen from, 1093

ultrastructure of adenowirus-infected KB cells, 817

vaccinia-infected mammalian cells, soluble antigens,500

vaccinia infection of synchronized cells, 1255vaccinia virus, deoxyribonucleic acid from, 1037vaccinia virus, morphology of deoxyribonucleic acid

from, 643vaccinia virus, multiplicity reactivation of, 45vaccinia virus, properties of messenger ribonucleic

acid, 550vaccinia virus, proteins, formation of, 16Venezuelan equine encephalomyelitis virus, in vitro

properties, 453

1282 J. VIROL.

SUBJECI INDEX

Venezuelan equine encephalomyelitis virus, in vivoproperties, 460

Venezuelan equine encephalomyelitis virus, primarycell interactions, 317

Venezuelan equine encephalitis virus, temperaturesensitivity, 128

vesicular stomatitis virus, infective substructure, 368vesicular stomatitis virus, monocyte as host for, 1139viral carcinogenesis, machanism, 576viral functions of bacteriophage a, 717viral inclusion bodies, separation by isopycnic cen-

trifugation, 646viral infection, effect on HeLa cells, 626viral infection, radiation effects, 509virogenic simian virus 40-transformed mouse cells, 968

virus fraction, non-neutralizable persistent, 478virus-induced interferons, 883virus particles, from Burkitt lymphoma cell line, 640virus particles, measurement in crude preparations,

1074virus particles in Peregrinus maidis, 1028virus pools, separation of mycoplasmas from, 1227virus-specific ribonucleic acid synthesis, 583viruses, blue-green algae, deoxyribonucleic acid, 344viruses, intrinsic interference, 334visna virus, immunofluorescence of, 1265

wound tumor virus in insect vectors, 1052

yellow fever virus, multiplication in cultures, 1096

VOL. 1, 1967 1283

INDEX TO DATE OF ISSUE

Date of Issue

2/18/674/17/676/19/678/29/6710/27/6712/22/67

Statement of Ownership, Management and Circulation requiredby the Act of October 23, 1962; Section 4369, Title 39, UnitedStates Code.1. Dote of Filing: 29 September 1967.2. Title of Publication: Journal of Virology3. Frequency of Issue: Bimonthly4. Location of known Office of Publication: Mount Royal and

Guilford Aves., Baltimore, Maryland 212025. Location of the Headquarters or General Business Offices of

Publisher: 115 Huron View Blvd., Ann Arbor, Michigan 481036. Publisher: American Society for Microbiology, 115 Huron

View Blvd., Ann Arbor, Michigan 48103Editor: Robert R. Wagner, School of Medicine, University

of Virginia, Charlottesville, Va. 22901Managing Editor: Robert A. Day, 4011 Rickover Road,

Silver Spring, Md. 209027. Owners: (If owned by a corporation, its nanme and address

must be stated and also immediately thereunder the names andaddresses of stockholders owning or holding 1 percent or more oftotal amount of stock. If not owned by a corporation, the namesand addresses of the individual owners must be given. If ownedby a partnership or other unincorporated firm, its name andaddress, as well as that of each individual, must be given.) Ameri-can Society for Microbiology, 115 Huron View Blvd., Ann Arbor,Michigan 48103.

8. Known bondholders, mortgagees, and other security holdersowning or holding 1 percent or more of total amount of bonds, mort-gages or other securities are: None

9. For completion by nonprofit organizations authorized tomail at special rates (section 132.122, Postal Manual): The purpose,function, and nonprofit status of this organization and the exemptstatus for Federal income tax purposes have not changed duringpreceding 12 months.

(a)* (b)t10. A. Total No. Copies Printed (Net Press Run) 4548 5110

B. Paid Circulation1. Sales Through Dealers and Carriers,

Street Vendors and Counter Sales none none2. Mail Subscriptions 3286 3886

C. Total Paid Circulation ... 3286 3886D. Free Distribution (including samples)

By Mail, Carrier or Other Means. ... 17 21E. Total Distribution (sum of C and D).... 3303 3907F. Office Use, Left-Over, Unaccounted

Spoiled After Printing ................. 1245 1203G. Total (Sum of E & F-should equal net

press run shown in A) 4548 5110

* Average number of copies for each issue during preceding 12months.

t Single issue nearest to filing date.I I certify that the statements made by me above are correct

and complete. (Signed) Robert A. Day, Managing Editor.

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