Upload
others
View
1
Download
0
Embed Size (px)
Citation preview
덕성여자대학교 약학과
조효선 교수
면역이란? -면역, Immunity 라틴어 immunitas ‘질병으로부터의 보호’ -자기와 비자기의 구분(self/non-self discrimination) -면역계, immune system 면역반응, immune response -Immune system: the body's primary defense system against invasion by foreign (microbes)
-Immune response
1) immunological recognition : detection of infection by white blood cells 항원인식
2) immune effector functions ; Complements(보체), Antibody(항체), T cells
3) immune regulation : self regulation by regulatory components
4) immunological memory : long lasting immunity by B, T cells 기억반응 (적응면역)
Chapter 1; 면역계의 개요
Chapter 1; 면역계의 개요
선천면역(Innate immune system) vs 적응면역(adaptive immune system)
- Adaptive immune system 효과적이고 강력하게 반응 antigen-specific response slow (take 7 to 10 days) memory antibodies (B-cell), T-cells vaccination, autoimmunity
- Innate immune system 감염에 대한 일차적인 방어선 nonspecific fast response no memory 대식세포(macrophages) 호중구( neutrophils) 자연살해 세포(NK cells) 보체(complement) 인터페론(interferons)
그림1-1
그림1-1 최신면역학(라이프사이언스, 2011)
적응면역(adaptive immune system)
Clonal selection (클론선택설) : each B cell or T cell expressing a receptor that best fits the antigen
divides, produces daughter cells (clones) that have the same receptor
Fig.2.2 Immunology for Medical Students(Mosby International Ltd 2002)
Chapter 1; 면역계의 개요
적응면역(adaptive immune system) Autoimmunity(자가면역) : the immune system that recognize self autoimmune disease e.g.,Diabetes mellitus(당뇨병) Vaccination (백신) : based on memory of a previous encounter with antigen e.g., HBV, influenza vaccine
그림1-5
그림1-5, 최신면역학(라이프사이언스, 2011)
Chapter 1; 면역계의 개요
그림 1-3
체액성면역(humoral immunity) vs 세포성면역(cell-mediated immunity)
Chapter 1; 면역계의 개요
B세포가 생산하는 항체에 의한 반응 면역글로불린(immunoglobulin)
T 세포에 의해 매개되는 반응 조력 T 세포(TH cell) 세포독성 T세포(TC cell)
그림1-3, 최신면역학(라이프사이언스, 2011)
그림 1-4
능동면역(ACTIVE immunity) vs 수동면역(PASSIVE immunity)
Chapter 1; 면역계의 개요
individual plays a direct role in responding to the antigen
transfer immune cells or serum from an immunized individual to an unimmunized individual
그림1-4, 최신면역학(라이프사이언스, 2011)
Chapter 2; 면역세포 및 면역기관
Bone marrow precursors cells of the immune system (Fig.1-3)
Myeloid lineage(골수계) vs Lymphoid lineage(림프계)
Progenitor 전구세포 Myeloid progenitor 골수계 전구세포 Lymphoid progenitor 림프계 전구세포
Myeloid (innate) Neutrophil 호중구 Eosinophil 호산구 Basophil 호염구 Monocyte 단핵세포 Macrophage 대식세포 Dendritic cell 수지상세포 Lymphoid (innate+ adaptive) B cell T cell NK (natural killer) cell