EFEYAN ALEJO RYC 2013 13546 · 2014-07-10 · , ALEJO ‐13546 ina [email protected]. mmals ic research, I suppressor pr ntribution of d ctions. Our res Efeyan et al., N pproach to dis ll

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sumen de lance my early sh.D., I studied hmed to dissect o exert tumor suf the DNA damaerformed a simoderate contribFor my postdocvolved in the pvery anabolic pand other hormoutrient signalingn nutrient sensammalian orgaTPases, my posmbryonic develf RagA activity ifeyan et al., Nacid and glucoseammalian phys

sumen del Cbrief, I obtainodels of breastobtained my Panuel Serrano e Extraordinaryapers in Natureor my postdoctond nutrient sendditional first‐addition, I wroteuthor. obtained five f

rontiers Scienceprovide a selectelected articles

RagA, bW, Sabatini DM

Rag GThang S, Gumperelected Articles

Limitedrtega‐Molina A

Inducti

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E ECONOMÍACOMPETITIV

EFEYAN RYC‐2013

a: Biomedicnico: efey

by mTOR in ma

a Memoria: steps in scientifhow the tumorthe relative couppression funage response (milar genetic abution of the cectoral studies, Ipathogenesis ofathway in the cones, and cuesg pathway has sing by mTORCanism was obscstdoctoral workopment and fois key for coordature 2013). The sufficiency tosiology, in parti

Currículum Vned my grade ft cancer. From th.D. degree froat the CNIO, oy Thesis Awarde and Cell Metaoral experiencensing signaling uthor paper pee four reviews a

fellowships (3

e Program Orgated list of publics from my Postdbut not RagB, iM. Re‐submissioTPase‐mediatedr I, Snitkin H, Ws from my Ph.Dd evidence for , Soria R, Colladon of p53‐depe

A VIDAD

, ALEJO 3‐13546 cina [email protected].

ammals

fic research, I r suppressor prntribution of dctions. Our resEfeyan et al., Npproach to disell cycle regulatI switched to thf cancer and diacell, and is. MTs from local nujust begun, trigC1 was restrictecure. By meansk pushed forwaor adult life, beidinating fastingis work also deo mTORC1. I acular, in cancer

Vitae: from the Univethis work, I pubom the Autonon the regulatiod. From my Ph.bolism) plus one, I joined David pathway in mending to be reas first‐author,

Ph.D. fellowsh

anization and Chcations: doctoral work: s essential for on in preparatiod regulation of Wolfson R, KirakD. Thesis: the in vivo rodo M, Fernandeendent senesce

AYUDASCONVO

edu

have been interotein p53 exerifferent inputs ults unequivocaNature 2006; Efssect the relevtor p21 (Efeyanhe study of a mabetes. When pTOR integrates sutrient abundaggered by the ded to cell cultus of generating ard this field byng RagA more responses, foremonstrated tham currently ir and aging.

ersity of Buenoblished three paomous Universn of tumor sup.D. work, I pubne first‐author rd M. Sabatini lamice. During msubmitted afteincluding one i

hips: FPI, CNIO

harles King�s T

development aon after first revmTORC1 by nu O, Sabatini DD

le of ATM in tez‐Capetillo O, Sence by the MD

S RAMÓN YOCATORIA

erested in masrts its cancer prthat activate pally showed thefeyan et al., Cavance of certain et al., Oncogemaster regulatopart of mTOR csignaling cues fance. Unlike thdiscovery of theure studies, annovel genetica

y: 1) demonstraimportant thanr the regulationhat the Rag GTPnvestigating th

os Aires, and mapers, on of theity of Madrid, ppression by p5blished 9 paperreview. ab at the Whitemy postdoctoraer first revision.n Nature Revie

O Predoctoral a

Trust).

and adult life. Evision. utrients is neceD, Sabatini DM.

the response tSerrano M. PLoDM2 antagonis

Y CAJAL A 2013

ster regulators rotection. In pa53 (DNA damage dramatic impncer Research in targets of pne 2007). or of cell growtomplex 1 (mTOfrom the organe growth factoe family of Rag nd whether thisally‐engineeredating that this nn RagB (Efeyan n of autophagy,Pases work as mhe impact of t

my undergraduem as a first autand my Ph.D. 53. My Thesis ws (4 first‐autho

ehead Institute l work, I publi. I also publisheews in Molecula

and FPU; and

Efeyan A, Schw

essary for neonNature. 2013 J

o oncogenic stoS One. 2009;4(t nutlin‐3a in m

SDD

SDE

DDC

SDP

of fundamentaarticular, by mege response anortance of onco2007; Efeyan ap53 in p53‐spe

th: the mechanORC1), this kinaismal nutritionor signal transdGTPases. Befors pathway hadd mouse modelnutrient sensinget al., submitte, and for endurmulti‐node nutrhe nutrient se

uate Thesis wathor. Thesis was pe

work obtained Oor papers includ

at MIT, where ished one firsted two papers iar Cell Biology,

2 Postdoctora

weitzer LD, Bilat

natal autophagyan 31;493(7434

tress. Efeyan A(5):e5475.(*: eqmouse cells of f

SECRETARÍA DEDE INVESTIGACDESARROLLO E

SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN

DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ

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al biological preans of geneticnd oncogenic sigogenic signalinand Murga et aecific protectio

nistic target of ase drives cell gnal state, eliciteduction, our unre my postdoctd any function ls to study the g signaling pathed); 2) showingring the neonatrient sensors, sensing signaling

as focused in e

erformed underOutstanding Cuding one in Nat

I currently studt‐author paperin Science and for which I am

l Fellowships:

te AM, Chang S

y and survival.4):679‐83

A*, Murga M*, qually contribufibroblast origin

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ENERAL CNOLOGÍA

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GENERAL HUMANOS TIGACIÓN

rocesses. Durinc engineered mgnaling) to its ag, compared toal., PLoS 2009) n, which show

rapamycin (mTgrowth by reguled by growth fanderstanding otoral research, in the contextfunction of thehway is essentiag that the regultal starvation pignaling both ag pathway in

experimental m

r the supervisioum Laude gradeture, and addit

dy the mTOR k in Nature, anCell Metabolis also correspon

Long Term Hu

S, Kirak O, Lam

Efeyan A, Zon

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g my mice, I ability o that I also wed a

TOR), ating actors of the work t of a e Rag al for ation eriod mino adult

mouse

on of e and tional

inase nd an m. In nding

uman

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tor B,

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006 Sep 14;443Genetic

errano M. Oncoelected articles

Establisfeyan A, Fabris V

MINISTERIO


o‐Miguel S, Herr biology: Polic(7108):159. c dissection of ogene. 2007 Mas from my undeshment of two V, Merani S, La

A VIDAD

rranz D, Vassilecing of oncogen

the role of p2ar 8;26(11):164ergraduate Thehormone responari C, Molinol

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ev LT, Serrano Mne activity by p

21Cip1/Waf1 in5‐9. sis: onsive mouse mo AA. Breast Ca

S RAMÓN YOCATORIA

M. Cancer Res. p53. Efeyan A,

n p53‐mediated

mammary carciancer Res Treat

Y CAJAL A 2013

2007 Aug 1;67(Garcia‐Cao I, H

d tumour supp

noma cell linest. 2004 Feb;83(3

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SDE

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(15):7350‐7. Herranz D, Vela

ression. Efeyan

s derived from a3):233‐44.





asco‐Miguel S,

n A, Collado M

a metastatic m


ENERAL CNOLOGÍA

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Serrano M. Na

M, Velasco‐Migu

ammary tumor

ature.

uel S,

r line.

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tulo: egulation of thsease

sumen de laood vessels areesponse to dives major endothgnificant imprond their differeechanism is thrterial‐venous dathological angngiogenesis indngiogenesis theegeneration. Thelated with endependent rolerder to improveangiogenic veith single‐cell reevelopment, th

the future, we To understanduring angiogene To identify nosease. y research prospects of the bnction during everal unique geo unveil new bio

sumen del Cy scientific careupervision of D

otch ligand Dll4ages of developnd Benedito etembrane, contalibre, a phenomfter finishing malf Adams, at tdvanced genetngiogenesis by

anonical Notch at express the

roject, while suntibodies and c

MINISTERIO


DOS SANRYC‐2013

a: Biomedicnico: Rui.

e biology of b

a Memoria: e an importanterse stimuli. Theelial receptors ovement in the ent functions che Notch cell‐todifferentiation giogenesis. Condependently oferapies, speciallhe overall aim ondothelial prolie of Notch, in de current angiorsus quiescent esolution and iere are still ma

e will pursue thed how the Notcesis and in quieovel and key d

oject has the pbiology of blootumor developenetic tools andological mechan

Currículum Veer started in Or. António Dua

4. In collaborapment due to dt al. BMC Dev.tinue to prolifemenon also ob

my PhD work, athe renowned ic tools and eusing a wide ra

ligand Jagged1 Fringe family N

upervising a tecchemical inhibit

A VIDAD

NTOS BENE3‐13209 cina benedito@c

lood vessels b

t therapeutic tae knowledge acas targets in ntreatment of man also be cono‐cell and memprogramme a

ntrary to the pf VEGF signalinly in situations of my future caiferation or mdifferent endotogenesis‐relatedvasculatures bn a high‐througny open questi

e following key ch signaling patescent vessels. downstream ta

potential to incd vessels. Millpment or metad use complemnisms with ther

Vitae: October 2002, arte. My main p

tion with Janetdefects in the g Biol. 2008). Lerate, and migrserved in zebrat the end of 20London Researequipment, weange of techniq

is a potent proNotch glycosyltr

chnician and mtors in vivo we

AYUDASCONVO

DITO, RUI M

cnic.es

y Notch and it

arget in cancer ccumulated durumerous theramany vascular rntrolled by othmbrane‐to‐nuclnd also plays revious undersng (Benedito eof known resisreer is to define

maturation, andthelial contextsd therapies. Baby using advancghput manner.ions that in ord

objectives : thway regulate

argets of Notch

crease significaions of peopleastasis, cardiovmentary indepenrapeutic relevan

in Portugal, whproject involved

t Rossant�s ggenesis and diffLater on we alsate excessivelyafish embryos (006, I decided trch Institute ‐ Ce studied the ques and genet

o�angiogenic rransferases (Be

aster studentswere able to d

S RAMÓN YOCATORIA

MIGUEL

ts downstream

and cardiovasring the last yeapies designed trelated diseaseer mechanismsleus signaling a fundamentastanding of theet al., 2012, Nstance to anti‐Ve with high spad characterize s, as a way of gased on our preced genetic too Despite the adder to be answe

s different pro

h, and underst

antly our undere around the wvascular diseasndent approachnce.

here I did my Pd the phenotyp

group in Torontferentiation of so found that y towards othe(Benedito et alto move abroadCRUK. With throle of the ditically modified

regulator that aenedito et al. Ce

. By using indudissect the expr

Y CAJAL A 2013

m gene regulato

cular diseases ears in the fieldto stimulate ores and cancer. Bs which compepathway, whicl role during de Notch functiNature) which VEGF, which ocatial and temposome of the

gaining further eliminary data, ols that will endvances in the ered require a m

cesses related

and their func

rstanding of keworld already bes or in age rhes that will dif

PhD in the vascpic characteriza

to, we discovethe first embrythe mutant en

er areas of the . BMC Dev. Biod and I startede knowledge afferent Notch mice. Through

antagonizes Dll4ell, 2009, PHH‐

ucible loss�of�ression and fun

SDD

SDE

DDC

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ory networks i

where their miof vascular bioinhibit the groBut VEGFs and ensate or overrh we found todevelopmental on, we recentwill be relevancur frequently oral detail how molecular meunderstandingwe will charactable us to modknowledge of tmore integrated

with endothelia

tion in vascula

ey molecular mbenefited with elated macularfferentiate our

ular biology anation of mutan

red that Dll4KOyonic arteries (Dndothelial cellsembryo, leadinol. 2008 and Bemy postdoctorcquired duringligands and m

h this methodo

4�Notch signaMP Prize 2009)

�function genenctional interac





in developmen

icrostructure cology allowed towth of blood vtheir receptorsrule the VEGF o be a key reg(Benedito et

tly found that nt for the desin cancer and aNotch controlsechanisms undg of the biologycterize the distidify and interrothe Notch funcd approach and

al proliferation

ar developmen

mechanisms invtherapies thatr degenerationresearch and h

nd Notch signalnt mice lacking

O embryos sucDuarte et al. Gs do not form ng to the reduenedito and Adral studies in thg my PhD and modulators dulogy we were a

aling in angioge). Later I started

etics in combinctions between


ENERAL CNOLOGÍA

NERAL IÓN

ÉCNICA


nt, homeostasis

an change locathe use of VEGFvessels. This leds do not work afunction. One ulator of the ial., 2009, Cell)Notch can regsign of future age‐related ma different procederlying this Vy of blood vessenct Notch funcogate gene funtion during vasd new technolog

n and differenti

nt, homeostasis

volved in impot modulate vasn. We will genave a high pote

ing fields undethe function o

ccumb at very enes and Dev. a stable basection of the arams, Science 2he laboratory othe access to ring developmable to find tha

enic endotheliald a second pos

nation with blo Notch and the

s and

ally in F and d to a alone such initial ) and gulate anti‐

acular esses VEGF‐els in ctions ction scular gies.

ation

s and

ortant scular erate ential

er the of the

early 2004 ment terial 009). of Dr. more ental at the

l cells t‐doc

cking e two

mInanauotentousstefo

MDY

ost important Vcontrast, VEGF

ntibodies can suuthor in this wother questions indothelial Notco supervise twosed advanced gem cells and thor the remodelin

MINISTERIO


VEGF ligands aFR3, the main ruppress the sprork and I receivin the field andh signaling (Beo PhD students genetic tools tohat influences thng of veins and

A VIDAD

nd receptors. Wreceptor for VErouting of endoved the Werner suggest that sunedito and Helthat gave impo show that theheir clonal expa the perivenou

AYUDASCONVO

We found that EGF‐C, is strongothelial cells witr Risau Prize 20uccessful theralstrom, Exp. Ceortant contributre is an endothansion (Wang es capillary plex

S RAMÓN YOCATORIA

Notch can congly modulated th low Notch si013 for outstanpeutic targetinell Res. 2013). Dtions to the vashelial compartmet al. Embo J., 2us during vascu

Y CAJAL A 2013

trol angiogeneby Notch, and ignaling (Benedding studies ing of VEGF receDuring the last pscular biology ament in the bon2013). The studular maturation

SDD

SDE

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sis independenVEGFR3 kinasedito et al. Naturvascular biologptors or their liperiod of my poand Notch signane marrow closent Manuel Ehln (Ehling et al., D





ntly of VEGFR2 e inhibition butre, 2012). I wasgy. These latesigands will depeostdoctoral stualling fields. Thsely associated ling showed thaDevelopment 2


ENERAL CNOLOGÍA

NERAL IÓN

ÉCNICA


and VEGF signanot ligand blo

s also correspont results raise mend on the statdies, I also hadhe student Lin Wwith hematopoat Notch is esse2013).

aling. cking nding many tus of time Wang oietic ential

NoReÁreCo TítFu

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tulo: unctional dissec

sumen de laancer cells are enes, leading toegulation of micf 18‐25 nucleotpecifically methechanisms in thon‐coding RNAs, Oncogene. 20uppressor non‐c

uring my postdmor microenvie have uncoveairpin RNAs (shequired for dise

or my independancer) to dissec

sumen del Cstudied Biologyith the 2nd Prxperience in sevrovided me witMadrid, Spain), mor‐suppresso

egulation of othudied the impahort‐Term Felloycle and 1 in Na

October 2009,cott Lowe, I moery aggressive dmiting liver damancer Discoverynderstand liver terference andreparation). Forresentation as

RNAi) field acquas endowed meaining has allowas facilitated mye role of senes

MINISTERIO


LUJAMBRYC‐2013

a: Biomedicnico: luja

ction of liver ca

a Memoria: characterized o their activatiocroRNAs and otides in length thylated in canhese pathologies, such as trans010). In theorycoding RNAs an

doctoral researronment, in pared a potentiaRNAs) targetinase maintenan

dent scientific t the involveme

Currículum Vy at the Universemio Extraordveral laboratorth excellent traunder the sup

or and metastaher non‐codingact of differentowship. My expature), and by t

, seeking to expoved to Cold Spdisease that lamage and hepay, Nature Cell Bcancer biology

d mosaic mouser my postdoctooral communic

uired while traine with a valuawed me to obtay developmentcence in tumor

A VIDAD

BIO GOIZUET3‐14331 cina mbia@mskc

ncer

by broad epigeon or inactivatiother non‐codinthat have a funncer and metaes (Lujambio etcribed ultra‐coy, this aberrannd reverting the

rch, I have shoart, through secl therapeutic tg known drug ce (manuscript

career, I plan ent of cellular s

Vitae: sity of Navarra,inario Fin de Cies, including thaining in molecpervision of Drasis‐suppressorg RNAs in canct microRNAs inpertise in the ephe "Premio Edu

pand my expertpring Harbor Lacks effective trtocellular carciBiology, and discy, but also to idee models of canoral research, I cations at seve

ning in Dr. Lowble experienceain extensive tht into an indeper suppression a

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TA, AMAYA

c.org

enetic and genon, respectivelyg RNAs in cancction in gene reastasis, demont al. Cancer Resnserved RNAs (nt methylation e tumor phenot

wn that p53 acreted factors target for c‐Mytargets in a c‐Mt in preparation

to exploit the senescence in li

and was awarCarrera by the he laboratoriescular biology te. Manel Esteller microRNAs (er (Oncogene)n the epigenetipigenetic and nuardo Gallego"

tise in cancer anboratory (CSHLreatment. First,noma. This wocussed in a revientify potentiancer, and identwas awarded aeral prestigious

we�s lab, I havee that will be vheoretical and endent, highly mnd to exploit se

S RAMÓN YOCATORIA

A

netic alterationy, and to the dcer. MicroRNAsegulation. By unstrating, for ts. 2007;Lujamb(UCRs) can be dcould be reve

type (Lujambio

acts non‐cell‐auhat modulate myc overexpressiMyc‐driven mun).

use of shRNA iver cancer init

rded with the PMinisterio de

s of Gines Moraechniques. In 2er, and supportCancer Resear. Moreover, I vic landscape ofnon‐coding RNA from the "Fun

nd attracted byL) as a postdoct, I studied the ork was publishiew in Current Bl therapeutic tatified a promisian "EMBO Longs meetings. Ta

e been activelyvery useful whepractical knowmotivated and enescence with

Y CAJAL A 2013

s. These alteradevelopment ofs (miRNAs) are ndertaking diffthe first time, io et al. PNAS. deregulated by ersed by epigeet al. Nature. 2

utonomously tomacrophage funng liver tumorsrine liver cance

libraries (and iation.

Premio ExtraordEdudación y C

ata (CBMSO) an2005, I started ted by an FPUrch, PNAS), anvisited the lab f cancer cells. A field is reflecdación Francisc

y the cutting‐edtoral scientist. role of p53 aned in Cell (ApriBiology. Moreoargets for liver ing target for cg‐Term Fellowsking advantage

y involved in then setting up aledge in the fiehard‐working s

h therapeutic pu

SDD

SDE

DDC

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ation can affectf cancer. Duringsmall, evolutioferent approachthat miRNAs 2008). Moreovepigenetic mec

enetic drugs, re2012).

o suppress tumnction (Lujambs. Briefly, by scer model, we ha

to a lesser ext

dinario Fin de CCiencia. As an nd Manel Estellemy PhD at theFellowship. Dud described, fof Reuven AgaFor these studted by the pubco Cobos".

dge technology I decided to fond cellular senel 2013) and waover, I have devcancer. For tha‐Myc overexprship". In additioe of my new e

e inception of tand leading myelds of cancer, sscientist with a urposes.





ct oncogenes og my PhD, I stuonary conservehes, I identifiedcan be regul

ver, I also demochanisms in caestoring the e

morigenesis by io et al, 2013, Ccreening a custave identified a

tent, the use o

Carrera by the sundergraduateer (CNIO). These Cancer Epigeuring my PhD, for the first tiami, at NKI (Ndies, I was awablication of thre

developed in tocus my researcescence of hepas highlighted bvoted my effortat, I have combressing liver tumon, my work haexpertise in th

the RNAi Core y laboratory. Fisenescence and strong desire t


ENERAL CNOLOGÍA

NERAL IÓN

ÉCNICA


r tumor suppreudied the epiged, non‐coding d several microated by epigeonstrated that oancer (Lujambioxpression of tu

promoting an Cell). More recetom library of a candidate ge

of mouse mode

same universitye, I gained resese early experieenetics Lab at I identified seme, the epigeederlands), whrded with an Eee reviews (2 in

the laboratory och on liver cancpatic stellate ceby Nature Meds, not only to bined the use ofmors (manuscras been selectee RNA interfer

at MSKCC. Thisinally, my acadd RNAi screensto continue to s

essor enetic RNAs RNAs enetic other o A et umor

anti‐ently, small ne as

els of

y and earch ences CNIO everal enetic here I Embo n Cell

of Dr. cer, a ells in icine, better f RNA ipt in ed for rence

s task demic s, and study

Th

MDY

he average imp

MINISTERIO


act factor of my

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y first‐author p

AYUDASCONVO

papers is 15, and

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d each has bee

Y CAJAL A 2013

n cited 155 tim

SDD

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ENERAL CNOLOGÍA

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NoReÁreCo TítIm

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sumen de labecame interesGMP facility at D34+ and CD13as involved in logenic transplaterest in trans

athological factornell Medical rogenitor cells emogenic cells ardiol. 2007). Ineveloping protonowledge on thnly I succeededith only 2 of throcess of nucleaook (Springer Pe genomic inte011; Stem Cells ansdifferentiatinctional neurouman blood ceurrently, I am rategies for theased on tempor

sumen del Carting my careanscriptional reem cells (CBSCeveral human ineprogramming to demonstrate anscription faciorgetti et al., duced pluripotSCs amenable med to characudies demonstNature, 2011; Pemonstrated thnd c‐MYC (GiorWO US2012/042013 I moved toudy the role ofor the in vitro ge

MINISTERIO


GIORGETRYC‐2013

a: Biomedicnico: agio

master transcrip

a Memoria: sted in haematthe Ospedale 33+ progenitor several clinicalantation of pedslational resea

ors on the mobCollege in Nein peripheral with a specifi

n 2008 I movedocols for the ghe biology of hd at demonstrathe 4 factors near reprogrammProtocol Handbegrity of huma2011; PNAS 20ion potential ons by the overeells directly intoworking at Joe in vitro generral regulation o

Currículum Veer as a stem egulation and tC). In 2008 I joinduced pluripotechnologies. Tthat CBSC canctors; OCT4 anNat Protocols tent stem cells to worldwide terize the genotrate that epigePNAS, 2012, Nhat these cells crgetti et al., PN2). In 2011, I joo Josep Carreraf lineage‐specifeneration of sp

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TTI , ALESSA3‐13221 cina orgetti@carr

ptional regulato

topoiesis and sMaggiore Policcells derived fl trials. The modiatric patientsrch. Moreover

bilization of circew York. Thereblood of patiec Id1/Id3 mole to the Center generation and ematopoietic cting that CB ceecessary to reping. The work rook Series, 201n iPSCs as well012 and Naturef these cells toexpression of So neuronal‐likesep Carreras Lration of specifiof specific trans

Vitae: cell biologist he biology of hned Stem Cell tent stem cell Then, I combine be reprogramd SOX2. These2010), a book from cord bloobanking and diomic integrity enetic aberratioNature Commucan be converteNAS 2012; 109:oined as head oas Leukemia Refic transcriptionecific blood cel

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ANDRA

erasresearch

ors in blood eme

tem cells durinclinico Milano) rom cord bloodost relevant on. This experiencr, during this

culating endothe, I was involveents with lung ecular signaturof Regenerativebanking of ne

cells I reasonedell could be repprogram other resulted in two 11) and a patenl as in the diffee Communicatioward other lineSOX2 and c‐MYC progenitor ceLeukaemia Resc blood cells foscription factor

during my firstematopoietic sBank of CMRB(iPSC) lines dered my previous mmed to pluripoe data resultedchapter (Sprinod. 06‐18‐2010istribution. Myof human iPSCons are a generunications, 201ed directly into 12556‐12561; Pof Laboratory osearch Institutn factors duringls for cell repla

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h.org

ergence and dif

ng my bachelorin 2004. Durind (CB) by DNA ne was focusedce allowed me period I cultiv

helial progenitoed in the searg cancer. We ire (American Joe Medicine of Bew lines induced that CB cells programmed tor types of soma high‐impact punt (WO 12/819erentiation of ions 2013. Moreeages. I have reC (PNAS 2012).ells that can besearch Instituteor cell replacemrs to improve th

t postdoctoral stem cells and tB (Barcelona) wrived from hea experience in otency faster td in two high‐g Protocol Han0. WO 12/819.0y expertise in reCs derived fromral feature of t13). Following functional neuPatent title: Coof Hematopoiese in Barcelona g hematopoiescement therap

Y CAJAL A 2013

fferentiation du

r thesis and Phng my PhD I semicroarray tec

d on the clinicato obtain the qvated interest

or cells. I continrch of biomarkdentified the eournal of HemBarcelona (CMRed pluripotent could be an ideo iPSC, but I alsoatic cells, thereublications (Cel9.059). I also coPSCs toward geover, my intereecently demon. This work dese expanded ande as staff invement therapies he differentiatio

training I focutheir clinical apwhere I activelylthy volunteersCBSC biology wthan fibroblastimpact publicandbook Series, 059) and suppoeprogrammingm fibroblasts anhe hiPSCs statemy long‐stand

urons by the forord blood‐derivsis and Blood das a staff juniois developmentpies.

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matology 2005, RB), as researchstem cells (hiPeal source of ho found that theby providing nlStemCell 2009ollaborated in twerm cells, studest on CB stemstrated that thcribed for the fd further differstigator. My loin hematologicon of blood line

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arch on gene ea particular intn the generatioacquiring invaledge of reprogrocytes by overeti et al., Cell Spatent (Patent CB as an alternarumental in fintic cell types. Tpendent of the on CB stem cen of two transcy expression ofbiomed Founda. Currently, myn order to dev


ENERAL CNOLOGÍA

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ment from iPSC

PhD with Dr. Lapression analysstdoctoral trainf CB CD34+ celr and strengthef physiological

Laboratory, at culating endothation of circulsc Res. 2006; ere, I participatsed on my preeneic therapiesd be reprogramtic insights intocol 2010), a chamed to charactpublished in Na

me into explorinnverted directlypossibility to cofunctional neuis to develop

My initial approaSC.

expression anaterest on cord bon (and bankinuable knowledamming technoexpressing onlyStem Cell 2009title: Generatioative, safe souralizing two proThe results of tsomatic cell so

ells I have recription factors Sf SOX2; 15‐06‐2ation. In Septey main interest elop new strat

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sumen del Cstarted my scieomplutense Uneatment. My re998 I received hemistry. After n tumor suppre

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53 and eliminate Faculty of Chs first‐author. A Dr. Serrano¿s ar4‐null mice. Trostate. My resolid backgroundstitute (New Yandolfi¿s lab I w

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a Memoria: e is focused ond my scientific ctional Centre o

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at it is possible theses on tumo

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e maximum quay, Madrid). Myinued my reseaancer Researchto reveal the tnd several co‐aouse models, weth Israel Deace consequence

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sing genetically

sms underlyingthe Complutend). Since then,

ge of p53 (�Su

p53� mice exhmature aging. Thganism withoutO) to study therrying two or thg. I have also t

ll background).p19ARF, a p53 no¿s lab I have aow a decrease plasia. This moate. ory at the Sloann). The lab has f informative mandolfi¿s lab wawith increased Png the regulatiocreased cell numre and reducedmitochondrial ro the fields of c

Biochemistry. I properties of audent Fellowshversity, Madrido¿s lab at the Neveral genetica

to increase canor suppression

ntitled �New m

alification of Cy thesis project arch focused on Centre (CNIO)umor suppressauthor articles which led me toconess Medicaes and potentia

Y CAJAL A 2013

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g tumor supprense University omy research fo

uper p53� mic

hibit an enhanche main contribt secondary effe effect of an hree functional tested the relev

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joined Dr. Rosallergens with thip from the Ed), obtaining theational Centre ally modified m

ncer resistancen, stress and a

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um laude by uled to 4 publican cancer biolog. One of my prosor role of Par4in prestigious co join Dr. Pier Pl Center (Harval benefits of el

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he tumor supprng large genomion of the endoeffect on cell sizcumulation, revis study showsment and meta

alia Rodriguez¿the final aim oducation and Sce Degree¿s Extof Biotechnologmouse models t

without acceleging. I received

for the study of

nanimity and tations in prestiy and mouse geojects was the g4, with particulacancer journalsaolo Pandolfi¿sard Medical Scevating PTEN.





eloping informthen joined Dr

cer biology and

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to DNA damagwork was the deging. To furthep53 in telomerp53 gene reveaumor suppress

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rk) and subsequecular biology ainvestigate in vressor PTEN anmic BAC clones (ogenous copy. ze. Interestinglyvealing PTEN s that PTEN proabolism.

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ENERAL CNOLOGÍA

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ative cancer mr. Manuel Serra mouse geneti

mouse model to

ge, are protecteemonstration ter challenge there‐driven agingled that moderor p19ARF for

p53� are resial for p53‐medor the pro‐apopice and are pror suppressor ro

uently at Beth and cancer genvivo the functiod the conseque(>100Kb) contaMice with increy, PTEN elevatias a key metaomotes a meta

tant Student alergy diagnosisy of Spain (MECze of the Faculart my thesis prer. In particular

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ased gene dosa

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mouse ano¿s cs. In

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lator that shiftser and obesity. g from the MECily basis with e‐Dr. Lew Cantlorking at the f

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towards tumorve been publisd the HFSP Lor, and establishs well as intergave me the o

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r suppression. shed as an articng Term Fellowh successful conational collabopportunity to

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herapeutic apprh at Pandolfi¿sthe opportuni

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roach lab I ity to rvard ntific y and

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sumen del Cam a complemmmunity, leads octoral thesis (órdoba. My PhDediated renal datl Acad Sci USAodel of the discluding 3 first aeing awarded in

2008, I movevestigated the nowledge of cod to 7 publicati2(1):137‐145; awas an invited s

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GOICOECRYC‐2013

a: Biomedicnico: e.go

tem dysregulat

a Memoria: ment biologist wan essential comodulation of ada

omplement begecular basis of monstrate thaivators are assoctors in complehew Pickering in

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s a postdoctoray to develop in he study of otniversity Collegopathy, describde Jorge, et al.,ogram of workpendent investinderstanding the dimerization et al. PNAS, 201road, I got to kdiverse experims an independl conferences ae is reflected inng an invited s

understanding ded by a FPI feiversity Autónomolecular basiral publicationsa‐Gordillo et al.p Med, 2007, 2ships, 3 reviewscommunication

ng�s group (erent animal mivo and to explmmentary and e1002981). Mo

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perial.ac.uk

st is the studywith crucial role

g in Prof. Santiayndrome (aHUSnction mutatioea de Jorge et aHUS to developelopment of the

ea of studying c

al researcher. our aHUS modther complemege London), I ibing for the fir, 2010). This fink and secure a igator. he biology of thstatus for som13) and led to tknow different mental techniquent investigatoand seminars. 26 publicationpeaker in 4 occ

g how dysreguellowship formoma of Madridis of atypical has having a majo Hum Mol Gen204(6)1249‐125s and one bookn.

(Imperial Collegmodels of renalore possible th 3 first authorsoreover, I partic

Y CAJAL A 2013

y of the comples in microbial

ago Rodríguez dS), a paradigm oons in complemal. PNAS, 2007)p. During my the first animal m

complement dy

During this timdel (Goicoecheaent‐mediated dentified a murst time a mutnding opened aJunior Researc

he CFHR gene fe of the CFHR pthe recent generesearch envirues. I have beeor and recogn

ns (7 peer‐reviecasions, and on

lation of comp Spanish Minisd (Spain) underaemolytic uremor contribution . 2005, 14(5):7056). Overall, du chapter. I also

ge London) asal disease, proherapeutic intehips (Lancet 20cipated in 5 inte

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de Córdoba�s of complementment regulato. I also demonshesis, I also perfmodel of aHUS

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e I completed a de Jorge et alrenal diseases utation in comant CFHR5 pronew avenue ofch Fellowship (

family and its aproteins and itseration of a patonments that hen involved in sised compleme

w first author ae patent.

plement systemstry of Science r the supervisiomic syndrome (aon the genetic03‐712), and onring this periodhad 9 internat

s a postdoctoroviding me therventions. The 010, 376(9743):ernational mee





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association wits functional imptent. have giving meseveral fruitful ent biologist,

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ENERAL CNOLOGÍA

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iation with disce, immune com

esis focussed oal disease. I waction mutationnfluence of muwith in collabore Jorge et al. J.

to Imperial Co

work demonstrI also expandelomerulopathieor H‐related 5 d with disease.he complementerial College, w

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profile journals

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ring my postdoLondon) in 201t steps of scientor H family ane of them a firsof a patent (Ptem. years of scientife scientific comnternational cont my work in se‐review first auer in 4 occasion

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oped a new resthe Centre for Cence. Since theion with diseascation (Proc N50258) where

ad, firstly as a ptending regula

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search avenue Complement aen, my main rse. My scientifatl Acad Sci USwe provide no

ostdoctoral andr meetings andthe complemennars. My scientimmunications in

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that allowed mnd Inflammatioesearch interesic contributionSA, 2013, 110(1ovel biological

d subsequentlyd by participatint field, I servedific contributionn conferences (

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ENERAL CNOLOGÍA

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rch Fellowship award launcheg the biology ow to date includmy work led tomodulation o

I have been actervising activititics and I have ent, 26 publicatand seminars, b

(JRF, d me of the des 3 o the f the

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sumen de lay first contact egree at Oviedorants program. pecifically involvn, I was able toice deficient forogression, andn parallel, I gotroject led to than being just act, restoration nce I got my Phnded by an EMegulation at thereponderant rooA is a master r

In summary, eukaryotic ce

athologies.

sumen del Cstarted in scient001, at Carlos LMEC).

Once I om the MEC, wlowed me to putophagy resea In July 2007,ópez‐Otín lab as

In Januoved to the labred senior post

uring my reseaesearch projectsf them as first o4), Cell Metaboted 1687 timesternational me

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MARIÑORYC‐2013

a: Biomedicnico: gmg

between autoph

a Memoria: with scientifico University, SpDuring this perved in autophao get insights inor each of these to the establist involved in the finding that pn epiphenomeof somatotrophhD, and given mMBO Long Terme metabolic levole for acetylatiregulator of aut

my research caells, and in the

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finished my Biwhich funded mperform a two‐mrch and establi, I obtained mys a hired postdouary 2010, and b of Prof. Guidotdoc at Guido K

arch career, I hs, as well as wror co‐first autholism, JCB, JCI, s, with an averetings and part

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hagy, aging and

research was pain. Just after riod, I started aagy. Initially, mynto the actual e two genes. Tshment of an ese study of prepremature aginnon, this metabh axis was suffimy interest in

m fellowship. Thvel. Through thon reactions intophagy, thus in

areer has been e elucidation o

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iochemistry deme during my month stage atshed ties with ty PhD. with theoc until decembgiven my intero Kroemer in PKroemer lab wh

have masteredriting scientific or) in top‐rankPNAS, EMBO Jrage rate of citticipated in a va

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d other human p

at Prof. Carlosgraduating, I jo new line of resy work was focphysiological rhis approach lessential and novmature aging, ang in mice activbolic reprogramcient to significthe links of mehere, I developehe use automatn autophagy regntegrating this

focused on theof autophagy

studying my Bad by a Collabo

gree, I obtainepre‐doctoral st Prof Noboru the prominent e qualification 'ber 2009, and frests in autopharis, funded byere also I help t

a large varietmanuscripts anked internationJ (x2) or EMBO tations per papariety of resear

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pathologies

s López‐Otín laoined López‐Otísearch focusedcused on the cloroles of autophed to the descrvel role for autoan ongoing linevates a pro‐survmming turned ocantly improve etabolic pathwaed and coordinted microscopygulation and vecatabolic pathw

e study of autoplinks with me

chelor in Biochration Grant (B

ed a FPU (Formstudies. During Mizushima labJapanese autop'Summa cum Lafinished some ohagy and in they an EMBO posto coordinate a

ty of techniquend handle revisal journals (inc Molecular Meper of 40 and arch projects of b

Y CAJAL A 2013

boratory in 20ín lab as a pre‐ on the study ooning and biochagins‐1 and ‐3ription of a newophagy in balane of research avival metabolicout to be essenthealth and enhays and longevnated a new liny and metaboloery recently, I sway in general

phagy, a catabotabolic alterat

emistry and MBeca de colabo

mación del Profthis period, Ioratory in Tokyphagy researchaude' at the Unof the projects te mechanisms ut‐doctoral Longautophagy‐relat

es and I have ion processes. cluding Cell, Sciedicine). Accordan h‐index of 1both national a

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olic pathway wiions underlying

olecular Biologyoración), from t

esorado Univewas awarded wyo, Japan. Ther community. niversity of Ovithat I had starteunderlying physg‐Term Fellowsted projects.

acquired the cTo date, I haveence, Nature Rding to ISI web 18. I have also nd internationa





ying my last yent under Spanisphagins (Atg4s)cterization of thgeneration andnction for autoand inner ear daboratory. My olving autophagelopment of prpan of progeroio Prof. Guido Kfocused on the ms, I was first afirst time that

ulation.

ith essential hog aging and a

gy at University the Spanish M

ersitario) pre‐dowith a mobilityre, I learned th

iedo. Then, I coed during my Psiological and pship. Since 2012

capacity to dese authored 45 sRev. Mol. Cell. B of knowledge, presented 14 al scope.


ENERAL CNOLOGÍA

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ear of Biochemsh Government, the only protehese enzymes. characterizatioophagin‐3 in tumdevelopment.participation ingy induction. Rarogeroid featured mice. roemer lab in Pstudy of autopable to describecytoplasmic Ac

meostatic funca variety of hu

of Oviedo (Spainistry of Educ

octoral grant (2y grant (MEC)e latest metho

ontinued workihD studies. pathological ag2, I am working

sign and coordscientific articleBiol., Molecula, my work has communicatio

mistry t FPU eases Later on of mour

n this ather es. In

Paris, phagy e the cetyl‐

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sumen de lahe focus of manslational focehavior. Autismepetitive/restricCDC, 2012), beissential to stuterventions. Fontnap2 mouse mesearch. This wo

hus, this mouseonsistently imphenotypes. Wetranasal admineatment in wilterestingly, wessociation of thxploring the nexytocin exerts it

y work includejections for geocus. The ultima

sumen del Creceived my Phpain. The focustellectual disabncient isolated fferent mutatioefore starting megative for Freurodevelopmendescribed mut006).

fter completinghere I continueuman Geneticsboratory, a leadneuropsychiatrehavior. It has ane of the primanimal models teuro‐anatomy,

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search on Neuro

a Memoria: y research is us, studying thm is a neuropsycted interests. Iing one of thedy the disordor the last yearsmodel of ASD, aork has been re

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g my PhD I beced my work ons,2007). In 200ding researcherric disorder chaa prevalence oary health issuhat faithfully rbrain develop

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on neuropsychhe molecular pychiatric disordIt has a prevalee primary healter at the mos I have been lea model that haecently publishe

es a new tool fhaviors. Currened an in vivo dhe neuropeptidates did not soxytocin levels stem and ASD, asis for the oxyffects.

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hiatric disordeathways and cer characterizeence of 1 in 88 th issues worldlecular level, eading a multi‐fas proven to haed in Cell (Peña

for mechanisticnt pharmacothedrug screeninge oxytocin drahow any behaare reduced inand clinical trytocin signaling

rization, in vivos to study the rpply findings in

ment of Geneticsyndrome, a mmon genetic o study the orrd Fragile X synducted some ctations in theby intellectual (Peñagarikano

ctoral researchdrome focusingmy knowledge n the Departmedeficits in two ren according toOne of the pr

m‐related behanal physiology

S RAMÓN YOCATORIA

A

rs and, specifcircuits that leaed by deficits inchildren accorddwide. Animal gain insight infaceted work, inave high constragarikano et al.,

c and therapeuerapy is used tg in Cntnap2 mamatically impravioral responsn the brains oials with oxytog deficits in the

o drug screeninrelationship ben mouse models

cs in the Schooneurodevelopm causes of Autiigin of unstableyndrome (Peñaclinical work sce MecP2 gendisability and

o et al., Human

her in the Depag on its molecuon the neuron

ent of Neurologbehavioral domo the latest estrimary reasons avior. During my and behavio

Y CAJAL A 2013

ically, Autism ad to abnormaln two behaviording to the latemodels that f

nto disease mnvolving anatomuct, face and p, 2011).

utic research ino mostly reduc

mutant mice tarroves social dese, suggesting af Cntnap2 mutocin in autistic e Cntnap2 mous

ngs, molecular etwee neurons,s of neuropsych

ol of Sciences omental disordeism. I studied te genes. Our regarikano et al.reening DNA sane. This geneautism‐like fea

n Genetics, 200

artment of Humlar basis (Peñanal basis of augy at the Univermains: social betimates from thfor the absenc

my late postdocoral characteriz

SDD

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Spectrum Diso behavior withral domains: soest estimates frfaithfully replicechanisms andmy, developmeredictive validit

ASD. In autismce stereotypic brgeting affectedeficits in this ma hyper‐reactivtant mice. Sevpatients show se model of au

biology, neuro brain circuits hiatric disorder

of the Universir which is the he stability of tesults were in a, American Jouamples of intelis responsib

atures. I found5; Tejada, Peñ

man Genetics agarikano et al.tistic behavior,rsity of Californehavior/commuhe Center for Dce of effective ctoral work I lezation of the





orders (ASD). h the purpose ocial behavior/crom the Centercate autism‐reld test potentient, physiology ty, which is crit

m, no drug has behaviors and d social behavmouse model. Svity to oxytociveral lines of epromising res

utism and the m

oanatomy, in viand behavior, rs towards hum

ity of the Basqmost commonthe FMR1 geneagreement witurnal of Medicllectually disabble for Rett sd a predicted dagarikano et a

at Emory Unive., Annual Revie, I joined Dr. Dnia at Los Angelunication and rDisease Controtreatments fo

ed a multi‐faceCntnap2 mou


ENERAL CNOLOGÍA

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My research hof restoring nocommunicationfor Disease Colated behaviorial pharmacoloand behavior oical for translat

yet been provenoncore associors and foundStrikingly, the sn in Cntnap2 mvidence suggeults. Currently mechanism whe

vo stereotaxic with a translat

man intervention

que Country, Bin form of inhee in Basques, ath the hypothescal Genetics, 2led cases who syndrome, anodeleterious andl., Clinical Gen

ersity, Atlanta, w of GenomicsDaniel Geschwes (UCLA). Autirepetitive/restrl (CDC, 2012), br ASD is the laeted work, invouse model of

has a ormal n and ontrol s are ogical of the tional

en to ciated d that same mice. st an I am ereby

virus tional ns.

ilbao, erited very sis of 004). were other d yet etics,

USA, s and wind's ism is ricted being ck of olving ASD

(PthMint Cuthasprw

MDY

eñagarikano ete leading Founedicine (Penagternational neu

urrently, I contiis devastating as a Voucher Awresented as peeill be published

MINISTERIO


t al., Cell, 2011ndations on Augarikano and Guroscience mee

inue to use thisaspect of the dward from theer selected orad shortly.

A VIDAD

1). This work wautism research.eschwind, 2012etings.

s mouse modedisease. For thise UCLA Clinicall presentations

AYUDASCONVO

as awarded the As a result of 2) a book chap

l to study theirs purpose I was and Translatis at Society for

S RAMÓN YOCATORIA

e "Top10 achief this work, I wpter on the sub

r deficits in socs awarded a Traonal Science Ir Neuroscience

Y CAJAL A 2013

evements in autwas invited to wbject (Peñagarik

ial behavior, siaining grant in nstitute (CTSI).2012 and Inter

SDD

SDE

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tism research iwrite a review kano and Gesch

nce there is cuTranslational R. The initial rernational Meet





in 2011" by Auon Autism in Thwind, 2013),

rrently no treaResearch by Auesults of these ting for Autism


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tism Speaks, oTrends in Moleand as a speak

tment indicatetism Speaks, asstudies have Research 2013

ne of ecular ker at

ed for s well been 3 and

NoReÁreCo TítM

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tulo: icroglial phagoc

sumen de laicroglia are theuroinflammatohich apoptosis urrent knowledostdoctoral traie adult brain ippocampal neuynamics in vivo chucarro Basquxperiments in vow cytometry, icroglia in conicroglial phagotations, a fully apacity to integonsolidated traj

sumen del CSc in Biology Comunidad de Mxtraordinary Awuthor; Young Inllow at Rockefe36 citations) anniversity, NY atations, impact esearch Profess

lial Cell Biology

013, as PI), Basqudents (Basquee board of dir

pringer book �

MINISTERIO


SIERRA SRYC‐2013

a: Biomedicnico: ama

cytosis in healt

a Memoria: he brain profeory response. Dis known to o

dge on the recining, I discoveis fast and effiurogenic cascadand allow us foue Center for vivo and in vitrogenomic and

ntrolling adult cytosis in brainequipped lab

grate previous jectory as a you

Currículum V1995‐2000 (U.Madrid). ward 2003; Felvestigator Awaeller Universitynd Glia 2008 (94nd Baylor Colle factor 25); Keysor at Achucar

since 09/2011

que Governmee Government ectors of the S

�Microglia in He

A VIDAD

SAAVEDRA,3‐12817 cina anda.sierra@

h and disease

essional phagoDespite the cenoccur, from braeptors involvedred that contracient, and is tide, where newor the first timeNeuroscience ao (organotypicsproteomic ananeurogenesis

n diseases that with 3 PhD stuknowledge andung leader in Ne

Vitae: . Complutense lowship for Phard (Workshop y, NY 2004‐20064 citations) ege of Medicinystone Symposiro Basque Cen

; 3 papers publ

nt (50.000�, 2PhD and UniveSpanish Glial N

ealth and Disea

AYUDASCONVO

, AMANDA

@ehu.es

ocytes, a moretral role of phain developmend its mechanisary to the assumghtly coupled born cells undee to illuminate as Ikerbasque s, primary cultualysis, and muland hippocamleads to delayeudents, and fud technical appeuroscience in

e, Madrid): Be PhD

hD students 20on Steroid Hor6; Postdoc Fello ne, TX, 2006‐20ia Scholarship 2ter for Neuros

lished, 1 submi

2012‐2013, as corsity of the Basetwork; memb

se�; Marie‐Cu

S RAMÓN YOCATORIA

e beneficial anagocytosis in mant to brain disesms of executiomptions in the to apoptosis (ergo apoptosis,the intricate inResearch Profeures) in mice ativariate statismpal‐dependened clearance annding from a Nproaches into aSpain and Euro

st College Repin Neuroscien

000‐2004 (Carlomones, CO). owship (Minist 011; 3 papers 2011. cience and Un

itted, 1 in prepa

o‐PI), and Minesque Country feber of the Euro

urie Fellow 201

Y CAJAL A 2013

nd less exploreaintaining tissueases such as eon, and its funliterature, micrSierra et al., C, I established anteraction betwessor, we curreand human tisstics to expandnt learning andd inflammationNational Reseaa coherent, inteope.

port in Biologce 2000‐2003 (os III); 12 pape try of Education published, 2 a iversity of the

aration; fundin

eco (125.000�ellowships); teaoglia meeting 2

1‐2014 (Co‐Fun

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ed role than e homeostasis epilepsy, strokenctional conseqroglial phagocyell Stem Cell 2a series of paraween apoptosis ently use a muue, as well as c these findingsd memory; 2, n. With 22 peerrch Plan from egrated, long‐te

y 2001; Fellow(Cajal Institute ers published s n); 4 papers pu Poss first autor, in Basque Countr

g from Ikerbasq

, 2012‐2015, asaching in two M2015 (Bilbao) o

nd Program).





its traditional in all the widese, Alzheimer s quences remainytosis in physio2010). Using asameters that quand phagocytoultidisciplinary confocal and es in two directThe patholog

r‐reviewed manMineco, I haveerm research p

wship for Techand U. Compl

summing 1236

ublished, 2 as fistdoctoral assocncluding Cell S ry, and Head o

que Foundatio

s PI); fully equipMaster courses;organizing comm


ENERAL CNOLOGÍA

NERAL IÓN

ÉCNICA


implication inspread conditioor Parkinson sns poor. Durinlogical conditios a model the uantify phagocyosis. In my lab aapproach involectron microsctions: 1,The rogical impairmennuscripts, over e demonstrateplan, and build

hnicians 1999‐utense): PhD Tcitations, 3 as Postdocirst autor: Glia ciate at Stony Btem Cell 2010 Ikerba

of the Laborato

n (144.000�, 2

pped lab with 3 elected membmittee; co‐edit

n the ons in s, our g my ons in adult ytosis at the olving copy, ole of nt of 1900 d my up a

‐2001 Thesis s first ctoral 2007 Brook (174

asque ory of

2011‐

3 PhD ber of tor of

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sumen de laelomeres, specelomeres consis

�end replicatioowever, embrylomeric repeatelomerase comlomeres to shoave shown thatnd genome intelomeres. Both ecombination, prikingly I have te lead to a losequirement for nd the importaster telomere cspecially in Ephpithelial tumoretastasis; This haracteristics bytranscription faepress telomeralomere maintend for the deve

sumen del CS in Biology froxcellent cum lauthe laboratoryn the study of hmodel. This wot al. (Chomosomstitute of BiomTelomere main. (Journal of Ceycle, 2012). 3 stresentations, 4 ork State Depareptember 2011

MINISTERIO


CANUDARYC‐2013

a: Biomedicnico: silvi

e maintenance d

a Memoria: cialized structust of TTAGGG D

n problem�, yonic, tumor ats to the endsplex. Recently orten dramaticat TIN2 is requiregrity. Cells lacphenotypes cpreventing theidentified thatss in sister teloHP1 at replicatnce of telomercohesin as wellithelial tumors.rs are the mosprocess happ

y tumor cells anactor is the keyase and regulatenance could inlopment of spe

Currículum Vom Universitat ude (2004). Supy of Dr. Fernanhomeotic gene ork resulted in 4ma Research, 2molecular Medicntenance and gell Biology, 200tays in internatposters) 5 natiortment of HealtI am working a

A VIDAD

AS PUIG, SIL3‐12598 cina a.canudas@

during tumor p

ures at the enDNA tandem re

in most somand stem cells of chromosomthe shelterin sually and stem cred to establishking TIN2 werecould be causee cells from re DC mutation cmere cohesionting telomeres,re maintenancel as the import. st common nepens in the latnd the acquisitiy inductor of EMtes telomere innterfere with caecific therapeut

Vitae: de Barcelona (ported by FPI fendo Azorín Marregulation and4 publications: 006). My interecine (New York genome integrit09), Canudas ettionally recognonal meetings, th (2006). In 20as postdoctoral

AYUDASCONVO

LVIA

gmail.com

progression

nd of chromosepeats and shel

tic cells, telomnormally mainmes. The humaubunit TIN2, waells to die earlyh or maintain coe unable to repaed by a failure epairing damagcluster in TIN2 n and interfere and further pre for stem cell tance of telome

eoplasic alteratte phases of ton of mesenchMT. My prelimntegrity importaancer treatmentic strategies.

(1998). PhD deellowship fromín at the Institu expression, wiEspinas et al. (Jest in Genome University) in Nty. This work ret al. (Gens & Dized centers (2. During My po

010 I was selectfellow at IMIM

S RAMÓN YOCATORIA

somes, are esslterin, a six‐sub

mere shortenintain telomeresan stem cell das found to be y. How these mohesion at teloair double stranto keep siste

ged DNA or leharbors a bindwith telomererovide insight infunction. Therere maintenan

tion in humanumorigenesis ahymal traits, a pinary, unpublisant for tumor pnt efficacy and

egree in Biologym Ministerio de ut de Biologia Mith particular emJCB, 1999), Espintegrity and mNew York as a esulted in 3 firstDev, 2011) and 2 in foreigners iostdoctoral studted to receive tM (Barcelona, Sp

Y CAJAL A 2013

sentials for gebunit complex (

g acts as a mos by expressingisease Dyskeramutated in ind

mutations resultomeres and thanded DNA brear chromatids cengthening teloding site for he length maintento the severe eby, my futurece in genomic

ns. Lethality isand is normalprocess known shed results shoprogression. Unshould prove u

y from the depEducación cultMolecular de Bmphasis on thepinas et al. (EMmaintenace led Postdoctoral Ret author publica1 second authinstitutions). 7 dies I obtained he Helen L. andpain).

SDD

SDE

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enome integritTRF1, TRF2, TIN

olecular clock g Telomerase, atosis congenitdividuals with Dt in very short tat this cohesionks and were alsclose enough fomeres via theeterochromatinenance by telomtelomere dysfue research aim integrity in tum

mostly associly associated tas epithelial‐meowed that durinderstanding Snuseful for the u

partment of Bioura y Deportesarcelona (IBMBe GAGA proteinBO Rep.,2000),me join to Susesearch Fellow ations: Canudashor, Benjamin Rcomunicationsfundings from d Martin S. Kim





ty and mainteN2, TPP1, POT1

leading to sena reverse tranta (DC) is causDC. The lack of telomeres is unn is essential foso prone to comfor them to une replication pn 1 (HP1γmerase. My daunction typical is to elucidate morigenesis an

iated to the pto the previouesenchymal trang EMT Snail1 nail1 mechanisnderstanding o

ochemistry ands, I conducted mB‐CSIC). My PhDn using Drosoph, Canudas et alsan Smith laborw in 2004. I was s et al. (EMBO JR. Houghtaling,s to internationHRSB Breast ca

mmel Stem Cell


ENERAL CNOLOGÍA

NERAL IÓN

ÉCNICA


nance. Mamm1, Rap1). Due to

nescence/apoptnscriptase that ed by mutatioTIN2 function cnknown. My stor telomere stampletely losing ndergo homolopathway called ;). Mutations inta suggest a unof TIN2 DC patthe mechanismd stem cell bio

presence of dius loss of epithansition (EMT). transcription fsm in stem cellsof particular can

d molecular Biomy graduate stD work was fochila melanogast. (NAR, 2005), Cratory at the Skspecially intereJ. 2007), Canud,Silvia Canudas nal meetings ( 3ancer research,Fellow award.

malian o the

tosis. adds ns in cause udies ability their

ogous ALT.

n this nique tients ms of ology,

stant helial Snail factor s and ncers

ology, udies cused ter as Costa kirball ested das et (Cell

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sumen de lahe candidate in003) and Biocupervision of Doctorate coursee was awarded niversity of Granta de Andaluc

uring his PhD hcanning Calorimroteins with incnd by using genesign of new caeer‐reviewed jo

he candidate obmolecular des

MBO Long Term

he candidate organization ande last round (soo‐translocationaagan Bayley is ocomplished his orresponding au

nally, I have heudents in the laequently prese

sumen del Che candidate hand correspondinas second autroperties [Rodr010], their actioat. Nanotech, 2014], aswell theom collaboratioxford Nanopor1/896,933 and Biophysical Sociniversity.

MINISTERIO


RODRIGRYC‐2013

a: Biomedicnico: davi

cs

a Memoria: itiated his resehemistry (2004r. Valery Shnyres on the Molea fellowship franada to carry cia (competitive

he has been inmetry (DSC), Isocreased stabilitynetic algorithmatalytic activitieournals (out of a

btained his PhDsign". After thism fellowship.

obtained the Ed is considered ource EMBO). Tal unfolding. Thone of the worproposal, resuuthor). Further,

eld collaboratioab and have gant my research

Currículum Vas 19 publicationg author), 1 Nthor and 1 as criguez‐Larrea Don mechanism 2013] and the deir study by moon with leadingre Technologie UK patent 1iety, Protein So

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arch career in t4). He conductrov and Professecular Mechanisrom Junta de Con his PhD une).

volved in the sothermal Titratiy and catalysis s for charge dies and in Molea total of 19), 4

D with "suma cus he obtained

EMBO Long Teone of the moThe candidate he candidate dld leaders in thulting in publica, he has patent

ns with industrave lectures in th at both nation

Vitae: ons in well recat. Nanotech, 1corresponding D et al, JMB 20[Ousden N. et

development ofolecular dynamg companies ins [Rosen* CB, 316849.7). Theociety,..), and h

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A, DAVID

‐larrea@che

the Departmented research osor Enrique Villsms of Biologicastilla y Leon (cnder supervisio

study of the bioon Calorimetryusing evolutionstribution optiecular Dynamic4 of them as firs

um laude" in 20a post‐doctora

erm fellowshipost prestigious fproposed a prodeveloped his pe use of single‐ations in Natured a methodolo

rial companies the University onal and internat

ognized intern1 Nat. Struct. Mauthor. These06], their desig al, Science, 20f biotechnologicics and designinn the biotechnoRodriguez‐Larre candidate phas been invite

S RAMÓN YOCATORIA

em.ox.ac.uk

nt of Biochemiston the study oar, obtaining tcal Processes oncompetitive feln of Professor

ophysical propy, Circular Dichrnary informatiomization. Furthcs simulations. st author and 5

008, with the thal contract in o

p in 2010. Thifellowships in toject for the usproposal in Pro‐molecule apprre Nanotechnology for the sing

such as Novozyof Granada. I ational meetings

ational peer‐reMol. Biol, 1 JACSe publications cgn for improve013], their studcal applicationsng new catalytiological sector rea*# D and Bpresents frequeed for talks at S

Y CAJAL A 2013

try, University oof erythrocite mhe Tesina (equn the same Unillowship) he moJose Manuel S

erties of proteroism, Fluorescon obtained wither, he has alsoFrom this peri as second auth

hesis "Energeticorder to finish

is fellowship ithe world. It is e of single‐molofessor Hagan roaches using nlogy (first authgle‐molecule de

ymes and Oxfoam member of s.

eviewed journaS, 3 JMB, 3 JBC,cover most of ed catalysis anddy at the singles [Rosen* CB, Ric activities by csuch as NovozBayley# H, Natently his workSEBBM, Jacobs

SDD

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of Salamanca amembrane proivalent to Mastversity (equivaoved to the DeSanchez‐Ruiz (2

ins using severence, Dynamicth bioinformatio been involvedod he publishehor

cs, kinetics and several researc

s granted by highly competecule approachBayley lab at Onanopores. Remor), Science anetection of post

rd Nanopore Tseveral scientif

ls, including 1 2 Biophys. J,...the fields in pd stability [Rode molecule leveodriguez‐Larreacomputational zymes [Rodrigut. Biotech, 201k at both inteUniversity, Oxf





after cursing theoteins by microters degree). Falent to Masterepartment of Ph2005‐2009) wit

ral techniques c Light Scatterinic analysis of sed in computatied several artic

evolution of prch projects wh

the European titive with a suches that allow tOxford Universmarkably, the cand Nature Biotet‐translational

Technologies. I fic societies, ac

Science, 1 Nat. Out of them, 6protein researcdriguez‐Larrea el [Rodriguez‐Laa*# D and Baylapproaches). S

uez‐Larrea D et14] (which has ernational and xford University


ENERAL CNOLOGÍA

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e degrees of Bioo‐calorimetry uFurther, coursedrs degree). Althhysical‐Chemisth a fellowship

such as Differeng and the desiequence alignmonal studies focles in internat

roteins: implicahile applying fo

Molecular Bioccess rate of 13the study of prity (U.K.). Profeandidate succesechnology (firstmodifications.

have been direted as referee

. Biotech (both6 are as first auh (their biophyD et al, Biochearrea D & Bayley# H, Nat. BioSome of them ral, JMB, 2006]lead to US panational mee

y, EMBL and Aa

ology under d the ough try at from

ential gn of ments or the tional

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h first uthor, ysical em. J, ey H, otech, result ] and atent etings arhus

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nd Sussane Dam

he candidate isatent US 61/89009] and [Rodras been grantedith 3 works in hB, Rodriguez‐Laniversity (Norw

MINISTERIO


as been awardehighly competite candidate has

didate took partia (entry "protees at the Univery (Toby Guram,mmers, undergr

s corresponding96,933. Has heliguez‐Almazan d with several chigh impact jouarrea*# D andway) and Cape T

A VIDAD

ed with nationative European s been involved

t in courses froeina", methodsrsity of Granada master studenraduate studen

g author on Rod collaborationC, JBC, 2008]. competitive felurnals: [Rodrigud Bayley# H, NTown University

AYUDASCONVO

al fellowships JuMolecular Biolo as researcher

m the Universit for denaturinga, both for firstnt at Oxford Unts at Munchste

osen* CB, Rodrns with several Has been invitlowships (EMBuez‐Larrea D & Nat. Biotech, 2y (South Africa)

S RAMÓN YOCATORIA

unta de Castillaogy Organizatioin grants from

ty of Zaragoza g proteins) andt year students niversity, Christer University).

riguez‐Larrea*# groups, leadinted to give talkBO Long Term bBayley H, Nat. 2014]. Further,).

Y CAJAL A 2013

a‐Leon (rejectedon (EMBO) Lonthe US governm

and the Spanis is member of and master stuian B. Rosen, P

# D and Bayleyng to two supeks at Oxford Unbetween othersNanotech, 201 broadened h

SDD

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d) and Junta deg Term fellowsment (NHGRI) a

h Chemical Socscientific societudents. The canhD student at A

y# H, Nat. Biotrvisor‐independniversity, Aarhu). Has been at 13], [Ousden N.is experience





e Andalucia (forship for his posand in an Advan

ciety, collaboraties SEBBM anndidate frequenAarhus Univers

tech, 2014 anddent publicatious University, EOxford Univers. et al, Science,with research


ENERAL CNOLOGÍA

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ÉCNICA


r his PhD). Has t‐doctoral resenced Grant from

tes in open prod SCUK. In addntly directs studsity, Sussane Bo

shares 33% oons [Halskau O,MBL, SEBBM,..sity since May 2, 2013] and [Roperiods at Be

been earch. m the

ojects ition, dents omke

of the , JBC, . and 2010, osen* ergen

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tulo: enetic and epig

sumen de lay line of reseaarticular througnd bioinformati

centered my effenome‐wide epxpression mapsWide Associationet cis‐regulator

verall the outcon the moleculaanscriptional pr

y current aim ipecific researchew insights intoubprogram to tr

sumen del Ctrained as a mndocrinology anorked in strict c

built up my moe Rangos Reseroject leading co several first au

ack at the Gasnowledge to stu

hroughout thes

2009 I moved nd training in ce epigenetic landerstand the ghis effort led tonder review. I ditorials as well

hroughout my cPIMETAB) and N

y current aim i

MINISTERIO


PASQUARYC‐2013

a: Biomedicnico: pasq

enetic suscepti

a Memoria: arch and my sghout my scientics fields with th

fforts in exploripigenetic marks in human pann Studies (GWAry networks to

ome of this linear mechanismsrogram of panc

s to combine m interest is in uo the molecularansition to an

Currículum Vmedical doctor nd dedicated acontact with th

olecular biologyearch Center focapacities. Duriuthorship publi

slini Institute inudy the human

e experiences I

to Prof. J. Ferromputational randscape of thgenomic regulao two first authad an unques as press releas

career I playedNIH (LINKBETA)

s to combine m

A VIDAD

ALI , LORENZ3‐12864 cina quali@clinic.

ibility to the de

scientific interetific career I couhe goal of unde

ng the epigeneks, including hncreatic islets tAS) uncovered athe mechanism

e of research os that underlacreatic beta‐cel

my clinical, humunderstanding gar defects thatindependent in

Vitae: and specialize large part of me molecular bio

y research skillsor Diabetes witng this experiecations in high

n Italy, I obtaimolecular gen

I published 11 b

rer�s lab at IDregulatory genohe insulin prodation of the islehorships in Nastionable leadinses.

d an active role consortia. I wa

my clinical, hum

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ested is centeruld mature anderstanding the g

etic landscape oistone modifico build a pancan enrichment oms underlying T

pened the pathay T2D and prls

man genetics angenomic regulat cause differenvestigator care

ed in pediatricsmy clinical residology lab conne

s at the Universth Prof. M. Trunce my focus oimpact factor j

ned my PhD ietics of monog

between paper

IBAPS, my curromics. I soon cucing pancreatts of Langerhanture Genetics, ng role in both

as investigatoas also awarded

man genetics an

S RAMÓN YOCATORIA

diabetes.

red on understd combine diffegenetic and ep

of the insulin pcations and opcreatic islet‐cellof Type 2 DiabeT2D.

h to understanrovided a refe

d bioinformatication of the pannt forms of dieer in this field.

s at the Gaslindency at the Rected to this ce

sity of Pittsburucco, acquiringon the susceptijournals.

n human geneenic diabetes.

rs and reviews,

rent institute, acould integratetic islet cells. Tns and shed ligone coauthors

h of my first‐au

r in several intd a fellowship f

nd bioinformatic

Y CAJAL A 2013

tanding the moerent expertise igenetic suscep

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VALIENTRYC‐2013

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a Memoria: widely acceptedmetastasis. Thio metastasis. Ancidence, extre

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nage cancer isncer is still assomonly affectedderstudied biourological compatients only in t, yet lethal when is associated ells, and what

steps of metarget the diseasmicroenvironmecolonization (Vf metastatic cen the brain. A veanalyzed we dtivity. The apprtion. In a broadnated disease inteps of brain me

y of Zaragoza of Pilar Zaragod to take part his disease. Unsues, sensoryjoin the laborarealized the laue the scientificAmong differenooking for. As cortex as the mel Valdeolmilloas a critical regallel I studied tdissected the ro with connexinte et al., 2010, e months at therector of the Fcation of threeNature; Martinf my research, the phenomenvailable at the

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the ability of ociated with ded during cancerlogy. Up to datplication of canthe U.S. Metasten developed. with the last sare the mecha

stasis will allowse more efficienent I have idenValiente et al., ells. Astrocytes ery limited numdiscovered thatoach followed der view the imn the brain. Myetastasis colon

(1998‐2003). Doza I developedin an ongoingder the supervy‐motor behaatory and starteboratory had vc career. I finalnt interviews I dI joined the lamain aim of myos, we charactegulator for thethe intracellulaole of Focal Adhn26 (Cx26). ThisJournal of Neue Sandford‐BurFunctional Gene reviews at then‐Ibanez et al., and even the sna of cancer cee laboratory of

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ghout the bodysociated deathoutstanding intates that by nummon that all ess given its muving from a prization of secona metastatic le

� heel� of cantal models of ich brain metasas identified nawhen sensing caver will succeedof this proteasminants requirvations of this a research proular regulation.

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GARCIA RYC‐2013

a: Biomedicnico: fgar

anisms of Prima

a Memoria: rked in the fieldd in which I plf the mechanis

microtubule‐br us to sense homeostasis, inalso known as cert syndrome (JS

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moved to the tute for Biologi

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e trafficking (19the future. Thuprimary cilia fu

ne protrusions oent (we see, sand limb patterhich include poers.

08‐2014) I havee genes for MKSy interact with cilia, in a regioowed that comal loss of compevels: the com

ave focused on plex that I charrane compositihe role specific

e laboratory of erested in obta teaching of fut

d not feel prepferent countrie

honors in 1998completed my P004 & 2005). Aet al. 2006, Hadat the School o

United States cal Studies (20

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999‐2006) and sus, the main gnction.

of the cell surfsmell and hearrning or feedinolycystic kidney

e made major aS and JS had b each other anon known as thmplete loss of fuplex function leamplex plays a su

the question oracterized and aon. This studyc lipids (such a

Dr. Jeremy Reiaining a Ramoture generation

pared for it. Myes, and in mult

8, I performed PhD in 2005 aftAfter 2005, somdjebi et al. 2008of Medicine and

of America. I f006‐2008), in w

Y CAJAL A 2013

stem cell biologoal of my curr

ace that functir through ciliag behavior. Fai disease (PKD),

advances in oueen identified, d are part of a he transition zounction of this ads to a mouseupportive role in

of how ciliary coanother ciliopaty will be submas phosphoinos

iter at the Univon y Cajal fellons of scientists.

y preparedness iple areas of b

my PhD at the ter publishing mme of my PhD 8) and one pated Dentistry of th

first spent threwhich I publishe

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derives from fiiomedicine, inc

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, I have becomee research is t

antennae. In huo regulate crity cilia to functiosyndrome (BBS

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regulated. This he nephronophlication in the the control o

rnia, San Francs would allow

ifteen years of cluding bioche

Barcelona, inclu lead author in blished in threeadellas et al. 20f Barcelona.

University of Che role of lipid


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e an expert in co achieve a de

umans, primarytical aspects ofon properly lea), Meckel synd

pathies, MKS anknown. I establermore, I foundzed mouse muouse phenotypedefined the fun its main funct

has led me to sthisis or NPHP next few moof ciliary memb

isco (UCSF), whme to becom

experience womistry, cell bio

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California San Ds in keeping hu

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Diego uman

emMapbais cil(Gro Th Sin Fr

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mbryonic stem ouse course atpplied this knowackground all caa great exampliopathy work aGarcia‐Gonzalo otations in our l

hank you very m

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rancesc R. Garci

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cell pluripotent Cold Spring Hwledge when I ame together tple of this seamas a coauthor in& Reiter 2012ab, two of who

much for your c

ia‐Gonzalo

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ncy (Garcia‐GonHarbor Lab, Newjoined my curto study primarmless integration a Cell paper (2). Besides my om decided to j

consideration.

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a‐Belmonte 200I became famSF, where my bciliopathies cas (Garcia‐Gonza11). More recenave also mentoerwards.

Y CAJAL A 2013

08). In 2007, I iliar with mousbiochemical, ceused by their malo et al. 2011)ntly, I have revored three gra

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ENERAL CNOLOGÍA

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r Embryology ond disease modand mouse gene in Nature Genblished some ournal of Cell Bioring their trime

of the dels. I netics netics of my ology estral

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was awarded w

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ROJAS GRYC‐2013

a: Biomedicnico: ana

Liver and Pancre

a Memoria: predoctoral trao in 2001. Durins, and gained a

toral stay at theDr. Brian Blackegulation of carrole and regulatin developmeexpertise in gen

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vet� program lop news reseac and liver emional factors arention to GATA ular and cellularasis for hepatic

these research nning.

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Plant MolecularI acquired expepmental gene r

stitute at the Us. The project d more iption factor Gammalian gene nd conditional k

ecular y Medic

2014. In CABIMh lines focus omphasis on trant of diseases as of research amation and in bession

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Biology at the s during embryeto‐Dapena et aal., Plant Physiooral training in years. During postdoctoral fecan Heart Asso as first author

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tarted to form

t lab we have dd liver developmdiabetes and hSubprograma nal Governmenhire personnelhas resulted so

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r Biology of IRNertise in molecuegulation in pla

niversity of CalI developed i

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ina Regenerativ

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my own grou

developed innoment and how hepatic fibrosisde Proyectos dnt, 2009). This . Our lab is curo far in the pu

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evilla (2001). Mlants. My worcular Biology, 1Almoguera et aof Dr. Brian Blaesearch focusedMinistry of EdWestern AffiliaDevelopment, 2as a second (Hhor of a reviewvances in Deve

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r the supervisiouiding generatio

rnia, USA, unden the study of

. During this penimal model. I

ave a contract

dent research gprocesses that oto understandand hepatic fib

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arch was focusePhD resulted inet al., DevelopmBiological Chemiovascular Resecriptional regulcience from 2005 to 2007. My t al., Moleculaolecular and Ceapter about caogy, 2007). In 2

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Biology, 2010; of which I am t2 book chapters

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ion, 2012, and ave also estabin my lab have

Y CAJAL A 2013

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sumen del Ccandidato está

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CAMPOSRYC‐2013

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a Memoria: en la trayector

do pre‐doctoraa estructura a bos experimentaaturalizado. Mcofactor FMN dirigida de apoe la proteína, sndiendo de la ponión entre apofe al estado natiemento de eneslado cuidadosaan el puente esrmedio en equel interior del e

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e hidrógeno. Merva que no con energéticameclusiones de est

Victor Muñoz,

abajar con técnorma, se obtien

os de moléculaho análisis confde molécula úompactación desnaturalizante

rficie para obtbtener los conodownhill" mediaambio estructu

ional de Bioteclacionados con

ersidad de Zaraho, con una begoza defendiendoxina de Anacos que generaand, EEUU.

Y CAJAL A 2013

cas espectroscó

o de técnicas b

, se desarrollarrio de apoflavoefecto de las me obtuvo una e

zantes localizado seleccionar

o de plegamient

Mediante un anontribuye a la ente favorable.te estudio perm

se han desarro

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a única FRET ofirma el compoúnica FRET con del estado desn, indicando un

tener trayectorocimientos neceante mutacioneural.

nología en Mael plegamiento

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ópicas y de mol

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neas de investig

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ula única de marrollo. as. Trabajo en

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era incluido, y dmico. Bajo su ts energético yo una calificacióimer autor, y r


ENERAL CNOLOGÍA

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ÉCNICA


amiento y unió

vestigación: on 25 mutantesnativo‐intermediario presenta

ón de la supente" o estabiliza

ó que el FMN se

utante de un puque sólo cuand

o de funcionam

gación, en este

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desarrollo dond

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decidió comenztutela, completestructural deón de sobresalrealizó en 2001

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nalmente, en erupo de investigarie Curie. Posste idioma durademás, está col

MINISTERIO


de la tesis, deMaryland (EEUUas, entre las qsladó al Centro 08‐2011), dondelaboración con

grupo al compambos cambiosde material y plaboratorio de

ee en su currícautor, incluyens, ha presentadCon respecto a

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A VIDAD

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leto se ha tras de localizaciópersonal en la l Dr. Victor Muñ

culum 22 publicndo un Nature Mdo su trabajo e la docencia, ha

se incluyen varla carrera, una

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una estancia poen parte por unn medidas cinéones Biológicasboratorio de téuñoz ha publica

sladado el añon del grupo denueva ubicacióñoz.

caciones, entre Methods y varien numerosos a colaborado en

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S RAMÓN YOCATORIA

ostdoctoral de na beca postdoéticas y técnicas en Madrid junécnicas de moléado 6 artículos,

o pasado al Cee trabajo, incluyón. Además, es

las que se inclios PNAS) y un congresos cienn dos cursos of

as que el candtoral FPU, una brimero por la ebajo de carácternos, incluyend

Y CAJAL A 2013

3 años (2004‐octoral del gobias de moléculanto con el restoécula única para, 4 como prime

entro Nacionalyendo el trasladstá a cargo de

uyen 20 artícucapítulo del libntíficos, incluyeficiales de la Un

idato ha disfrubeca postdoctoestancia de 3 añr netamente ino alguno extran

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‐2008) con el gerno español, d única. Tras esdel grupo, disfa continuar conr autor.

l de Biotecnolodo de instrumela gestión de l

los publicados bro "Estructuraendo varias preniversidad de Za

tado, incluyenoral del gobiernños en EEUU y nternacional, donjero.





grupo del Dr. Vdonde completstos años residfrutando de unn su trabajo. D

ogía. El candidental y la organla unidad de té

en revistas de a de proteínas" esentaciones oaragoza durant

do una beca dno español y undespués por eonde el inglés e


ENERAL CNOLOGÍA

NERAL IÓN

ÉCNICA


Victor Muñoz, tó el aprendizadiendo en EEUa beca postdocurante este pe

dato ha colabonización y puesécnicas de molé

medio‐alto impde la editorial

orales en conge 2 años.

de colaboracióna beca postdocl continuado uses utilizado siem

en la je de U, el ctoral riodo

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sumen de lahe main challenformation of reancer patients brofile.) The firsthis database wi

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he main goal ofrugs, based on ontribute to maroject will be br

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) A system to auhe fourth and frugs on new tumourse of over twensitivity and re

sumen del Cfter obtaining mocused on the tctors binding spplying these mata to produce

then moved to orking in the eveloped in conalyze the func

MINISTERIO


GONZALRYC‐2013

a: Biomedicnico: abe

s

a Memoria: nge I would likesponse to drugbased on their t step would beill also collect a

ell lines and xeost similar primwill take into acroximal' tumorsrmine which dru

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methods to 30 bsound hypothe

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LEZ PEREZ, A3‐14554 cina ldavidgp@gm

e to address isgs from cell linemolecular profe to develop a kall information

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would like to pnomic, transcriredictions of tho four major pa

se of tumors tort of the projecon on the patte

ance and sensitd part of the pral targeted dru

w tumors of the project nd their respons

redict the effecte project will coOne first key pahigh‐throughpgeted drugs co

Vitae: Biochemistry, I regulatory netwgenomes of th

bacteria to makeses on the evo

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ABEL

mail.com

s the integratioes, xenografts afiles, whereas tknowledgebaseavailable on th

n, I plan to dell lines or xenognal architecturelow to make prtion of drugs wo

pursue consistsptomic and ephe putative resarts:

o targeted drugsct will be a knowern of response

tivity to targeteproject will be ugs. They will b

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t of targeted caonsist in develoart of this systeut biology. It wnstructed in the

did my PhD inwork of gammahese organismske them easily alution and dyna

s at the Biomedted platform foenomics mediceotide variants

S RAMÓN YOCATORIA

on of data on dand clinical triahe latter will hee of genomic anhe pattern of re

evelop metrics grafts to a patie of the tumorredictions on thould better targ

s in identifying pigenomic altersponse of patie

s wledgebase of to drugs by pr

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be accompanied

of metrics, ruledrugs.

ancer drugs oping a bioinfom will be the inwill also build ue second part o

Bioinformaticsa‐proteobacteri. Then, I designaccessible to thamics of the ga

dical Genomicsor the analysiscine company. s and small in

Y CAJAL A 2013

driver and actiols. (The formerelp us determinnd epigenomic esponse to dru

�using machient's tumor, gir under analysishe clinical evoluget its specific p

biomarkers ofrations observeents' tumors to

genomic and eimary or secon

ations (biomarkd by mechanisti

es and/or meth

ormatics systemnformation on upon the set ofof the project.

s at the Nationia. I developed ned and implemhe microbiologicmma‐proteoba

s Group of the s of next geneI specifically pdels. I then de

SDD

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onable alteratior should allow une the treatmealterations detegs by primary o

ine learning apven its genetic s.) Retrieving aution of the patprofile of molec

resistance anded in the tumoo targeted drug

pigenomic altedary tumors (fr

kers) that predic hypotheses.

hods to retrieve

ms to automaticfunctional intemechanistic hy

nal Bioinformatcomputational

mented a web‐bcal research coacteria transcrip

University Pomeration sequenparticipated in eveloped two m





ons from primaus to stratify, oents that are beected across thor secondary tu

pproaches� toand epigenetic

all available clintient's tumor. Scular alteration

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tics Center, in Cl methods to idbased databasemmunity. Furthptional regulato

mpeu Fabra in ncing data fromthe developmmethods aime


ENERAL CNOLOGÍA

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ÉCNICA


ary tumors withr even individuetter suited for housands of tumumors (from cl

o retrieve fromc alterations prnical informatioimilarly, it wouns.

tumors to targt ultimately aimr cancer types.

ed across thousals), cancer cell

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possess both a nswers throughnalyze large caenerated by them.

n the informatind I have expeatabases, mostave some knowwelve years of bripting, most co

MINISTERIO


his functional immethods to idenucleotide variane to cancer gening in them. Walysis we finallyets.

broad biologicah the analysis oncer genomics e most commo

ics side, I am flerience using Hly in MySQL, awledge of softwbioinformatics ommonly to co

A VIDAD

mpact both forntify genes respnts and copy nunomics researchWe also used thy set up a web‐

al knowledge aof big datasetsdatasets. I haon high‐throug

uent in the twHTML, CSS, andnd have workeware engineerifiddling, I haveonnect their inp

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r germline variponsible for theumber variantshers to analyzehis pipeline in‐h‐discovery tool

llowing me to a. In recent yeave a good grasghput cancer g

o programmingd PHP for web‐ed on most curng, mostly oriee come across sut and output t

S RAMÓN YOCATORIA

ants (Condel) ae initiation of tus. Eventually, the their own cohhouse to analy(IntOGen‐muta

ask meaningfulars, I have focusp of the biologenomics platfo

g languages tha‐oriented progrrently existing ented towardsseveral dozens together to for

Y CAJAL A 2013

and somatic mumorigenesis achese methods, worts of somaticze most publications) aimed a

l questions, andused mainly onogy of tumors aorms, and the

at are most comramming. I alsLinux distributdesign and imof programs, wm pipelines. Fin

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utations (Transcross cohorts owere assemblec mutations in cly available cot supporting re

d the statisticalthe developmand a solid combioinformatics

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sFIC). I then mof cancer patiened within a comcancer patientshorts of tumoresearchers in th

l and informatiment of bioinfomprehension otools and app

n bioinformaticxperience woruiring good adof workflows.

ested, on top ofperience using


ENERAL CNOLOGÍA

NERAL IÓN

ÉCNICA


oved on to devnts. I looked botmplex computats looking for spr samples. Withhe analysis of ca

cs skills to find rmatics methoof the types of proaches to an

cs, PERL and Pyking with relatministration skDuring my rouf which I have comp

velop th on tional ecific h the ancer

their ds to data alyze

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énetica Molecue characterizat

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ystem. Part of t

013 (Paris, Fran

supervising thee scientific PhD

r. Laura Senoviiminates cells tetween hyperpumber of chroembrane. Surfastablishes a lonress response worrelated local esponse with inc

sumen del CEDUCATION

1 UNIVERSITY DhD by the Univerector: Dr. C. VS, Biology (Mole

2. SPECIALIST, Opecial training i1/06/2012, 80 h

ternational Adv

oncepts�. Schleminar of compourse of moder6/10/2003, 30 h

RESEARCH EXP

MINISTERIO


SENOVILRYC‐2013

a: Biomedicnico: laur

nosurveillance

a Memoria: lla is a scientiser biology and er last year of u

ular (IBGM, Valltion of multifu

esis entitled �the PhD Prize fLaura Senovillalowship (2007‐

2 � present). Hond or last authMBO J. Her mai

this work has b

nce). At present

e work of Dr. JoD training of Mr

illa recently disthat bear moreloidy, stress of omosomes cauace exposed CRng term anti‐tuwere monitoreimmune respocreased nuclea

Currículum V

DEGREES AND Dersity of ValladILLALOBOS. Disecular Biology s

ONGOING, TECn animal experhours.

vanced ICAS/Ap

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PERIENCE

A VIDAD

LLA GONZA3‐14285 cina rasenovilla@

st with more thimmunology asuniversity (200

ladolid), to the nctional pituita

�Phenotypical afor the best thea is working in ‐2009, Marie C

Her scientific suhor) in peer ren scientific inte

been published

t, Dr. Laura Sen

osé Manuel Brars. Norma Bloy.

scovered a newe chromosomethe endoplasmses ER stress RT serves as a smoral immunited using tissue onses with redr size (in non‐re

Vitae:

DIPLOMAS olid. School of stinction Cum laspeciality). Univ

CHNICAL, PROFErimentation for

popTrain Traini

rg, Günzburg (Gd microscopy. Uapplied to biom

AYUDASCONVO

LEZ, LAURA

hotmail.com

han 12 years ofs well as broad 1/2002), as a c

four years as Pary cells under

and functional esis from the Mthe laboratoryCurie stipend; 2

uccess is reflectview journals, erest focused o

in Science in 2

ovilla is the he

vo � San Pedr.

w control mechs than usual (Smic reticulum (Ewhich subseqsignaling entityty. To investigabiopsies obtaiuced nuclear sesponders to ch

Medicine, Univaude. versity SEK of Se

ESSIONAL TRAINr senior biologis

ing Course on �Germany). Date University of Vamedicine. Natio

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A

m

f experience inexperience in acollaboration b

PhD Student (2r the supervisio

characterizatioMedical School oy of Prof. Guido2009‐2011, Fo

ted by her list oincluding Scienon the relation

2012 and has b

ad of the �Plo

ro, Dr. Fernando

hanism of tumScience, 2012). ER) and immunquently leads ty that stimulateate the translatined from 60 wsize (in responhemotherapy).

versity of Vallad

egovia (Spain)

NING sts, Level I. Min

�Advances in

of end of trainlencia (Spain). onal Center for

Y CAJAL A 2013

research. She animal models. etween SEK Un

002 � 2006, Fon of Prof. Jav

on of multifuncof the Universito Kroemer at tndation pour l

of publications nce, Aging, Trennship between

been honored

oidy and Immun

o Aranda and D

or proliferationThis work highosurveillance. to the transloces an immune rtional relevancewomen affectednders to chemo

dolid (Spain) 04

22/02/2002.

nistère de l'alim

cell death rese

ing: 20/07/200Date of end of r Biotechnology

SDD

SDE

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has a multidis niversity (Segov

PI fellowship, IBier García‐Sanc

tional pituitaryy of Valladolid.he Insitut Gusta Recherche M

which covers mnds Immunologcancer cell plo

by the Institut

nity� team in G

Dr. Michaela Se

n by the immuhlighted for theDr. Laura Senovcation of calreresponse whiche of these findd by locally advotherapy) and

4/07/2006 Dire

mentation, Paris

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sciplinary backg

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BGM, Valladolicho and Dr. Ca

y cells� in July. tave Roussy (VMédical fellow)

more than 50 pgy, Nature Revioidy and its eff

Necker � Fon

Guido Kroemer

emeraro. She is

une system, whe first time thevilla found thateticulin (CRT) h in turn elimindings, the ploidvanced breast the absence o

ector: Prof. J. GA

s (France). Date

basic principles

7/2004, 50 hourd (Spain). Date


ENERAL CNOLOGÍA

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ÉCNICA


ground in endo

situto de Biolo

d) she was studarlos Villalobos

y 2006 (summa

illejuif, France)) and as assoc

papers (more thiew Drug Discofect on the imm

ndation Tourre

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also responsib

hich recognizese existence of at the increase ito the cytoplaates these cellsy status and thcancer. The reof such an imm

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TEACHING EXPresent: Supervisichaela SEMERourse 2012/201nit of Pr. KROEMourse 2009/201SCIENTIFIC PRI

013 Prix Ins007 Extraoralladolid, Spain

MINISTERIO


OSITION

resent: As

ejuif (France)

of their regulatrst and co‐auth

others (please rABORATORIES

31/12/2012: Poance)) under su

31/01/2007: Ph

y of Valladolid

cterization of msome of the mb.

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NSERM Unit U8

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Trends Immun

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Calcium and ce

Pr. J. GARCIA‐S

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tholic Universit

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ENERAL CNOLOGÍA

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ave Roussy Cam

tetraploid cells

Oncogene, EM

itut Gustave Ro

Molecular Gen

ct �Phenotypic

first‐authored

Pr. C. DENEF.

under supervisio

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sumen del CDUCATION

ecember 2008

eptember 2003

CIENTIFIC EXPER

ay 2009‐Date

ept 2003‐May 2

ne‐Sept 2002

UBLICATIONS

MINISTERIO


ABAD MRYC‐2013

a: Biomedicnico: mab

escence to cell

a Memoria: ological Science

berto Sols� (Msenescence; mritical regulatorls (two of which

to the Tumou

stem cells anddemonstrate fossues can be ctriggers the acqogrammed in viresults bear vework was namseveral scientifirojects developEpub ahead oferation.

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Ph Un

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h.D. in Biochemniversidad Autó

achelor Degree Autónoma de

ostdoctoral Felloional Cancer ReManuel Serran

h.D. student

InvestigacionesIgnacio Palmer

ndergraduate stf Cambridge, DAlfonso Martin

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ow esearch Centre o, PhD.

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tudent epartment of Gez Arias

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m

nisms.

a de Madrid in

n of Dr. Ignaciothis period wasesponse. My doview article.

y Dr. Manuel Se

enesis. I have pular reprogrampotent stem ceures; the in vivowork as a full rregenerative mf 2013" by Naty media coverastem cells andtions focus in e

r Biology and Brid, Spain.

iology and Bioc

(CNIO), Madrid

Alberto Sols�,

Genetics, UK.

Y CAJAL A 2013

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M, Mosteiro L, o M. in vivo producet 17;502(7471)

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a: Biomedicnico: scas

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a Memoria: stdoctoral resePérez‐Martín ath, UK), both necllows polarizednly in physiologe disseminationn) allowed me

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worked on hogenetic programn cells requiredsecond‐author

ed to direct my

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d to continue wying to understd me to publis

Vitae:

Post‐dostituto de Biolo

Post‐doterson Instituteanchester (UK) ost‐doctoral Scieentro Nacional dadrid (Spain)

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Babak Razagh

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usal.es

as allowed meand cell migratses for the epipithelial cells tof cells, but alsnoma cells fromimplication of E

w developmenms. Furthermor for cell migratpapers.

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group at the Psion. This workd invasion. This

working in the mtand the implicsh this year a

octoral Scientistogía Molecular yoctoral Scientiste for Cancer Re

entist de Biotecnologí

. CSIC Individual Fellowship Ministernoma de Madr

i; Lindsay McD

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e to analyze thtion (postdoctothelial‐mesencto convert to so in the pathom primary epitEMT in metasta

ntal decisions lere, I analyzed tion and invasio

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Paterson Instituk has made an iwork allowed m

migration‐invascation of cancefirst author pa

t y Celular del Cát esearch (PICR)

ía (CNB)

owship rio de Ciencia y rid

Donald; Ameer

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he responsible oral position wchymal transitiomotile mesencogenic programhelial tumors. Masis using mous

eading to differthe polarity groon. This work al

rch focusing my

ute for Cancer Rmportant contme to publish, f

sion processes,er disseminatioaper (manuscr

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but from a moon and prognosipt in preparat

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n require resettduring the patublish seven pa

studying the rol

I focused my reunderstanding

wo of them as fi

ore clinical prossis using moustion) and a se

Sala

onia Castillo‐Llu


ENERAL CNOLOGÍA

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(PhD student aterson Instituty conserved cet process has n and metastastion (Dr Jesús P

ting of the cell hogenic prograapers, three of t

e of Rho GTPas

esearch on studg of how the GTrst‐author.

spective. I joinese models of becond author p

amanca (Spain)

uva; et al.,; P.

with te for ellular been sis by Pérez‐

cycle am, a them

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onia Castillo‐Lluf the GTPase Ra

nacio Flor‐Parrepends on a vir

onia Castillo‐LluhytopathogenicCIENCE.120 ‐ 9,

Castillo‐Lluva; JLANT CELL.17 ‐

Garrido; U Vosngus Ustilago m

Castillo‐Lluva; T different stage

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1 controls ROS g

uva; Chong Tan;ration by regula

uva; Michael H.ac1 is required f

ra; Sonia Castilulence‐specific

uva; Isabel Alvac fungus Ustilagpp.1584 ‐ 1595

J Perez‐Martin 12,pp. 3544 ‐ 3

ss; P Muller; S Cmaydis depend

T Garcia‐Muse;es of plant infec

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; M Daugaard; ating Rac1 degr

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lo‐Lluva; Jose Pc cyclin. PLANT C

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Poul Sorensen;radation.migrat

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1‐dependent NA

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lis G. Jaffray; RTURE CELL BIO

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Perez‐Martin .Tein. GENES & D

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ri; Ronald T. HaN.32 ‐13,pp. 173

icky D. EdmondLOGY.12 ‐ 11,p

n the infectious0/2007

g; Jose Perez‐Mpendent kinase

he phytopathog

The induction oDEVELOPMENT.

ed family of APSCIENCE.117 ‐ 1

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regulated by cA156.08/2004


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NICATION. 4 ‐ 2

r suppressor H

Malliri.SUMOyl

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and virulence iy. JOURNAL OF

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sumen del Ccademic Backgr007‐present: Po003‐2006: PhD 002‐2003: Mast

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n Eduard Batlleribing the TGF‐hologist that pesearch on cang as correspont, I studied the erential activitimachinery and trise to six publi

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my project, Sergnally, we very on et al., 2013)he transcriptionnd CDX2 protethe TGF‐beta pr‐reviewed jour

Health and medular and Cellula

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m

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duard Batlle, atment upon TGF‐

e of the TGF‐beof patients likee technology ane origin of high

pervise one PhDociated Fibroblagio Palomo andrecently publis). n factors CDX1 eins during intepathway. My wrnals, three of t

dical Research)ar Biology

hip.

C

sociated fibrob

T AL. in Revision

aberrant activa

Y CAJAL A 2013

t the IRB Barcel‐beta stimulatio

ta response sigely to benefit fnd develop a dia TGF‐beta in CR

D student, Elisaasts mediating d Mar Iglesias shed a review o

and CDX2 in thestinal homeoswork was grantehem as a first a

blasts and their

n, Molecular On

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a Espinet, with colon cancer pare now both on CAF‐suppor

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gnosis and progs based on TGFr the clinical setnection with tu

whom I am curogression. Thepreparing withrted tumor gro

f Jean‐Noël Freused on their Madeleine Sch

al colonic fibro

hway.


ENERAL CNOLOGÍA

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metastasis deptly published in

gnosis of CRC asF‐beta inhibitotting. umor hypoxia (C

urrently prepare lab technicianh my help theirwth and metas

eund in Strasboinvolvement inaeverbeke rese

oblasts in color

pends n the

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W OrCA TGCA TG*CCA DeCA Cd*CBO InGR DiCA FuCA MCH DiGA InStA DeCDCDDi

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rigin of TGF‐betALON A; LONAR

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GF‐beta in CAF‐Corresponding aALON A.*, TAUR

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testine‐specificROSS I., DULUC

fferent effects ALON A., GROSS

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fferential regulAUTIER A., DOM

ternational Meromal TGF‐b SigStromal TGF‐Beependency of CDX2 in InflamedDX2 in a Murinefferential inter

MINISTERIO


NTAGNI E., CAL

ta in CRC and itRDO E.; TAURIE

ng in Cancer AsNET E.; TAURIEL

‐mediated tumoauthors RIELLO DT., BAT

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ble homeobox onhomme C. co, CALON A*., M

c homeobox geC I., BENAMEUR

of the Cdx1 anS I., LHERMITTE

action betweenS I., DAVIDSON

t X‐ray micro‐CLON A., BRETO

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d Cdx2 homeobE B., MARTIN E.

the homeopro I., KEDINGER M

CT visualization N E., BECK F. et

ucose‐6‐phosphN A., FREUND JN

Cancer Metastagram promoteser on a TGF‐bete and Associateammatory Bowen CDX Homeot

AYUDASCONVO

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with tumor hypoMO PONCE S.ET

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metastasis.

ss, Sem Can Bio

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evelopment witally to this workNE S ET AL. Onc

ases mobility anET AL. Oncogen

box genes in a m. et al. GUT 200

otein CDX1 and M. ET AL. Nucle

of colon malfot al. C R biol. 20

hatase TATA boN. ET AL. Nuclei

asis 2013 speaks Metastasis Initta‐driven progred Colorectal Cawel Disease and tic proteins and

S RAMÓN YOCATORIA

A X.ET AL. in Re

oxia. T AL. in Prepara

s colon cancer pAL. in Preparat

ol., 2013.

ram in Stromal ET AL. Cancer C

th limited effeck cogene 2008

nd antagonizese 2008

murine model o07

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ox by intestine‐ic Acids Res. 20

ker tiation in Colorram in stromal ancer 2006 spein Associated Cd specific partn

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evision Nature C

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progression. tion 2014

Cells for MetasCell 2012

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of intestinal inf

onal machinery07

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specific homeo003

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2012 speaker

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g protein.

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ey transducer inf cell death (Fouman tumors p(IF1) of the H+reast epithelial e over‐express

etrograde ROS sence, IF1 emermor developmor this purpose rotein (Formento deepen into turpose we startxpressing IF1 inroviding knowle

sumen del Cersonal informaaura Formentin7/02/1980, Fireddress:c/ S.Nicoail:lformentini@

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FORMENRYC‐2013

a: Biomedicnico: lform

hase: a critical h

a Memoria: earch career in enze. Since themitochondria pare concerned ws the connectiofunctionally intg the mechanisyperactivated. gement and nec

to Spain wheren energy consermentini* et alproviding a sign‐ATP synthase cells but highlysion of IF1 in csignal to the nrges as a most ment. The study I have developtini et al., EMBOhe knowledge ted an internatn colon. This medge based on a

Currículum Vation: i enze,Italy olas 8,28013,[email protected]

oday:

post‐doc positieptember 2012

rva�post‐doc pember 2010: n in J.M.Cuezva

macology and T

laude� (Spani

A VIDAD

NTINI , LAUR3‐13693 cina mentini@cb

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2005 in Italy, ue beginning my play key roles nwith the identifon existing betwtegrated despitsms contributinIn particular,

crosis, highlight

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Vitae:

Madrid,Spain

on in J.M.Cuezv2:

position in J.M.

a group, CBMSO

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sh homologatio

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nder the superinvestigation wnot only in enefication of the sween oxidativee the many forg to NAD and mwe demonstrting the nucleu

aboratory of PrH+‐ATP synthaseSignal., 2012). Te progression aominent role inll carcinomas dells triggers a mtivates cellular hondrial proteiF1 in cancer hal and tissue spe

main objective oogy of IF1 and ation with Profw to understany for prevention

va group, CBMS

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on: 2012)

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nd cell fate.

rvision of Profewas focused onergy provision bstructural and me phosphorylatirms and shapesmitochondrial Arated that PARus‐mitochondria

rofessor J.M. Ce, an enzyme cThe expression and response tn human carcinderived from thmetabolic reproproliferation ain in defining eas been the maecific mouse mof my research its implication f. Smits from thnd the relevann, diagnosis and

SO, UAM Unive

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sity, Madrid

ence.

Y CAJAL A 2013

ssors F. Moronn energy metabbut also in cell molecular links ion and cell des of cell death. AATP loss once tRP‐1 indirectly a cross talk invo

uezva due to homplex that weof the catalytio therapy. We nogenesis. IF1 eese tissues (Forogramming to aand resistance energy metaboain field of my podels able to eline (now suppin colon inflamhe University ofnce of the inhid therapy of co

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gi in the Schoomplication in ceon and in ROS chondrial functo master tasks oeffort during mzyme polyADPrh mitochondriaath (Formentin

he bioenergeticonstrated to behe H+‐ATP syntd that the ATPaegligible in nor., Oncogenesis,erobic glycolysFormentini et aeath programsvestigation durman IF1 or a mmpetitive fellower onset and proith the aim of gH+‐ATP syntha


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ol of Medicine oell death. Nowaand Ca2+ signations. An exampof mitochondrimy PhD was direribose polymeraal function cani et al, J.Biol.Ch

cs of cancer cele a master reguhase is repressase Inhibitory Fmal colon, lung 2013). Accordisis also promotal., Mol Cell, 2s needed to supring the last 5 yutant version o

wship by the AECogression. Withgenerating a mse in colon in

of the adays aling. ple of a are ected ase 1 using hem.,

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esearch ProyectMinistero italiaComunidad de CIBERER; 2007BFU2007‐6525BFU2010‐1890Comunidad de

apers: Number

0)Formentini L e9)Buonvicino D,8)Formentini L*7)Formentini L*6)Sánchez‐Arag5)Gerace E et al4)Formentini L e3)Moroni, F et a2)Pittelli M, For1)Sánchez‐Ceniz0)Formentini L eMoroni F, FormFormentini L etFormentini L etFormentini L etPellicciari R et aPorcu M et al., Faraco G et al.,Fossati S, FormCozzi A et al., J

eaching duties: 006‐2009: Assistant at Facraduate Courseeminars and ve

009‐Today: rofessor at Depraduate Courseeminars and ve

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of papers: 20;

et al., EMBO J (, Formentini L e*, Sánchez‐Arag*, Sanchez Araggó M, Formentinl, Eur J Neuroscet al., Mol Cell.al., Br. J. Pharmrmentini L et al.zo L, Formentinet al., IUBMB Limentini L et al., t al., J. Biol Chet al., Biochem Pt al., Br J. Pharmal., ChemMedCCornea, 2007 J, Mol Pharmaco

mentini L et al., BCereb Blood Fl

culty of Medicines: Motor Scienerbal communic

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First name pap

(in press). CLAVet al., J Biol Chegó M* et al., Ongó M* et al., Anni L et al., Cell Cci. 2012 Jul;36(1 2012 Mar 30;4

macol, 2012 Mar., J.Biol.Chem, 2ni L et al., J.Biolife, 2010 Jul;62Br J. Pharmacom, 2009 Jun 26Pharmacol, 200macol, 2008 DeChem, 2008 JunJan;26(1):73‐9. ol, 2006 Dec;70Biochem Cell Blow Metab, 200

ne, University oces; Science ancations

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VE: A. IF:9,8 em. 2013 Dec 20ncogenesis 2013tioxidants & ReCycle, 2012 Aug1):1993‐2005. I45(6):731‐42. IFr;165(5):1487‐52010 Oct 29;28.Chem, 2010 Au2(7):554‐60. IF:4ol, 2009 Jul;1576;284(26):176689 May 15;77(10c;155(8):1235‐4n;3(6):914‐23. IFIF:2,1

0(6):1876‐84. IFiol, 2006 Oct;8406 May;26(5):6

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Documents

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