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Effect of gender, age, height and weight in healthy individuals on
exhaled nitric oxide (FENO) values: a systematic review
Class nr. 1: Afonso Castro; Ana Sá; Cátia Reis; Daniel Melo; Daniela Duarte; Joana Lyra; José Silvano; José Penêda; Margarita Yakubovich; Marta Costa;
Pedro Pires; Rita Filipe; Rui Magalhães; Tiago [email protected]
Tiago António Queirós Jacinto - [email protected]
INTRODUCTION TO MEDICINE 2008/2009
ASTHMA
FENO – fractional exhaled nitric oxide
GENDER
AGE
HEIGHT
WEIGHT
Are the exhaled nitric oxide (FENO)
values of healthy people affected by
age, gender, height and weight?
Systematic reviewSeptember 2008 – July 2009
Research Method 1. Define query
2. Search different databases
3. Read abstracts
4. Apply inclusion and exclusion criteria
5. Get full papers
6. Analyze the papers - apply inclusion and
exclusion criteria
7. Select the relevant studies
8. Extract data
9. Discuss the selected data
10. Take conclusions
11. Formulate results
12. Communicate our results by writing (and
hopefully publishing!) an article on our
systematic review!
Query:
((age OR age factors) OR (weight OR body weight) OR (height OR body height) OR (gender
OR sex)) AND (exhaled nitric oxide OR FENO) AND (healthy individuals OR (reference values
OR normal values OR normative values) OR effect)
The following terms were used as MeSH terms for search on PubMed:
age factors, body weight, body height and exhaled nitric oxide
Inclusion Criteria Exclusion Criteria
Population: healthy individuals Full-text not available
Assessment of FENO values of individuals of different age, gender,
height and weight Duplicated articles (same articles
from different databases)
Measuring equipment of FENO values: Niox®, Sievers®, Logan®
(...)
Articles written in English, French, Spanish or German
FENO measurement done by the standardized online method (50 mL/s)
AuthorPublication
Yearn Method
Measurement Equipment
Factors
Sepponen A 2008253 schoolchildren (7-13
years old)four flow rates (10, 50, 100, and
200 ml/sec)Not Mentioned
(alveolar NO concentration, bronchial NO flux, bronchial wall NO concentration, and
bronchial diffusing capacity of NO)
Sutherland TJ 2008
79 women (obese patients with asthma (n = 20), normal-weight patients with asthma (n = 19), obese patients without asthma (n = 20), and normal-
weight patients without asthma (n = 20))
Corticosteroid withdrawal, between-group differences in
spirometric values, lung volumes, exhaled nitric oxide, induced sputum cell counts,
biomarkers of inflammation in sputum supernatant and blood measurement and interactions
exploration
Not Mentioned Weight, Asthma
Hauswirth DW 2008270 healthy African American
subjects without asthma between 18 and 40 years old
Simultaneous measurement of EBC pH, EBC nitrite, nitrate, and FeNO (measured in triplicate and
averaged)
Sievers 280i Nitric Oxide Analyzer Race
Gabriele C 2008187 Infants (median age 6.9
weeks)
Questionnaires prospectively administered during pregnancy
and after birthNot Mentioned
Pre- and post-natal smoke exposure
Cobos Barroso N 2008Cooperating children and
children unable to cooperateSingle-breath online
measurementsChemiluminescence FENO analyzer Not Mentioned
Thank you for your
attention!