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Electrolytes
Hyponatremia
• What is the serum osmolarity?– 2(Na+) + BUN/2.8 + Glucose/18
• Hyper-osmolar (>290)– Hyperglycemia– Mannitol
• Iso-osmolar (270-290)– Hyperproteinemia
Multiple myelomaAmyloidosisMGUS
– Hyperlipidemia– Hyper & Iso-osmolar hyponatremia is also called
pseudo-hyponatremia
Hyponatremia
• Hypo-osmolar– What is the volume status on physical exam
• Hypovolemic– Dehydration
Vomiting Diarrhea
– Treat by calculating and replacing the sodium deficit body wt in kg x 60% x 10meq Select your IV fluid and rate Watch for central pontine myelinosis during
correction • Hypervolemic
CHF ESLD Nephrotic syndrome
Hyponatremia
• Euvolemic– Addison’s disease– Drugs
• HCTZ• SSRI• ACE-I
– Hypothyroidism– Psychogenic polydipsia– SIADH
Hyponatremia
• SIADH– Etiology
• Pulmomary– Small cell carcinoma– TB– Pneumonia– Lung Abscess
• CNS– Head injury– CVA– Meningitis / Encephalitis
• Drug– Vincristine– Cyclophosphamide– Carbamazepine
Hyponatremia
•SIADH– Diagnosis
• Urine Sodium or osmolarity– Both should be elevated
– Treatment• Treat the underlying cause• Fluid restriction• Demeclocycline• Vaprisol
Hypernatremia
• What is the volume status– Hypovolemic
• Dehydration– Vomiting– Diarrhea– Insensible and sweat losses
• Treatment– Calculate the free water deficit
Total body water x (serum Na+ -140)/140– Careful for cerebral edema during correction
– Hypervolemic• Conn’s syndrome
– Renin to Aldosterone ratio
Hypernatremia
• Euvolemic– Diabetes Insipidus
• Central DI– ADH insufficiency– Caused by
Neoplasm Infiltrative lesions Surgery Radiotherapy Head injury
• Nephrogenic DI– ADH resistance– Caused by
Sickle cell disease Pyelonephritis Drugs: lithium, demeclocycline, colchicine
Hypernatremia
• Diabetes Insipidus– Diagnosis
• Compare plasma and urine osmolarity after dehydration (water deprivation test) and after vasopressin
– Treatment• Central DI
– Hormone replacement with vasopressin• Nephrogenic DI
– HCTZ or amiloride enhances the reabsorption of fluid from the proximal tubule
Hyperkalemia
•INCREASED POTASSIUM RELEASE FROM CELLS• Pseudohyperkalemia
– Mechanical trauma during venipuncture– Cooling of the sample and specimen
deterioration because of increased length of storage
– May also represent severe intravascular hemolysis rather than a hemolyzed specimen
– Marked leukocytosis or thrombocytosis (white cell or platelet count greater than 100,000 per mm3 or 400,000 mm3, respectively), as may occur with leukemia or a myeloproliferative disease
Hyperkalemia
•INCREASED POTASSIUM RELEASE FROM CELLS• Metabolic acidosis• Insulin deficiency• Increased tissue catabolism
– Any cause of increase tissue breakdown result in the release of potassium into the extracellular fluid
– hyperkalemia may occur in this setting, particularly if renal failure is also present
– Clinical examples include trauma
Hyperkalemia
•INCREASED POTASSIUM RELEASE FROM CELLS• Beta-adrenergic blockade• Exercise• Hyperkalemic periodic paralysis• Digitialis• Succinylcholine
Hyperkalemia
•REDUCED URINARY POTASSIUM EXCRETION
– Hypoaldosteronism• Type 4 RTA
– Potassium-sparing diuretics– Renal failure– Effective circulating volume depletion
Hyperkalemia
•Treatment– Antagonism of membrane actions of potassium
• Calicum– Drive extracellular potassium into the cells
• Insulin and glucose• Sodium bicarbonate, primarily if metabolic acidosis• Beta-2 adrenergic agonists
– Removal of potassium from the body• Loop or thiazide diuretics• Dialysis, preferably hemodialysis if severe• Cation exchange resin
– Sodium polystyrene sulfonate (Kayexalate)
Hypokalemia
•Major causes– Decreased potassium intake– Increased entry into cells
• An elevation in extracellular pH• Increased availability of insulin• Elevated Beta-adrenergic activity
– Stress or administration of beta-agonists• Hypokalemic periodic paralysis• Marked increase in blood cell production
– Administration of vitamin B 12 or folic acid to treat a megaloblastic anemia
– Granulocyte-macrophage colony-stimulating factor (GM-CSF) to treat neutropenia
• Hypothermia• Chloroquine intoxication
Hypokalemia
•Major causes– Increased gastrointestinal losses
• Vomiting• Diarrhea• Laxative abuse
– Increased urinary losses• Diuretics• Primary mineralocorticoid excess• Hypomagnesemia• Amphotericin B• Bartter's or Gitelman's syndrome
– Increased sweat losses– Dialysis– Plasmapheresis
Hypokalemia
•Treatment– 10 meq KCl will raise serum K+ by 0.1
• Be careful in renal failure
Hyperphosphatemia
•Causes– MASSIVE ACUTE PHOSPHATE LOAD
• Tumor lysis syndrome• Rhabdomyolysis• Lactic and ketoacidosis• Exogenous phosphate
– Renal failure– Increased tubular reabsorption of phosphate
• Hypoparathyroidism• Acromegaly
– Due to insulin-like growth factor• Vitamin D toxicity• Bisphosphonates
– Pseudohyperphosphatemia• hyperglobulinemia
Hypophosphatemia
•Major causes– Internal redistribution
• Increased insulin secretion• Refeeding syndrome• Hungry bone syndrome
– Decreased intestinal absorption• Inadequate intake• Antacids containing aluminum or magnesium• Steatorrhea and chronic diarrhea• Vitamin D deficiency or resistance
– Increased urinary excretion• Hyperparathyroidism• Vitamin D deficiency or resistance
Hypophosphatemia
•Signs and symptoms– Mineral metabolism
• Release of bone calcium contributes to the hypercalciuria
• More prolonged hypophosphatemia leads to rickets and osteomalacia due to decreased bone mineralization
– CNS• Metabolic encephalopathy• Confusion, seizures, delirium, and coma
– CVS• Myocardial contractility may be impaired with ATP
depletion• The reduction in cardiac output may become clinically
significant, leading to congestive heart failure, when the plasma phosphate concentration falls to 1.0 mg/dL
Hypophosphatemia
•Signs and symptoms– Skeletal and smooth muscle
• Proximal myopathy, dysphagia and ileus– Hematologic dysfunction
• Hypophosphatemia can also affect each of the components of the hematopoietic system
•Treatment– Oral (Neutra-Phos)– IV (K-Phos)
Hypermagnesemia
•Causes– Renal failure– Magnesium infusion
• Severe preeclampsia or eclampsia– Oral ingestion– Magnesium enemas
• Substantial quantities of magnesium can be absorbed from the large bowel
• Among patients with renal failure, the administration of a magnesium enema can be fatal
Hypermagnesemia
•Treatment– Most cases of symptomatic
hypermagnesemia can be prevented by anticipation
– Dialysis– When the toxic effects of magnesium
must be reversed more quickly in a patient with severe symptoms, intravenous calcium can be given as a magnesium antagonist
Hypomagnesemia
•Causes– GI losses– Renal losses
• Both loop and thiazide diuretic can inhibit net magnesium reabsorption
• Alcohol– Appears to reflect alcohol-induced tubular dysfunction
that is reversible within four weeks of abstinence• Hypercalcemia
– Calcium and magnesium seem to compete for transport in the thick ascending limb of the loop of Henle
• Nephrotoxins– Aminoglycoside– Amphotericin B– Pentamidine– Cyclosporine
• Loop of Henle or distal tubule dysfunction– Bartter’s syndrome
Hypomagnesemia
•Signs and symptoms– Neuromuscular
• Tetany– Positive Chvostek and Trousseau signs, and
generalized convulsions Can occur in the absence of hypocalcemia
– Hypokalemia– Bone and calcium metabolism
• PTH resistance• Vitamin D deficiency
– CVS• Severe magnesium depletion can lead to prolongation of the
PR interval, progressive widening of the QRS complex, and diminution of the T wave
•Treatment– PO or IV replacement– Usually under treated
Serum Calcium
• Normal value– 8.0 to 10.0
• Total body calcium • 99% in stored in bone• 1% in extracellular fluid
• 3 forms of calcium in the blood– Bound to protein (40%-45%)
• Correct for albumin– Free ionized (45-50%)
• Order ionized calcium– Bound to anions (5-10%)
• Phosphate, bicarbonate, citrate
Calcium physiology
• Calcium is:– Absorbed from the gut – Stored in the bone– Excreted by the kidneys
• Three endogenous chemicals regulate serum calcium– Parathyroid (PTH)– 1,25-(OH)2-D3 (Vit D)– Calcitonin
• From the thyroid C cells • Can be considered a PTH antagonist• It slows down the osteoclasts causing a
decrease in bone resorption
Calcium physiology
• Decrease serum calcium, by reduced negative feedback, causes– Increased PTH
• Causes a release of bone calcium stores• Decreased renal excretion of calcium• Increases activity of kidney hydroxylase
causing increased 1,25-(OH)2-D3– Increased Vitamin D
• Increases Calcium absorption from the gut
Hypercalcemia
• Symptoms (>11.5-12)– Urinary
• Polyuria• Polydipsia• Nephrocalcinosis • Renal failure
– CNS• Personality
disturbance• Mental obtundation
or coma• Neuromuscular
weakness• Easy fatigability
– GI• Anorexia• Weight loss• Constipation• Nausea / vomiting• Abdominal pain• Pancreatitis
– CV• Hypertension• Arrhythmias
– Short QT
Hypercalcemia
•Severe hypercalcemia (>15)– Medical emergency
• IV fluids• Lasix• Bisphosphonates• Calcitonin
Hypercalcemia
• Causes– Primary hyperparathyroidism
• One gland hyperplasia (most common)• Hyperplasia of all four glands• Parathyroid cancer is a rare cause • Can also be part of the MEN 1 & 2
– Maliganancy (PTH like hormone)• Lung (Squamous Cell)• Breast• Myeloma
– Activation of osteoclasts– Others
• Granulomatos diseases (Sarcoid)– Vit D activation by macrophages
• Familial benign hypocalciuric hypercalcemia• Drugs (lithium, Vit D, HCTZ, milk-alkali syndrome)• Immobility
Hypocalcemia• Etiology
– Decreased PTH secretion• Thyroid surgery and loss of parathyroid glands
– Hypomagnesemia• Alcholics• Patients with bowel disease• Magnesium is required to secrete PTH
– Vitamin D deficiency• Osteomalacia
– Called rickets when in occurs in youth– Loss of calcium
• Occurs with pancreatitis– Severe hyperphosphatemia
• Calcium chelates with the phosphate– PTH resistance
• Pseudohypoparathyroidism– Albright's hereditary osteodystrophy
Hypocalcemia
• Clinical findings– Neuromuscular
• Tetany– Chvostek sign (percussion of CN VII)– Trousseau sign
• Laryngospasm• Cramping• Seizures
– CV• QT prolongation• Refractory CHF• hypotension
Hypocalcemia
• Diagnosis– Suggested when the serum calcium is low
• Check albumin• Check ionized calcium• PTH may be low or high depending on the
etiology• Check serum magnesium
• Management– In the acute stages IV calcium can be given– Maintenance therapy includes oral calcium