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Electronic Laboratory Notebook in the Graduate Level Laboratory Informatics
Program
Mahesh Merchant, Paresh Sanghani*, Sonal Sanghani*
Mahesh Merchant
Indiana University School of Informatics
* Department of Biochemistry and Molecular Biology
• Five master’s degrees:– Bioinformatics– Chemical Informatics/Laboratory
Informatics– Health Informatics– Human Computer Interaction– Media Arts & Sciences
• Now offering Ph.D. in Informatics• Masters in Biochemistry and
Molecular Biology
Graduate Programs
• Laboratory Information Management Systems (LIMS)
• Electronic Laboratory Notebooks (ELNs)
• Data Visualization• In-house Databases• Enterprise Resource Planning, SAP
Data Integration
Data consumers
Data sourcesLab instrumentation Office
applications
LIMSVisualizationand analytics
softwareE-Notebooks Discovery
Databases
Print and file data
The integration challenge
©2004 Waters Corporation
• Two commercial LIMS (Labware and LabVantage)
• Currently, one commercial ELN (LabTrack)• Currently, one Enterprise Content
Management System (Cerity) • Data Visualization Software (Spotfire)• Chromatography Data System
(PerkinElmer)
Software at Indiana University
• ELNs are taught in the Scientific Data Management Class as part of the Laboratory Informatics curriculum
• Two student projects involving Gene Expression using microarrays and the Protein Data Bank are highlighted in today’s presentation
• Students use an Enterprise Content Management System (ECMS) in conjunction with the ELN
ELN in a Classroom
ELN – Methods in Cell Biology
• This course involves discussions and hands on experimentation in basic and advanced cell biology techniques
• Students are required to keep a laboratory notebook describing the objective, methods, results and conclusions of their experiments
• Homework questions associated with each experiment are answered in the laboratory notebook
ELN – Challenges for the Cell Biology Class
• This course involves multiple instructors with laboratories located in different buildings
• The handouts for the laboratories are in different formats, e.g. PowerPoint Slides, Reference Articles, Laboratory Procedures
• Analysis of data is performed using a variety of software packages
• Resources
ELN – Future Directions
• Integration with SDMS and other software
• Open architecture to allow products from multiple vendors to communicate with each other
• Use of Tablet PCs in the Laboratory
Integrating SDMS into your overall business process
Data consumers
Data sourcesOffice
applications
Waters NuGenesis SDMS
View
Extract
LimsVisualizationand analytics
softwareE-notebooks
Discoveryand clinicalDatabases
Lab instrumentation
©2004 Waters Corporation
SDMS Data from eLab Notebook
SDMS Vision Data Source
Select Data to View
©2004 Waters Corporation
Data is selected then sent to the eLab Notebook