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Embryology of the Genital Embryology of the Genital OrgansOrgans
Per BrodalPer BrodalInstitutt for medisinske basalfagInstitutt for medisinske basalfag
Universitetet i OsloUniversitetet i Oslo
9th Semester 20089th Semester 2008
The Mesonephric Duct
Cloaca
Mesonephros
Metanephros
Mesonephric duct
Ureter bud
34 days (~ 5 weeks) 6 mm CR-length
Mesonephric excretory tubules
2P. Brodal
Early Gonadal Development
Primordial germ cells
Yolk sac
Gonadal ridge
Coelomic cavity
Mesonephric duct
Mesonephric ridge
3P. Brodal
Early Development of The Internal Genitals
4P. Brodal
Neural tube
Dorsal aorta
Notochord
Dorsal mesentery
Coelomic cavity
Mesonephric duct
Mesonephric tubules
Gonadal (genital) ridge
The Gonadal Ridge
4 week embryo
Langman
Gonadal ridge Primitive sex cordsProliferating
coelomic epithelium
Mesonephric duct
6 week embryo
5P. Brodal
Further Development - Male
Tunica Albuginea
Testis cords
6P. Brodal
Undifferentiated stage (6 w)Mesonephric tubules
Gonadal anlage
Mesonephric duct(Wolff’s duct) ♂
Paramesonephric duct (Müller’s duct) ♀
Urogenital sinus (from the cloaca)
Primordia of accessory glands7P. Brodal Netter
Male and Female Gonadal Development
The mesonephric duct
The paramesonephric duct
Medullary sex cords
8P. Brodal
Male Female
The Female Genital Tract – Further Development
9P. Brodal
Malformations of the Uterus
10P. Brodal
Development of the Urogenital Sinus
Allantois Cloaca
Rectum
Future bladder
Definitive urogenital sinus
Defective partitioning of the cloaca results in anomalies of anorectal, urinary or genital structures; e.g rectourethral fistula or rectovaginal fistula 11P. Brodal
Further development
12P. Brodal
Netter
External Genitals
4 weeks 6 weeks
Genital tubercleCloacal fold
Cloacal membrane Urogenital membrane
Urogenital fold
5 months Newborn
13P. Brodal
Hypospadia
14P. Brodal
Descent of the Testes
Scrotum
Peritoneum
Retentio testis (kryptorchismus):
When the testes do not reach the scrotum
Inguinal hernia
when tunica vaginalis still communicates with the peritoneal cavity (processus vaginalis persists)
15P. Brodal