Emerging Dilemmas in Statin Use: Incident Diabetes, HIV Dyslipidemia,

and Drug-Drug Interactions

Program Goals

Get With The Guidelines

The Framingham Study

Copenhagen Male Study: Risk of Ischemic Heart Disease (IHD) Associated With Higher TG and

Lower HDL-C

Intensive Statin Therapy

Guideline Recommendations

Approximate Dose Equivalency of Statin LDL-C Efficacy

The Statin Armamentarium: Individual Metabolism

Characteristics

CYP Inhibitors: Drug-Drug Interactions

Statin Use in Diabetes: Cardiovascular Events

Effect of Statins on New-onset T2D

JUPITER: Rosuvastatin and New-Onset T2D

Glucose Control: Differential Influence of Statins

J-PREDICT: Pitavastatin May Reduce New-Onset T2D

Dyslipidemia in HIV

Statins and HAART Drug-Drug Interactions

Lipid-Lowering Therapy in HIV

Glucose Control in HIV

INTREPID: Effects of Pitavastatin vs Pravastatin in HIV Dyslipidemia

Summary

Abbreviations

Abbreviations (cont)

References

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