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Epidemiology of HCV
Jonathan Moorman, M.D. Ph.D.
Professor of Medicine and Division Chief, Infectious Diseases
Co-Director, Center of Excellence in Inflammation, Infectious
Diseases and Immunity
ETSU Quillen College of Medicine
Disclosures
Grant funding from NIH NIAID, NIDDK, NIA, and VA Merit
No financial interests involved in this presentation
Acute HCV 2015: 2,436 cases of HCV reported from 41 states
0.8 cases/100,000 in U.S.
TN: 2.6 cases/100,000
10 states accounted for about 60% of the cases
ACTUAL acute cases estimated to be 13.9 times that rate in any given year
Estimated 33,900 new cases in 2015
https://www.cdc.gov/hepatitis/statistics/2015surveillance/index.htm
https://www.cdc.gov/hepatitis/
https://www.cdc.gov/hepatitis/statistics/2015surveillance/index.htm
How many?
Hepatitis C Incidence in United States, 1982-2014
https://www.cdc.gov/hepatitis/statistics/2014surveillance/index.htm
https://www.cdc.gov/hepatitis
Where?
Where is it most concentrated?
Patrick et al. Hepatitis C Virus Infection Among Women Giving Birth—Tennessee and United States, 2009-2014. MMWR 2017; 66: 18, p. 470-473.
Local epidemiology
Patrick et al. Hepatitis C Virus Infection Among Women Giving Birth—Tennessee and United States, 2009-2014. MMWR 2017; 66: 18, p. 470-473.
It’s a rural thing
Xc
Zibbell et al. Increases in Hepatitis C Virus Infection Related to Injection Drug Use Among Persons Aged <30 years---Kentucky, Tennessee, Virginia,
and West Virginia, 2006-2012. MMWR 2015; 64: 17, p. 453-458.
What age groups?
Men or women?
What are the risk factors?
CDC, National Notifiable Diseases Surveillance System
CDC, National Notifiable Diseases Surveillance System
Locally…
Zibbell et al. Increases in Hepatitis C Virus Infection Related to Injection Drug Use Among Persons Aged <30 years---Kentucky, Tennessee, Virginia,
and West Virginia, 2006-2012. MMWR 2015; 64: 17, p. 453-458.
Van Handel et al. J Acquir Immune Defic Syndr 2016; 73(3): 323-331.
Why we worry
HCV in the U.S. 2.7-3.9 million in the U.S. with chronic HCV
Estimated 19,659 deaths in 2014
HCV is the leading indication for liver transplants in the U.S.
Denniston et al. Ann
Intern Med
2014;160;293-300.
Mortality
Ly et al. Ann Intern Med 2012;156;271-278.
Mortality Estimates going forward
Rein et al. Dig Liver Dis 2011;43:66-72.
