Upload
tinelawrence
View
215
Download
0
Embed Size (px)
Citation preview
8/3/2019 ER DRUGSTUDY
1/67
#&$%&!
#&%$ $
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
234530
7,3/3,20
!!,72,0,99,39.
234530,25
%041,25
,881.,943
39,892,9.!!705,7,9438
48,0
39,29.0/,3.70,80/
1300/0/
3.70,808900;041.!
708:933-743.4/,943
743.-743.485,82
,8/7,90
,:80,;4293
,-/423,5,3/,770,
0,/,.038423,
/3088
,30970890883088970247
5,59,9438
!49039,,9,
43;:8438.,7/,.
,7792,854903843
,3/8://03/0,9,1907944
7,5/'30.943
W/238907945703,395,903984303.0,7
300/0/3043,9,9,..,7/,99073088,3/9/7,,
,530,4-807;0/0324907870.0;0/,39308:5:39
/0;07
W,:9435,903934994.047.7:803907..4,90/920/700,8014728
W;0220/,90700,806://48,0147289144/1
0110.984..:7W4349;0920/700,80
147289144/908084:/-0;0343,302598942,.
7-01470477,190720,8W,39,3,/06:,90/7,943
W43947708:9841807:29045300;08.,701:
,3/,77,3014770/:.0//48,01807:20;080.00/
907,50:9.7,30412.2
W%,0807:28,250894/090723050,904530
.43.0397,943/7,323,1907,3'4,/3/480
W43947147.3.,83841,/;07800110.985,79.:,71
807:29045300;08,70
8/3/2019 ER DRUGSTUDY
2/67
349,;,,-0
W38:709,9/,05,2870,/,;,,-094970,9
80:708W%,098/7:0,.9,8
5708.7-0/1,920/700,80574/:.985708.7-0/9,098
/7:43,302598942,.7-01470477,190720,8
W434994.047.7:8920/700,805705,7,9438
W/23890770.9,84:94347
8:554894708,1907025939070.9:2W92,-030.088,7949,0
98/7:,74:3/90.4.147,/06:,90.4397441,892,
,99,.8W;4/0.088;039,041.4110090,.4.4,.4,
-0;07,08.4.4,90W$243.,709908474907
94-,..4574/:.9825,.9890/7:80110.9;03088%734994
824049190.,70574;/0718243,-98.,300
9,398/7:W706:039-44/908982,-0
30.088,794243947900110.94198/7:,3/94038:708,10
,3/0110.9;0/48,0005,,5543920398147-44/90898
,3/49072439473W%0808/00110.982,4..:7
,:80,48841,5509909,398/7:9144/2,051
8/3/2019 ER DRUGSTUDY
3/67
9,390220/,90700,8047
6://48,014728/11.:980053/05708843024943,
,-970;078-0W#054793,:80,;4293
80;0705,37089088308880:708770:,70,79-0,9
8/3/2019 ER DRUGSTUDY
4/67
#&$%##
#&%$ $
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20#
##7,3/3,20
34439,-47/,7430
47/,74303$,3/424/,7430
9,-
,881.,943,7/,.7:8
48,0!39,2
9208/,14770/:.0942
9.0/,147,1:7907
472
#4:90
706:03.
4.8549,88:2
.47/00,/39457443,943
41,.943549039,
/:7,943
'0397.:,7,3/8:57,;0397.:,7
,7792,8
:070/8.447,94341
83549480389;9
507507,30:745,9
5,7,08908,245,9
,9,,9702473,:80,
;4293209,.9,890
54974/82507974/82
,450.,8005/89:7-,3.08
.4730,2.74/054898
491:80880,930,79
-4.-7,/.,7/,
83:8,7708905,9494.9
0,791,:70
!49039,,9,!:243,7
94.9
3.:/3
W43947.,7/,.792.4393:4:8
W43947147,30903/0/5074/03/48,0,/:8920398
,702,/0W439471478,10,3/0110.9;0
807:20;082.2W480841/436:3/30
574.,3,2/0503943,3/,71,732,300/94-0
70/:.0/43097/94430,103,24/,7430889,790/
W;0/7:920,894/0.70,80574-028
W77,30147459,244.0,28700;,:,90,9,38341
459.30:745,9W77,301475074/..089
7,940;,:,905:243,789,9:80;0724
W77,3014770:,75074/.-44/90898147;0703208
974/4724300;08W7:/48,0-0.,30/
370,943947085438041,7792,84:300/94-0
4859,0//:7339,94341/7:907,54:-0
.4802439470/03/48,0
8.,30/
8/3/2019 ER DRUGSTUDY
5/67
5:243,7
1-7488,3/3907899,
530:2439805,9494.9
97494.9'0397.:,7
,7792,85:243,7
,;04980,.07-,94341
,7792,8,3/7,708074:8;07
3:70307,35,903989
/4808,3/,;3
5700893,-3472,90841/11:843
.,5,.9
W,;070:,720/.,144
:5243947341.,7/,.792.0897,000,2
-44/90898W%0808/00110.982,4..:7
,3083;843,48/700880389;99490,7
8:3,880824394790548:703,:80,;4293
48841,5509909,0920,80,982,1706:039
20,880389;994908:3:80,8:38.70034757490.9;0
.493034:9/4478
.43895,943,,,9;02,-0
47/070/970247899.3/308848841.447/3,943
/4349/7;04507,90/,3074:82,.30747:3/079,09,889,9706:70.447/3,943:39
/7:0110.9889,-0,3/4:7-4/,/:898949
W#05479:3:8:,-00/347-7:8310;07.8
39407,3.0940,947.4/8479308841-70,9/11.:9
-70,93.4:80341,30847130785,59,9438
/11.:99;843
8/3/2019 ER DRUGSTUDY
6/67
#&$%&%#!$&%
#&%$ $
%
%
$
%#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
974530$:1,90
7,3/3,20
30853,2597454
,25:740/
974530$:1,90,258459497453000/7458!
!,72,0,99,39.974530,25
,881.,943
,7/4;,8.:,77:8:8.0#0,,398
/7,9.7:839/490809413
03987:8&80/3$:-89,3.0
0503/03.0
48,0'7,/.,7/,2.0;07238
%49,2'7,34548547:8
54843320;07238:39
2:8.,73.0110.98
3,39
.4307.9,93-98
,.09.430,990
5,7,825,909.
30:740110.947:3.94303,3.0890
.43/:.94341'34/0,3/
3.70,8080,797,90
7,/.,7/,
7,34548547:8548433
724:9
/85,,.43895,943
1:83,3//730884183
9,..,7/,
5,59,9438,7792,82/7,88
549454-,..450,
7,80/397,4.:,7
57088:70
%4./4808.,:80
9,..,7/,507570,
70890883088.431:843
0.902039,:.3,9438/07:2,3/
2,574708894.7.:,947
1,:70,3/70857,947
/057088430
W38:70,/06:,90/7,943
574;/003;7432039,.43974902507,9:7094570;039
507570,W,;05,9039;4/-01470
9,320/.,9431:73,7
709039438,574-02W03:80/5704507,9;04734907,.:9089:,9438
3.47547,9090,.3,-4:990/7:990,.3,-4:990
574.0/:7090459,2.84:9438:80/2,3,.:90
,3/349-0801,/2389070/-905,9039
901443,559447,20/.,9431474:95,90398
W%,0,85708.7-0/23-0147020,8,;4/0.088;0
/48,0W;4/4903;743203984:
-00,939407,39,3//,3074:870,.94382,4..:7
W%0808/00110.982,4..:73088.431:843
:80.,:943/7;34750714723,,7/4:89,88
.43895,943038:70,/06:,90
8/3/2019 ER DRUGSTUDY
7/67
/8,550,747,974530
94.9,550,78
472
#4:90
706:03.
/7458
$8902.
94.90850.,3
./70343574430/:80
2,0,/94779,943
50702,0/02,,3/
.43:3.9;983.70,80/
397,4.:,757088:70
3,,943
730884124:9974,9
!49039,,9,
97,,7792,8
'/884.,943
2:950;0397.:,7
0.945.8
1:/39,0574507/09/7
24:98:.8:,70884030850714721706:039
24:9.,702,-097,38039-:770/;84380389;994
970;078-0,;4/9,889,9706:70,.:90;8430,7
8:3,88083-799254903.070;078-0
/11.:93:73,943025990-,//075747949,3
/7:W#054797,81:8300
5,3/11.:9-70,93970247848841.447/3,943
770:,70,79-0,95,59,94380,/,.0
,-/423,/8903943,:.3,943880;07047507889039/724:9/11.:9
8,43/11.:93:73,943.43895,943
80389;9949
8/3/2019 ER DRUGSTUDY
8/67
#&$%&&%
#&%$
$%
%$ %#%$
'#$#%
$%$
$#$!$%$
0307.3,20
:209,3/0
7,3/3,20
:730,25
:7309,-
,881.,943
$:143,2/0:709.8
48,0
472
#4:90
706:03.
3-98$4/:2,3/47/0
70,-8475943,990,8.03/3
44541030
4397,3/.,90/95,90384
,7080389;09490/7:
:8.0.7,258/3088
549038430,/,.0
3,:80,25,70/
0,7357:79:8.,3082:8.:48009,
5,37,8.089/8.421479703,
1,:705702,9:70
0,.:,943
9742-4.94503,54,02,542,308,02
,543,9702,
507:7.02,507.02,
54.,.,02,
W;09144/47294570;039:5809
W,7.,03/,7847:807023/07813907299039
907,58-089147970,93
0/02,W;0830/4800,73/,843.70,80/:73,943349
/89:7-8005W;4/':80147,:808
5488-0W77,3094243947807:2
00.974908/7,943;07
1:3.943/:73439072907,5W!74;/0/097.3549,88:2
478:5502039,549,88:2W#0.47/,9073,90/,47
3907299039907,543,.,03/,747/,90/03;04508
W%,090/7:0,73/,843.70,80/:73,943349
/89:7-80059,09144/4720,894570;039:5809
W04:780143,70:,7-,88,9908,20920,3/3
908,20.49370.47/9009434:7.,03/,7
8/3/2019 ER DRUGSTUDY
9/67
W%0808/00110.982,4..:7
3.70,80/;4:20,3/1706:03.41:73,943
/308810031,3943,783/7483088,;4/7,5/
548943.,308,,7/4:8,.9;9088:.,8/7;3,3/
,.44.438:2594380389;9948:39:80
8:3,88088:38.70030,757490.9;0.4933.70,80/
97898:.8:,708840308:801706:03924:9.,70488
41-4/549,88:2,549,88:27./0947
8:5502039-0300/0/W#0547909.,30412470
9,3-3/,8033,3084713078:3:8:,-00/347-7:833,:80,
/30889702-33:2-30881,9:02:8.00,308847
.7,258
8/3/2019 ER DRUGSTUDY
10/67
#&$%&&&%
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20,.:2:.43,90
7,3/3,20
,881.,943
0.974908
48,00.974908!
224/,
472
6:/
#4:90
!07702
706:03.
705,.08,.:2,3/
2,39,38,.:20;0
54.,.,02,39/490380;070
5072,308,02,$0;070
507,,02,
4397,3/.,90/95,903984
,850780389;9
390/7:
779,9438419988:0
.,.1.,9438384:347
30.7488,1907$3
507.,.,02,.,7,.90780/-
,3470,3,:80,;4293
.43895,943,-/423,5,3
2:8.00,3088
2039,/89:7-,3.08
54/58,54:7,
30574.,.3488703,.,.:
.,9,890491:808,3/
507507,;,84/,943
!49039,
,9,,7/,.
,7792,8,3/.42,
W,08:705708.7-07850.108147241.,.:294-0
;03.7,8.,7982,.439,3-49.,.:2:.43,90,3/
.,.:2.47/0W%05,9039949,047,
.,.:2944:78,190720,81:58094..:78
W;030.9433:90,70433,/:98,3/3,907,
9331,398&8074:90433020703.080334
'74:908,;,,-0-0.41779,94341988:0-.,.:2
8,98W%05,9039949,047,
.,.:29,1:,8841,907
W43947.,.:20;081706:039507.,.02,
2,708:9,1907,70/48083.743.703,1,:70#05479
,-3472,908
8/3/2019 ER DRUGSTUDY
11/67
#&$%&!%!#
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20,59457
7,3/3,20
.04.
,881.,943
3-9478
48,0
2
4729,-09
#4:90
!
706:03.
70/:.08$4/:2,3/
,907709039434078-44/
57088:70
5079038430,791,:70 4397,3/.,90/945,903984
850780389;09490/7:
/;0780#0,.9438
549038439,..,7/,
.0895,35,59,9438
57:79:8507,,02,
!74903:7,,340/02,
837,8089,890/89:7-,3.0
343574/:.9;0.4:0,/,.0
!49039,
,9,0:974503,
:8:,4..:78932941
89,793907,50850.,3
5,903989703,/81:3.943
47.4,03/80,808
507,,02,3,5,.9.
70,.9438
/2389077-01470477,190720,8
W0798:7043,3/2,75,90398.,799349.09,9
.,594578-039,0390,34903831472,943
8:-806:03994.425038,9477033700,80/:738:707
-0-4.0/549038432,-070;0780/9;4:20
05,3843W439475,9039.4801471,
3!80.43/,79470/:.94331:/;4:200.088;0
507857,943,3//0/7,943;4293/,770,0.088;0
549038432,4..:7W#0/:.0/48,035,90398
925,70/703,1:3.943W%,0/7:7-01470477
,190720,8/43499,09144/4349894594:9
.438:934:70,9.,70574;/07
W0.,701:41/7453-44/57088:704..:78248941903
9/,770,80,93;4293/0/7,94319
0,/0/308847/30884..:78.438:94:70,9.,70
574;/07
8/3/2019 ER DRUGSTUDY
12/67
W;4/4;0790.4:3907
20/.,94380850.,.4:.4/,0720/.,94389,9
2,.439,3370/03989,93907,.99
3-9478438:94:70,9.,70574;/07
W%0808/00110.982,4..:7:580948841,550990
.,3039,890507.05943290/0110.985,88
24:98470850714721706:03924:9.,707,81,890,79
7,90/308890,/0/3088:8:,5,8808,1907901789
10/,8.,3054894384,3/294:7,.9;908
9494809,9/4349706:70,0793088,3/570.843W#0547924:9847088470
974,910;07.88034190,3/81009770:,7
0,79-0,9.0895,3880341901,.000858943:0
/11.:9-70,93
8/3/2019 ER DRUGSTUDY
13/67
#&$%&
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,2043/30
7,3/3,20
,9,5708
,881.,943
907
395079038;08
48,02.
472%,-09
#4:90!
706:03.%
$92:,908,5,
70.059478,3/3-98.0397,
;,8424947.0390784078
507507,;,8.:,7
70889,3.0-44/57088:70
,3/0,797,90
5079038430345,:8,
1:837,30
5745,8
4397,3/.,90/95,90394
850780389;09490/7:
724:9/7483088
/30880,/,.0
.43895,943254903.0;;/
/70,28:73,770903943/7
9.3-:7338038,943390
001:/4700.97490
2-,,3.0:58095,7,9.
0:8479489,9.54903843
0,308880/,943
57:79:82,,
:79.,7,3,:80,38423,
,7792,8,9,943
#0/:.0/2499,99208
2,.,:805,7,9.0:8
W%,0/7:7-01470477,190720,8/43499,09
144/4349894594:9.438:934:70,9.,70
574;/07W0.,701:41/7453-44/
57088:704..:782489419039/,770,80,93
;4293/0/7,943190,/0/308847/30884..:78
.438:94:70,9.,70574;/07
W;4/4;0790.4:390720/.,94380850.,.4:
.4/,0720/.,94389,92,.439,3370/03989,9
3907,.993-9478438:94:70,9
.,70574;/07W%0808/00110.982,4..:7
:580948841,550990.,3039,890507.05943
290/0110.985,8824:98470850714721706:039
24:9.,707,81,890,797,90/308890,/0/3088
:8:,5,8808,190790178910/,8.,30548943
84,3/294:7,.9;9089494809,9/4349706:70
,0793088,3/570.843
8/3/2019 ER DRUGSTUDY
14/67
!49039,
,9,%7,38039
5079038434757414:3/
5490384370857,947
/05708843.43;:843
43/309/7,,
83/7420.4:/-010
970,90337,/.,7/,
.42,,3//89:7-,3.083
.43/:.94333/;/:,895700893
/80,80841$'34/08
4;07/4804743/9,8
W#0547924:9847088470
974,910;07.88034190,3/81009770:,7
0,79-0,9.0895,3880341901,.000858943:0
/11.:9-70,93W%,098/7:0,.9,8
5708.7-0/4349288/48084349/8.4393:090/7:
:3088843897:.90/4349/8.4393:0,-7:5910
970,9033,/;07800110.982,4..:714:97,;09,0,3
,/06:,908:5541/7:W&809097,38/072,88902,8
5708.7-0/7010794/70.943835,.,03807947.439,.94:7
0,9.,70574;/0796:08943808:70947024;04/889028-01470,553
304308W99025910890.,3089,9
70/:.04:7!89458243,3/:83,.44480
0970897.939,04184/:28,9007.80
70:,7W&80.,:9439,.44
4:780389;92,3.70,800:8398/7:
W%0808/00110.982,4..:77483088/30889
0,/0/30880,/,.00,30884190397,38039
4-807;0.,:943/7;3475071472349079,889,9
8/3/2019 ER DRUGSTUDY
15/67
706:70,07930884758.,
/09079/724:98:.438:,70884030847.0.58
:58090,982,1706:03920,8/70,28392,708
70;078-0/308890,/0/3088034:.,30
54894309:584:80.,:943.2-389,78
254903.0490780:,/81:3.943/0.70,80/-/4
/8.:889.,70574;/078-70,8903,7020398470
-70,8985,59,9438W#05479:73,770903943
.,3083;843-,3.341130787,8
8/3/2019 ER DRUGSTUDY
16/67
#&$%&!
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
,05,2
7,3/3,20',:2
,881.,943
349.8
48,0
22
472
#4:90
706:03.
-034
/,05309,9574-,-
549039,908900110.9841
/0570880890
$
8:55708808908570,/41
80:70,.9;9
#00141
,309,9,943
903843/:09458.430:749.
89,90897,38039
89:,943,
/89:7-,3.08
7483088
/8,797,8:770/8500.970247
97,38039,2308,1,9:0,9,,
0,/,.038423,
5,7,/4.,
,309,:.3,943
W4349,/238907397,
,7907,2,574/:.0,7907485,82,37030
W,301742'907,59447,907,5,88443,8
5488-0W4349:8082,;038
/478:241,3/47789147
'30.943W#0/:.0/480413,7.49.
,3,08.89'/,05,2/48084:/-070/:.0/-,9
0,8943097/47023,90/W,701:243947!!
70857,943/:73',/23897,943
W,39,35,9039870.0;35,703907,-034/,053083
-0/1477/434950729,2-:,9475,90398944507,90
,;0.01443,330.943
W4394735,90398970,90/14789,9:805059.:8
80:7082,70.:7,190739,.439745708:2,--0.,:8041
8479/:7,94341/7:0110.9W43947;07,3//30
1:3.943/:73439072907,5
8/3/2019 ER DRUGSTUDY
17/67
W%,507/48,07,/:,,1907
439072907,50850.,305059.5,90398
W77,3014705059.5,90398940,720/.,,079
3/.,939,990,7005059.89,398
20/.,943W8.:887841109,
,-3472,90895,90398/087394-0.4205703,39
8/3/2019 ER DRUGSTUDY
18/67
#&$%&!#
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
503/7,230
7,3/3,2003,/7
,881.,9433989,230
48,022
472
#4:90
706:03.
!70;0398
89,23020/,90/
708543808/7:574;/084.,
,308908,,3/8:55708808
.4:7010
,10;07
:79.,7,;,8424947
7398,3430:749.
0/02,/7:80389,943
807:2503.370,.943.439,.9
/072,998,945.0.02,4907
,07./072,94808
57:79:8144/80389;9
5,7384382249438.3088
',3/$
0110.98-44//847/078
/89:7-,3.08,392:8.,73.
0110.98,3/,07.
70,.9438
W43947.,701:,88088147
.431:843/07:24907,39.4307.8/00110.98,3/
1,783899:9020,8:70894570;0391,8
W8808824;02039/847/07-01470,3/,1907,/23897,943
W,:9435,903934994:8047,%/503/7,230574/:.989,34907574/:.9.439,33
/503/7,2303.:/3574/:.98:80/945.,
W9.,3.,:800.9,9433./703,:9435,7039847
.,70;078,-4:9574507/480
.,.:,9434;07/48,0
0850.,331,398,3/./703.,3.,:80,:.3,943880:708
47/0,9314725,90399,998/7:2,.,:80/724:9
706:03947,7380844/47,030,3/8:,7088:247
.,3/2,2320980110.9491/039891/724:9
507889814724709,3008
8/3/2019 ER DRUGSTUDY
19/67
#&$%&!!#
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
5305730
7,3/3,205305730
9,797,90
,881.,943$25,942209.
48,0
22
472
#4:90
706:03.
,9:7,
4..:77330:7497,3829907
900110.9841.,70
20/,90/-,5,47-09,
70.05947839,70947,38110.9843,5,
70.0594783.:/0;,84.43897.943
.4397,.94341/,9472:8.08
4178110.9843-09,70.059478
3.:/05489;0.74349745.,3/
349745.0110.9843900,79
-09,70.059478
-743.4/,943;,84/,943,3/
:9073070,,943-09,
70.059478/0.70,80/
574/:.94341,6:04:8:247
.:90,892,9.
,99,.8/;,3.0/
.,7/,.108:55479
/7483088
0,/,.0307;4:83088
9702478.070-7,
02477,0/3088
0,3088;07945,3
W439470,797,90
W&80097020.,:94303.,.:,93,3/5705,73/4808
053057308,;07549039/7:82,0774783/48,0.,3.,:80
8074:8,/;07800110.984:-0.0.50/,97./48,0
W&80232,/4808147232,5074/841920053057301,893088,147241/7:9407,3.0
.,34..:79574430/:80W!7490.9/7:84:943817429
0970200,9,3/17003/4349:805347-74384:94387:
84:943884:/-0.0,7,3/.447088/408349,5594
8:850384314730.943W$,0908:850384314730.943
0-014709/7,390/480W#49,90$30.943890894
570;03930.748824394730.94389081706:039
W005,7,5/,.93,5,,/70307.-4.0750394,230
47,;,84/,947,397,9070,/,;,,-03.,80410.088;0
5079038;070,.943W,;0,3,5,,/70307.-4.07
471,.90814739072990395489;057088:70-70,9370,/,;,,-0
8/3/2019 ER DRUGSTUDY
20/67
3.,805:243,70/02,4..:78
W005,-09,,/70307.-4.0757457,344,.,7/4800.9;0-09,
-4.078:.,8,9034484:/-0:80/35,90398970857,947
/89708870,/,;,,-03.,80.,7/,.,7792,84..:7
W43490.00/70.42203/0//48,0413,,943574/:.98
,/23890757088:70/3,,943/7:14728/:7380.43/,141
3857,943-0.,:8090,7,8,704503/07,3/90,07484
/897-:9438247009038;01,80.43/3,,9438300/0/
,/238907,950,0110.941570;4:8/48023
W&80945.,3,8,84:943843147,.:9089,908/4349:8014743079,3/,8,3//4349
0.00/70.42203/0//48,0#0-4:3/3,8,.4308943.,3
4..:7,1907;,84.43897.9438:-8/08
W43490.00/70.42203/0//48,0,/;07800110.984748841
0110.9;030882,708:9#0,/903897:.94389,9.4209
70857,9473,,39574/:.98,3/.438:94:70,9.,70574;/0747
5,72,.8914:,;0,36:089438
W%4;000/74580/4347990,/-,.,7/,3/44:5
4//745507,-4;000/74520/.3038/0407/0
8/3/2019 ER DRUGSTUDY
21/67
443:5434994:./74550794
001307847,38:71,.0#00,80407/005004503,3//4
349-3147,90,8980.55039057088:7091307894
38/0.47307419000147,-4:923,9,90,8923-01470
:83490700/7458W%0808/00110.982,4..:7
3088/74830881,9:0,557003843:80.,:9431/7;3
47507147239,889,9706:70,0793088,309024943,
.,3083,:80,;4293.,3039,8900,91706:03982,20,8
1,890,797,90,8,84:9432,.,:80-:733478933031789
:80/97,3803959,2.84:9432,.,:80898933031789:80/97,38039
0,/,.047-74,.043/:7390178910/,8
W#05479.0895,3/308838423,0,308897024747
770:,70,79-0,970857,9473,,393,8,84:943/11.:9
-70,93574/:.9;0.4:1,:7094708543/94:8:,/48,0
70857,9473,,39/0.70,803;8:,,.:9459,2.
8/3/2019 ER DRUGSTUDY
22/67
#&$%&$
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
:74802/0
7,3/3,20
54:74802/0
,881.,943
445/:709.8
48,0
22
472
#4:90
706:03.
3-98$4/:2,3/
47/070,-8475943,9
905742,,3//89,
9:-:08,3/90,8.03/3445
41030
/02,507903843
'07940,/,.0
/30885,708908,
0,308870890883088
10;0734.9:7,4:7,
54:7,
:7830,8:708W43947!,1907,/23897,943
W/2389079144/47294570;039:5809
W#0/:.0/48,01;0394907,395079038;0870,/:89
/48,07,/:,,8!708543/8W;00,7390/,849,9
3.70,80/:73,943349/89:7-8005
W;4/':80147,:808,9,5488-0
W434925,703907,84:9439,./.84:94389
5-04W4349054809492,
/8.4479,-0984784:943/4349:80/8.4470//7:4784:9438
W8.,7//:90/84:943,19077
W#01707,9047,84:943W0,8:70,3/70.47/0994
2439471:/.,308W77,3094243947807:2
00.974908/7,943;071:3.943
W77,30147549,88:27./09478:5502039,549,88:2,8
300/0/
8/3/2019 ER DRUGSTUDY
23/67
#&$%##
#&%$ $
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
/7,,30
/74.47/0
7,3/3,20$:5708
,881.,943,39507903843
48,022
472
#4:90
706:03.
,/70.9,.93507507,
;,84/,9479,970,08
,79074,7824492:8.08
475079038;05,9039
%,..,7/,5,59,943
,33,50.9478
80;0700,/,.0
/308809,3
/89:7-,3.08
57:79:87,8083,:80,
,3/;4293
W;047,/7:9144/943.70,80-4,;,,-9/7:
84:/-0;033,.4388903970,94385930894341144/
147.438890397085438094907,5
W7:2,.,:80,83/742070802-388902.:5:8
07902,948:8$77,30147.05705,7,9438,3/
99078-01470,3/5074/.,/:73574430/
907,50;03390,825942,9.5,9039
8.4393:01-44//8.7,8,84..:7#00;,:,90907,51
4790898,705489;0W77,3014757/43015,9039
/0;0458825942841507507,30:798
W439475,9039147479489,9.54903843.82489
2,70/39024733,3/3490,907,3/9,.4447
007.80
8/3/2019 ER DRUGSTUDY
24/67
#&$%#%$$&$&%
#&%$ $
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20/74.4798430
84/:28:..3,90
7,3/3,20
/74479$4:
47901
,881.,943.479.489074/
4724308
48,02222
472
#4:90
706:03.
0.70,80831,22,943
2,3-89,-3
0:4.9084842,
202-7,3088:55708808
22:3070854380
892:,908-4302,774,3/
31:03.085749031,9,3/
.,7-4/7,90209,-482
3/4.73002,944.
70:2,9..4,03
/847/078/072,944.
45970853045,89.
/80,8080/02,94:8
89,908.439744180;070
3.,5,.9,93,07.
.43/9438%203398
8:-,7,.34/-4.47
2503/3-4.03:80/
.43.:770399,557457,90
,39%.024907,5
84.80.43/,794,/7034.479.,
38:11.03.4784.
:37085438;094
:/,3/00.97490
/89:7-,3.08/0.70,80/
.,7-4/7,909407,3.0
25,70/4:3/
0,39317,083
2:8.00,3088
89074/245,9
48904547488,8059.
30.74885059.
:.07,9435488-0
507147,943.,9,7,.98
3.70,80/397,4.:,7
,3/397,.7,3,
57088:70749
709,7/,943
W;0/,-014709422.3472,50,/:73,
.479.489074/0;08,3/2320!8:55708843
W$5,.02:950/48080;03974:4:990/,
W4349;030.943815,9039,89742-4.94503.
5:75:7,W#49,9089084170548947
30.943894,;4/4.,,9745
W&80232,/4808147232,/:7,943942320
,/;07800110.98W%,507/480803
/8.4393:3/48047439072907,5
W77,301473.70,80//48,0035,903988:-0.994
:3:8:,897088W&80,9073,90/,
2,3903,3.0907,598479,.93.479.489074/8
030;075488-0W4349;0;0;7:8
;,..308922:348:557088;0/480841
/74.4798430
8/3/2019 ER DRUGSTUDY
25/67
.43;03943,
907,503,/7034.479.,
38:11.03.2,-05708039
:834/
89,90574903.,9,-482
58../07,3020398
0459,2482,8341
310.9438,853
83/742080:708
203897:,770:,7908
W!74;/0,39,./8-09003
20,89405,;4/5059.:.07
8/3/2019 ER DRUGSTUDY
26/67
#&$%&$$#%#%
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,2084847-/0
2434397,90
7,3/3,202/:7
,881.,943
48,0
472
#4:90
706:03.
%4:99470/:.0.,7/,.
403/02,3/-/0.70,83
5704,/,3/,19074,/7:
,842,3.70,80-44/
14974:90.4,907,
.4743,7;08808
!745,.9.970,9203941
,33,50.9478
0,/,.054903843
/3088,3/3,:80,
9,..,7/,
W43947!,3/0,797,90W880884.,943/:7,943
390389,3/570.59,931,.947841,33,5,3
8/3/2019 ER DRUGSTUDY
27/67
#&$%&$$#%#%
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,2084847-/0
/397,90
7,3/3,20
8409'
,881.,943
,39,33,/7:
48,0$94.'
,2522480
22
472
#4:90
706:03.
84847-/0/397,908,
824492:8.070,,3998
5,79.:,70110.9;043
;,8.:,7,3/-743.,
824492:8.09888902.
.,7/4;,8.:,70110.98,70
2,3/:094,/0.70,803
;034:8709:73544341
-44/390507507,
;034:88890243806:039
;0397.:,703//,894.
57088:70,3/;4:20,70
/2380/9:870/:.3
.,7/,.47,3/25.9
24.,7/,
&37085438;0019;0397.:,7
1,:7080.43/,794,.:90
80;07047:389,-0,33,
50.9478
$0;070.070-7,14/01.03.
,3//0.70,80/.4743,7
5071:8432,/0;045397,90
0,/,.0,3/3,:80,
W43947!,3/0,797,90W880884.,943/:7,943
390389,3/570.59,931,.947841,33,5,3
8/3/2019 ER DRUGSTUDY
28/67
403
706:7020398%0,7907,
;08808,70/,90/,80
94:94,08807/0700
%8708:983,89/7453
,479.,3/88902.-44/
57088:70700;390
24.,7/:21742,5,7941
98,19074,/%080397,90
3/:.0/.,308,..4:39147-4990
,39,33,
0110.984184847-/0/397,90,3/147
98-0301.,0110.98390
970,9203941.43089;00,79
1,:70
8/3/2019 ER DRUGSTUDY
29/67
#&$%&$&$&%
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
,308:2
$:1,90
7,3/3,20
3,308:2
$:1,90
,881.,943
,39.43;:8,39
48,0
22
472
#4:90
706:03.
,/0.70,80,.09.430
700,80/-307;025:808
-:998,39.43;:8,39
20.,3828:3343
%70,9203941542,30802,
,..425,30/-83841909,3
.4397441%03.05,45,9
.43;:8438570;03943
.4397441
.43;:84383
5,903985700.,258,47
0.,258,570;0394341
542,30802,35,90398
70.0;3%!
1:8380,93
549038432:8.:,7
0,308880/,943
.431:843/0.70,80//005
903/4370100870855,7,88
W43947901443'#,5/,/23897,943
2439473;9,838/005903/437010082,308:2
.,.:2,3/549,88:20;08703,1:3.943/:73
,/23897,943-89097.8!,903989,9:83.:/3;9,838
4038,9:7,943/005903/437010080;041.438.4:83088
109,0,797,902,9073,:90730,.9;97,#03,1:3.943
2,308:20;08-4024;020398
8/3/2019 ER DRUGSTUDY
30/67
#&$%&!###
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
0507/30
/74.47/0
7,3/3,20
02074
,881.,943
39;0794/7:
48,0
22
472
#4:90
706:03.
3/8945,9070.059478
390$,9073
507.0594341,3/024943,
70854380945,3
#0014124/07,9094
80;0705,35704520/.,943
8:5547941,30894-8909
,3,08,
#0857,947/05708843
.7.:,947/05708843
70857,947,7708984.
.,7/,.,77089/89:7-,3.09
0,/0/3088/3088
80/,9433,:80,;4293
80,930:547,
/8547,0,3088
0,/,.0970247,9,943
:3.447/3,90/2:8.0
24;02039880;070
.43;:843897,38039
,:.3,9438/847039,943
;8:,/89:7-,3.0
1:83
W,0548943.,30884,3/389,085,79.:,71742
70.:2-03994:5795489:700/43220/,9019
0,/0/308847/30884..:78W0/43031003
3,:80,90/,3/94349158.,31988259425078898,:80,
,550,7894478039,2-:,943
W;4//7;3,3/4907549039,,,7/4:8,.9;908
:3970,.94394/7:83434/0302,25,7,-994
50714729,88706:732039,,0793088,3/9070147094
W43499,0,.44474907$/057088,398:3088,5574;0/
-58.,3W507,.9;0.4:2,-0
088030/-,;4/3779,3988:.,88243/:891:208,3/
4907,754:9,398:2/1.,94341,2-039,7
2,574;/084207001W4349-70,89100/09,3
98/7:
9,..,7/,
8/3/2019 ER DRUGSTUDY
31/67
9,..,7/,
-7,/.,7/,5,59,943
5490384383.450
50-98:73,770903943
,07.70,.94385,3,9
30.943890,3/4.,988:0
779,943
8/3/2019 ER DRUGSTUDY
32/67
#&$%&%!#
#&%$ $
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
094.457,2/0
7,3/3,20
54094.45,07,3
,443:094.457,2/0
.9,2/0!$#0,3
,881.,943
,390209.,3985,824/.
48,0
22
472
#4:90
706:03.
$92:,908249941
:550797,.93.70,808407
0845,0,853.9079430
,3/-4.8/45,230
70.059478,990.02470.05947
9707430
89:7-,3.08412499
3,:80,;429341
.0397,507507,473
,884.,90/8:707
209,-4./80,808
310.94:8/7:3/:.0/
/80,8081,.9,9082,
-4039:-,9437,/44.,
574.0/:70841%
97,57,2/,
70,.9438/7483088
1,9:0,889:/0
,3090881706:039
38423,0,/,.0
/30883,:80,
,,.94770,30.42,89,
-40/89:7-,3.08
W43947!.,701:/:73',/23897,943
W43947147097,57,2/,70,.9438,3/.438:958.,31
904..:7W43947/,-09.5,90398
,77,30147,907,943338:3/480479231/,-09..43974
8.42574280/-,907,9438392341144/,-8475943
W005/503/7,23030.94370,/,;,,-03.,80
097,57,2/,70,.94384..:72
W,;050394,23070,/,;,,-03.,80415079038;0
.78824890944..:79:3/,3480/
504.7424.942,
#& $%& ##
8/3/2019 ER DRUGSTUDY
33/67
#&$%#
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
/,4,2
/74.47/0
7,3/3,20
472.:2
,881.,943
5349.880/,9;08
48,0
22
472
#4:90
706:03.
,549039,90900110.9841
/05708890$,3/
8:557088908570,/41
80:70,.9;9
89:7-,3.08418005792
38423,085/11.:93
1,3,8005090739,47
,19075702,9:70,,033
9,-380/,943357020/-01470
8:7.,47/,3489.
574.0/:7083/:.943
2,3903,3.041,3089
#,70.,7/470857,947
,/;07800;03983,:80,
;42930,/,.0
..4:8,73485,82
/85340,,:.3,943
4;0780/,943/7483088
,9,,7,85,7,/4.,
70,.9438,2308.
0584/08
W4349,/238907397,,7907,.2,574/:.0
,7907485,8247,37030W4349:8082,;038/478:2
41,3/47789147'30.943W/23890730.9438/005
3942:8.0W43947'30.943890147
097,;,8,943W77,309470/:.0/48041
2/,4,215,90398,84-03;03454/,3,08.870/:.0
/48,0-,90,89,3/2439475,9039.480
W439470;041.438.4:83088574794/:73,3/147,90,89
7,1907,/23897,943412/,4,2
W,701:243947!!,3/70857,9438.,701:/:73
,/23897,943W005708:8.9,9;01,.908
70,/,;,,-0,;01:2,03,;,,-0,8,39/49014;07/480
84:/4..:7W0055,903983-0/1477/4
34950729,2-:,9475,90398944507,90,;0.01443,3
30.943W77,3094243947;07,3/
/301:3.943,3/,9
3907;,8/:73439072
8/3/2019 ER DRUGSTUDY
34/67
907,5W89,-88,109570.,:94381
$.,3084..:7:808/07,8,..425,3,2-:,93
5,9039W!74;/0.42147920,8:708,3/
70,88:7,3.01475,9039870.0;3/,05,2147909,3:8
W77,30949,507/48,07,/:,,1907439072907,5
W!74;/05,903997990331472,94370,7/370.4;07
,3/144:5.,70/,4,28,549039,2308,.,3/20247
2,-0,9070/
#&$%!$&%
8/3/2019 ER DRUGSTUDY
35/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20475308:1,90
7,3/3,20
473
,881.,943
3,08.854/
48,0
/:92
$7$0;07047.743.
5,3/32$7
7,302
7272292.
292.7,2
3,08.0110.9!0/
2.$72,2/480
472.84'!7045
2.2,2/480
9078507.05943,3/024943,
70854380945,3
#0014124/07,909480;0705,3349
7085438;0943433,7.49.
,3,08.8!7020/
3,08.
,/:3.930307,,308908535,3
,884.,90/.,3.07
8:7070;,908
,309
,884.,90/80;0705,35349.147
5,370,90/80050883088
90,/0/3088/3088
80/,9433,:80,;4293
.43895,94380,93
W,:9435,903934994.047.7:8.439740/700,805705,7,9438
W:90,3/,/23890784'942320044/41,/;0780
0110.98W%05,9039940/43/:73
',/23897,943
W005454/,39,4389,3/1,.908147,88890/47.439740/70857,94370,/,;,,-0
/:73',/23897,943W&80.,:9430330.93$
47394.0/,70,84735,90398954903843473
84.25,70/5071:8432,
/0,,-847594397050,90//4808,30.088;0,24:392,-0,-847-0/03.7.:,9438
7089470/W#0,88:705,903989,990,70
:3094-0.420,//.90/24895,90398470.0;0454/8
14720/.,70,8438/4349/0;045/0503/03.083/74208
#&$%!##
8/3/2019 ER DRUGSTUDY
36/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
.,7/530
/74.47/0
7,3/3,20
,7/0530
,881.,943
,.:239,43898
48,0
48,0'31:843:9094
22.43.41
39,31:8437,90
27997,90/480:59427
:39/0870/907,50:9.
708543808,.0;0/!
22$!22
472
,.:2.,330-4.07
9,93-98,.:243
31:,.7488.,7/,.,3/
824492:8.0.08,84
/,908.4743,7,790708,3/
,7907408
5079038;0020703.0847
:703.0850745548945
%5079038;0
89,90841!5,90398
!07507,0/02,
0,/,.09,..,7/,
5,59,94384.,0/
9742-450-98
54903843
W!,90398905,9.25,7203984:/70.0;0407
/480W43947-44/57088:704
,90,89/,8-09003/48,0,/:89203994,.0;0890,/
5,82,0;08W/;805,903994705479
220/,901050703.3.0895,3
#&$%&%!%
8/3/2019 ER DRUGSTUDY
37/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
%5,9.
7,3/3,20
05439397,3970974:7
974/8.%7,38/072974
,881.,943
3933,7:8
48,0
$9,793/48027483
8.0/:0,5,9.435074/41
7/,5,9.4115074/41
7
472
#4:90
706:03.
397,909,970/:.08.,7/,.
403/02,3/-/0.70,83
019;0397.:,703//,894.
57088:70,3/94,0880709039
88902.;,8.:,7
70889,3.0,843.70,808-44/
14974:.4,907,
.4743,7;08808
!70;0394341,33,50.9478
/:094.4743,7,7907/80,80
0,/,.0%7,38039
0584/084190,/0/3088
31706:03954903843
$3.450.708.03/4
,33,70-4:3/%,07.
,3,5,.94/70,.9438
#,7080;070,55.,943890
779,943
W/23890797,38/072,8890289483890170041,7,3/349
8:-0.9942:.24;02039$,;0,70,89,9,;0,4941
,74349,5594/89,09702908,30890889
94/0.70,8090.,3.0414.,779,943,3/80389,943
#024;097,38/072,88902-01470,9902593/01-7,94347
.,7/4;07843W%4:8097,38/072,8890284:
2,300/948,;0,3,70,147,55.,9435594,89
/1107039,70,0,./,&80.,701.,33-7,3/80,.88902
,8,/1107039.43.0397,943
#&$%&!#%
8/3/2019 ER DRUGSTUDY
38/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
!,7,.09,24
7,3/3,20
03
,881.,943
3,08.843
54/395709.8
48,0
/:9./3_72
^720503/343
80;07941.,80/4802,-0
7050,90/7380;070.,808/480
2,-0,/2389070/-'
;0784
472
#4:90
706:03.
!74/:.0,3,08,-
-4.35,325:808-
3-9383908841
57489,,3/33$700;08
10;07
!70,41:3343473
0;075,3,884.,90/
.42243
./44/
/847/078943898:5507
708597,.9310.94385489
22:3,94370,.9438,1907
94380.9424907.43/9438
!70;039434110-70
.43;:8430,/,.0.4/
83:8982:8.05,3,79798
9449,.0
02,944.,834907
,07.70,.9438
W&806:/1472147./703,3/5,903984,;0/11.:9
8,43W3./703/4390.00/1;0
/480834:78W/;805,90399,9/7:843
14784799072:80,3/94.438:99058.,31;394./703147
43079,3/,847,/:9814743079,3/,8
W/;805,903947.,70;079,92,34;0790.4:3907574/:.98
.439,3,.09,234503-0,,70419803.,.:,93949,
/,/480W,735,90399,9/480847
:38:507;80/439072:80.,3.,:80;07/,2,0
#&$%&!%
8/3/2019 ER DRUGSTUDY
39/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
!03943
7,3/3,20
,393
,881.,943
39.43;:8,398
48,0
/:939,29/
,3903,3.02/,
/3_739,2
9/8:-806:039/48,084:/-0
,/:890/,..47/394907,50:9.
7085438072-/2,-0
3.70,80/9429/476/!0/,
2/,39,306:,
/;/0//4808,2
/,
,89,-0
30:743,202-7,308,3/2980:70
,.9;9-0907-
3.70,83011:47
/0.70,8331:41,
438,.7488.0202-7,303
9024947.4790/:73
0307,94341307;025:808
%43..43.
.42505,79,58.424947902547,4-0
570;03943970,9203941
80:7084..:773/:73
47144330:748:707
/89:7-,3.08
,9,,8:770/8500./545,389,2:8
2039,.431:8430,/,.0
/30883;,
5075,8,78:982
507.02,489042,,.,
W880884.,943/:7,943
1706:03.,3/.,7,.90789.84180:70,.9;92,-02439470/5074/.,
974:4:9907,58808847,030'474:847,.0,33
-033393/,84139,94341503943907,5
2,05.439743;,5075,8,
8/3/2019 ER DRUGSTUDY
40/67
#&$%&%#&%
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$0307.3,20
%07-:9,30
7,3/3,20
7.,3
,881.,943
39,892,9.
!
48,0
39,892,9.
!!705,7,9438
472
#4:90
706:03.
#0,08-743.,
824492:8.08-892:,93
-09,70.059478
4770;078-0,7,8
4-897:.9433,892,!
0.70,808:90730
.4397,.992,-0:80/94
,770895702,9:70,-47
30970247418009,2:8.0
085,3/85,59,9438
9,..,7/,307;4:8903843
0,/,.0507507,
;,84/,943
W&80232,5074/841920/7:9407,3.0.,34..:79
574430/:80W005-09,,/70307.-4.07
70,/,;,,-03.,80.,7/,.,7792,84..:7
W434970.42203/0//48,0
#&$%&'#!##
8/3/2019 ER DRUGSTUDY
41/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
'07,5,2/74.47/0
7,3/3,20
,,3,,3$#
4;07,$8459384593
$#'070,3'070,3!
,881.,943
,.:239,43898
48,0845939,-/:9
29/6/,2
/,/372-/9/
:5942/,./3^7
2-/9/84593$#
4743,738:11.03.9,-
-/&8:,/,/4802
5079038439,-
0.70,808
24.,7/,.4397,.99,3/403
/02,3/9,84/,908.4743,7
,790708,3/,7907408
8459384593
$#88039,507903843.743..4743,7
38:11.03.,33,50.9478
5,7482,8:57,;0397.:,7
9,..,7/,9,.,7792,8
439072970,92039,1907
84593$#88039,
507903843
43895,943
/30883,:80,#,70;0794
0,/,.054903843
,300/02,1:831,9:0
307;4:830880797420,,
5,7,08908,30:745,9
-7,/.,7/,.,7792,8
8530,
W439475,9039.,701:!
.,7/,.792,3/4:95:90/7:8-03997,90/94907,50:9./48048,02,-0
3.70,80/24707,5/34859,0/5,90398:3/07.480
8:507;843W38:709,95,90398,48$#
9,-09840/4349.:9.7:847.0902
W43947!;07.,701:9.43.:77039/480841
,395079038;08W43947.,7/,.792
70:,7/:7389,-,94341/48,0,3/5074/.,/:73
439072907,5W/2389078:89,30/700,80
1472390247339144/94/0.70,80:5809
W!7490.9'84:94317429W439475,903989703,47
05,9.25,72039.,701:1475488-0/7:,..:2:,943,3/
,/;078070,.9438
39024733
84593$#
8/3/2019 ER DRUGSTUDY
42/67
59,-39024733
1706:70/,19073.70,80/480
949,-/,84593,252
84'1706:70/2
,190723%031706:70/
.4393:4:8/7531:84341
27:5942/,33,
50.94787,5/023,94341
9,.,7792,8,25'1706:70/-/9/
472
#4:90
706:03.
#&$%&!#%#!&%
8/3/2019 ER DRUGSTUDY
43/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
57,9745:23,,943
7,3/3,20
974;039
,881.,943
39,892,9.!
!705,7,9438,39.4307.847
,392:8.,73.8
48,0
/:93.:/3
0/07,/408.0397
.:90,99,.8;,2,7050,9
/4808:395,9039889,-0
472
#4:90
706:03.
9478-
-3/394850.1.70.059478
.,0/2:8.,73.
70.059478390,7,053
9470,90824492:8.0
4190,7,03:80/94
970,9,7:3334809478
-/0.70,8390574/:.943
411:/390,3/89,930
903,8,5,88,08
743.4/,947
147970,9203941-743.485,82,884.,90/
!3.:/3
.743.-743.98
025802,,3/,892,
0,/,.03,:80,
/724:93.70,80/0,797,90
5,59,94384.:,7
,..4224/,943/89:7-,3.08
2499/89:7-,3.08
:73,7709039434.:,78/00110.98
.4:4.,779,943
-743.4.43897.943837,8
,340/02,:79.,7,
,73485,82,3,5,.9.
70,.9438
W!7490.984:9431473,,943
17429$9470:3:80/;,831454:.W&8030-:0724:950.0
3890,/411,.02,894,;4/-:770/;84347,7,;,94341
3,774,30,:.42,W,32,-:9074330-:07
147:5947W38:70,/06:,90/7,943
.4397403;7432039,902507,9:7094570;039
507570,W,;05,9039;4/-01470
9,320/.,94394,;4/:73,770903943
W%0,.5,9039574507:80413,,947
#&$%&%#!#%#!
8/3/2019 ER DRUGSTUDY
44/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
034907457,9745:2-742/0
7,3/3,20
074/:,
,881.,943
39,892,9.
!!705,7,9438
48,0
074/:,
3,,943843/:93.:/3
0/07,/408.0397
%70,92039412147220/,90
82594270013907299039
439072970,920392
1470,.,/23897,943:5
946/4/07,90-743.485,8247
,88890/
4790
570;03943,3/970,920394170;078-0
-743.485,82,884.,90/9
-743.,,892,,3/
0850.,.743.
-743.9894794:9
025802,
!70;03943,3/
970,920394182594283.743.
4-897:.9;0,7,/847/078
970;078-0-743.485,82
3097024741
8009,2:8.08307;4:8308870890883088
5,59,94380881706:039
9,..,7/,/308847
0,/,.0724:9974,9
779,94347,07.70,.9438
.4:5,7,/4.,
-743.4.43897.9437,70&73,7
709039432,4..:73
5,79.:,735,90398
57008934:91497,.9
4-897:.943
W!7490.984:9431473,,943
17429$9470:3:80/;,831454:.W&8030-:0724:950.0
3890,/411,.02,894,;4/-:770/;84347,7,;,94341
3,774,30,:.42,W,32,-:9074330-:07
147:5947W38:70,/06:,90/7,943
.4397403;7432039,902507,9:7094570;039
507570,W,;05,9039;4/-01470
9,320/.,94394,;4/:73,770903943
W%0,.5,9039574507:80413,,947
;039,943
2/3
8/3/2019 ER DRUGSTUDY
45/67
7%70,9203941
,99,.823907299039
439072970,92039
21470,.,/23897,943:5
946/4/07,90-743.485,8247
,88890/;039,943
2/37-4/9
&5942:5949/074/:,
&'/:9./37.:90,892,
0584/08;,3
;0780;070.,808;,8,70300/0/3907299039
439072970,92039;,:5
946/
472
#4:90
706:03.
#&$%&&$
#& $ %$ %# '#$ $ $
8/3/2019 ER DRUGSTUDY
46/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
:/0843/0
7,3/3,20
$2-.479
,881.,943
479.489074/8
48,0
2.
/48082./4808
2./4808
472
#4:90
706:03.
47-
70/:.331,22,943.058
980;07,.43/9438
7,331742,892,94
,0708947438
/80,80
#0:,7
970,9203941,892,070:8041,
.42-3,9433,0/
.479.489074/,3/43,.93
-09,,43898,557457,90
-/423,5,3
.43:3.9;985300.4:/,770,
0,7310.9434731,22,943
10;071:3,310.9433
24:90,/,.03,8,
4783:831,22,943
3480-00/5,37,870857,947
310.9438942,.47
390893,31,22,943
974,931,22,943
;7,310.943;4293
003
W%,50788902.89074/8
.,701:/:7397,38107943,,943,89074/8/0,981742,/703,38:11.03.,;0
4..:770/W77,30147:8041/0.43089,39
3480/7458941,.9,90503097,94310/02,0.088;0
80.709438,705708039W!720:39-01470:80147
!:2.479%:7-:,07,;05,9039738024:9,19070,.:80
W&80,0748493244145033$,00-014700,.
:80W$9470#085:08:579,3/
57490.90/174290398,0-01470:80450303;04508
84:/-0/8.,7/0/,1907
#&$%&&%#!#%#!&%
#& $ %$ %# '#$ $ $
8/3/2019 ER DRUGSTUDY
47/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
-:9074,3/57,9745:23,,943
7,3/3,20
42-;039
,881.,943
743.4/,9478
48,0
/:95:1189/6/,
5:118/,&39/480;,/:9
./37;,0;077
/37/7458/480
2,2.418,-:9,240;07
7
472
#4:90
706:03.
:8.08390
,7,8,3/3.70,80,7149490
:38
,3,0203941
70;078-0-743.485,82,884.,90/9
4-897:.9;0,7,/80,808
35,903984706:702470
9,3,830-743.4/,947
3097024741
8009,2:8.05,59,94380,/,.0
/3088307;4:83088
/730884124:9974,9
779,943:73,770903943
W&8030-:0724:950.0
3890,/411,.02,894,;4/-:770/;84347,7,;,943413,774,30,:.42,
W,32,-:9074330-:07147:5947
W38:70,/06:,90/7,943.4397403;7432039,
902507,9:7094570;039507570,
W,;05,9039;4/-014709,320/.,94394,;4/:73,7
70903943W%0,.5,9039574507:8041
3,,947
#&$%&$&%
#& $ %$ %# '#$ $ $
8/3/2019 ER DRUGSTUDY
48/67
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
$&%
7,3/3,20
074'039
,881.,943
-743.4/,947
48,0
/:9./3
2
472
#4:90
706:03.
6/
:80/9,39
31,22,94720/.,94394570;039,892,
,99,.8$420419080
20/.308,70:80/94970,990
825942841,892,.743.
-743.98025802,
,3/4907:3/80,8080
49078,70:80/94570;03990
8259428
970,9203941
,.:9080;070,892,,3/374:930
2,3,0203941.743.
-743.485,82:37085438;094
.43;03943,907,5
3088
80;070100341.43779,94347
8033974,91:83
4770/30884183;08
3.70,80/8479308841
-70,9837,8803411,.0
584700/89930883.089
47003974:-0/
-70,93
W88088:384:3/85:80,3/
-44/57088:70-01470,/23897,943,3//:7350,4120/.,943490,24:39.447
,3/.,7,.9074185:9:2574/:.0/
W439475:243,71:3.94390898-0147039,93907,5,3/
5074/.,974:4:9.4:78094/09072300110.9;0308841
20/.,943W-807;01475,7,/4.,
-743.485,820031.43/9434..:7894/
20/.,943,3/349158.,34749070,9.,70574108843,
220/,90W3897:.924907949,02880/
/480,88443,870202-070/85,.3702,33/4808,9
70:,73907;,84349/4:-0/4808473.70,8090/48047
1706:03.41/4808W314729024907349948240
30,790./,3/94,;4/70857,947779,398
W/;80902490794738090./824:99,907,1907
0,.3,,943/480942320/724:9
8/3/2019 ER DRUGSTUDY
49/67
#&$%&%#&%$&%
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
%#&%$&%
9478-
/,9345033 90
700141
-743.485,8234-897:.9;0
0,/,.0
3,:80,;4293
W&80232,5074/841920
/7:9407,3.0.,34..:79574430/ :80
8/3/2019 ER DRUGSTUDY
50/67
$&%
7,3/3,20
!:243
,881.,943
39,892,9.74.4/,947
48,0
/:92/7032
472
#4:90
706:03.
4503390
-743.4084190:38-
70,3902:8.08,74:3/
902%8,48147
0,807,714394,3/4:941
90:38
4-897:.9;0
,7,/80,808
;4293
5,59,94389,..,7/,
80,93/7483088
574430/:80
W005-09,,/70307.-4.0770,/,;,,-03.,80.,7/,.
,7792,84..:7W434970.42203/0//48,0
#&$%&!#$&
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
!#$&
..007,908
1472,94341,399742-3
970,92039,3/
5745,8419742-402-4.
$910;07
0,/,.0.83,:80,;4293
W,8030-44/.4,:,943
90898.9-#,3/5,9009.4:39857479439,94347
8/3/2019 ER DRUGSTUDY
51/67
7,3/3,20
7994305,73,
,881.,943
39.4,:,398395,90098
-7349.8%742-49.8
48,0
:2
:2
472
#4:90
706:03.
9742-3.4250,3/
/0,.9;,9089742-3
570;0393.43;0784341
1-73403941-73
/847/078
.43895,9430589,8
-7:8389,02,9:7,83
30.7488$348904547488
,450.,50780389;9
70,.94383.:/0:79.,7,
.43:3.9;987398,892,
,340/02,,3/,3,5,.9.
84.!7,582!49039,,9,05,733/:.0/
9742-4.94503,
94794:99742-488-00/3
5
907,5,3/,970:,73907;,8974:4:9907,5
W43947!%%0;08.480W7,-44/147.4,:,943
9089823-014700,.8.0/:0/$473907299039'
/480,3/,55742,90614759870.0;3.4393:4:8'
05,73/:73/48,0,/:89203985074/1907/48,0
8089,-80/908982,-0/43043.0/,
W!98;,7/0390770,.9439405,73784102477,0
,550,7870,908934203,5,90398,3/5,903989;07/80,8047703,
38:11.03.
W43947;9,870547910;07/7453!7,5/5:80,3/4907$$4102477,0
W-807;0,300/08908/,14702,942,,3/83841
31,22,943W,;043,3/5749,230
8:1,90850.1.05,73
,39,4389
#&$%&$##
#&%$ $
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
$##
,88
,39,7792.,3/:97,8479
8:57,;0397.:,7
9,..,7/,54894507,9;0
54903843
-7,/.,7/,0,791,:70
W439475,9039.,701:!
.,7/,.792,3/4:95:90/7:8-03997,90/94
8/3/2019 ER DRUGSTUDY
52/67
7,3/3,20
70;-4.
,881.,943
09,-4.078
48,0
22
472
#4:90
706:03.
,.93800.9;0-09,-4.07
9,9/0.70,8080,797,90
.4397,.99,3/-44/57088:70
5 5
9,..,7/,47507903843
343.425038,947
83:89,..,7/,8
397,4507,9;09,..,7/,47
507903843:389,-0,33,
343$%80203900;,943
4.,779,943/,547088
507507,8.,02,
/30888423403.0
.431:8431,9:0
5,7,08908,507507,
30:745,90,/,.0
0,3088779,-9
/85340,3,:80,;4293
-:770/;843
:73,77090394310;077472:8.:,7
5,3!49039,,9,!7414:3/
-7,/.,7/,'-4.
.,7/403.
84.,88940-743.485,82
907,50:9./48048,02,-03.70,80/24707,5/3
4859,0/5,90398:3/07.4808:507;843
W43947.,7/,.79270:,7/:7389,-,94341
/48,0,3/5074/.,/:73439072907,5
8/3/2019 ER DRUGSTUDY
53/67
#&$%&
#&%$ $%
%$ %#%$
'#$#%
$%$
$#$!$%$
0307.3,20
8250,907
84:-08:,79,923208
147
54.02,
4.,5,3;03
779,9439742-450-98
W4394731:8437,90
1706:0391838411:/4;074,/9:73411'/75
8/3/2019 ER DRUGSTUDY
54/67
7,3/3,20
!
!,72,0,99,39.097480
,881.,943
397,;034:8907
$9070$4:9438
48,0
472
#4:90
706:03.
.430403088,3/57424908
,3,-48235,90398480
47,.,47.39,08290/
988:030.74883900;03941
097,;,8,943:/00.97490
2-,,3.0054,02,
542,30802,
545485,902,0/02,47,907
394.,943
31:8432,708:931:/4;074,/
W0.'8901706:039,3/13197,94383490/
9:73411'/75W,9.4:9147838411:/
4;074,//8903/0/30.;038'7,5/
70857,94388,49/,;4:20130,:8.:9,947
.7,.08/8530,,3/507507,0/02,
W,9.4:9147838413197,943803,3/5,3
,74:3/'890
#&$%&!%$$
#&%$ $
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307. 3,20 #05,.08 147 :.07,943 W 43947 807:2 549,88:2
8/3/2019 ER DRUGSTUDY
55/67
0307.3,20
!%$$
7,3/3,20
!!,72,0,99,39.
!49,88:247/0
,881.,943
0.974908
48,0
20682
472
#4:90
706:03.
#05,.08
549,88:2,3/2,39,38
549,88:20;0
147
54,02,,.:90
:.07,943
842092089,02477,0
,3/507147,943479,90
1472,94341897.9:708
144390:804103907.
.4,90/
.47/0
5705,7,943507,,02,
7,,:80,;4293
50-9,3/,-/423,
.7,258'!,34750-98.,7/,.94.9
43947807:2549,88:2
0;08703,1:3.943,3/807:2-.,7-43,90
W5,3945,90395:75480419020/.,943,3/90300/94
9,0,8/70.90/0850.,03.43.:77039/4347
/:709.8,709,032880//48084:/-09,03,88443,8
70202-070/9371349709:739470:,7/4808.0/:0
4349/4:-0/480W25,80.4770.92094/41
,/23897,943779,94347:.07,9432,708:91742
.0303907..4,90/9,-0984738:11.039/:943416:/
4754/0714728$4200903/0/700,809,-098,70.439,30/3,,2,979,9
2,-00500/3908944%84..:7703.08349
831.,39W3897:.95,903994,;4/8,9
8:-899:9084748,9247144/:3088,5574;0/-0,9
.,70574108843,W!,903984:/-0,/;80/94
70,/,,-0894570;0390.088549,88:239,0
W/;805,903970,7/384:7.0841/09,7549,88:2
W3.4:7,0.425,3.09
70.42203/0//09
W3897:.95,903994705479/,79,7747-44/89448
0,3088 :3:8:, 1,9:0 47
8/3/2019 ER DRUGSTUDY
56/67
0,3088:3:8:,1,9:0479334109702908
W4910,9.,70
574108843,13,:80,;4293/,770,478942,./8.4214795078898
W48,02,706:70,/:89203925,8090
25479,3.04170:,7144:50,2894243947807:2
0;08,3/5747088
#&$%#
#& %$ $ %$ %# '#$ $ $
8/3/2019 ER DRUGSTUDY
57/67
#&%$ $
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
0307.3,20
##7,3/3,20
--499/4.,30
,881.,943
3,08909.84.,
0307,
48,0
2;,
472
#4:90
706:03.
.,88,39,7792.
9,9/0.70,80890
/054,7,943,:942,9.9
,3/0.9,-9390;0397.08
/:7390/,894.5,80
-/70.9,.9434390988:08
0850.,90!:730
30947
4.,477043,,308908,
#0890883088307;4:83088
/30889339:8-:770/;843
:580982:8.099.3
.43;:84383:2-30884190
943:054903843-7,/.,7/,
2090244-3,02,109,394.,943
W0./7:.43.0397,943.,701:2,3
.43.0397,9438,70,;,,-0W#0/:.0/48,09
05,9.47703,1,:70W4393:4:8243947
7085438003:80/,8,39,7792.4730.90/,8
4.,,308909.W005108:55479
06:52039,3/;,845708847870,/,;,,-03.,80
80;070,/;078070,.943$'4770857,947
4..:7803/4.,30830.90/
W89,-88,109570.,:94381$.,308
4..:7,;0'/,05,2478479,.93-,7-9:7,90
945039,9,2,70,/,;,,-03.,8041
80:708
W439471472,3,395079072,,2:8.085,827/9,;010
8:5547906:52039,3/'/,39740304389,3/-
W%97,90/48094232:2300/0/147.,7/,.89,-9
03:83/4.,30,8
,39,7792.W#0/:.0/48,003
970,93 ,7792,8 3
8/3/2019 ER DRUGSTUDY
58/67
970,93,7792,83/9,894.99'
-4.,3/07,97.5,90398
W439471:/4,/.,701:2470.43.0397,90/84:9438.,3-0:80/94970,9
,7792,835,90398431:/70897.9438
W,;05,903984,;070.0;0//4.,30,8,853,
,308909.702,331,91477,1907,7/,3/
038:709,990,70,/06:,90/7,90/94
232078410,/,.0W0./4.,305705,7,943.,701:
053057308,//0/94
84:943841/4.,3094709,7/90,-847594341904.,,308909.174290
30.94389008:709,98:.84:9438,70:80/
W4394574/:.04.,,308908,%08084:9438
84:/-030.90/.,:94:8
3-4/,70,88:550/-03/,790708,3/:80/.,:94:835,903989
507507,;,8.:,7/80,8050790384397494.488
47/,-0908W&80.,:94394570;039
.43!,90392,,;0
/11.:98,431443:804147,945.,
,308909. 4 349 ;0 144/
8/3/2019 ER DRUGSTUDY
59/67
,308909.4349;0144/47/731477,1907:8041
47,,308909.
W%70,92090244-302,9209030-:02'4;0723
W55/4.,304392039847.70,2894,,:047
-,3/,0-01470,553949083
W439471478,10,3/0110.9;0807:2/7:
.43.0397,9438,39,7792.:80
2.248082.2,70:8:,94.
#&$%&$%
#& $ %$ %# '#$ $ $
8/3/2019 ER DRUGSTUDY
60/67
%$ % %$ #% %$ #$!$%$
0307.3,20$&
#%
7,3/3,20
4857,$4/:2.,7-43,90
,881.,943
,3078
48,0
262
262
472
#4:90
706:03.
#0894708-:11073
.,5,.94190-4/,3/
30:97,080.088,./
209,-4.,./488
88902.47:73,7
,,3,943,39,./.,7/,.
,77089
%09,30/02,,897.
/8903943-0.3
1,9:03.054,02,
209,-4.,,488
5073,9702,.02.,
.0:98-0.,:8041,,39
5,3779,943988:030.7488
:.07,9434784:3,990
890413197,943
W/43499,0/7:9294,;4/507.,.02,,-3472,
,,393988:08,3/1:/847/30894308
W/4349;0945,903989209,-4.4770857,947,,488
,3/39480954.,.02,3.,,4882,574/:.0
909,350790384380:708470,791,:70
W243947147,,488-4-9,33-44/5!,!
,3/00.974900;08
#&$%&!
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
8/3/2019 ER DRUGSTUDY
61/67
0307.3,20
!7,3/3,20
397453
,881.,943
/70307.8
$25,942209.8
48,0
222
22
472
#4:90
706:03.
$92:,908
/45,2307.,3/,5,-09,70.05947814790
825,909.307;4:888902
708:933,5489;0
349745.0110.9
,3/3.70,80/.,7/,.4:95:9.9438/480
70,90/,70/4808.,:80
2,3,5,892:,943
84.,3/
024/3,2.2-,,3.0854903843
0.945.-0,98
9,..,7/,,33,5,35,59,943
54903843;,84.43897.943
;0397.:,7,7792,8
507903843
0,/,.0,309/,90/5:583,:80,
;4293/0.70,80/:730
4:95:9/8530,
W43947;9,838,3/
.480974:4:9907,5W4394770:,73490/0.70,8083:7304:95:9
W43947.0397,;034:857088:70475:243,70/0
57088:7015488-0/:7331:843
W490831.,39.,3083
;9,838.,308/090747,94341507507,5:808,3/47.4/24990/
09702908
#&$%&&%
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
8/3/2019 ER DRUGSTUDY
62/67
0307.3,20
&%7,3/3,20
4-,970
,881.,943
/70307.8
48,0
22
472
#4:90
706:03.
$92:,908
0,798-09,70.059478943.70,80
24.,7/,.4397,.99,3/
89740;4:203.70,808
.,7/,.4:95:9
-/0.70,83507507,;,8.:,7
70889,3.070/:.3
;0397.:,71357088:70
,3/1,.9,93
'34/0.43/:.943
3.70,80/
.,7/,.4:95:9384799072970,9203941
.,7/,./0.425038,943
.,:80/-/0570880/
.4397,.99
3.70,80/
8894.!3.70,80/0,797,90.0895,3
3.70,80/3:2-0741
5702,9:70;0397.:,7-0,98
0,/,.0
9338038,94385,708908,
3,:80,;4293
/8530,50-984.,
31,22,943
,19073197,9430.7,258
W43947;9,838
.,7/,.4:95:95:243,7.,5,70/057088:70.0397,;034:857088:70,3/:73,7
4:95:9.,701:974:4:931:843
W439475,903.,3/5,.0203941'.,909079470/:.07841
097,;,8,943,3/50-98
W,9.4:91478259428414;07/48,08:.,80.088;05079038439,..,7/,
3,:80,;42939702470,/,.0.0895,3
#&$%&!#
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
8/3/2019 ER DRUGSTUDY
63/67
0307.3,20
!#
7,3/3,20
4.,30
,881.,943
39,7792.
,0394.,,308909.
48,0
22
22
472
#4:90
706:03.
.98,8,3
,308909.-89,-39030:743,
202-7,30-3-9390
43.1:08706:70/14790
39,943,3/
.43/:.9434125:8089070-
0110.934.,,308909.
,.94384,.98,8,3
,39,7792.
-/0.70,8390/054,7,943
,:942,9.9,3/0.9,-9
390;0397.08/:7390
/,894.5,80
-,/70.9,.9434390988:08
0850.,90!:730
30947
;0397.:,7
,7792,8.,:80/-.,7/,.
2,35:,94347.,7/,.
.48/08
-7,/.,7/,
.,7/,.,77089'.4,58054903843
,557003843.431:843
/3088/7483088
,:.3,9438
0,/,.090,/0/3088244/.,308
307;4:830889702478
.43:3.9;,50702,
.4730,0590,
.,308/545,9339:8;8:,
/89:7-,3.083,:80,
;429307902,
5090.,0
0/02,30.94389070,.94383.:/3
-7:83-:733
.439:843
W5,39,9,/;078070,.9438
70,90/9490$0/7483088.431:8435,708908,8.43;:8438
70857,947,77089.,34..:7,3/,70,708:941$94.9
W/;805,90399,9/7:2,.,:80/308847/7483088,3/
94,;4/09934:941-0/47
,394:9,8889,3.0W/;805,903989,98370,.94383.:/307902,
5090.,0,3/0/02,2,4..:79397,/072,30.943
W$8902.0110.98.,34..:71443945.,:80:804089
5488-0/48094,;4/8074:8
94.984.470,79-4.W4349:8035,903989.43039,47/45,9.
2090244-302,47331,3984:3079,32441,04
,7070.0;32090244-33/:.3/7:8
W&809.,:943,3/3407
/480835,90398970/:.0/.,7/,.4:95:9/9,894.9,3/30/075,90398
94:9
3;4;020394190,:94342.
8890209079 99
02477,0
4.,70,.94383.:/3
84703088,9 9 9
8/3/2019 ER DRUGSTUDY
64/67
.4397,.99
8894.,7907,
-44/57088:70,974;0397.:,7'
.43/:.943;04.9347
,-84:907017,.947
5074/8,9070/-:8:,
907,50:9./4808
30.943890
;034:8
9742-4884750-98097,;,8,943
-:7338933
84:370857,947
/0570884347,77089
50780389;970,.9438
#&$%&%
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
8/3/2019 ER DRUGSTUDY
65/67
0307.3,20
%7,3/3,20
82974
,881.,943
48249./:709.
48,0
3....
472
#4:90
706:03.
3.70,808
48249.57088:70414207:,7
197,90/7:00;,9085,82,
4824,9
9089/480147
2,70/4:7,478:850.90/3,/06:,90703,
1:3.9434:7,94
70/:.0397,4.:,747
397,.7,3,
57088:70/:70883/7:394.,943
3.70,80/
:73,9433,:80,7:333480;4293
80;070,07.70,.94387,8
;089.3/11.:9
-70,93
993088390.089803419024:9
1,.05847943:0-:770/
;843.0895,3.847
10;07.431:843
/0.70,80/,0793088/11.:9
:73,93097020
/3088097020978947
/724:91,89
47770:,70,79-0,90,/,.0
2:8.0.7,2585,370/308847
803,990
W43947;9,8383.:/3
'!,3/1:/39,0,3/4:95:9W4394709703,1:3.943,3/807:284/:2,3/549,88:2
0;08/,W,9.4:9147825942841
4;07/48,08:.,80.088;05079038439,..,7/,
3,:80,;4293970247
0,/,.0.0895,3W%4700;09789;01706:03924:9.,70,3/1:/8
30.943890
0,3088
8/3/2019 ER DRUGSTUDY
66/67
#&$%&%#$%#$&%
#&
%$
$
%
%$ %#
%$
'#$
#%
$
%$
$
#$!$%$
8/3/2019 ER DRUGSTUDY
67/67
%$ % %$ #% %$ #$!$%$
0307.3,20%#$
%#
$&%
7,3/3,20
430
,881.,943
84943.54943.$4:943
48,0
2-49908/0974802
,907
472
#4:90
706:03.
!74;/0884208:,7147
.0:,7209,-482,3/
8:5508-4/,907
1:/705,.02039,3/
.,47.8:5502039,943
35,903984.,392,39,3
,/06:,9047,39,047,70
70897.90/1742/4384
3.70,8081700,907,3/2,
.,:80397,.0:,7
0/02,1:/4;074,/
3197,943803,3/
5,3,931:843890
W4394731:8437,901706:0391838411:/
4;074,/9:73411'/7531:8432,708:931:/
4;074,/W0.'8901706:039,3/1
3197,94383490/9:73411'/75
W,9.4:9147838411:/4;074,//8903/0/30.;038
'7,5/70857,94388,49/,;4:20130,:8.:9,947
.7,.08/8530,,3/507507,0/02,
W,9.4:9147838413197,943803,3/5,3
,74:3/'890