A. Quayle et al. / Biological Psychology, 37 (1993) 43-71 45 ERP changes after a single dose of methylphenidate on a visual continuous performance task K. Bailey, P. Perros and G. Price Clinical Electrophysiology Unit, WolstorzPark Hospital, Wacol, Queensland 4076, Australia Event-related potentials (ERPs) were recorded from 54 children (7-17 years old) both before and 90 min after a single dose of methylphenidate (MPH). Of these children 27 were subsequently diagnosed as having atten- tion deficit hyperactivity disorder which responded favourably to long term treatment with MPH. ERPs were elicited using a continuous performance task double (CPTD) in which a response was required to identical letter pairs within a continuously presented series of stimuli. The ERP data were analysed in terms of Target versus Non Target, long-term Responder group versus Non-Responder group and Pre-medication versus Post-medication. Before medication, the Responder group showed a trend towards lower amplitude Nl and P3b components which did not reach significance. The Responder group showed a significant increase in P3b amplitude after medication, while the Non-Responder group showed a non significant de- crease. A comparison of the post-/pre-medication amplitude ratio of P3b also showed a significant difference between the Responder and Non-Re- sponder groups. Separation of components in the evoked cardiac response after correction for respiratory sinus arrhythmia R.J. Barry ‘, J. Kaiser ’ and J. Bener 2 ’ Department of Education Studies, Unicersity of New South Wales, Kensington, NS W 2033, Australia 2 Jagiellonian Uniuersity, Krakow, Poland The cardiac component of the orienting response was examined under different instructional conditions. Previous work had defined ECRl as the initial deceleration following stimulus presentation, conceptualized as an index of stimulus registration. Under conditions of processing load, a bipha- sic cardiac response is obtained, due to the addition of ECR2, an accelera- tion component reflecting task demands. We investigated the separation of these response elements.

ERP changes after a single dose of methylphenidate on a visual continuous performance task

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A. Quayle et al. / Biological Psychology, 37 (1993) 43-71 45

ERP changes after a single dose of methylphenidate on a visual continuous performance task

K. Bailey, P. Perros and G. Price

Clinical Electrophysiology Unit, Wolstorz Park Hospital, Wacol, Queensland 4076, Australia

Event-related potentials (ERPs) were recorded from 54 children (7-17 years old) both before and 90 min after a single dose of methylphenidate (MPH). Of these children 27 were subsequently diagnosed as having atten- tion deficit hyperactivity disorder which responded favourably to long term treatment with MPH. ERPs were elicited using a continuous performance task double (CPTD) in which a response was required to identical letter pairs within a continuously presented series of stimuli. The ERP data were analysed in terms of Target versus Non Target, long-term Responder group versus Non-Responder group and Pre-medication versus Post-medication.

Before medication, the Responder group showed a trend towards lower amplitude Nl and P3b components which did not reach significance. The Responder group showed a significant increase in P3b amplitude after medication, while the Non-Responder group showed a non significant de- crease. A comparison of the post-/pre-medication amplitude ratio of P3b also showed a significant difference between the Responder and Non-Re- sponder groups.

Separation of components in the evoked cardiac response after correction for respiratory sinus arrhythmia

R.J. Barry ‘, J. Kaiser ’ and J. Bener 2

’ Department of Education Studies, Unicersity of New South Wales, Kensington, NS W 2033, Australia 2 Jagiellonian Uniuersity, Krakow, Poland

The cardiac component of the orienting response was examined under different instructional conditions. Previous work had defined ECRl as the initial deceleration following stimulus presentation, conceptualized as an index of stimulus registration. Under conditions of processing load, a bipha- sic cardiac response is obtained, due to the addition of ECR2, an accelera- tion component reflecting task demands. We investigated the separation of these response elements.