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Establishing a Platform for Rapid Innovation Uptake: Perspective of
Kyrgyzstan
Kadyrov A.S.
2019, Wolfheze, Netherlands
Goal: To increase the treatment
success rate among patients with
multidrug - and extensively drug-
resistant tuberculosis (M/XDR-TB)
Improvement of treatment success rate requires introduction of effective regimens and methods of
treatment
INTRODUCTION OF A SHORTER TREATMENT REGIMEN FOR NEW MDR-TB CASES
INTRODUCTION OF AN INDIVIDUALIZED TREATMENT REGIMEN FOR M/XDR-TB PATIENTS
DURATIONFROM 9 TO 12MONTHS INSTEAD OF 2 YEARS
THE COST IS2-3 TIMES LESS
NEW ANTI-TUBERCULOSIS DRUGS
LESS ADVERSE EVENTS
Creating a Sustainable Program Capable of Rapid Adaptation of Innovations in Diagnosis and Treatment
• Diagnosis• Treatment regimen design• Safety and efficacy monitoring• Drug management• Patient support• Infection control• Contact evaluation• Recording & reporting• Digital Health
Stages of the Introduction of New M/XDR-TB Treatment Regimens
5
July-Sept2015
Oct-Dec 2015
Jan-March 2016
Apr-June2016
July-Sept2016
• Guidelines and SOPs finalization
• Trainings for clinical and laboratory staff
• Site selection/evaluation
• National Plan development
• Drugs needs estimation
• On-site trainings
• Start of the enrollment
• Approval of manuals
• Development of a diagnostic algorithm and treatment regimens
• Guidelines and SOPs development
• National Plan implementation
Development of guidelines and SOPs
January2017
January2018
• New regimens and new drugs are available all over the country
• Support was provided to all the patients
New Biomaterials and Anti-TB drugs Transportation System
2 le
vel
1 le
vel
NCT/NRL
FPGFOO
FPGFOO
CFMGPC
FPGFOO
FPGFOO
FPGAO
FPGFOO
Transport Agent
Sch
ed
ule
dit
ine
rary
Re
cord
ing
and
re
po
rtin
g
Payment of travel expenses to providers for the delivery of sputum specimens from FPG/FOO to CFM/GPC (as per the Order of the Ministry of
Health of the RK)
Diagnosis
• Module-based reference-laboratory of the NCT was launched in 2013.
• Ensured access to rapid molecular TB diagnosis (Xpert, SL-LPA)
• Started implementation of new laboratory TB diagnostic methods (QuantiFERON assay, whole genome sequencing)
• Introduced drug susceptibility tests to Bedaquiline and Delamanid
Treatment 1
• Strengthened capacity of the regional DR-TB consilia
• TB treatment is according to the latest WHOrecommendations:
• New anti-TB drugs (Bedaquiline, Delamanid)
• Shorter and individualized MDR/XDR-TB regimens
• Active adverse events monitoring
throughout the country
Treatment 2
• 100% provision of anti-TB drugs for all patients:
– Since 2016, first line anti-TB drugs have been procuredwith the state budget
– Since 2018, second-line anti-TB drugs (15% of the totalneed) have been procured with the state budget
– Pediatric formulations (suspensions, etc.) are available
The modality of directly supervised treatment
Clinical follow-up, evaluation and monitoring
Treatment adherence: evaluation and monitoring
Psychological and social follow up
Patient-Centered TB ServicesTB
CA
SE M
AN
AG
EMEN
T
To improve individual treatment outcomes and minimize the risk of TB transmission by providing medical services, social and psychological follow up from the moment of diagnosis to the completion of treatment
Development of information products for
TB systems (EMR, LIS, Notification, etc.)
ТB facility
Electronic TB patient card
Drug management
Laboratory information system
TB IS SERVER
Transportation IS
Dashboard
1
2
3
4
5
Information security
Information security
MORE THAN 1,000 PATIENTS ON NEW
TREATMENT REGIMENS
• In all the regions of
Kyrgyzstan
• Treatment is completely
free of charge• Leaders in TB control!
78%
16%
6%
PRELIMENARY TREATMENT OUTCOMES, 2017 (N=119)
Успех лечения Потерянные для наблюдения Неэффективное лечениеTreatment failureTreatment success
Lost to follow up
Slide 3
Text 3PREVIOUS TREATMENT REGIMEN
First cohort, January – March 2017, 31 patients
EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS
INDIVIDUALIZED TREATMENT REGIMEN
ONLY
CURED CURED
Further Steps
• Transition of the country to new, effective TB treatment regimens (injectable-free, new regimens and anti-TB drugs)
• Expansion of the coverage and availability of rapid XDR-TB diagnostic methods by scaling up the implementation of the transportation system in other regions of the country
• Developing mechanisms for effective state procurement of prequalified anti-TB drugs and other materials
• Further expansion of TB Case Management System in PHC facilities across the country
• Building capacity of health professionals in using modern approaches to diagnosis and treatment of TB, DR-TB, and TB Case Management
Acknowledgement
• USAID• Challenge TB/KNCV• Defeat TB/Abt Associates• UNDP/GF• Supranational Reference Laboratory• WHO• MSF• ICRC• NGO• National Red Crescent Society
Thank you for your attention!