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Ethanomedica 2016
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Ethanomedica A Technical Publication of Govt. College of Pharmacy, Aurangabad
Year 2015-2016
Government College of Pharmacy, Aurangabad
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MISSION
Foster universal pharmacist
VISION
To become centre of excellence in pharmacy education
To promote overall development of students by creating outstanding
learning ambience
To develop students to meet the global challenge of pharmacy profession
To be the interface between industry, academia and healthcare system
To inculcate social responsibility in the student
To promote service to humanity
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PHARMACIST’S OATH
I wear by the code of ethics of pharmacy council of india in relation with
the community and shall act as an integral part of the health care team.
I shall uphold the laws and standards governing my profession.
I shall strive to perfect and enlarge my knowledge to contribute to
advancement of pharmacy and public health.
I shall follow the system which I consider the best pharmaceutical Care
and counseling of patients.
I shall endeavour to discover and manufacture drugs of quality to
alleviate sufferings of humanity.
I shall hold in confidence the knowledge gained about patients in
connection with my professional practice and never divulge unless
compelled to do so by law.
I shall associate with organizations having their objectives for betterment
of the profession of pharmacy and make contribution to carry out the
work of those organizations.
While I continue to keep this oath unviolated, may it be granted to me to
enjoy life and the practice of pharmacy respected by all, at all times!
Should I trespass and violate this oath, may the reverse be my lot.
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Table of Contents
Standardization of Herbal drugs ............................................................................................................. 9
Development And Validation of simultaneous estimation of Rutin, Quercertin And Liquiritin in
Cocculushirsutus by HPTLC ..................................................................................................................... 9
Recent Advances In Herbal Drug Technology ....................................................................................... 10
Title: Herbal remedies: for treatment of disease ‐ A Review. .............................................................. 10
Phytosomes: Biomedicinal Technique .................................................................................................. 12
Development and Evaluation of Herbal Formulation for Alopecia....................................................... 12
Herbal Remedies: A New Era For Treatment Of Diseases .................................................................... 13
QSAR Study: Further Substitution On Feruloyl Derivatives Does Not Increases It’s Antitumor Activity
.............................................................................................................................................................. 13
Investigation Of Widely Grown Uncommon Fruits Of Marathwada Region For Nutritional And
Therapeutic Value‐ A Research ............................................................................................................ 14
Microwave Assisted Extraction of Picroside‐I and II from Picrorrhiza kurroa using Experimental
Design Approach ................................................................................................................................... 14
Ultrasound Assisted Extraction of , 3’, 5‐dihydroxyflavone‐7‐O‐β‐D‐galacturonide‐4’‐O‐β‐D‐
glucopyranoside: An Oral Bioavailability Enhancer of Rifampicin from Cuminum cyminum ............... 15
Global Regulatory Aspects For Herbal Medicines ................................................................................. 15
Standardisation Of Herbal Formulation ................................................................................................ 16
Herbal drug standardization ................................................................................................................. 16
Pharmacognostic Studies In Leaf Drugs Of Argyreia Nervosa (Burm. F.) Boj. ...................................... 17
Herbal Drug Standardization ................................................................................................................. 17
Global Regulatory Aspects On Herbal Drugs......................................................................................... 18
Bioprospecting Terminalia pallida Brandis. by Allium cepa genotoxicity assay ................................... 19
Herbal remedies: A new era for treatment of disease: A Review on Herbal Medicinal Plant for
treatment of Diabetes Mellitus ............................................................................................................ 19
HERBAL REMEDIES : A New Era For Treatment Of Diseases ................................................................. 20
Herbal Remedies: A New Era For Treatment Of Diseases .................................................................... 20
Herbal Remedies A New Era For Treatment Of Disease ....................................................................... 21
Chitosan‐based drug delivery systems ................................................................................................. 21
Herbal Drug Nanosuspensions – A Formulative Approach ................................................................... 22
Herbal Drug Standardization ................................................................................................................. 22
Ionic liquid mediated synthesis of bisindole derivates ......................................................................... 23
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Recent Advances In Herbal Drug Technology:‐Genetic Transformation .............................................. 24
Chemometrics: A new scenario in herbal drug standardization ........................................................... 24
HPLC analysis and standardization of Brahmi vati – An Ayurvedic poly‐herbal formulation ............... 25
Solid phase extraction: A powerful Approach ...................................................................................... 25
A Review on Standardization and evaluation of herbal drug ............................................................... 26
Standardization of herbal drugs ........................................................................................................... 26
Herbal Remedies : A New Era For Treatment Of Disease ..................................................................... 27
Herbal remedies. A new era for treatment of disease ......................................................................... 27
Global Regulatory Aspects for Herbal Medicine ................................................................................... 28
Recent Advances In Herbal Drug Technology ....................................................................................... 28
Development Of Herbal Drug Formulation And Evalution ................................................................... 29
Natural Indicator: A Better Alternative to Neutralization Indicator ..................................................... 29
Preparation And Evaluation Of Poly‐Herbal Hand Wash ...................................................................... 30
Cost effective extraction and isolation of polyphenols ........................................................................ 30
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Hon. Speakers and Chair Persons in Etahnomedica
Prof. (Dr.) Chandrakant Kokate
Mr. Mahesh D. Shivankar
Dr. Prabhay. Bhogaonkar
Mr. Rahul Prabhakar Phate
Mr. Abhay Madhukar Harsulkar
Mr. Udaykumar Rakibe
Dr. Prakash Rambhauji Itankar
Dr. Pravin Shridhar Wakte
Dr. Anil Kumar Uttamchand Tatiya
Dr. Vinod Kumar Mohan
Dr. Mohan G. Kalaskar
Dr. Sanjay Shivnarayan Toshniwal
Dr. Kishorkumar Balkrishna Burade
Dr. Anil. P. Battase
Dr. Aquil‐Ur‐Rahim Siddiqui
Dr. Uday Arvind Deokate
Dr. Hiralf Majmudar
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Standardization of Herbal drugs Abstract There is a increasing awareness and general acceptability of the use of herbal drug in today’s medical practice. Standardization of drug means confirmation of its quality and purity and detection of nature of adulterant by various parameter like morphological, microscopical, physical, chemical, and biological observation. Standardization of herbal drug like turmeric cream by HPTLC using pure curcumin as a bioactive chemical marker. Standardization of herbal drug is done by two ways physical and chemical method. In physical (i.e.viscosity, melting point ,solubility, moisture content, density, ash value, bitterness value) and chemical (i.e detection of carbohydrate and glycoside, detection of protein and free amino acid, detection of alkaloid, limit test for heavy metals) According to WHO, standardization of quality control of herbal drug is the process involved in the physiochemical evaluation of crude drug covering aspects such as selection and handling of safety, efficiency, stability, and assements of finished product
Development And Validation of simultaneous estimation of Rutin, Quercertin And Liquiritin in Cocculushirsutus by HPTLC Suresh Sable, Pradeep Londhe, *Vandana Patil &Hiral Majmudar Yash Institute of Pharmacy Aurangabad. ABSTRACT: Background:Rutin, Quercetin and Liquiritin are polyphenol flayonoids and exhibits anti‐ inflammatory, antihepatotoxic, antiulcer,antiallergic,antidiabetic, antiviral and antioxidant activity. They are found in many herbal plats, oneOf them is cocculushirsutus.Objective: The objective of this research work is to develop and validate a new, accurate, precise and economic HPTLC method for simultaneous estimation of Rutin, Quercetin and Liquiritin in ethanolic extract of Cocculushirsuts leaves. Methodology: the simultaneous estimation of Rutin, Quercetin and Liquiritin has been done by HPTLC on silica gel 60 F254 TLC plats using N‐butanol: acitic acid: water : Formic acid (7:1:1:0.25 v/v/v/v/)as mobile phase and quantified bydensitometric scanning at 254nm .Result and discussion :Rutin,QuercetinandLiquiritin were resolved satisfactorily with Rf values0.47+‐0.03. 0.63+‐0.03 and 0.82+‐0.02 respectively. The accuracy and reliability of this method was assessed by evaluation of linearity (1500‐4000,500‐3000 & 100‐700 ng per spot for Rutin ,Quercetin & liquiritin respectively). Precision intra day and interday RSD values were always less than 2 for them,accuracy (99.25%+‐5% for Rutin,99.29%+‐5% for Quercetin & 94.04+‐6% for liquiritin) & Specificity ,in accordance with ICH guidelines .Conclusion: the statistically validated results indicated that the proposed new method has good accuracy & precision .thus new HPTLC method has been successfully applied for the simultaneous determination of Rutin, Quercetin & Liquiritin in the herbal plant & there products.
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Recent Advances In Herbal Drug Technology Kaushik S. Muley, Pavan B. Shinde B. Pharm. Final Year, Govt. College of Pharmacy, Aurangabad. ABSTRACT: Though Herbal medicines have been used since the dawn of civilization to maintain health and to treat various diseases, recently people are getting attracted towards herbal medicines due to various advantages. Herbal medicines make up a significant constituent of the tendency toward alternative medicine. Herbal medicine is becoming ever more popular in today’s world as people seek out natural remedies. To compete with the growing pharmaceutical market, there is an importance to use and scientifically authenticate more medicinally useful herbal products. This rise in the use of herbal product has also given rise to various forms of abuse and adulteration of the products leading to consumers’ and manufacturers’ disappointment and in some instances fatal consequences. The development of authentic analytical methods which can reliably profile the phytochemical composition, including quantitative analyses of marker/bioactive compounds and other major constituents, is a major challenge to scientists. Standardization is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs. Recent advancements includes DNA fingerprinting, metabolomics technique, differential pulse polarography, chemo metric X‐ray diffraction, etc are observed. Capillary electrophoresis and chromatographic techniques contributions towards standardization of herbal drugs is also reported. This article provides a general idea of herbal medicines and intended to explain the therapeutic effectiveness of various herbal medicines, adverse drug reactions, drug interactions, standardization and stability testing of herbal medicines, pharmacovigilance and regulatory status of herbal medicines.
Title: Herbal remedies: for treatment of disease A Review. Authors name: Miss. P. Khadake*, Miss. P. Devre, Mr. M. Mubashir. DR. VEDAPRAKASH PATIL PHARMACY COLLEGE, AURANGABAD ABSTRACT: Herbalism ("herbology" or "herbal medicine") is use of plants for medicinal purposes, and the study of such use. Plants have been the basis for medical treatments through much of human history, and such traditional medicine is still widely practiced today. Herbal medicine is therapeutic use of plants to treat diseases and enhance general health and well‐being. Archaeological evidence indicates that the use of medicinal plants dates at least to the Paleolithic, approximately 60,000 years ago. Written evidence of herbal remedies dates back over 5,000 years, to the Sumerians, who created lists of plant. A number of ancient cultures wrote on plants and their medical uses. The ancient Greeks and Romans were also renowned herbalists. Surgeons traveling with the Roman army spread their herbal expertise throughout the Roman Empire, in Spain, Germany, France, and England. Dioscorides (c. 40‐c. 90) and Galen (131‐200 A.D.), both Greek surgeons in the Roman army, compiled herbals that remained the definitive materia medica texts for 1500 years. Traditional herbal medicines are getting significant attention in global health debates. Herbal remedies can be a safer, less expensive alternative to pharmaceuticals, and you can grow many of them in your backyard. The plants contains various extractives like alkaloids, glycosides, resins, tannins, volatile oils, gums, waxes etc. are widely used for preparation of medicinal herbal drugs. The objective of our representation is to review the variety of herbal drugs and their use in treatment of diseases. It can be proved that herbal remedies should be good source alternative to synthetic drugs. ABSTRACT: Standardization of herbal formulation is essential in order to asses the quality of drugs for therapeutic value. According to an
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estimate of World Health Organization (W.H.O) nearly 80% of populations of developing countries rely on traditional medicines. The World Health Organization (WHO) in 1999 has given a detail protocol for the standardization of herbal drugs comprising of a single content, but very little literature is available for the standardization of poly‐herbal formulation. Four marketed preparations and in‐house preparations were used for the study. performed The various parameters including organoleptic characteristics and physicochemical . was carried out for quantitative analysis of all the formulations. The set parameters were found to be sufficient to standardize the Sitopaladi Churna and can be used as reference standards for the quality control/ quality assurance study mostly on plant drugs for their primary health care needs. Abstract: There is a increasing awareness and general acceptability of the use of herbal drug in today’s medical practice. Standardization of drug means confirmation of its quality and purity and detection of nature of adulterant by various parameter like morphological, microscopical, physical, chemical, and biological observation. Standardization of herbal drug like turmeric cream by HPTLC using pure curcumin as a bioactive chemical marker. Standardization of herbal drug is done by two ways physical and chemical method. In physical (i.e.viscosity, melting point ,solubility, moisture content, density, ash value, bitterness value) and chemical (i.e detection of carbohydrate and glycoside, detection of protein and free amino acid, detection of alkaloid, limit test for heavy metals) According to WHO, standardization of quality control of herbal drug is the process involved in the physiochemical evaluation of crude drug covering aspects such as selection and handling of safety, efficiency, stability, and assements of finished product Authors Name‐ Navade Apurva M. , Choudhari Manisha V
Herbal Radio Modulators Radical Approach In The Modern Era Of Herbal Remedies. Presented by‐ Pooja Solanke, Vaishali Adchitre (M.PHARM) GOVERNMENT COLLEGE OF PHARMACY, AURANGABAD. Radiation has always been there in nature. Radiotherapy is used to treat cancer. Radiation is like a double‐edged sword as it cures as well as it destroys if used indiscriminately. Other significant health impacts of low level radiation is causing inherited disabilities in later generations, such defects range from minor problems like colour blindness to very serious maladies like mongolism & other Genetic defects. Then question arises how to mitigate the deleterious effects of ionising radiation. Hence the development of Radio Modulators‐ "The Agents that Reduces the Damaging Effects Of Radiation when administered to living organism”, there are two types of Radio Modulators i.e., Radioprotectants and Radio‐ sensitizers. These hold immense promise for clinical and field applications in space, reactor spillages, wars and terrorist attack. Synthetic Radiomodulators like AMIFOSTINE‐is Gold Standard in Radioprotection approved by USFDA but received refusal from US Army due to its toxicity at effective dose(narrow therapeutic window) therefore one turns to develop less toxic herbal Radio Modulators as they posses long history of safety in terms of traditional usage in human for several years.
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Phytosomes: Biomedicinal Technique Santosh D. Borde*, Hrishi H. Rajput and Sadhana R. Shahi, GOVT COLLEGE OF PHARMACY, AURANGABAD The term Phytosomes, also known as herbosomes are promising carriers for formulation of herbal products. The term "Phyto" means plant while "some" means cell‐like are emerging technology bridging the drawbacks of conventional drug delivery system. These carriers depict better absorption and also aid in desired pharmacokinetic and pharmacodynamic profile. Phytosome results from the reaction of a stoichiometric amount of the phospholipid (solubilizer/ emulsifier) with the standardized phyto constituent or poly phenolic constituents in a non‐polar solvent. For better and improved bioavailability, natural phyto constituents must possess good balance between hydrophilicity (helps in dissolution in gastro‐intestinal fluids) and hydrophobicity (helps to cross lipid rich cell membranes). Phytosomes are evaluated for their surface properties, particle size, vesicle stability, interaction of phospholipids with phyto constituent along with physic‐chemical interactions by different analytical techniques. The paper highlights the importance of phytosomes as a carrier for application in various herbal products to meet the rising demands of herbal formulations and products.
Development and Evaluation of Herbal Formulation for Alopecia Mokate D.M., Wagh J.G.,Deshmukh V.K. MES COLLEGE OF PHARMACY, SONAI. Abstract: Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. This invention relates to herbal hair treatment compositions for AlopeciaOnion[Allium Sepa],Garlic[Allium Sativum],Butterfly Pea[Clitoria Ternatea],Clotropus Giganatea and Castor Oil is a well known Ayurvedic herb with purported claims of hair growth promotion.Hair formulation of Onion[AlliumSepa]10%w/v,Garlic[AlliumSativum]5%w/v,ButterflyPea[Clitoria Ternatea]5% w/v,Clotropus Giganatea 2% w/v and Castor Oil 2% v/v concentration in the form of herbal oil were studied and showed excellent hair growth activity with standard [ 2 % minoxidil ethanolic solution] in wister albino rats. Hair growth initiation time was significantly reduced to half on treatment with the oil, as compared to control animals. The time required for complete hair growth was also significantly reduced. Quantitative analysis of hair growth after treatment with oil exhibited greater number of hair follicles in anagenic phase which were higher as compared to control [. The result of treatment with oil were better than the positive control minoxidil 2 % treatment. It holds the promise of potent herbal alternative for minoxidil and perfect herbal treatment for Alopecia. Key‐words: Alopecia, hair growth, minoxidil.
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Herbal Remedies: A New Era For Treatment Of Diseases PRESENTED BY: BHUSHAN SIRSIKAR, SAYALI SHIRKHEDKAR GOVERNMENT COLLEGE OF PHARMACY, AURANGABAD Abstract : Use of herbal medicine since its civilization is not new to Mankind. The number of patients seeking alternate and herbal therapy is growing exponentially. Herbal medicines are the synthesis of therapeutic experiences of generations of practicing physicians of indigenous systems of medicine. The demand of herbal medicines are increasinglogarithmically in the developing world primarily in healthcare not because they are inexpensive but also due to good therapeutic value with minimal side effects. Traditional usage of herbal medicine can offer us with valuable data for selection, preparation and application of herbal formulations. Governments, international agencies and corporations are increasingly investing in traditional herbal medicine research. Yet little literature addresses ethical challenges in this research.
QSAR Study: Further Substitution On Feruloyl Derivatives Does Not Increases It’s Antitumor Activity Mr. Khan Sharuk.L* , Mr. Khan Arif.I , Mr. Sonwane G.M, Dr.Mrs.Kale.M.A. Email: [email protected] GOVERNMENT COLLEGE OF PHARMACY, AURANGABAD Abstract: First time, ferulic acid (4‐hydroxy‐3‐methoxycinnamic acid, FA) was isolated from Ferula foetida, family‐ Umbelliferae. Feruloyl is a derivative of ferulic acid, and it has wide biological applications. The QSAR study shows that further substitutions on feruloyl derivatives does not increases it’s biological activity. Keywords: Feruloyl, QSAR, Antitumor activity.
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Investigation Of Widely Grown Uncommon Fruits Of Marathwada Region For Nutritional And Therapeutic Value A Research Sonwane PP*1, Gond NY2 1Oyster Institute of Pharmacy,Aurangabad. 2Department of Pharmacognosy, Nanded Pharmacy College, Nanded. ABSTRACT: The compound used as immunostimulant as an alternative to the drugs, antibiotics and chemicals currently being used to control diseases man many have focused on the use of widely grown uncommon fruits and medicinal plant as potential therapeutic tool for altering the immune response to prevent and control diseases. The possible use of naturally available fruits such as Ziziphus jujuba, Ramnaceae (Ber), Buchania lanzan, Anacardeaceae (Charr,/Chironji), Coccinia grandis, Cucurbitaceae (Tindori,Tindora), Phoenix sylvestris, Arecaceae (Shinole,Shindi), Grewia tiliifolia vahl var, Tiliaceae (Dhaman.), Madhuca longifolia, Sapotaceae. (Moha.), Cordia dichotoma foret Boraginaceae. (Bhokar), Aegle marmelos Corr. Rutaceae. (Beal), Diospyros melanoxylon roxb, Diospyros decandra, Ebenaceae. (Tendu,tembhurni), Rumex vasicarius, Polygonaceae. (Hummayd and hammad ,sour‐wort), etc. has been discussed in this article. The aim of this paper is to review research currently being carried out on the widely grown uncommon fruits that have been nutritional and therapeutic value. Key words – Nutritional value, therapeutic value, widely grown, uncommon fruits
Microwave Assisted Extraction of PicrosideI and II from Picrorrhiza kurroa using Experimental Design Approach *Dr. Sachin S. Bhusari, Ms. Shweta B. Ganorkar, Mr. Ajit A. Patil, Dr. Pravin S. Wakte Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad Abstract: The response surface methodology was employed to study the optimization of microwave‐assisted sample preparation of picroside I and picroside II from Picrorrhiza kurroa Royle rhizomes. The optimized sample preparation involves the investigation of quantitative effects of sample preparation parameters viz. solid to solvent ratio, extraction temperature, extraction time and solvent on yield of picroside I and picroside II using Box–Behnken design. The experimental data were fitted to second‐order polynomial equation using multiple regression analysis and analyzed using the appropriate statistical method. By solving the regression equation and analyzing 3‐D plots, the optimum extraction conditions were found to be: solid to solvent ratio, 10:90 w/v; temperature, 60 °C and extraction time, 60 sec. Optimum extraction conditions demonstrated picroside I and picroside II yield of 41.23 ± 2.09 and 6.12 ± 0.54 mg/g feed respectively, which was in good agreement with the predicted values. Solid to solvent ratio showed significant effect on the picroside I and picroside II yield. Application of microwave‐assisted sample preparation in the extraction of picroside I and picroside II from P. kurroa dramatically reduced extraction time.
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Ultrasound Assisted Extraction of , 3’, 5dihydroxyflavone7OβDgalacturonide4’OβDglucopyranoside: An Oral Bioavailability Enhancer of Rifampicin from Cuminum cyminum *Dr. Sachin S. Bhusari, Ms. Prarthana P. Mistry, Ms. Shweta B. Ganorkar, Dr. Pravin S. Wakte Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad‐431004, INDIA Abstract: It is reported that, 3’, 5‐dihydroxyflavone‐7‐O‐β‐D‐galacturonide‐4’‐O‐β‐D‐glucopyranoside (CC‐I), a flavonoid glycoside from Cuminum cyminum enhances the oral bioavailability of rifampicin. The report demonstrates the isolation of CC‐I using conventional hot percolation technique. In order to improve the extraction yield of CC‐I, ultrasound assisted extraction was investigated. The aim of present study was to select suitable solvent for extraction and to optimize the extraction process variables such as solvent concentration (25‐75 %), solid‐to‐solvent ratio (5‐15 mL/g) and extraction time (10‐50 min). The experiments were designed using Box‐Behenken design. For the optimization of extraction variables, response surface methodology was successfully employed. From the ANOVA results, it was found that model used for the optimization was adequate (R2= 0.9805). Ethanol and water combination was found to be the suitable solvent for extraction. The optimized extraction process variables were: ethanol concentration 61.64 %, solvent‐to‐material ratio 13.14 mL/g and extraction time 46.16 min.
Global Regulatory Aspects For Herbal Medicines GOVERNMENT COLLEGE OF PHARMACY, AURANGABAD ABSTRACT: HERBAL DRUGS are not simple task since many factors influencing the biological efficacy and therapeutic effect. The legal process of regulation and legislation of herbal medicines changes from country to country. The reason for this involves mainly cultural aspects and also the fact that herbal medicines are rarely studied scientifically. Thus, few herbal preparations have been tested for safety and efficacy. This review highlights the current advances in knowledge about the safety, efficacy, quality control, marketing and regulatory aspects of botanical medicines. Phytotherapeutic agents are standardized herbal preparations consisting of complex mixtures of one or more plants which contain as active ingredients plant parts or plant material in the crude or processed state. The WHO has published guidelines in order to define basic criteria for evaluating the quality, safety, and efficacy of herbal medicines aimed at assisting national regulatory authorities, scientific organizations and manufacturers in this particular area. PRESENTED BY : DIPALI ATOLE, MAYURI BANKAR, B.pharm,IIndYear, Govt. College of Pharmacy,
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Standardisation Of Herbal Formulation Nandgave M. S., Government College of Pharmacy, Kathora Naka, Amravati‐444 604 Abstract : Herbal medicines are not a simple task since many factors influence the biological efficacy and reproducible therapeutic effect. Standardized herbal products of consistent quality and containing well‐defined constituents are required for reliable clinical trials and to provide consistent beneficial therapeutic effects. Pharmacological properties of an herbal formulation depend on phytochemial constituents present therein. Development of authentic analytical methods which can reliably profile the phytochemical composition,including quantitative analyses of market/bioactive compounds and other major constituents, is a major challenge to scientists. An overview covering various techniques employed in extraction and characterization of herbal medicines as well as herbal nanomedicines standardization is reported. In addition, phytosomes increased bioavailability, bhasma as ametalnanobarrier drug delivery system, potential of metabolomics in the development of improved phytotherapeutic agents, DNA based molecular markers in adulterants, and SCAR markers for authentification and discrimination if herbs from their adulterants are reported. Nanotechnology based herbal drugs possess improved solubility and enhanced bioavailability. Key words: WHO, Herbal formulation, Standardization, Quality control, Nanoherbal drugs, Phytosomes.
Herbal drug standardization Pooja Darole, Mayuri Patil, Bhagyashri Pawar SHRI BHAGWAN COLLEGE OF PHARMACY, AURANGABAD Standardization means formulation, publication and implementation of guidelines, rules, and specifications for common and repeated use aimed at achieving optimum degree or order of uniformity in a given context, discipline or field.Majority of Ayurvedic practitioners uses traditional herbal preparations for their treatment of disease. So it is necessary to improve safety of herbal drugs by developing certain quality control parameters and by following the WHO guidelines for herbal medicines. Nowadays , old methods are necessary but there are lots of limitations to these methods due to storage of many drugs, unavailability or limited source, adulteration, lack of knowledge of drug identification and adverse effect of drug toxicity. Adultration, substitution, ignorance of dealers create problem. So there is need to standardize ayurvedic herbal preparations. This can be achieved only if herbal products are evaluated and analyzed using sophisticated modern techniques. Herbal drug standardized by UV visible, TLC, HPTLC, GCMS, spectroscopy and other methods as Phytochemicals finding, fingerprinting content, appearance, pH, viscosity, refractive index, saponification value and spreadability. After post General Agreement on Tariffs and Trade (GATT) era there is big surge in herbal based medicines to find out their potential for treatment and cure of disease and ailments which can or cannot by cured by well established allopathic formulations. Hence for preparations of any herbal formulation identification, valuation and standardization is mandatory. Identification involves physical, chemical and biological parameters. From above poster presentation we want to aware the importance of standardization in herbal drug formulations.
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Pharmacognostic Studies In Leaf Drugs Of Argyreia Nervosa (Burm. F.) Boj. RUPALI M. BIRADAR, VIKAS S. GAMBHIRE1, ARVIND S. DHABE2 INDRARAJ ARTS, COMMERCE AND SCIENCE COLLEGE, SILLOD DIST. AURANGABAD ABSTRACT: Argyreia nervosa (Burm. f.) Boj. is an extensive twinner belonging to family convolvulaceae. Its leaves are medicinally exploited to treat several diseases and disorders. Pharmacognostic studies in this leafy drug are carried out to standardize and detect the adulteration in it. Pharmacognostic studies include details of trichomes, stomata, epidermal characteristics and anatomical features of leaves. Physical characters of leaf powder like colour, odour, taste, dry matter and phytochemical characters like nitrogen, crude protein, water soluble nitrogen, crude fat, crude fiber, total ash, acid insoluble ash, acid soluble ash, calcium, gross energy, reducing sugar, total sugar, non‐reducing sugar, cellulose, extractive values etc were also undertaken. The above parameters can be applied in combination to standardize this leaf drug. Key words‐ Pharmacognostic studies, Argyreia nervosa, phytochemical characters.
Herbal Drug Standardization Prerna Gangawane, Suchita Deshmukh, Mayuri Bankar, Bharm,Iind Year, Govt. College . Of Pharmacy, Aurangabad. ABSTRACT : HERBAL DRUGS are not simple task since many factors influencing the biological efficacy and therapeutic effect. Standardized herbal products of consistent quality and containing well‐defined constituents are required for reliable clinical trials and to provide consistent beneficial therapeutic effects. Pharmacological properties of an herbal formulation depend on phytochemical constituents present therein. The world is witnessing an unprecedented growth in the usage of herbal products at national and international levels. These have necessitated development of modern and objective standards f or evaluating the safety ,quality and efficacy these drugs.
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Herbal Remedies For The Treatment Of Antepartum And Postpartum Depression. Parekh R.A. ,Barik R. Guided by:Ogale S.C. VIVA INSTITUTE OF PHARMACY, VIRAR(E). Pregnancy has typically been considered a time of emotional well being, but up to 20% of women suffer from mood or anxiety disorders during pregnancy. Depression is not the same as a passing blue mood. True clinical depression is a mood disorder in which feelings of sadness, loss, anger, or frustration interfere with everyday life for an extended time. The mood swings can either be really draining or benumbing or confusing, making many feel helpless and out of control. Depression disturbs the equilibrium of life by affecting body mechanism and thus day to day life. Depression during pregnancy also called antepartum depression is a mood disorder just like clinical depression. During pregnancy, hormone changes can affect brain chemicals, which are directly related to depression and anxiety. People suffering from depression cannot come out of that state despite their willingness to do so. Thus Antidepressants like fluoxetine (Prozac), paroxetine (Paxil) have been widely used, but these synthetic compounds usually produce deformation of organs of new born and many associated disorders. Before planning for pregnancy, women must start Complementary and Alternative Medicine Therapy (CAM Therapy) to prevent side effects from synthetic drugs. This therapy includes yoga, exercise, aroma therapy, use of herbal drugs. Herbal drugs include St. John's Wort, Rhodiolarosea, camucamu ,Ashwagandha etc. In this area we are highlighting the most neglected disorder i.e Antepartum and Postpartum depression in women. We feel that health care professionals have an important role in working closely with maternal and child health workers and offering consultative and training services in early detection and referral.
Global Regulatory Aspects On Herbal Drugs. GOVERNMENT COLLEGE OF PHARMACY, AURANGABAD ABSTRACT: Herbal drug has practiced in many countries centuries, there are particularly strong and established traditions in some Asian countries, notably in China and India but also in Europe including the UK. The sector is diverse and and many of the traditions have been now exported to other countries. The working group expressed concern that the European legislation had not achieved all of its objective it that it had failed to encourage the licensing or accreditation of safe herbal products in order make them available to the public following implements of the Directive. Although the UK has been at the forefront of the new licensing arrangements, with over 300 herbal products achieving Traditional Herbal products. There are herbal Registration accreditation, this is only a small percentage of the number of products being used. At present a number of herbal ingredients are banned or restricted in their use because of concerns that they may be harmful to health. The list of banned substances has not been reviewed in recent years. SO here is a review on GLOBAL
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Bioprospecting Terminalia pallida Brandis. by Allium cepa genotoxicity assay Salve A. P., Dhabe A. S. Dr. Babasaheb Ambedkar Marathwada University, Aurangabad‐ 431005 Abstract: Nature’s superior ability of phytochemicals in exploring plants reproductive fitness and protection against infection, is also unleashing perspectives of Human heath‐ A Bioprospecting approach. Focusing this, an endemic species of dry deciduous forests of Tirumala and Telakona (District‐ Chitoor). ‐ Terminalia pallida Brandis., was assayed for genotoxicity effects using Allium cepa root chromosome aberration assay This assay will describe clastogenic aberration and mitotic index, achieved due to effect of aqueous bark extracts on roots of Allium cepa L. Keywords: T. pallida Brandis, Allium cepa L. root chromosome aberration assay, clastogenic aberrations, mitotic index.
Herbal remedies: A new era for treatment of disease: A Review on Herbal Medicinal Plant for treatment of Diabetes Mellitus *Ashish A. Gawai, Sapna A. Gawai, Sadhana More, Rupali Petkar, K.R. Biyani Abstract: Diabetes mellitus is a common condition in which the amount of glucose in the blood is too high because the body is unable to use it properly. It can occur at any age but incidence increases with age. Food is taken in and travels through the gut. The pancreas secretes insulin when we eat. Food is broken into smaller molecules in the gut. Some of these are GLUCOSE. Type 1 develops when there is a severe lack of insulin in the body because most or all insulin producing beta cells in the pancreas have been destroyed. This is treated by insulin injections and diet. Type 2 develops when pancreas still produces insulin but there is cellular resistance and insulin cannot be used properly by the body. This is treated by diet alone or diet and tablets, or diet and insulin injections. The name “diabetes mellitus means sweet urine. It stems from ancient times when physicians would taste a patient’s urine as a part of a diagnosis. Plants used in the treatment of Diabetes Mellitus Dioscoreaopposita (Yam),Gymnemasylvestre(Gurmar), Momordicacharantia(Karela, bitter gourd)Syzygiumcumini(Jamun, Jambul),Azadirachtaindica(Neem), Aloe vera and Aloe barbadensis and more are used for the treatment of DM. Corrosponding Author: Dr. Ashish A. Gawai, Associate Prof. Dept of QA, Anuradha College of Pharmacy, Chikhli, Dist‐Buldana, M.S, India.
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Herbal Remedies : A New Era For Treatment Of Diseases SYED ASHFAQUE ALI, SHAIKH MALIK GOVERNMENT COLLEGE OF PHARMACY, AURANGABAD Y.B. CHAVAN COLLEGE OF PHARMACY, AURANGABAD Abstract: Herbal remedy: A medication prepared from plants, including most of the world's traditional remedies for disease. Most people think of herbal remedies as products sold over the counter as "supplements", such as saw palmetto extract or goldenseal ointment. However, many over‐ the‐counter and prescription drugs are based on ingredients originally derived from plants, including aspirin and digoxin. Lab tests have shown that some herbal remedies are indeed effective against illness. One should use these drugs as carefully as prescription medicines, taking care to avoid overdose, interactions with other medications, and misuse. For centuries, herbal remedies have increased overall health, vitality, and life expectancy. They are used to treat illness and to restore the body to health. The low risks and potential for no side effects make these remedies appealing when compared with commercial drugs. Herbal remedies are a safe and effective alternative for treatments from conditions ranging from indigestion to diabetes Medicinal herbs can provide natural, safer remedies to dozens of common ailments Herbal medicine, also called botanical medicine or phytomedicine, refers to using a plant's seeds, berries, roots, leaves, bark, or flowers for medicinal purposes. Herbalism has a long tradition of use outside conventional medicine. It is becoming more mainstream as improvements in analysis and quality control, along with advances in clinical research, show the value of herbal medicine in treating and preventing disease.
Herbal Remedies: A New Era For Treatment Of Diseases Chanchal Mede & NoorulSaba Bagwan Govt. College Of Pharmacy Aurangabad. In the last few years there has been an exponential growth in the field of herbal medicines and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects. These herbal remedies aim at permanently curing the illness which is not in the case of most pharmaceuticals, and hence can be a less expensive alternative to such pharmaceuticals. Due to increasing development in science and technology, new plant drugs usually find their way into medicine as purified substances rather than in the form of older galenical preparations. The future of phytopharmaceuticals (herbal remedies) is because it serves as a cheap and steady source for varied range of therapeutic agents which are of great significance in healthcare of mankind.Their use is more prevalent in patients with chronic diseases such as cancer,diabetes, asthama and end‐stage renal disease, liver cirrhosis, kidney stones, etc. Examples of some herbal remedies for common ailments such as: Aloe for Acne and Burns Ginkgo for Alzheimer’s disease Garlic and Green tea for Angina and
Arteriosclerosis Capsicum, Ginger, Turmeric for Arthritis Coffee and Tea for Asthama Ginseng for Boils Eucalyptus & Liquorice ‐ Cough & Cold Garlic, Ginseng, Mushrooms, Raspberry,
Pomegranate, Cocoa for Cancer. Yohimbe for Impotence Fenugreek for Diabetes The regulatory requirements of herbal drugs varies from one country to another. Some countries accept traditional, experience based evidence while some consider herbal remedies as dangerous or of questionable value. Unfortunately, many medical authorities still disparage medicinal herbs as these herbs are weak in action. But, we don’t need medicine that’s stronger, we need a medicine that’s smarter!
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Herbal Remedies A New Era For Treatment Of Disease Mayuri Ganesh Narkhede And Sheetal Munindra Oholkar GOVERNMENT COLLAGE OF PHARMACY, AURANGABAD. ABSTRACT: Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. However, in addition to their chemical structure diversity and their biodiversity, the development of new technologies has revolutionized the screening of natural products in discovering new drugs. Applying these technologies compensates for the inherent limitations of natural products and offers a unique opportunity to re‐establish natural products as a major source for drug discovery. In this poster we attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach commonly referred to as “natural product drug discovery”.
Chitosanbased drug delivery systems Gomkale M. B. 1* ,Deore S.L. GOVERNMENT COLLEGE OF PHARMACY, Kathora Naka, Amravati‐444 604. Abstract: Within the past 20 years, a considerable amount of work has been published on chitosan and its potential use in drug delivery systems. In contrast to all other polysaccharides having a monograph in a pharmacopeia, chitosan has a cationic character because of its primary amino groups. These primary amino groups are responsible for properties such as controlled drug release, mucoadhesion, in situ gellation, transfection, permeation enhancement, and efflux pump inhibitory properties. Due to chemical modifications, most of these properties can even be further improved. Within this review, an overview on the advantages of chitosan for various types of drug delivery systems is provided. Keywords: Chitosan, Drug delivery, Mucoadhesion, Permeation enhancement.
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Herbal Drug Nanosuspensions – A Formulative Approach Pankaj Ramesh Khakale Abasaheb Bapurao Hanvate (B.Pharm Final Year) Guided by: Mr. Mohammad Shakir Ghouse, Asst. Professor (Dept of Phrmacognosy) Mrs. Surekha Bharatsingh Barwal Asst. Professor (Dept of Phrmacognosy) DR. VEDPRAKASH PATIL PHARMACY COLLEGE, GEORAI TANDA, AURANGABAD. Abstract: Herbal medicines make up an important component of the trend towards alternative medicines. Herbal medicines have been used since the dawn of civilization to maintain health and to treat various diseases. To compete with the growing pharmaceutical market there is an urgency to utilized and scientifically validate more medicinally useful herbal products. Herbal drugs or phytomedicines or phyto pharmaceuticals are sold over the counter products in modern dosage forms such as tablets, capsules and liquids for oral use. Dietary supplements containing herbal products are also called as Neutraceuticals available in modern dosage forms. Herbal drug technology is used for converting botanical material into medicines where standardization and quality control with proper integration of modern scientific techniques and traditional knowledge is important. Standardization of drugs means confirmation of its identity and determination of its quality and purity, detection of nature of adulterants by various parameters like morphological, microscopically, physical, chemical and biological observation. Herbal drugs make up a significant constituent of the tendency towards alternative medicines. Herbal medicine is becoming ever more popular in today’s era as people seek out natural remedies. Recently people are attracted toward herbal medicines due to many advantages. The herbal formulations have reached extensive acceptability as therapeutic agents for several diseases. Nanosuspensions are important carriers to develop a noble drug formulation. Large proportions of newly discovered drugs are water insoluble and therefore poorly bioavailable contributing to deserted development efforts. The use of drug nanosuspension is a universal formulation approach to increase the therapeutic performance of these drugs in any root of administration. Poorly water soluble and poor bioavailability of drugs can be improved by the nanosuspension technology. Medicinal plants or their phytocompounds are frequently considered to be less toxic and free from side effects than synthetic drugs. More than 40% of the new chemical entities are being generated through drug discovery programs which are poorly water soluble.
Herbal Drug Standardization Shraddha L. Jain, Renuka V. Tiwari GOVERNMENT COLLEGE OF PHARMACY, AURANGABAD ABSTRACT: Standardization of Herbal formulations is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs. Methods of standardization should take into consideration all aspects that contribute to the quality of the herbal drugs. Standardization includes various parameters for drug evaluation viz. organoleptic, botanical, physical, chemical and biological testing. This can be achieved only if the herbal products are evaluated and analyzed using sophisticated modern techniques of standardization such as UV‐visible, TLC, HPLC, HPTLC, GC‐MS, spectrofluorimetric, DNA fingerprinting and other methods. In recent times a wide range of development is seen in the area of herbal drug standardization and techniques. Advance techniques in chromatography and spectroscopy analysis have brought a wide developmental scope for standardization of herbal drugs. The advancement of analytical techniques serves as a rapid and specific tool in the herbal research, thereby, allowing the manufacturers to set quality standards and specifications so as to seek marketing approval from regulatory authorities for therapeutic efficacy, safety and shelf‐ life of herbal drugs.
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Development of Herbal drug formulation and evaluation. Kulkarni Vishakha D. Atre Manali V. Third year B. Pharm GOVERNMENT COLLEGE OF PHARMACY, AURANGABAD. ABSTRACT: Traditional herbal medicines are plant derived substances with least or no industrial processing which are used to treat illness. The practice of drug delivery has changed significantly in last few decades and even better changes are welcome in future. In various drug systems herbal drugs are widely used and are with superior therapeutic efficacy than that of allopathy having less toxic effects. Herbal medicines have numerous active constituents for several diseases but the proper knowledge must be necessary for preparation and standardization of herbal formulation otherwise active constituent will be damaged. Evaluation is a way of confirmation of its identity and determination of quality and purity of herbal drugs. Evaluation of crude drug becomes necessary because of the following aspects viz. deterioration due to treatment and storage, substitution and adulteration, variability, geographical parameters etc. Therefore, the purpose of research work on formulation and evaluation of herbal drug is of utmost importance.
Ionic liquid mediated synthesis of bisindole derivates Saroj R. Bembalkar, Suresh U. Shisodia, Rajita D. Ingle, Sanjay B. Ubale and Rajendra P. Pawar* Department of Chemistry, Deogiri College, Aurangabad, 431005, (MS) India. Keywords: Bisindoles, ionic liquid, green approach etc. ABSTRACT: An expeditious and green method for the synthesis of bisindoles derivatives has been investigated using ionic liquid at 78 0C. The reported method is highly efficient in terms of excellent yields, short reaction time, operational simplicity, easy workup, recyclability of reaction medium and catalyst.
NH
CHO
R1 NH
NH
R1
2
R2
R2 = H,Br
R2R2
78 C
Ionic Liquid
Recent advances in herbal drug technology Abstract: Herbal drug technology is used for converting botanical materials into medicines, where standardization and quality control with proper integration of modern scientific techniques is done. Recently the use of herbal medicines has been increased due to their miraculous therapeutic effects and fewer adverse effects as compared to the modern allopathic medicines. Advances are being done in processing, standardizing, extraction, identification and purification techniques to increase the production and improve the quality of herbal drugs. Participants: Sumeet Vaibhav Katke, Madhura Santosh Joshi, 3rd yr B.Pharm, Govt. college of pharmacy, Aurangabad.
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Recent Advances In Herbal Drug Technology:Genetic Transformation MOHSIN SHAIKH, AFROZ KHAN B PHARM 3rd Year GOVT. COLLEGE OF PHARMACY, A.BAD ABSTRACT: Herbal plant are the most important source of lifesaving drugs for the majority of the worlds population. Plant secondory metabolites are economically important as drugs, fragrances, pigments and pesticides. The biotechnological tools are important to select, multiply, improve, analyse herbal plants in vitro production of secondary metabolites in plant cell suspension culture has been reported from various herbal plant and bioreactors are the key step towards commercial production of secondary metabolite by plant biotechnology. Genetic transformation is a powerful tool for enhancing the productivity of novel secondary metabolites, especially by agarobacterium tumefacians. Combinatorial biosynthesis is another approach in the generation of novel natural products and the production of rare and expensive natural products. DNA profiling techniques like DNA microarrays serves as suitable high throughput tools for the simultaneous analysis of multiple genes and analysis of gene expression that becomes necessary for providing clues about regulatory mechanism, biochemical pathways and broader cellular function.
Chemometrics: A new scenario in herbal drug standardization Shamal R. Patil Government College of Pharmacy, Kathora Naka, Amravati444 604. Abstract: Chromatography and spectroscopy techniques are the most commonly used methods in standardization of herbal medicines but the herbal system is not easy to analyze because of their complexity of chemical composition. Many cutting‐edge analytical technologies have been introduced to evaluate the quality of medicinal plants and significant amount of measurement data has been produced. Chemometric techniques provide a good opportunity for mining more useful chemical information from the original data. Then, the application of chemometrics in the field of medicinal plants is spontaneous and necessary. Comprehensive methods and hyphenated techniques associated with chemometrics used for extracting useful information and supplying various methods of data processing are now more and more widely used in medicinal plants, among which chemometrics resolution methods and principal component analysis (PCA) are most commonly used techniques. This review focuses on the recent various important analytical techniques, important chemometrics tools and interpretation of results by PCA, and applications of chemometrics in quality evaluation of medicinal plants in the authenticity, efficacy and consistency. Key words : Chemometrics ; Herbal drugs; PCA; OPA
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HPLC analysis and standardization of Brahmi vati – An Ayurvedic polyherbal formulation Sonali Agarkar, Prarthana Mistry , Shweta Ganorkar, Department of Chemical Technology,BAMU, Abad. Abstract: The aim of the present study was to standardize Brahmi vati (BV) by simultaneous quantitative estimation of Bacoside A3 and Piperine adopting HPLC–UV method. BV very important Ayurvedic polyherbo formulation used to treat epilepsy and mental disorders containing thirty eight ingredients including Bacopa monnieri L. and Piper longum L.
Solid phase extraction: A powerful Approach Aditi Subhash Kabade and Ismat Hashmi GOVERNMENT COLLEGE OF PHARMACY, AURANGABAD Abstract: Herbal drug technologies are meant for converting botanical materials into medicines. One of the important step in conversion of crude drug into medicine is extraction of chief constituents. Now a days, recent developing technique in extraction technology is solid phase extraction (SPE). SPE uses the principle of affinity of solutes dissolved or suspended in a mobile phase to separate the mixture into desired and undesired components .the result is that either desired analytes or undesired impurities in the sample are retained on the stationary phase. SPE is the very popular technique currently available for rapid and selective sample preparation. The mechanism in SPE comprises of polar interactions, non‐polar interactions, ionicinteractions.Depending upon the types of interactions, the SPE are further classified as reverse phase SPE, normal phase SPE, ionic phase SPE. The basic steps involved in SPE are : Conditioning, Equilibration, Loading, Washing, Eluting Solid Phase Extraction is preferred over other extraction techniques because of : Reduction in solvent consumption. Accuracy over other extraction technique is
greater. Highly purified extracts. Ability to simultaneously extract analytes of
wdie polarity range. High recovery and concentration of
analytes. Compability with instrumental analysis. Ease of automation. The SPE is recently used in the extraction of different toxins such as podophyllotoxin from the plant Sinopodophyllumhexandrum, different alkaloids like phenolic alkaloids from Nelumbonucifera, anthraquinones from rhubarb species,sesquiterpenoids like artimeisinin from Artemisia annua. Thus, Solid phase extraction has appeared an alternative to liquid‐liquid extraction owing to simplicity, low cost and easy automation. The SPE can be a powerful method for sample preparation technique for isolation, concentration, cleanup and medium exchange.
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A Review on Standardization and evaluation of herbal drug Ashish A. Gawai*,Faizal Shaikh,BhagyashreeSonune,Sapna A. Gawai,K.R.Biyani ANURADHA COLLEGE OF PHARMACY, CHIKHLI, Dist‐Buldana, M.S, India. Abstract: All medicines, whether they are of synthetic or of plant origin, should fulfill the basic requirements of being efficacious and safe, and this can be achieved by suitable clinical trials. The term “herbal drugs” denotes plants or plant parts that have been converted into phytopharmaceuticals by means of simple processes involving harvesting, drying, and storage.In general, quality control is based on three important pharmacopoeia definitions:Identity, Purity, Content or assay. There are two types of standardization,In the first category, “True” standardization, a definite phytochemical or group of constituents is known to have activity. Ginkgo with its 26% ginkgo flavones and 6% terpenes is a classic example. These products are highly concentrated and no longer represent the whole herb, and are now considered as phytopharmaceuticals. In many cases they are vastly more effective than the whole herb. The other type of standardization is based on manufacturers guaranteeing the presence of a certain percentage of marker compounds; these are not indicators of therapeutic activity or quality of the herb.
Standardization of herbal drugs Name of Students: Waghmare Jayshree.s *, Patil Payal.V * College Name : OYSTER INSTITUTE OF PHARMACY ,GOLATGAON ,AURANGABAD. ABSTRACT: For preparation of any herbal formulation identification, evaluation and standardization is importent. Identification involves the morphology, microscopy parameter of plants, evaluation and standardization of herbal drugs includes physical, chemical and biological parameters. These parameters are crucial for preparation of accurate and potent formulation. Reason of these studies involve the safe and accurately selection and handling of crude materials, ensure efficacy and stability of finished product, documentation of safety and risk based on experience, provision of product information to consumer and product promotion. Standardization is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs. WHO specific guidelines for the assessment of the safety, efficacy and quality of herbal medicines as a prerequisite for Standardized herbal products of consistent quality and containing well‐defined constituents are required for reliable clinical trials and to provide consistent beneficial therapeutic effects. Pharmacological properties of an herbal formulation depend on phytochemial constituents present therein. Development of authentic analytical methods which can reliably profile the phytochemical composition, including quantitative analyses of market Key words: Herbal drugs, Herbal formulation, standardization, evaluation.
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Herbal Remedies : A New Era For Treatment Of Disease Gulve G.Snehal1, Kakde S.Pooja1, Badak D.Dhanshree2 SHRI BHAGWAN COLLEGE OF PHARMACY, AURANGABAD ( B.Pharm IIIrd yr.) Abstract: The art or practice of using herbs and herbal preparation to maintain heath and to prevent, alleviate or cure disease. A plant or an extract or mixture of these used in herbal medicine”. The different system include Ayurveda, Siddha, Homeopathy and Unanai. In Unani system of medicine there are several home remedies which can be used in routine for the beautification and protection of face and skin from various problems. The concept of beauty especially for female having desire to look beautiful, charming and young by different beauty ways, use in various herbs, are the things since centuries. The used of Turmeric (Curcuma longa linn.), Saffron (Crocus sativa linn.)etc. for bodily decorations ,Sandal surkh (Petrocapous santalinus linn) Sandal safaid (Santalum album linn.) for beautification and Henna (Lawsonia inermis linn.) for dyeing hair in different color different ingredients. The techniques for making face powder, perfume powder and Ubtan (cleaning pest) are used to make natural cosmetics at home. Some of them are Gazza (face powder of lemon pulp , Haldi , Ustukhuddus , Babchi) Ubtan semisolid preparation (lubdi) remove the dirty particles from the skin ( Basen , Haldi , Sandal safaid , Khas Jasmine oil) Paste For Pimples fine paste (Sufoof of Sandal powder and Haldi) Sunburn Relief Gel (Alovera or Badam, Almond and oil of Lavender ) Fruit Facial ( Pineapple, Apple, Badam , Lemon) The main objectives of poster presentation to know the people the herbal remedies for skin care in Unanai as cosmetics.
Herbal remedies. A new era for treatment of disease Pawan G. Darade1, Dattatray D.Doifode1, Naganath L. Ibitdar2 Shri Bhagwan college of Pharmacy , Aurangabad ( B.Pharm IIIrd yr.) Abstract Allopathic medicines are very costly. In contrast, herbal medicines are very cheap. This cost effectiveness makes them all the more alluring. Herbal medicines can be brought without prescription and they are available in all most all health stores. Some herbs can even be grown at home. A herb is a plant part used for it's scent, flavour or the therapeutic Properties. Herbal medicine are one type of dietary suppliment. They are one sold as tablet, capsule fresh plant & teas. People use herbal medicine to try to maintain or improve their health. Herbal medicine is the therapeutic use of plant to treat disease & enhance general health & wellbeing. The objective of this study presentation was to review & explore the top fifteen currently herbal remedies in the treatment of various disease like Psoriasis, Hypokakmia, etc.This Herbal remedies overcome the adverse effect, a diagnostic Effect & bioavailability of drugs. Example: Quinine from Cinchona; Morphine, codeine from Poppy, Digoxin from foxglove. After herbal drug discovery modern medicine Digoxin from Digitalis; Capsaicine from chilli; Taxol from taxus bacata
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Global Regulatory Aspects for Herbal Medicine Kanadje V. Prakash1, Kayande P. Ashok1 Jadhav K. Sudhakar2 Shri Bhagwan College of Pharmacy, Aurangabad Abstract: According to the WHO definition herbal medicine contain as active ingredients plant parts or plant materials in the crude or processed state plus certain excipients, i.e., solvents, diluents or preservatives. Herbal medicine is standardized herbal preparations consisting of complex mixtures of one or more plants which are used for the management of various diseases. In last few decades, public interest in herbal medicine, has increased not only in developing as well as industrialized countries. Therefore it is important to set regulatory guideline for the herbal medicine. World Health Organization has set specific guidelines for the assessment of the safety, efficacy and quality of herbal medicines as a prerequisite for global harmonization. The Medicines and Healthcare Products Regulatory Agency’s, UK has launched ‘yellow card’ scheme for ADR reporting for monitoring the safety of herbal medicines. The legal process of regulation and legislation of herbal medicines changes from country to country The reason for this involves mainly cultural aspects and herbal medicines are rarely studied scientifically. As per WHO 2004 herbal medicine are categorized Indigenous herbal medicine;Herbal medicine in system;Modified herbal medicine and Imported/exported products with a herbal medicine base. WHO also Emphasis on well‐controlled and randomized clinical trials to prove the safety and efficacy of herbal medicines. Who play role in domestication, production and biotechnological studies and genetic improvement of medicinal plants. The intellectual property of herbal drugs is urgently needed. E.g.Recently CSIR launched scientifically validated Ayurveda drug for TYPE‐2 Diabetes. CSIR Lucknow is set to release an antidiabete herbal drug christened BGR‐34.Hence from above poster we want to conclude that tremendously how importance of natural product is increasing, how we should give safety medicine to community, wha tresearch should carry in this field and what regulatory bodies are their to control it to make country healthy and economically strong..
Recent Advances In Herbal Drug Technology Madhura A.Dapkekar1; Varsh N.Kamble1, Shubham K.Dahake2 Shri Bhagwan College of Pharmacy, Aurangabad Abstract: Study of plants for medicinal purpose and study for such ethanomedicinal use is known as Herbal Drug Technology. For certain ailments, herbal medicines are considered to be more effective than allopathic medicines and do not have any side effects, as they are free from chemicals. They are also milder than allopathic medicines. A large number of herbal drugs possess the wide spectrum of therapeutic activity. But the potential use of these herbal drugs is limited due to their poor absorption and poor bioavailability after oral administration. Hence different formulation such as tablets,capsules, Phytosomes,and herbal cosmetics using more and more herbs in their formulation. The world is emerging from macro to nano technology and we are still playing with physic‐chemical properties of herbs rather than to know how fast compounds are absorbed after administration. Now a days we use with modern technology like HPLC, TLC, Spectroscopy, Mass‐spectroscopy.With help of biotechnological knowledge we can increased the production of secoundary metabolite. The several drugs used in modern medicine have come from medicinal plant. eg. Taxol (anticancer), Sagwan (bronchitis), Swertia chirayata (anti T.B.), Curcumin (anticancer), etc. The main objective of above poster presentation to know the people ‘Recent Advance in Herbal Drug Technology’ to help in finding new potent molecule for formulation using advance analytical technique and increase efficacy of drug.
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Development Of Herbal Drug Formulation And Evalution Vidya R.Kale1,Snehal K.Chavan1,Pooja P.Dandge2 Shri Bhagwan college of Pharmacy, Aurangabad ( B.Pharm IIIrd yr.) Absract: Herbal drug are crude plant material such as leaves flowers, fruits, seeds, steams, wood, bark, roots, rhizomes or other parts of plant. Herbal medicine consisting of either crude or semi processed plant. Herbal drug formulation means a dosage form consist of one or more herb in specific quantity to provide specific nutritional cosmetic benefit and also use to diagnose treat, mitigate diseases of human beings or animal. Phytomedicine or phytopharmaceuticals sold as over the counter (OTC) product in modern dosage form such as tablet, capsule, liquid for oral use. Ayurvedic herbal drug formulations are Churna, Bhasma, Bati/pill/gulika, Capsule, Emulsion, Avaleha/ Pak, Kwatha, Gritha Taila Ark. The modern herbal formulations are Tablet, Suspension, Injection, Ointment, Cream, Gel. In ancient Ayurveda we are using mostly whole herb without isolating its natural chemical constituent. Ayurvedic treats entire body as whole. Modern medicine treats symptoms only. Herbal formulation are prepared by Grinding Extraction methods‐Decoction, Cold percolation, Solvent extraction, Filtration, Concentration and Spray drying.herbal formulation evaluation is done to determine the quality herbal formulation. e.g.TLC HPLC, HPTLC, UV, NMR, COLORIMETRY. According to formulation different evalution paramaters are checked for adsorption, distribution metabolism and excretion. Hence from above, we come to know formulation and evaluation methods using herbs.
Natural Indicator: A Better Alternative to Neutralization Indicator Anuj R Bhutada NANDED PHARMACY COLLEGE, NANDED ABSTRACT: Neutralization indicators are used in various acid base titrations. But almost all neutralization indicators are synthetic and replacing synthetic hazardous chemicals with natural safe substances is need of hour so attempt has been made to prepare various natural indicators by using aqueous extracts of beetroot, tradescantia palida and chafa. Alcoholic extracts of rose kaner and clitoria ternatea. So this time to say adieu to synthetic neutralization indicators. The manufacturing process of these indicators is very easy as compared to conventional and industrial process it means; this can be prepared in labs of schools and institutions.
The raw material requires to prepare these natural indicators is available at cheap cost across the India. Also the extracts of chafa and clitoria ternatea is impregnated on whatmann grade filter paper which can effectively use as alternative to litmus paper which has limitations such as price, availability, need of skilled person, complex method of manufacturing, required lichens for manufacture which are not easily available etc. so this indicators and papers are the best alternatives for synthetic indicators and litmus paper respectively as per its availability, economicaly and ease of manufacturing process.
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Preparation And Evaluation Of PolyHerbal Hand Wash Sana Juveria Khan NANDED PHARMACY COLLEGE, NANDED ABSTRACT: Hand washing for hand hygiene is the art of cleaning the hands with the use of water or another liquid or with the use of soap, for the purpose of removing soil, dirt, and micro‐organisms to prevent, control and reduce the infectious diseases such as Measles, Chiken pox, Influenza and Tuberculosis. The main purpose is to prepare poly Herbal Hand Wash by using Reetha,Shekekai,Neem,Tulsi,Lemon juice, BHT (Butylated hydroxyl tolune) SLS (Sodium Lauryl Sulphate) CMC (Carboxy Methyl Cellulose) and prepared hand wash was evaluated by using reported methods. Key Words: Poly‐ Herbal Hand Wash, Evaluation tests, Comparative study with marketed hand washes.
Cost effective extraction and isolation of polyphenols Rumana sheikh and Aditi dongre NANDED PHARMACY COLLEGE, SHYAM NAGAR, NANDED Abstract: As polyphenols have great health advantages, hence focus has been emphasized on its cost effective extraction. Plants rich source of polyphenols such as Wodfordia fruticosa and Terminalia catappa were extracted with alcohol. The obtained alcoholic extracts were concentrated in vacuo and then dissolved in 10% NaOH (as phenols are soluble in NaOH). Then this basic solution of phenolics was mixed with sufficient quantity of dil. HCL till precipitation ceases. The obtained precipitate of polyphenol was separated, purified and tested for presence of phenol functional groups. The purified fraction was further subjected to chromatographic and spectroscopic standardization. The same method can be selectively applied by adjusting proper pH conditions. The method saves the cost of extraction solvent such as alcohols, ethyl acetates in addition to time by bypassing column separation.
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Participation of Pharm D. students in International Seminar at
Govt Hospital and Medical College, Aurangabad
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