European HIV/AIDS programmes: EDCTP as a model of Europe-Africa partnership

19 July 2011IAS 2011Rome, Italy

Charles S MgoneEDCTP Executive Director

About EDCTP

• Partnership between European member states, European Commission and Africa in collaboration with like minded organisations in fighting diseases of poverty – HIV/AIDS, malaria and tuberculosis

• This is realised by funding clinical trials and research capacity to accelerate development of intervention tools including drugs, vaccines, microbicides and diagnostics against these diseases

The partnership

• Benin• Botswana • Burkina Faso• Cameroon• Congo• Cote d’Ivoire• Democratic Republic of Congo• Ethiopia• Gabon• Ghana• Guinea• Guinea-Bissau• Guinea-Conakry• Kenya• Liberia• Madagascar• Malawi• Mali

• Mozambique• Namibia• Nigeria• Rwanda• Senegal• South Africa• Sudan• Tanzania• The Gambia• Togo• Uganda• Zambia• Zimbabwe

• Austria• Belgium• Denmark• France• Germany• Greece • Ireland• Italy• Luxembourg• Netherlands• Norway• Portugal

• Spain • Sweden• Switzerland• United Kingdom

EDCTP-EEIG member states

Sub-Saharan African countries

Strengthening of clinical trials capacity and the enabling environment

1

2

3

4

5

6

EDCTP Regional Networks for Clinical Trials

Western Africa: WANETAMWebsite: www.wanetam.org Project Coordinator: Prof. Soleymane Mboup• Burkina Faso• The Gambia• Ghana• Guinea-Bissau•Mali• Nigeria

• Senegal• United States

Southern Africa: TESAWebsite: www.tesafrica.orgProject Coordinator: Dr Alexander Pym• Botswana• Malawi • Mozambique • South Africa • Zambia • Zimbabwe • France

• Germany• Netherlands• United Kingdom

Eastern Africa: EACCRWebsite: www.eaccr.orgProject Coordinator: Dr Pontiano Kaleebu• Kenya• Sudan• Ethiopia• Tanzania• Uganda• Germany• Sweden

• United Kingdom• United States

Central Africa: CANTAMWebsite: www.cantam.orgProject Coordinator: Prof. Francine Ntoumi• Cameroon• Congo, Republic of the• Gabon• France• Germany

Funded projects including clinical trials 2003-2011

•Treatments

13

•Vaccines

9•Mi

crobicides

4

HIV/AIDS26 clinical trials

108.30 M €

•Treatments

7 •V

accines

7•D

iagnostics

4

Tuberculosis18 clinical trials

103.33 M €

•Treatments

10

•Vaccines

2

Malaria12 clinical trials

69.63 M €

EDCTP has funded 174 projects in 29 African countries including 56 clinical trials on HIV/AIDS, malaria and TB

HIV/AIDS treatment and prevention trials

• Evaluation of paediatric formulations: fixed drug combinations/scored dispersible tablets

• Evaluation of second-line treatment

• HIV/TB co-infections

• Prevention of Mother to Child Transmission of HIV (PMTCT)

HIV preventive vaccine trials

• Capacity building in preparation for HIV vaccine trials- Joint EDCTP/BMGFgrant

• DNA+MVA-CMDR (rgp 140/GLA-AF) phase I/II clinical trial (TaMoVac + AfrEVacc) in healthy young adults

• DNA + MVA-HIVA phase I/II in healthy infants born to

HIV1 and HIV2 uninfected and infected mothers

Microbicide trials

• Site preparation/capacity strengthening

• Establishment of cohorts

• Characterisation of novel safety markers

• PRO 2000 vaginal gel phase III clinical trial

EDCTP-II

• Consolidation of the current focus on clinical trials• Phase II and III clinical trials

• Expansion to phase I and IV clinical trials• Health services/optimisation studies• Neglected Tropical Diseases including co-morbidities

• Open collaborative projects with other developing countries beyond sub-Saharan Africa

Thank you

http://www.edctp.org