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Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson, Michael S. Lawrence, Carrie Sougnez, Chip Stewart, Andrey Sivachenko, Lili Wang, Youzhong Wan, Wandi Zhang, Sachet A. Shukla, Alexander Vartanov, Stacey M. Fernandes, Gordon Saksena, Kristian Cibulskis, Bethany Tesar, Stacey Gabriel, Nir Hacohen, Matthew Meyerson, Eric S. Lander, Donna Neuberg, Jennifer R. Brown, Gad Getz, Catherine J. Wu Cell Volume 152, Issue 4, Pages 714-726 (February 2013) DOI: 10.1016/j.cell.2013.01.019 Copyright © 2013 Elsevier Inc. Terms and Conditions

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

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Page 1: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia 

Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson, Michael S. Lawrence, Carrie Sougnez, Chip Stewart, Andrey Sivachenko, Lili Wang, Youzhong Wan, Wandi Zhang, Sachet A. Shukla, Alexander Vartanov, Stacey M. Fernandes,

Gordon Saksena, Kristian Cibulskis, Bethany Tesar, Stacey Gabriel, Nir Hacohen, Matthew Meyerson, Eric S. Lander, Donna Neuberg, Jennifer R. Brown, Gad Getz, Catherine J. Wu 

Cell Volume 152, Issue 4, Pages 714-726 (February 2013)

DOI: 10.1016/j.cell.2013.01.019

Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 2: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure 1

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 3: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure 2

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 4: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure 3

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 5: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure 4

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 6: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure 5

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 7: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure 6

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 8: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure 7

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 9: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure S1

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 10: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure S2

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 11: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure S3

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 12: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure S4

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 13: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure S5

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 14: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Figure S6

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions

Page 15: Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson,

Cell 2013 152, 714-726DOI: (10.1016/j.cell.2013.01.019) Copyright © 2013 Elsevier Inc. Terms and Conditions