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Figure 11.12 The Biology of Cancer (© Garland Science 2007)
Figure 11.7 The Biology of Cancer (© Garland Science 2007)
Figure 11.9 The Biology of Cancer (© Garland Science 2007)
Progressive Accumulation of Genetic Lesions in Colon Cancer
Progressive LOH
The Corresponding genetic lesions
Figure 7.24a The Biology of Cancer (© Garland Science 2007)
APC , β-CATENIN & REGULATION OF THE INTESTINAL LINING
Figure 11.20 The Biology of Cancer (© Garland Science 2007)
Comparative Genome Analysis
Figure 11.22b The Biology of Cancer (© Garland Science 2007)
In Vivo Studies With Monozygotic Twins Show Requirement For More Than 1 Genetic
Modification
Table 11.2 The Biology of Cancer (© Garland Science 2007)
Oncogene Collaboration
Figure 11.24a The Biology of Cancer (© Garland Science 2007)
In vivo Study in Mouse Model Shows effect of Collaborating Genetic
Lesions
Figure 11.28 The Biology of Cancer (© Garland Science 2007)
Tumor Initiators and Tumor Promoters - Phenomenology
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†
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Figure 11.29 The Biology of Cancer (© Garland Science 2007)
Initiators & Promoters – Possible Mechanisms I
Figure 11.30 The Biology of Cancer (© Garland Science 2007)
Initiators & Promoters – Possible Mechanisms II
Table 11.4 The Biology of Cancer (© Garland Science 2007)
Figure 11.37b The Biology of Cancer (© Garland Science 2007)
Inflammation and Liver Cancer
Figure 11.38c The Biology of Cancer (© Garland Science 2007)
Inflammation, Cyclooxygenase-2 (COX-2), Prostaglandin E2 & Tumor
Promotion
Table 11.3 The Biology of Cancer (© Garland Science 2007)
Alcohol – head & neck
Figure 11.42 The Biology of Cancer (© Garland Science 2007)
Mutagens vs Promoters