Figure. S1

Week

Perc

ent o

f VO

2pea

k

1 2 3 4 5 6 7 8 9 10 11 12

Repeat CPET

Figure. S1 (cont)

13 14 15 16 17 18 19 20 21 22 23 24

Week

Perc

ent o

f VO

2pea

k

6 month CPET

Figure. S2

743 Total Patients Screened

561 Excluded 526 ≥40 miles distance from Duke 14 medically ineligible 12 miscellaneous reasons 9 receiving radiation and/or androgen deprivation therapy

50 Randomized

25 Randomized to Usual Care 25 Received usual care as assigned

25 Randomized to Aerobic Training 25 Received aerobic training as assigned

2 Did not complete 6-month follow-up visit 2 unreachable

2 Did not complete 6-month follow-up visit 2 unreachable

23 Completed 6-month follow-up visit 23 Completed 6-month follow-up visit

25 Included in the analysis of the primary and secondary outcomes

25 Included in the analysis of the primary and secondary outcomes

182 Total Patients Eligible132 Reasons for Non-Consent 66 not interested 36 travel requirements 30 time commitment

Figure. S3

Patient ID

Patient ID

Δ p

erce

nt c

hang

e in

VO

2pea

k (m

L.kg

.-1m

in-1

)Δ

per

cent

cha

nge

in V

O2p

eak (

mL.

kg.-1

min

-1)

Aerobic Training

Usual Care