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Finding disease genes on AWS, Azure, and Alibaba using serverless
HEALTH AND BIOSECURITY
Denis Bauer | PhD, hon A/Prof May 2019, C3DIS
Serverless Innovation for Health | Denis C. Bauer | @allPowerde
• Cusp of a medical revolution.
• Cure diseases that were untreatable.
• Potentially prevent diseases altogether.
#FutureOfHealth
is digital
Community effort
Serverless Innovation for Health | Denis C. Bauer | @allPowerde2 |
AU’s leading national e-Health centre
Serverless Innovation for Health | Denis C. Bauer | @allPowerde
World-first clinical substantiated mobile health app
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Bioinformatics | Denis C. Bauer | @allPowerde
The genome holds the blueprint for every cell in our body.
Serverless Innovation for Health | Denis C. Bauer | @allPowerde4 |
Bioinformatics | Denis C. Bauer | @allPowerde5 Bioinformatics | Denis C. Bauer | @allPowerde
Genomics affects the way we look.
https://www.bioinformatics.csiro.au/thumb
Bioinformatics | Denis C. Bauer | @allPowerde6 Bioinformatics | Denis C. Bauer | @allPowerde
Genomicsalso affects disease risk.
By 2025 it is estimated that 50% of the world population will have been sequenced.
20 EB Storage / yearStephens et al. BigData: Astronomical or Genomical (2015)
Data acquisition of BigData disciplines in 2025
GenomicsYouTube
Astronomy
Frost&Sullivan
Serverless Innovation for Health | Denis C. Bauer | @allPowerde7 |
Bioinformatics | Denis C. Bauer | @allPowerde
Data size is astronomicalgenomical
• 2 meters per genome.
• 100 trillion cells in our body.
• Information in us is larger than the Universe.
Serverless Innovation for Health | Denis C. Bauer | @allPowerde8 |
Bioinformatics | Denis C. Bauer | @allPowerdeServerless Innovation for Health | Denis C. Bauer | @allPowerde
Powerful disease gene discovery
“Analyzes 3000 individuals with 80M features in 30 minutes“
“Requires 80% fewer samples to detect statistical significant signal“
Faster Smarter
Use
d b
y
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Serverless Innovation for Health | Denis C. Bauer | @allPowerde
Credit: National Institute on Aging, National Institutes of Health
Finding the cure for ALS
*familial+mouse model: Iannitti, et al. Mol Ther Nucleic Acids. 2018
Can the genome of neurons be modified to
prevent the disease?
• Mutations in SOD1 gene causes ALS*
• Silencing SOD1* slows neuronal death+
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Serverless Innovation for Health | Denis C. Bauer | @allPowerde
Genome Editing: Revolutionize medicine
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Serverless Innovation for Health | Denis C. Bauer | @allPowerde
Why is it difficult?
Finding the right grain of sand…
… that is unique on a beach.
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Recruiting instantaneous appropriately powered compute
On-premServer
Cloud Server
Autos-scale Cloud server
Serverless
Focus Full control Lower maintenance Flexible Agility
Flexibility
No Overhead ✕
Scalability ✕ ✕
Cost-effective ✕
Serverless Innovation for Health | Denis C. Bauer | @allPowerde
by blacklane.com by madd.org
Analogy
own car car rental chauffeur ride share
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One of the first Serverless Applications in Research
Serverless Innovation for Health | Denis C. Bauer | @allPowerde15 |
Serverless workflow set up across three cloud providersGT-Scan architecture across different providers
Bioinformatics | Hon A/Prof Denis C. Bauer | @allPowerde
Jason, Sabith Simon Waight
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Bioinformatics | Denis C. Bauer | @allPowerde
Once you go serverless you never go back.- Rapid prototyping and scaling to production.
- Allowing burstable workloads.
- Innovation becomes affordable.
AWS SummitCanberra ‘18
17 | Serverless Innovation for Health | Denis C. Bauer | @allPowerde
By 2025 serverless will be a USD 20 billion market.
Grand View Research, Inc.
Bioinformatics | Denis C. Bauer | @allPowerde
Three things to remember
• ‘Datafication’ demands ‘wide’ ML for more disciplines
(VariantSpark).
• Serverless architecture will be the future - enabling rapid
prototyping and scalability.
• Business and life-science research are not that different:
let’s build a healthier future together!
Serverless Innovation for Health | Denis C. Bauer | @allPowerde18 |
Bioinformatics | Denis C. Bauer | @allPowerde
Let’s build a healthier world together
Denis Bauer, PhD
Rob Dunne, PhD
Piotr Szul
Transformational Bioinformatics
Collaborators
News
Software
Lynn Langit
Top 10 Australian IT stories of 2017
You?
We are hiring…
…email Denis
#InCoB 2019 | Jakarta
KEYNOTE
SuzanneScott
Serverless Innovation for Health | Denis C. Bauer | @allPowerde
Oscar Luo, PhD
ArashBayat, PhD
Natalie Twine, PhD
Genome Insight
YatishJain
Aidan O’Brien
Laurence Wilson, PhD
Brendan Hosking
Aidan Tay
Daniel Reti
Digital Genome Engineering
SuzanneScott
Mumbai2019
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