F I N D I N G D R U G D ATA S TAT

WEB-BASED INFORMATION RESOURCES:

OBJECTIVES

• Discover techniques for effectively locating and utilizing web-based information resources.

• Analyze the most appropriate drug information resources, including primary, secondary, and tertiary sources for answering questions related to clinical research and practice.

• Analyze evidence-based medicine resources and clinical guidelines/trial resources used in the literature retrieval process.

• Realize the vast number of resources available for drug information.

• Describe key advantages and disadvantages of using free web-based search engines versus online subscription web sites.

OVERVIEW OF DRUG INFORMATION RESOURCES

• Primary literature:• Most up-to-date resource available• Journal articles

• Secondary literature resources:• Indexing and abstracting systems• Easy retrieval of primary resources

• Tertiary Resources:• Condense and summarize data from the primary literature• Textbooks• Electronic databases

SEARCH ENGINES

General Web-searching principles apply.

Caveat Emptor – “Let the buyer beware”

Verify, validate, and confirm the information is correct

Web search engines may help quickly locate relevant materials.

Not reliable for producing a comprehensive, verifiable, repeatable set of citations – use MEDLINE, EMBASE,

IPA, etc.

Features of Electronic Tertiary Databases

Clinical Pharmacology Facts & Comparisons answers LexiROM Micromedex

Drug Identification Search by NDC number search by partial or complete NDC Comprehensive 23,000 U.S and Foreign Drugs

Drug Interactions drug-drug, drug-drug, drug-disease, duplications, drug-drug, drug-drug, duplications, drug-food, allergy, drug-food, ethanol, lab, drug-lab, drug-food, duplications, allergy, ethanol, lab, tobacco, tobacco, pregnancy, lactation allergy, herbal, drug-food, ethanol, caffeine pregnancy, OTC lab, tobacco, pregnancy, lactationIV Compatibility Trissel's 2 Trissel's 2 King's Guide to Trissel's 2 Parenteral Admixtures Laboratory Chart of normal Chart of normal laboratory Pertinent information Individual laboratoryInformation laboratory values values in monographs value monographs chart of normal laboratory values

Patient Counseling English and Spanish Drug, oncology-specific administration, Drug, disease and Drug, disease, and

Materials OTC administration techniques, procedural information; procedural; English, disease-focused; English and Spanish 19 languages including Spanish, and 13 other English and Spanish languages; customizableInert Located in how supplied Located under product list Not readily available Through Tox andingredients section Drug Product LookupTeratogenicity Pertinent information Uses Briggs' Drugs in Pregnancy ThroughTOXNET, Through REPRORISKinformation in monographs and Lactation Hazardous substance database Breastfeeding Pertinent information Uses Briggs' Drugs in Pregnancy ThroughTOXNET, Through REPRORISKinformation in monographs and Lactation Lactmed Investigational Yes, readily referenced Limited information Limited Yes, readily referenceddrug monographs Complimentary and Yes Through review of Natural Through Natural Yes; AltMedDexalternative medicine Products Product Database FDA recalls No Weekly FDA news thread Link to FDA NoDrug shortages No Weekly FDA news thread Link to FDA NoMaterial Safety Data No No No Yes; AltMedDexSheets Referencing Comprehensive Limited Limited ExtensiveAvailable platforms Web-based, PDA Web-based, PDA, print Web-based, PDA. Print Web-based, PDACost Subscription required; Subscription required for basic and Subscription required Subscription required;

30 day free trial available advanced packages for individual Various package free access to students components; package proves available prices available

NATIONAL LIBRARY OF MEDICINE

• Medline is freely accessible via PubMed• http://nlm.nih.gov

FREELY ACCESSIBLE DRUG INFORMATION

• National Library of Medicine• Databases• PubMed/MEDLINE• MeSH• UMLS• ClinicalTrials.gov• MedlinePlus• TOXNET• Images from the History of Medicine• LocatorPlus• All NLM Databases & APIs

NATIONAL LIBRARY OF MEDICINE

• Find, Read, Learn• Search biomedical literature• Find medical terminologies• Search NLM collections• Read about diseases• Learn about drugs• Explore history• Find a clinical trial• Use a medical dictionary• Find free full-text articles

NATIONAL LIBRARY OF MEDICINE

• Drug Information from the National Library of Medicine• Drug Information Portal• The Portal provides users a comprehensive gateway to information on more than 20,000 drugs (over 200,000 unique searchable drug

names and their synonyms) not only from NLM but also from other U.S. government agencies. It covers drugs from the time they are entered into clinical trials through their entry into the U.S. market place. The Drug Portal touches on all related information resources at NLM to provide for a comprehensive view. It is intended as a "middle ground" resource which includes information for the consumer, health professionals, and researchers.

• Drugs, Herbs and Supplements• Learn about your prescription drugs and over-the-counter medicines from MedlinePlus, the National Institutes of Health's Web site for

patients and their families and friends. Read about side effects, dosage, special precautions, and more. Browse dietary supplements and herbal remedies to learn about their effectiveness, usual dosage, and drug interactions.

• Pillbox• Developed to aid in the identification of unknown solid dosage pharmaceuticals, Pillbox combines high-resolution images of tablets and

capsules with appearance information (imprint, shape, color, etc.). It enables users to identify solid dosage forms based on physical criteria: imprint (characters or number printed on a medication), shape, color, size, and scoring. Users are shown thumbnail images of possible matches. These images are continually updated as the user enters additional information. Pillbox is designed for use by emergency physicians, first responders, other health care providers, Poison Control Center staff, and concerned citizens.

• DailyMed• DailyMed provides information about marketed drugs, including FDA labels (package inserts). It provides health information providers

and the public with a standard, comprehensive, up-to-date, look-up and download resource of medication content and labeling as found in medication package inserts.

• Dietary Supplements Labels Database• The database links you to the information from the labels of over 4,000 dietary supplement products in the marketplace, including

vitamins, minerals, herbs or other botanicals, amino acids, and other specialty supplements. It includes name, form, active and inactive ingredients, amount of active ingredient, manufacturer/distributor information, label claims, warnings, percentage of daily value, and additional label information. The database can be searched by product names, text terms found on product labels, specific dietary ingredients, and manufacturers.