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15%
75%
10%
Glomerular
Fascicular
Reticular
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Figure 7-7, steps 1–2a
Most hydrophobic steroids are bound to plasma protein carriers. Only unbound hormones can diffuse into the target cell.
Some steroid hormones also bind to mem-brane receptors that use second messenger systems to create rapid cellular responses.
Steroid hormone receptors are typically in the cytoplasm or nucleus.
Cellmembrane
Interstitialfluid
Cytoplasmicreceptor
Nucleus
Nuclear receptor
Rapid responses
Steroidhormone
Bloodvessel
Proteincarrier
Cell surface receptor
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2a
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2
2a
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Figure 7-7, steps 1–4
Most hydrophobic steroids are bound to plasma protein carriers. Only unbound hormones can diffuse into the target cell.
Some steroid hormones also bind to mem-brane receptors that use second messenger systems to create rapid cellular responses.
Steroid hormone receptors are typically in the cytoplasm or nucleus.
The receptor-hormone complex binds to DNA and activates or represses one or more genes.
Activated genes create new mRNA that moves into the cytoplasm.
Cellmembrane
Interstitialfluid
Cytoplasmicreceptor
Nucleus
Nuclear receptor
DNA
Rapid responses
Transcriptionproduces mRNA
Steroidhormone
Bloodvessel
Proteincarrier
Cell surface receptor
2
3
1
4
2a
1
2
2a
3
4
16
Figure 7-7, steps 1–5
Most hydrophobic steroids are bound to plasma protein carriers. Only unbound hormones can diffuse into the target cell.
Translation produces new proteins for cell processes.
Some steroid hormones also bind to mem-brane receptors that use second messenger systems to create rapid cellular responses.
Steroid hormone receptors are typically in the cytoplasm or nucleus.
The receptor-hormone complex binds to DNA and activates or represses one or more genes.
Activated genes create new mRNA that moves into the cytoplasm.
Cellmembrane
Interstitialfluid
Cytoplasmicreceptor
Endoplasmicreticulum
Nucleus
Nuclear receptor
DNA
Translation
Rapid responses
Transcriptionproduces mRNA
Steroidhormone
Bloodvessel
Proteincarrier
Newproteins
Cell surface receptor
2
3
1
4 5
2a
1
2
2a
3
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Figure 20-12: Aldosterone action in principal cells 27
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Figure 20-13: The renin-angiotensin-aldosterone pathway29
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