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APM0922 34828 DiaSorin Inc. | 1 800 328-1482 | www.diasorin.com For 25 years DiaSorin has been setting the standard. The DiaSorin LIAISON ® offers a fully automated, high throughput, cleared assay that measures both D 2 and D 3 for a TOTAL 25 Vitamin D result. Follow the Leader in Vitamin D Testing During the past two decades, DiaSorin assays have been used in the vast majority of clinical studies worldwide to define normal circulating 25(OH)D levels. s .ATIONAL (EALTH AND .UTRITION %XAMINATION 3URVEY .(!.%3 ))) s .URSES (EALTH 3TUDY .(3 s 7OMENS (EALTH )NITIATIVE 7() s (EALTH 0ROFESSIONALS &OLLOWUP 3TUDY (0&3 BY (ARVARD &OR MORE INFORMATION CONTACT US AT 800-328-1482 or [email protected]. More than 125 million Vitamin D tests distributed worldwide

Follow the Leader in Vitamin D Testing - Clinical Chemistry

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APM0922 34828 DiaSorin Inc. | 1 800 328-1482 | www.diasorin.com

For 25 years DiaSorin has been setting the standard.The DiaSorin LIAISON® offers a fully automated, high throughput, cleared assay that measures both D2 and D3 for a TOTAL 25 Vitamin D result.

Follow the Leader in Vitamin D Testing

During the past two decades, DiaSorin assays have been used in the vast majority of clinical studies worldwide to defi ne normal circulating 25(OH)D levels.

� �������� ���� ��� � ������� ����������� � ��� ������ ����� � ���� ���� �� �� ����� ������ ���� ��������� ����� ���� ������������� ������! " �� �� ����� #� ������

��� ��� ����������� $����$� � �� 800-328-1482 or [email protected].

More than 125 million Vitamin D tests distributed worldwide

Information for Authors

Clinical Chemistry is published by the American Association forClinical Chemistry (AACC). The journal welcomes contributions oforiginal information, experimental or theoretical, that advance thescience of clinical chemistry. Submissions should adhere to the “Uni-form Requirements for Manuscripts Submitted to Biomedical Jour-nals” (http://www.icmje.org/).

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Clinical Chemistry (ISSN 0009-9147) is published monthly by theAmerican Association for Clinical Chemistry, 1850 K Street, NW,Suite 625, Washington, DC 20006.

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Editorial Office Address. For additional information about manu-script submission and reviewing, contact the editorial office.Telephone 202.420.7678; fax 202.833.4576; e-mail [email protected]. Address for regular mail or courier: ClinicalChemistry, 1850 K Street, NW, Suite 625, Washington, DC 20006.

Subscriptions: Contact the AACC Subscriptions Department at1850 K Street, NW, Suite 625, Washington, DC 20006. Telephone800.892.1400 or 202.857.0717; fax 202.887.5093; or websites http://www.clinchem.org or http://www.aacc.org. Annual 2011 rates: Printand online institutional subscription USA $1,158, elsewhere $1,337.Individual subscription USA $350, elsewhere $542. Airmail deliveryoutside USA is an additional $290. Online only (no print) institu-tional subscription $776; individual subscription $235. Individualsubscriptions are for personal use and not to be used in a library.

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Advertising Inquiries: Contact Scherago International, Inc., 525Washington Blvd., Suite 3310, Jersey City, NJ 07310. Telephone201.653.4777; fax 201.653.5205; e-mail [email protected]; Internethttp://www.scherago.com.

Copyright © 2011 The American Association for Clinical Chemistry.All rights reserved. Printed in the United States of America. Photo-copying beyond that permitted by Sections 107 or 108 of the USCopyright Law is authorized by the American Association for Clini-cal Chemistry, for internal or personal use, provided that (a) the feeis paid directly to the Copyright Clearance Center, Inc., 222 Rose-wood Drive, Danvers, MA 01923; or (b) a photocopy license has beengranted by the CCC. Fees are subject to change. This consent does notextend to other kinds of copying, such as for general or externaldistribution, resale, advertising, promotional purposes, or for creat-ing new collective works; for these purposes, contact the Director ofPublications, AACC, 1850 K Street, NW, Suite 625, Washington, DC20006. Telephone 202.857.0717; fax 202.833.4568, e-mail [email protected].

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AACC OfficersAnn M. Gronowski, PresidentGreg Miller, President-ElectCatherine A. Hammett-Stabler,

Past PresidentElizabeth L. Frank, SecretaryD. Robert Dufour, Treasurer

AACC Board of DirectorsDavid E. BrunsDavid G. GrenachePatricia M. JonesDavid D. KochRobert L. MurrayGregory J. Tsongalis

6A

Quick Guide toSubmission

For additional article types and detailed instructions, please see our Information for Authors athttp://www.clinchem.org/info_ar/info_authors.shtml.

Type of Submission*WordLimit

Structured (S) orUnstructured (U)

Abstract: Word Limit

MaximumNumber ofReferences

Total Number ofTables/Figures

Article 3,500 S: 250 40 6

Brief Communication 1,500 S: 250 20 1 each

Citation Classics 600 Nonapplicable 6 Nonapplicable

Clinical Case StudyCase descriptionCase discussion3–5 questions and up to 5 pointsto remember

5001,000 Nonapplicable 10 2

Clinical Case Study Commentary 300 Nonapplicable Nonapplicable Nonapplicable

Editorial 1,500 Nonapplicable 15 Nonapplicable

Letters to the Editor / Reply 750 Nonapplicable 5 1

Mini-Review 3,500 S: 250 40 4

Opinion 1,500 Nonapplicable 15 1

Perspective 1,500 Nonapplicable 5 1

Q&A 3,500 Nonapplicable Nonapplicable Nonapplicable

Review 5,000 S: 250 75 6

What Is Your Guess?Case description3 questionsCase discussion

75

75Nonapplicable 5 1

�This chart represents common types of submissions to Clinical Chemistry.

Manuscript Formatting▫ Double-spaced text, 1-inch margin, 12-point font size in Arial, Helvetica, or Times New Roman▫ Numbered pages with references numbered sequentially in main text▫ Title page listing title, authors (first name, middle initial, last name), each author’s affiliation during

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▫ Reference list formatted according to Information for Authors with Journal abbreviations in the reference listchecked against the National Center for Biotechnology Information database (http://www.ncbi.nlm.nih.gov/)

▫ SI units used throughout manuscript according to Information for Authors

Metadata (to be entered online)▫ A valid and unique e-mail for each author▫ Authors’ current institution, address, telephone, and fax▫ Author Disclosure Forms and Contribution Forms to be completed by each author before submission.

Copyright Transfer Agreement to be completed by each author after acceptance.▫ Clinical Chemistry manuscript number of any companion papers (if applicable)

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is required for all studies or trials of the diagnostic accuracy or performance of a diagnostic test; a CONSORTdiagram is required for all randomized and Phase III trials; a MIAME checklist is required for all studies thatpresent data for microarray experiments.

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Pediatric Reference Intervals, 7th Edition

Edited by Steven J. Soldin, Edward C. Wong, Carlo Brugnara, and Offie P. Soldin

2011, 303 pages, softcover, ISBN 9871594251016 Price $84, AACC Members $67, Product #6116

The seventh edition of Pediatric Reference Intervals is a valuable reference providing instant and accurate reference intervals for over 250 chemistry and hematology analytes in an alphabetized, user-friendly format. Changes to this edition include:

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Point-of-care testing (POCT) is now considered a key enabler of reform and quality improvement in healthcare. Written by an international list of authors, this book brings together:� � ���������� � �� � � ����� � � � � ������� ����� including the move to patient-centered care � ��������� ������� � � ���� � ����� �� �� � developments in this field � �� � ���� � �� ���� ���� � ���� � � ������ environment � ���������� � ���� � � ��� � ������� � ����� �� the improved outcomes that results from POCT � � �������� � �� ����� � � � ��������� ������ technology in the complex environment of healthcare, and the leading role that POCT will play in transforming healthcare delivery.The technological developments described in this book demonstrate how all in vitro tests can potentially be delivered at the point of care in the future. The challenge for developer, manufacturer, purchaser, provider and user is to determine which tests will offer the greatest benefit and ���� �� �� ����� � � � � ������� � ��� ����� � ��������� technology, experience indicates that the biggest challenge for all stakeholders will be transforming the practice of healthcare in order to generate these benefits. This is a ‘must read’ book for all developers and manufacturers of POCT technology, those who develop healthcare policy, those who purchase or commission healthcare services, and those who will use this innovative technology.

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Biochemical and Molecular Basis of Pediatric Disease, 4th Edition, includes new chapters in the areas of neonatology, iron metabolism, coagulation, endocrinology, and allergy. All other chapters have been extensively updated, covering nearly all aspects of pediatric disease and the many advances that have been made in recent years. Fifty-two pediatric academic faculty, all nationally known for their pediatric clinical and laboratory expertise, have contributed to this new edition, designed not only for trainees in pediatrics and laboratory medicine, but also for well-established practitioners who wish to keep up with advances in the field and those who would like to better understand the unique aspects of pediatric disease and the clinical laboratory.

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