Free Classroom Resources from HHMI for Teaching Evolution, Part
2 Megan Stine [email protected] June 19, 2014
Slide 2
Evolution: Behind the Scenes
Slide 3
Evolving Switches, Evolving Bodies Film guides Virtual lab
Classroom activities: Using Genetic Crosses to Analyze a
Stickleback Trait Modeling the Regulatory Switches of the Pitx1
Gene in Stickleback Fish
Slide 4
Evolving Switches, Evolving Bodies Film
http://www.hhmi.org/biointeractive/making-
fittest-evolving-switches-evolving-bodies
http://www.hhmi.org/biointeractive/making-
fittest-evolving-switches-evolving-bodies
Slide 5
Which phenotype is dominant? Assumption: single-gene trait, 2
alleles, normal dominance Cross between a marine stickleback and
one from Bear Paw Lake Parents are homozygous F is dominant, f is
recessive
Slide 6
Predict the results of the crosses FF f f Ff Pelvic spines
present:absent = 0:1 1:0 Ff F f FF Ff ff Pelvic spines
present:absent = 3:11:3 1 st generation2 nd generation
Slide 7
Sorting by Phenotype With pelvic spinesWithout pelvic
spines
Slide 8
Do the data support your hypothesis? Sort the F 1 cards: Fish
with pelvic spines Fish without pelvic spines Sort the F 2 cards
Ratio of fish with:without pelvic spines in F 1 ? Ratio of fish
with:without pelvic spines in F 2 ? 1:0 3.4:1 Was our initial
assumption correct? Is this a single-gene trait? Was your
hypothesis correct? Which phenotype is dominant?
Slide 9
Virtual Lab
Slide 10
Natural Selection in Humans Film guides Classroom resources:
Nature of Science Mendelian Genetics, Pedigrees, and Chi- square
Analysis How Fibers Form Population Genetics
Slide 11
Natural Selection in Humans Film
http://www.hhmi.org/biointeractive/making-
fittest-natural-selection-humans
http://www.hhmi.org/biointeractive/making-
fittest-natural-selection-humans
Slide 12
Mendelian Genetics Activity Punnett squares Pedigree analysis
Pedigree creation Chi-square analysis Data prediction Important
notes: A is normal allele S is sickle cell allele AA has normal RBC
phenotype AS has sickle cell trait SS has sickle cell disease
Slide 13
Question #1: Intro Punnett AS A S Chance of normal RBC in high
and low oxygen? Chance of SCD? Chance of 3 children with SCD?
Chance of 2 children with sickle cell trait and 1 with SCD? Child
without SCD, what chance he/she has trait? AA AS SS 1/4 1/64 1/16
2/3
Slide 14
Question #6: Intro Pedigree Genotype of: 1 st gen male? 2 nd
gen daughter? Individual #3? If family moves to lowlands of E.
Africa, 4/5 males will have two genetic advantages. What are they?
AS SS AS
Slide 15
Human Evolution Click & Learn
Slide 16
Teacher Guides
Slide 17
Holiday Lecture Series
Slide 18
BioInteractive.org
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Coming in Fall 2014
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