From Biofuels and Beyond Inspired Science to Deliver Sustainable Solutions for a Growing World Joel Velasco April 2014

From Biofuels and BeyondInspired Science to Deliver Sustainable Solutions for a Growing WorldJoel VelascoApril 2014

2Copyright © 2012 Amyris, Inc. All rights reserved.

This presentation and oral statements accompanying this presentation contain forward-

looking statements, and any statements other than statements of historical facts could be

deemed to be forward-looking statements. These forward-looking statements include, among

other things, sizes of markets that may be addressed by Amyris’s current and potential

products, Amyris’s expected product pipeline, sales volumes and average selling prices,

production volumes and costs and associated product launch timing expectations, operation

of production facilities, commercial relationships, and financial results, that involve risks and

uncertainties. These statements and other forward-looking statements that may be provided in

the presentation and/or oral statements accompanying it are based on management’s

estimates and current expectations and actual results and future events may differ materially

due to changes in Amyris’s business and various risks and uncertainties, including those

associated with any delays or failures in development, production and commercialization of

products, liquidity and ability to fund capital expenditures, Amyris’s reliance on third parties to

achieve its goals, and other risks detailed in the “Risk Factors” section of Amyris’s quarterly

report on Form 10-K filed on April 2, 2014. Amyris disclaims any obligation to update

information contained in these forward-looking statements whether as a result of new

information, future events, or otherwise.

Cautionary Note re: Forward Looking Statements

3Copyright © 2012 Amyris, Inc. All rights reserved.3Copyright © 2012 Amyris, Inc. All rights reserved.

The Renewable Fuel Standard (RFS2)


RFS2 as Imagined

2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022

Conventional Biofuels 10.5 12 12.6 13.2 13.8 14.4 15 15 15 15 15 15 15 15

Non-celulosic Advanced 0.1 0.2 0.3 0.5 0.75 1 1.5 2 2.5 3 3.5 3.5 3.5 4

Biomass-based Diesel 0.5 0.65 0.8 1 1 1 1 1 1 1 1 1 1 1

Celulosic Advanced NaN 0.1 0.25 0.5 1 1.75 3 4.25 5.5 7 8.5 10.5 13.5 16

3

8

13

18

23

28

33

38B

illi

on

s o

f G

allo

ns

LOWER GHG

Source: EISA of 2008, U.S. Environmental Protection Agency (RFS-2) Final Rule.


RFS2 as Expected

2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022

Conventional Biofuels 10.5 12 12.6 13.2 13.8 14.4 15 15 15 15 15 15 15 15

Non-celulosic Advanced 0.1 0.2 0.3 0.5 0.75 1 1.5 2 2.5 3 3.5 3.5 3.5 4

Biomass-based Diesel 0.5 0.65 0.8 1 1 1 1 1 1 1 1 1 1 1

Celulosic Advanced NaN 0.1 0.25 0.5 1 1.75 3 4.25 5.5 7 8.5 10.5 13.5 16

3

8

13

18

23

28

33

38B

illi

on

s o

f G

allo

ns

Source: EISA of 2008, U.S. Environmental Protection Agency (RFS-2) Final Rule.

Assuming current EPA approach, RFS mandated volumes only increase to the extend total gasoline

consumption increases…

Blend Wall (10% Gasoline Demand)


EIA’s Gasoline and Diesel Consumption Outlook

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

2032

2033

2034

2035

2036

2037

2038

2039

2040

0

2

4

6

8

10

12

14

US

mo

tor

gas

olin

e an

d d

iese

l co

nsu

mp

tio

n

(mill

ion

barr

els

per

day)

AEO2013

AEO2007

AEO2010Gasoline

AEO2007AEO2010

AEO2013

Diesel

Source: EIA, Annual Energy Outlook 2007, Annual Energy Outlook 2010, Annual Energy Outlook 2013

7Copyright © 2012 Amyris, Inc. All rights reserved.7Copyright © 2012 Amyris, Inc. All rights reserved.

From Biofuels and Beyond


Amyris: The Industrial Synthetic Biology Company

• Founded in 2003 by post-doctoral fellows from the University of California, Berkeley.

• Headquartered in the San Francisco Bay Area and with operations in Brazil.

• 390 full-time employees, of which one-third are PhDs.

• Backed by leading investors and strong partnerships with global brands.

Best-in-Class Tech

Scaled Manufacturing

No Compromise® Products

AMYRIS PLANT IN BRAZIL

AMYRIS HQ IN CALIFORNIA


Isoprene (C5)

F&F Molecules

FARNESENE (C15)

Living Factories Delivering Better Products

• Diesel• Jet Fuel

Fuels

• Base Oils• Finished Lubricants

Lubricants

• Polymers• Solvents and Fluids

Performance Materials

• Cosmetic Emollients• Flavor & Fragrances

Consumer Care

Amyris engineers living factories and produces renewable products


From Curing Malaria to Better Fuels and ChemicalsDelivering sustainable growth for the worlds leading brands

BIOLDINGinvestment

LEADING INVESTORS


Significant Addressable MarketsDiverse Production Portfolio Today with Improving Profitability


Amyris Business Model: Partner-funded product collaboration pipeline, long-term annuity from sales, and industry leading gross margin

Strategic & Capability Building Partners

COLLABORATIONS RENEWABLE PRODUCTS

COLLABORATION INFLOWSExpect to continue at

$60M to $70M annually

PRODUCTION & SALESExpect to double year-on year

during the next few years

PROVIDES CASH FORR&D OpEx and CapEx

Investments in high-value Farnesene Industry leading cash gross margin

Over 15 new molecules under

contract with 1 to 3 new product

launch per year

DRIVER OF Revenue Growth

Earnings through Long-Term SupplyOperations OpEx and CapEx

Customers


• Developed high-throughput strain engineering system to code and screen over 100,000 yeast strains per month at 95% lower cost.

• Generated over 600,000 unique farnesene strains in last year, surpassing 3 million strains.

• Tested over 5,000 unique strains in actual fermentation to date and now predict 200,000 liter fermentation performance from 2 liter scale tests.

• Reduced time to target isoprenoid molecule from years to months, with thousands of molecules to be accessed.

Amyris Synthetic Biology Technology PlatformThe Science of Genentech with the Engineering of Intel

Design based on Learnings

Build: Robotics & Automation

Test: 100,000 strains/month


The Leading Innovator in Industrial Biotech


Summary

TECHNOLOGY• Leading technology

platform capable of making 50,000 molecules.

• Engineer yeast to convert sugar into renewable hydrocarbons.

MANUFACTURING• Access to lowest cost

feedstock (sugarcane).• Lowest carbon footprint.• First plant operating with

capital light approach.

PRODUCTS• Anti-malarial drug

precursor (no profit).• No Compromise® fuels

and specialty chemicals, with initial sales ongoing.

INTEGRATED RENEWABLE PRODUCTS COMPANY


For Further Reading

Visit our website at investors.amyris.com



• 2004 Amyris, a “virtual company” licenses back Synthetic Biology patent portfolio.

• 2005 Amyris opens with a $15M of a five-year grant from the Bill and Melinda Gates Foundation to develop anti-malarials with Synthetic Biology platform.

• 2006 Amyris takes venture capital to apply SynBio platform to hydrocarbon fuels & chemicals.

• 2007 John Melo, former president of BP’s US Fuels division

• 2007 Amyris team makes “first drops” of renewable diesel in the lab

• 2008 key technical milestones in anti-malarial drug production

– partners with Sanofi-Aventis to scale-up & commercialize anti-malarial drug

• 2008 Amyris opens Pilot Plant for fuel in Emeryville; “first gallons” of diesel

• 2009 Successful Artemisinin technology transfer to Sanofi-Aventis

• 2009 Amyris produces “first barrels” of diesel

• 2010 Partnership with Total

• 2010 IPO (AMRS)

• 2011 Begin sales of Diesel and Squalane

• 2012 Amyris produces 2 Million liters of Diesel and Squalane

• 2013 Launch Artemisinin 70-120 million malaria cures (Sanofi)

A Brief History of Amyris

Documents

From Biofuels and Beyond Inspired Science to Deliver Sustainable Solutions for a Growing World Joel Velasco April 2014