From genes to ecosystems, From the laboratory into the community, From the West towards Europe… Presentation of OUEST-genopole ® December 2008

From genes to ecosystems,From the laboratory into the community,

From the West towards Europe…

Presentation of OUEST-genopole®

December 2008

Page 2OUEST-genopole® presentation December 2008

What is OUEST-genopole®?History

1998 - First genopole at Evry based on an original

concept:

To gather, in the same place, research laboratories, biotech

companies and universities

1999 - Creation of the National network genopole

Objective: to coordinate genomics and post-genomics

activities at a national level

8 genopoles labelled between 1999 and 2002


OUEST-genopole®

…labelled on January 1st, 2002Director: Michel RENARD

What is OUEST-genopole®?The French genopoles

With the support of :


GIS IBiSA

Health biology and Agro infrastructures

IBiSA was created in May 2007 further to the dissolution of the

CNRG (regrouping the CNS, CNG and RNG) and, consequently, the

National network genopole

IBiSA members: Inserm, CNRS, Inra, CEA, Inria, INCa (National

Cancer Institute), CPU (University presidents conference), as well as two

departments dependent on the Ministry of research.

2008 labelling campaign:

Open to core facilities that don't yet have the national label (RIO)

Allows to apply for ANR and INCa future tenders or to benefit from

privileged ITA support

The respect of the core facilities charter is a necessary condition to get

the label

5 OUEST-genopole core facilities labelled in October 2008

Website: http://www.ibisa.net


What is OUEST-genopole® ?

January 2002: OUEST-genopole® is labelled

Interregional programme: both Brittany and Pays de la Loire regions

Associates the major research bodies (Afssa, CNRS, Ifremer, Inra,

Inria, Inserm), the 5 main universities of western France, as well as

university hospitals and "grandes écoles" (i.e. higher education

establishments)

Network of over 50 research units: 2,000 people including 800

researchers and teaching researchers

Genopoles meet the following conditions:

A large-scaled biology project

A excellent campus for training and research

A high-level bioinformatics unit

A structured project for biotechnology company creation


Two regions: Brittany and Pays de la LoireWhat is OUEST-genopole®?

QUIMPER

PLOUFRAGAN

RENNES

NANTES

ANGERS

BREST

ROSCOFF

LORIENT


To support the research in genomics and post-genomics, the

setting-up and creation of new biotechnology companies

To mutualize the resources and the skills

To participate collectively to the technological evolution

To integrate the genopole network and take part in European

research programs

To attract young researchers

What do we do at OUEST-genopole®?Missions and objectives

Agriculture – Food processing

Photo Inserm

Human Health

INRIA / Photo : A. Eidelman

Bioinformatics

Marine Biology


What is OUEST-genopole® ?

Marine Biology

AgricultureFood-processing

HumanHealth

Bioinformatics

4 main fields

5 technological core facilities = 20 technical facilities


Technological core facilities

Production of viral vectors (Nantes) Production of synthetic vectors (Brest - Rennes) Xenope Transgenesis (Rennes) Rat Transgenesis (Nantes) Functional imaging PRISM (Rennes) Cell biochips (Rennes) (emerging) Histopathology (Rennes)

Sequencing/Genotyping

Transcriptomics

Proteomics

Functionalexploration

Bioinformatics

High-throughput protein identification (Rennes) Customized monoclonal antibodies (Angers) Biopolymers - Interactions - Structural biology (Nantes) Recombinant protein production (Nantes) Protein chips (Nantes) Interactome (Nantes)

Transcriptomics (Nantes and Rennes)

Sequencing (Roscoff, Nantes and Rennes) /Genotyping (Le Rheu) (emerging)

National core facility (Rennes)

In yellow: IBiSA pre-labelled core facilities

**

**

**

*: core facilities labelled by IBiSA in October 2008


Technological core facilities

Collective purchase of equipment

Development of specific abilities

Recruiting of 29 engineers

Access to core facilities: 50% guaranteed


To study the structure and the functioning of genomes from

marine organisms (bacteria, seaweeds and invertebrates)

To identify the genetic variety of various coastal, oceanic

and deep natural populations, and to understand their

adaptations to the environment

To look for new molecules for biotechnology or human

health fields

Marine biology7 research units

Marine Biology


Agriculture – Food processing17 research units

To study biological organisms of economical importance in

France, especially in Western France:

Field vegetable and crops, fruit trees, ornamental plants

Fish, pigs, chicken

Micro-organisms used in milk transformation

To work on agricultural products of high quality and safety,

with reduced environmental impacts

Agriculture


Human health25 research units

To characterize specific genetic diseases in Western France, e.g.

iron-metabolism disorders, cardiovascular and hematological

diseases, cystic fibrosis

To confirm an internationally-recognized, scientific expertise in

cancerology, reproductive biology and development,

immunotherapy, transplantation, autoimmunity, muscle diseases,

and gene therapy

To play a major role in the Cancéropôle Grand Ouest national

programme:

Cellular therapy

Valorisation of sea products

Pharmacogenomics and pharmacogenetics

Tumoral vectorisation

Human health


Bioinformatics5 research units

To search and extract signatures for identification and

prediction

To construct specialised databases and development of data

banks devoted to transcriptome analysis, powerful structures

for knowledge and data management

To study gene and protein functions (classification, modelling

of interactions in cellular and molecular systems)

Bioinformatics

© INRIA / IRISA


From Western France to Europe……OUEST-genopole® takes part in many projects

European projects Aquafirst

NoE "Marine Genomics Europe"

NoE "MED-VET-NET"

NoE NanoToLife

RISET (Immune Tolerance)

TOXDROP

"INTERREG" project (in progress)

National projects

Agenae (Analyse

du GENome des Animaux d'Elevage)

Cancéropôle Grand Ouest

GenoGRID

Génoplante

GIS Génomique Marine…

Competitiveness clusters

Atlantic Biotherapies

(Nantes / Angers)

Pôle Mer Bretagne

(Brest / Roscoff)

Végépolys (Angers)

Valorial, l'aliment de demain

(Brittany)


Crossroads between life qciences, ecology, environment, bioinformatics

and high technologies within a multicultural European network.

Devoted to the development and spreading of high-throughput approaches

for the investigation of the biology of marine organisms.

Aimed at promoting, developing, and spreading throughout the European

Union a better understanding of the functioning of marine ecosystems and

the biology of marine organisms.

Involves about 450 scientists from 44 institutions of 16 countries (within and

outside Europe).

Coordinated by Dr Catherine Boyen, Station Biologique de Roscoff, CNRS,

France, and funded under the framework programme FP6 by the European

commission.

Network of Excellence Marine Genomics Europe (MGE)

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Education and valorisation

OUEST-genopole® promotes the creation and development of

new training programmes in all fields of life sciences

OUEST-genopole® helps academic laboratories and researchers

to respond to entrepreneurial opportunities and facilitates the

emergence of start-up companies in collaboration with our

regional incubators and venture capitalists

OUEST-genopole® plays a vital role in the dynamism of Western

France and thus contributes to the economic development of our

bio-region


Valorisation

Company creation (stemming from research activities of core facilities): Innova Proteomics (High-throughput protein identification facility) ProtNeteomix (Protein chips facility) Korilog (Bioinformatics facility) Cimna (Transcriptomics facility) Cytune Pharma (Interactome facility) …

Technological and/or commercial partnerships: Production of clinical vectors in the field of gene therapy (with the French Blood

Establishment) Transcriptomics facility: clinical transfer of activities to Nantes and Rennes

university hospitals Production of viral vectors facility and CleanCells Xenope Transgenesis facility and Biopredic International Rat Transgenesis facility and Genoway Functional imaging PRISM facility and Spin Safety Other partnerships:


OUEST-genopole® assets

Genomics and post-genomics targeted on major

economical sectors:

Marine Biology – Agriculture – Human Health – Bioinformatics

Keys to successKeys to success: : to to capitalise oncapitalise on complementarities complementarities

within a network culturewithin a network culture

Multisite and multiactivity

Will for sharing and competingfor scientific excellence


The annual meeting of Western France researchers and biotech companies to:

Present the advancement of scientific projects led within OUEST-genopole® as well as the future prospects

Accelerate development projects while discovering the services proposed by the research units and technological core facilities

Better know innovative companies linked to OUEST-genopole® fields Meet future partners and prospective customers

Gen2Bio 2008The annual Biotech symposiumorganised by OUEST-genopole®

www.gen2bio.org


Christelle Hays – Internal and external communications

02 23 23 45 85 – [email protected]

Jocelyne Le Seyec – Scientific coordination and technological core facilities


Eric Mathieu – Valorisation and education


Céline Quéron – Chef de projet européen


Marilène Vallois – Personal assistant


Quality assurance (to be hired)

More information…


Thank you for your attention!

Documents

From genes to ecosystems, From the laboratory into the community, From the West towards Europe… Presentation of OUEST-genopole ® December 2008