Infectious Disease Testing

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Bio-RadLaboratories

Clinical Diagnostics Group

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Full Dengue Offer

Detection of Acute Dengue (NS1 Ag and IgA)

Secondary Dengue Differentiation (High Levels of IgG)

Platelia™ Dengue IgA Capture

Dengue NS1 Ag STRIPRDT Dengue IgA/IgGPlatelia™ Dengue NS1 Ag

Platelia™ Dengue IgG Capture

72830 Platelia™ Dengue NS1 Ag, 96 tests72831 Platelia™ Dengue IgA Capture, 96 tests72832 Platelia™ Dengue IgG Capture, 96 tests70700 Dengue NS1 Ag STRIP, 25 tests70701 Dengue IgA/IgG RDT, 25 tests

Ordering InformationCatalog # Description

Platelia™ Assays(1) Rapid Test Assays(1)

98.7%* Sensitivity 95,0%*

96,4%* Specificity 92.0%*

*Product IFU(1) Combined NS1 Ag and IgA Results

Specificity

Dengue Negative Samples 100.0%*

Primary Dengue Infections 85.9%*

Sensitivity

Secondary Dengue Infections 97.8%*

*Product IFU

Missing Dengue Is Not An Option

16039-REV A-Full Dengue Offer-EN-v5.indd 1-2 16/03/2016 14:08

Today, Dengue ranks as the most important mosquito-borne viral disease in the world in terms of morbidity, mortality and socio-economic costs.

The disease is now endemic in more than 100 countries, and potentially concerns 40% of the world’s population (2.5 billion people).

Appropriate clinical management, involving early and reliable specific Dengue diagnosis and appropriate patient monitoring, could dramatically reduce mortality from Dengue.

Full Dengue Offer

Clinical Stage

Early Acute(< 5 days of fever)

Late Acute(> 5 days of fever)

NS1 Ag ✘

IgA/IgG ✘

NS1 Ag + IgA/IgG

What is the Combination for any Acute Dengue Reliable Diagnosis?

■ Assays that are easy to use and implement

■ Unitary format for rapid and individual diagnostics with plasma, serum and whole blood

■ Automated EIA format for large volumes and standardized processes

■ Bio-Rad NS1 Ag recognized as the reference for all 4 serotypes NS1 Ag detection

■ Combining NS1 Ag and anti-NS1 IgA Assays to detect up to 100% of Acute Dengue infection whether primary or secondary

■ Differential detection of IgG and IgA

■ Ensuring better patient management by identifying high risk secondary Dengue infection (Platelia™ Dengue IgG Capture)

■ High clinical value of IgA marker for an enhanced detection of secondary Dengue infection

The Comprehensive Bio-Rad Solution

Biological Markers of Dengue Infection

To Meet Your Laboratory NeedsTo Meet the New Dengue Challenges

+/- Symptoms

Incubation

Viremia

IgM IgG

t

Mosquito Bite IgA

+/- Symptoms

Incubation t

Mosquito Bite

Viremia IgM

IgG IgA

I = 3-7 days

I = 3-7 days

S = 3-6 days

D+10/+15D0

6-8 weeks

S = 3-6 days

Primary Dengue

Secondary Dengue

+/- Symptoms

Incubation

Viremia

IgM IgG

t

Mosquito Bite IgA

+/- Symptoms

Incubation t

Mosquito Bite

Viremia IgM

IgG IgA

I = 3-7 days

I = 3-7 days

S = 3-6 days

D+10/+15D0

6-8 weeks

S = 3-6 days

Primary Dengue

Secondary Dengue

Poster ID 0321F01, 3rd International Conference on Dengue and Dengue Haemorhagic Fever, Bangkok, Thailand, October 21-23, 2013.

Bio-Rad projections based on publications.Grace Yap et al. (2011, PLoS NTDS)A. Balmaseda et al. (2003, Clin. Diag. Lab. Immunol.)

Rash

Fever

Fatigue

Joint painMuscle pain

HeadacheVomiting

Eye pain

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