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Full name: Naoki Hiki
Office address: Gastroenterological Center
Department of Gastroenterological Surgery
Department of Director, Gastric Surgery
Department of Director, Clinical Nuturition
Cancer Institute Hospital
3-8-31 Ariake, Koto-ku, TOKYO 135-8550, Japan
TEL: ++81-3-3520-0111 (Int. 7037), FAX: ++81-3-3570-0343
Mail: [email protected]
Academic degree’s M.D., Ph.D.
Present Position: Department Director
Thesis: Title: Endotoxin binding and elimination by monocytes
Year:1999
University: The University of Tokyo
Professional specialties:
1) Gastrointestinal Surgery
2) Laparoscopic Surgery (Laparoscopic gastric Surgery)
3) Clinical Nutrition
Research fields:
Sepsis, Endotoxin and Surgical response
Minimal invasive surgery
Laparoscopic gastric cancer surgery
Clinical Nutrition
Endoscopy and endoscopic treatment
Editorial Boards:
Gastric Cancer
Langenbech`s Archives of Surgery
British Journal of Surgery
Etc.
December 4, 2016 Naoki Hiki M.D., Ph.D.,
CURRICLUM VITAE
Ⅰ. Personal Data
Name: Naoki HIKI
Sex: Male
Birth Date: December 15, 1962
Birth Place: Fukuoka, JAPAN
Citizenship: JAPAN
Marital Status: Married, 1990; Two children
Present Address: 4-15-16-B206 Takanawa Minatoku, Tokyo, JAPAN 108-0074
Ⅱ. All Academic Degrees Obtained
1990,May Medical Docter, Kitasato University, School of Medicine
Kanagawa, JAPAN
1998, April Ph.D. , The University of Tokyo, Tokyo, JAPAN
Ⅲ. All Stages of the University Education
1984, Apr. - 1990, Mar. M.D., cum laude, Kitasato University
School of Medicine, Kanagawa, JAPAN
1995, Apr.- Present The University of Tokyo, Postgraduate School
Ⅳ.Professional Training and Employment:
1990, April Passed the Examination of National Board
1990, Jun -1991, Jun. Medical Stuff in General Surgery, University of Tokyo
1991, Jul -1991, Dec. Medical Stuff in Trauma and Critical, Care Center,
Teikyo University, Tokyo
1992, Jan -1992, Jun Medical Stuff in Anesthesiology, University of Tokyo
1992, Jul.-1993, Jan. Research Fellowship in General Surgery,
University of Ulm, Ulm, Germany
1993, Feb.-1993, Mar. Medical Stuff in General Sugery, University of Tokyo
1993, Mar-1995 March Medical Stuff in General Surgery,
Ohme-City Hospital, Tokyo
1995, April-1998 April The University of Tokyo, Postgraduate School
1995,Oct-1997, Oct. Research Fellowship in General Surgery, University of
Ulm, Ulm, Germany
1998 April-2005 March Assistant Professor in Department of Gastrointestinal Surgery
The University of Tokyo
2005 April-Present Department of Gastroenterological Surgery
Divsion Director, Gastric Surgery
Department of Director, Clinical Nuturition
Cancer Institute Hospital, Tokyo
2014 April-Present Visiting Professor
Department of Surgery, Institute of Gastroenterology
Tokyo Womens Medical University
Ⅴ. Study and Research in Germany
(1) 1992, Jul. - 1993, Jan, (2) 1995, Oct – 1997,Nov
University of Ulm, Department of Surgery
Research fellowship
Financed by German Research Association
Hans G. Beger, M.D., FACS, Professor of Surgery
University of Ulm, Steinhoevelstrasse 9,
89075 Ulm, Germany
I affirm that the above statement is true and correct in every respect.
Tokyo, 16 January, 2020
Publications in English
1 Hiki, N., Berger, D., Buttenschoen, K. 1, Endotoxemia and specific antibody behavior against
different endotoxins following multiple injuries. 1995, J Trauma 38: 794-801,
2 Buttenschoen, K., Berger, D., Hiki, N. Plasma concentrations of endotoxin and antiendotoxin
antibodies in patients with multiple injuries: a prospective clinical study. 1996, Eur J Surg
162: 853-860,
3 Hiki, N., Mimura, Y. 1, Effect of renal denervation on phosphate excretion in endotoxemic
rats. 1997, Endocr J 44: 739-744,
4 Hiki, N., Berger, D., Prigl, C. 1, Endotoxin binding and elimination by monocytes: secretion
of soluble CD14 represents an inducible mechanism counteracting reduced expression of
membrane CD14 in patients with sepsis and in a patient with paroxysmal nocturnal
hemoglobinuria. 1998, Infect Immun 66: 1135-1141,
5 Hiki, N., Mimura, Y. 1, Atrial natriuretic peptide has no potential to protect against endotoxin-
induced acute renal failure in the absence of renal nerves. 1998, Endocr J 45: 75-81,
6 Beger, H.G., Treitschke, F., Gansauge, F., Hiki, N. Tumor of the ampulla of Vater: experience with
local or radical resection in 171 consecutively treated patients. 1999, Arch Surg 134: 526-532,
7 Hiki, N., Berger, D., Dentener, M.A. 1, Changes in endotoxin-binding proteins during major
elective surgery: important role for soluble CD14 in regulation of biological activity of systemic
endotoxin. 1999, Clin Diagn Lab Immunol 6: 844-850,
8 Hiki, N., Berger, D., Mimura, Y. 1, Release of endotoxin-binding proteins during major elective
surgery: role of soluble CD14 in phagocytic activation. 2000, World J Surg 24: 499-506,
9 Buttenschoen, K., Berger, D., Hiki, N. Endotoxin and antiendotoxin antibodies in patients with
acute pancreatitis. 2000, Eur J Surg 166: 459-466,
10 Kanauchi, H., Mimura, Y., Hiki, N. Catecholamine and cytokine response to laparoscopic
adrenalectomy in patients with pheochromocytoma. 2000, Biomed Pharmacother 54 Suppl 1:
191s-193s,
11 Ogawa, T., Mimura, Y., Hiki, N. Ischaemic preconditioning ameliorates functional disturbance
and impaired renal perfusion in rat ischaemia-reperfused kidneys. 2000, Clin Exp Pharmacol
Physiol 27: 997-1001,
12 Asai, K., Hiki, N., Mimura, Y. 2, Gender differences in cytokine secretion by human peripheral
blood mononuclear cells: role of estrogen in modulating LPS-induced cytokine secretion in an ex
vivo septic model. 2001, Shock 16: 340-343,
13 Hiki, N., Mimura, Y., Ogawa, T. 1, Pathophysiological relevance of the CD14 receptor in surgical
patients: biological activity of endotoxin is regulated by the CD14 receptor. 2001, J Endotoxin
Res 7: 461-466,
14 Hiki, N., Kurosaka, H., Tatsutomi, Y. 1, Case of gastric outlet stenosis with features of pyloric
stenosis diagnosed by using peppermint oil solution as a new antispasmodic. 2003, Digestive
Endoscopy 15: 224-227,
15 Hiki, N., Mimura, Y., Hatao, F. 1, Sublethal endotoxin administration evokes super-resistance to
systemic hypoxia in rats. 2003, J Trauma 54: 584-589,
16 Hiki, N., Kurosaka, H., Tatsutomi, Y. 1, Peppermint oil reduces gastric spasm during upper
endoscopy: a randomized, double-blind, double-dummy controlled trial. 2003, Gastrointest
Endosc 57: 475-482,
17 Kubota, K., Nakanishi, H., Hiki, N. Quantitative detection of micrometastases in the lymph nodes
of gastric cancer patients with real-time RT-PCR: a comparative study with
immunohistochemistry. 2003, Int J Cancer 105: 136-143,
18 Tsuji, E., Hiki, N., Nomura, S. 2, Simultaneous onset of acute inflammatory response, sepsis-like
symptoms and intestinal mucosal injury after cancer chemotherapy. 2003, Int J Cancer 107: 303-
308,
19 Kubota, K., Hiki, N., Shimizu, N. 2, Utility of [13C] urea breath test for Helicobacter pylori
detection in partial gastrectomy patients. 2003, Dig Dis Sci 48: 2135-2138,
20 Hiki, N., Takeshita, Y., Kubota. 1, A seasonal variation in the onset of postoperative adhesive
small bowel obstruction is related to changes in the climate. 2004, Dig Liver Dis 36: 125-129,
21 Hatao, F., Muroi, M., Hiki, N. Prolonged Toll-like receptor stimulation leads to down-regulation
of IRAK-4 protein. 2004, J Leukoc Biol 76: 904-908,
22 Hatao, F., Hiki, N., Mimura, Y. 2, The induction of super-resistance using synthetic
lipopolysaccharide receptor agonist rescues fatal endotoxemia in rats without excessive
immunosuppression. 2005, Shock 23: 365-370,
23 Kubota, K., Shimizu, N., Nozaki, K., Hiki, N. Efficacy of triple therapy plus cetraxate for the
Helicobacter pylori eradication in partial gastrectomy patients. 2005, Dig Dis Sci 50: 842-846,
24 Hiki, N. ,Kaminishi, M.1, Pylorus-preserving gastrectomy in gastric cancer surgery--open and
laparoscopic approaches. 2005, Langenbecks Arch Surg 390: 442-447,
25 Shimoyama, S., Imamura, K., Hiki, N. Performance of outpatient regimen of S-1 in combination
with fractional cisplatin for advanced or recurrent gastric cancers: a phase I study. 2005, Int J Clin
Oncol 10: 251-255,
26 Hiki, N., Shimizu, N., Yamaguchi, H. 1, Manipulation of the small intestine as a cause of the
increased inflammatory response after open compared with laparoscopic surgery. 2006, Br J Surg
93: 195-204,
27 Hiki, N., Shimoyama, S., Yamaguchi, H. 1, Laparoscopy-assisted pylorus-preserving gastrectomy
with quality controlled lymph node dissection in gastric cancer operation. 2006, J Am Coll Surg
203: 162-169,
28 Mizuno, S., Kato, K., Ono, Y., Hiki, N. Oral peppermint oil is a useful antispasmodic for double-
contrast barium meal examination. 2006, J Gastroenterol Hepatol 21: 1297-1301,
29 Yamamoto, N., Nakai, Y., Sasahira, N., Hiki, N. Efficacy of peppermint oil as an antispasmodic
during endoscopic retrograde cholangiopancreatography. 2006, J Gastroenterol Hepatol 21: 1394-
1398,
30 Nozaki, K., Nomura, S., Shimizu, N., Hiki, N. Helicobacter pylori-negative / API2-MALT1
translocation-negative low-grade MALT lymphoma. 2006, Gastric Cancer 9: 229-234,
31 Kubota, K., Katayama, A., Takeshita, Y., Hiki, N. Effect of imatinib mesylate in a patient with a
metastatic gastrointestinal stromal tumor with a c-kit mutation in exon 11. 2007, Dig Dis Sci 52:
1725-1729,
32 Hiki, N., Fukunaga, T., Yamaguchi, T. 1, Laparoscopic esophagogastric circular stapled
anastomosis: a modified technique to protect the esophagus. 2007, Gastric Cancer 10: 181-186,
33 Tokunaga, M., Ohyama, S., Nunobe, S., Hiki, N. Advanced gastric cancer with a duplicated
hepatic artery: preoperative diagnostic value of multidetector-row computed tomography for
surgical resection. 2007, Gastric Cancer 10: 191-195,
34 Nunobe, S., Hiki, N., Fukunaga, T. 2, Laparoscopy-assisted pylorus-preserving gastrectomy:
preservation of vagus nerve and infrapyloric blood flow induces less stasis. 2007, World J Surg
31: 2335-2340,
35 Nunobe, S., Hiki, N., Ohyama, S. 2, Survival benefits of pancreatoduodenectomy for gastric
cancer: relationship to the number of lymph node metastases. 2008, Langenbecks Arch Surg 393:
157-162,
36 Hiki, N., Yamamoto, Y., Fukunaga, T. 1, Laparoscopic and endoscopic cooperative surgery for
gastrointestinal stromal tumor dissection. 2008, Surg Endosc 22: 1729-1735,
37 Nunobe, S., Ohyama, S., Sonoo, H., Hiki, N. Benefit of mediastinal and para-aortic lymph-node
dissection for advanced gastric cancer with esophageal invasion. 2008, J Surg Oncol 97: 392-395,
38 Tokunaga, M., Ohyama, S., Hiki, N. Endoscopic evaluation of reflux esophagitis after proximal
gastrectomy: comparison between esophagogastric anastomosis and jejunal interposition. 2008,
World J Surg 32: 1473-1477,
39 Shimoyama, S., Imamura, K., Hiki, N. Nutritional comparisons between a pylorus-preserving
gastrectomy with and without suprapyloric lymph node clearance: a preliminary report. 2007,
Hepatogastroenterology 54: 2401-2405,
40 Nunobe, S., Hiki, N., Fukunaga, T. 2, Previous laparotomy is not a contraindication to
laparoscopy-assisted gastrectomy for early gastric cancer. 2008, World J Surg 32: 1466-1472,
41 Seki, M., Ninomiya, E., Takano, K., Hiki, N. Pancreatogram findings for carcinoma in situ (CIS)
of the pancreas seen on endoscopic retrograde cholangiopancreatography and postoperative
pancreatography of resected specimens: can CIS be diagnosed preoperatively? 2008,
Pancreatology 8: 142-152,
42 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Quality control and educational value of laparoscopy-
assisted gastrectomy in a high-volume center. 2009, Surg Endosc 23: 289-295,
43 Seto, Y., Fukuda, T., Yamada, K., Hiki, N. Celiac lymph nodes: distant or regional for thoracic
esophageal carcinoma? 2008, Dis Esophagus 21: 704-707,
44 Tokunaga, M., Shirabe, K., Yamashita, N., Hiki, N. Bowel obstruction due to sciatic hernia. 2008,
Dig Surg 25: 185-186,
45 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Does age matter in the indication for laparoscopy-
assisted gastrectomy? 2008, J Gastrointest Surg 12: 1502-1507,
46 Hiki, N., Fukunaga, T., Yamaguchi, T. 1, The benefits of standardizing the operative procedure for
the assistant in laparoscopy-assisted gastrectomy for gastric cancer. 2008, Langenbecks Arch Surg
393: 963-971,
47 Hiki, N., Fukunaga, T., Tokunaga, M. 1, An effective duodenum bulb mobilization for
extracorporeal Billroth I anastomosis of laparoscopic gastrectomy. 2009, J Gastrointest Surg 13:
230-235,
48 Hiki, N., Fukunaga, T., Yamaguchi, T. 1, Cut-and-Screw Insertion: A Method for Safe and Speedy
Secondary Trocar Insertion in Laparoscopic Surgery. 2008, Surg Technol Int 17: 121-125,
49 Fukuda, T., Seto, Y., Yamada, K., Hiki, N. Can immune-enhancing nutrients reduce postoperative
complications in patients undergoing esophageal surgery? 2008, Dis Esophagus 21: 708-711,
50 Hiki, N., Maetani, I., Suzuki, Y. 1, Reduced risk of peristomal infection of direct percutaneous
endoscopic gastrostomy in cancer patients: comparison with the pull percutaneous endoscopic
gastrostomy procedure. 2008, J Am Coll Surg 207: 737-744,
51 Tokunaga, M., Hiki, N., Ohyama, S. 2, Effects of reconstruction methods on a patient's quality of
life after a proximal gastrectomy: subjective symptoms evaluation using questionnaire survey.
2009, Langenbecks Arch Surg 394: 637-641,
52 Hiki, N., Fukunaga, T., Yamaguchi, T. 1, Increased fat content and body shape have little effect on
the accuracy of lymph node retrieval and blood loss in laparoscopic distal gastrectomy for gastric
cancer. 2009, J Gastrointest Surg 13: 626-633,
53 Nunobe, S., Ohyama, S., Miyata, S., Hiki, N. Incidence of gastric cancer in the remnant stomach
after proximal gastrectomy. 2008, Hepatogastroenterology 55: 1855-1858,
54 Tokunaga, M., Ohyama, S., Hiki, N. Therapeutic value of lymph node dissection in advanced
gastric cancer with macroscopic duodenum invasion: is the posterior pancreatic head lymph node
dissection beneficial? 2009, Ann Surg Oncol 16: 1241-1246,
55 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Laparoscopy-assisted distal gastrectomy with D2 lymph
node dissection following standardization--a preliminary study. 2009, J Gastrointest Surg 13:
1058-1063,
56 Tokunaga, M., Ohyama, S., Hiki, N. Investigation of the lymphatic stream of the stomach in
gastric cancer with solitary lymph node metastasis. 2009, World J Surg 33: 1235-1239,
57 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Better prognosis of T2 gastric cancer with preoperative
diagnosis of early gastric cancer. 2009, Ann Surg Oncol 16: 1514-1519,
58 Tokunaga, M., Hiki, N., Fukunaga, T. 2, Effect of individual fat areas on early surgical outcomes
after open gastrectomy for gastric cancer. 2009, Br J Surg 96: 496-500,
59 Saiura, A., Yamamoto, J., Kokudo, N., Hiki, N. Intrahepatic cholangiocarcinoma: analysis of 44
consecutive resected cases including 5 cases with repeat resections. 2009, Am J Surg,;
60 Yoshikawa, K., Hiki, N., Fukunaga, T. 2, Increased risk of lymph node metastasis in mucosal
gastric cancer with extra indication for endoscopic mucosal resection. 2009, J Am Coll Surg,
1045-1050,
61 M. Tokunaga, N. Hiki, T. Fukunaga, H. Kuroyanagi, A. Miki, T. Akiyoshi, and T. Yamaguchi.
Laparoscopic surgery for synchronous gastric and colorectal cancer: a preliminary experience.
Langenbecks Arch.Surg. 395 (3):207-210, 2010.
62 Ohyama, S., Tokunaga, M., Hiki, N. A clinicopathological study of gastric stump carcinoma
following proximal gastrectomy. 2009, Gastric Cancer 12: 88-94,
63 Fukunaga, T., Hiki, N., Tokunaga, M. 2, Left-sided approach for suprapancreatic lymph node
dissection in laparoscopy-assisted distal gastrectomy without duodenal transection. 2009, Gastric
Cancer 12: 106-112,
64 Akiyoshi, T., Kuroyanagi, H., Oya, M., Hiki, N. Laparoscopic rectal resection for primary rectal
cancer combined with open upper major abdominal surgery: initial experience. 2009,
Hepatogastroenterology 56: 571-574,
67 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Better 5-year survival rate following curative gastrectomy
in overweight patients. 2009, Ann.Surg.Oncol 16 (12):3245-3251,
65 Hiki, N., Sano, T., Fukunaga, T. 1, Survival benefit of pylorus-preserving gastrectomy in early
gastric cancer. 2009, J Am Coll Surg 209 (3); 297-301,
68 N. Hiki, T. Fukunaga, M. Tokunaga. 1, An effective duodenum bulb mobilization for
extracorporeal Billroth I anastomosis of laparoscopic gastrectomy. 2009, J.Gastrointest.Surg 13
(2):230-235,
69 N. Hiki, T. Fukunaga, T. Yamaguchi, T. 1, Increased fat content and body shape have little effect
on the accuracy of lymph node retrieval and blood loss in laparoscopic distal gastrectomy for
gastric cancer. 2009, J.Gastrointest.Surg 13 (4):626-633,
70 M. Tokunaga, S. Ohyama, N. Hiki, T. Investigation of the lymphatic stream of the stomach in
gastric cancer with solitary lymph node metastasis. 2009, World J.Surg 33 (6):1235-1239,
71 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Laparoscopy-assisted distal gastrectomy with D2 lymph
node dissection following standardization--a preliminary study. 2009, J.Gastrointest.Surg 13
(6):1058-1063,
72 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Quality control and educational value of laparoscopy-
assisted gastrectomy in a high-volume center. 2009, Surg.Endosc 23 (2):289-295,
73 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Better prognosis of T2 gastric cancer with preoperative
diagnosis of early gastric cancer. 2009, Ann.Surg.Oncol 16 (6):1514-1519,
74 M. Tokunaga, S. Ohyama, N. Hiki. Therapeutic value of lymph node dissection in advanced
gastric cancer with macroscopic duodenum invasion: is the posterior pancreatic head lymph node
dissection beneficial? 2009, Ann.Surg.Oncol 16 (5):1241-1246,
75 M. Tokunaga, S. Ohyama, K. Kuraoka, N. Hiki. Twenty-two metachronous multiple signet-ring
cell carcinomas treated with repeated gastrectomies and repeated endoscopic mucosal resections:
report of a case. 2009, Surg.Today 39 (5):430-433,
76 M. Tokunaga, N. Hiki, T. Fukunaga, T. 2, Effect of individual fat areas on early surgical
outcomes after open gastrectomy for gastric cancer. 2009, Br.J.Surg. 96 (5):496-500,
77 D. Ichikawa, N. Hiki, T. Fukunaga. 2, Usefulness of standardization in spreading of laparoscopy-
assisted distal gastrectomy. 2010, Hepatogastroenterology 57 (101):975-979,
78 H. Katai, M. Sasako, H. Fukuda, N. Hiki. Safety and feasibility of laparoscopy-assisted distal
gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a
multicenter phase II trial (JCOG 0703). 2010, Gastric.Cancer 13 (4):238-244,
79 M. Tokunaga, S. Ohyama, N. Hiki. Can superextended lymph node dissection be justified for
gastric cancer with pathologically positive para-aortic lymph nodes? 2010, Ann.Surg.Oncol 17
(8):2031-2036,
80 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Laparoscopy-assisted gastrectomy for patients with earlier
upper abdominal open surgery. 2010, Surg.Laparosc.Endosc.Percutan.Tech 20 (1):16-19,
81 M. Tokunaga, N. Hiki, T. Fukunaga. 2, Laparoscopic surgery for synchronous gastric and
colorectal cancer: a preliminary experience. 2010, Langenbecks Arch.Surg 395 (3):207-210,
82 Y. Yamamoto, J. Fujisaki, T. Hirasawa, N. Hik. Therapeutic outcomes of endoscopic submucosal
dissection of undifferentiated-type intramucosal gastric cancer without ulceration and
preoperatively diagnosed as 20 millimetres or less in diameter. 2010, Dig.Endosc 22 (2):112-118,
83 H. S. Ahn, J. H. Yook, C. H. Park, Y. K. Park, W. Yu, M. S. Lee, H. Sang-Uk, K. W. Ryu, T. S.
Sohn, H. H. Kim, S. H. Choi, S. H. Noh, N. Hiki, T. Sano, and H. K. Yang. General perioperative
management of gastric cancer patients at high-volume centers. Gastric.Cancer 14 (2):178-182,
2011.
84 N. Hiki, M. Kaminishi, T. Hasunuma, M. Nakamura, S. Nomura, N. Yahagi, H. Tajiri, and H.
Suzuki. A phase I study evaluating tolerability, pharmacokinetics, and preliminary efficacy of L-
menthol in upper gastrointestinal endoscopy. Clin.Pharmacol.Ther. 90 (2):221-228, 2011.
85 N. Hiki, M. Kaminishi, K. Yasuda, N. Uedo, H. Honjo, N. Matsuhashi, T. Hiratsuka, C. Sekine,
S. Nomura, N. Yahagi, H. Tajiri, and H. Suzuki. Antiperistaltic effect and safety of L-menthol
sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized,
double-blind, placebo-controlled study. Gastrointest.Endosc. 73 (5):932-941, 2011.
86 N. Hiki, M. Kaminishi, S. Tanabe, J. Fujisaki, J. Yoshino, M. Iguchi, H. Kobayashi, K. Ashida, T.
Kawabe, T. Kawano, S. Nomura, N. Yahagi, H. Tajiri, and H. Suzuki. An open-label, single-arm
study assessing the efficacy and safety of L: -menthol sprayed onto the gastric mucosa during
upper gastrointestinal endoscopy. J.Gastroenterol. 46 (7):873-882, 2011.
87 X. Jiang, N. Hiki, S. Nunobe, T. Fukunaga, K. Kumagai, K. Nohara, H. Katayama, S. Ohyama, T.
Sano, and T. Yamaguchi. Long-term outcome and survival with laparoscopy-assisted pylorus-
preserving gastrectomy for early gastric cancer. Surg.Endosc. 25 (4):1182-1186, 2011.
88 X. Jiang, N. Hiki, S. Nunobe, T. Fukunaga, K. Kumagai, K. Nohara, T. Sano, and T. Yamaguchi.
Postoperative outcomes and complications after laparoscopy-assisted pylorus-preserving
gastrectomy for early gastric cancer. Ann.Surg. 253 (5):928-933, 2011.
89 X. Jiang, N. Hiki, H. Yoshiba, S. Nunobe, K. Kumagai, T. Sano, and T. Yamaguchi. Laparoscopy-
assisted gastrectomy in patients with previous endoscopic resection for early gastric cancer.
Br.J.Surg. 98 (3):385-390, 2011.
90 X. Jiang, N. Hiki, S. Nunobe, K. Nohara, K. Kumagai, T. Sano, and T. Yamaguchi. Laparoscopy-
assisted subtotal gastrectomy with very small remnant stomach: a novel surgical procedure for
selected early gastric cancer in the upper stomach. Gastric.Cancer 14 (2):194-199, 2011.
91 K. Kubota, Y. Tatsutomi, M. Kitajima, K. Mafune, K. Ohta, M. Yoshida, T. Suwa, J. Kuroda, N.
Hiki, Y. Seto, and M. Kaminishi. Physiological evaluation of residual stomach motility after local
resection in conscious dogs. Surg.Today 41 (5):680-687, 2011.
92 K. Kumagai, N. Hiki, S. Nunobe, X. Jiang, T. Kubota, S. Aikou, R. Watanabe, S. Tanimura, T.
Sano, Y. Kitagawa, and T. Yamaguchi. Different features of complications with Billroth-I and
Roux-en-Y reconstruction after laparoscopy-assisted distal gastrectomy. J.Gastrointest.Surg. 15
(12):2145-2152, 2011.
93 S. Mine and N. Hiki. [Nutritional management for esophageal cancer]. Nihon Rinsho 69 Suppl
6:438-443, 2011.
94 S. Nunobe, N. Hiki, S. Tanimura, T. Kubota, K. Kumagai, T. Sano, and T. Yamaguchi. Three-step
esophagojejunal anastomosis with atraumatic anvil insertion technique after laparoscopic total
gastrectomy. J.Gastrointest.Surg. 15 (9):1520-1525, 2011.
95 S. Nunobe, N. Hiki, S. Ohyama, S. Aikou, T. Sano, and T. Yamaguchi. Outcome of surgical
treatment for patients with locoregional recurrence of gastric cancer. Langenbecks Arch.Surg. 396
(2):161-166, 2011.
96 A. Saiura, J. Yamamoto, N. Kokudo, R. Koga, M. Seki, N. Hiki, K. Yamada, T. Natori, and T.
Yamaguchi. Intrahepatic cholangiocarcinoma: analysis of 44 consecutive resected cases including
5 cases with repeat resections. Am.J.Surg. 201 (2):203-208, 2011.
97 M. Tokunaga, N. Hiki, T. Fukunaga, A. Miki, S. Ohyama, S. Miyata, and T. Yamaguchi. Learning
curve of laparoscopy-assisted gastrectomy using a standardized surgical technique and an
established educational system. Scand.J.Surg. 100 (2):86-91, 2011.
98 M. Tokunaga, N. Hiki, T. Fukunaga, S. Ohyama, S. Nunobe, K. Yamada, and T. Yamaguchi. Is
preservation of the celiac branch of the vagal nerve effective in preventing stasis following
pylorus-preserving gastrectomy? Hepatogastroenterology 58 (107-108):1046-1050, 2011.
99 M. Tokunaga, S. Ohyama, N. Hiki, T. Fukunaga, N. Yamamoto, and T. Yamaguchi. Incidence and
prognostic value of lymph node metastasis on c-Kit-positive gastrointestinal stromal tumors of
the stomach. Hepatogastroenterology 58 (109):1224-1228, 2011.
100 Y. Akashi, N. Hiki, S. Nunobe, X. Jiang, and T. Yamaguchi. Safe management of anastomotic
leakage after gastric cancer surgery with enteral nutrition via a nasointestinal tube. Langenbecks
Arch.Surg. 397 (5):737-744, 2012.
101 N. Hiki, M. Kaminishi, K. Yasuda, N. Uedo, M. Kobari, T. Sakai, T. Hiratsuka, K. Ohno, H.
Honjo, S. Nomura, N. Yahagi, H. Tajiri, and H. Suzuki. Multicenter phase II randomized study
evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa
for upper gastrointestinal endoscopy. Dig.Endosc. 24 (2):79-86, 2012.
102 X. Jiang, N. Hiki, S. Nunobe, K. Kumagai, K. Nohara, T. Sano, and T. Yamaguchi. Postoperative
pancreatic fistula and the risk factors of laparoscopy-assisted distal gastrectomy for early gastric
cancer. Ann.Surg.Oncol. 19 (1):115-121, 2012.
103 T. Kubota, S. Ohyama, N. Hiki, S. Nunobe, N. Yamamoto, and T. Yamaguchi. Endocrine
carcinoma of the stomach: clinicopathological analysis of 27 surgically treated cases in a single
institute. Gastric.Cancer, 2012.
104 S. Mine, K. Yamada, H. Grabsch, T. Sano, A. Ishiyama, T. Hirasawa, N. Yamamoto, N. Hiki, and
T. Yamaguchi. The prognostic significance of tumor laterality in patients with esophageal
squamous cell carcinoma. J.Surg.Oncol. 105 (1):66-70, 2012.
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107 T. Yoshikawa, N. Hiki, M. Taguri, T. Sano, S. Nunobe, H. Taniguchi, R. Fukushima, H. Cho, S.
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109 X. Jiang, N. Hiki, S. Nunobe, K. Kumagai, T. Kubota, S. Aikou, T. Sano, and T. Yamaguchi.
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110 N. Takemura, A. Saiura, R. Koga, J. Arita, R. Yoshioka, Y. Ono, N. Hiki, T. Sano, J.
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112 H. J. Lee, N. Shiraishi, H. H. Kim, N. Hiki, I. Uyama, S. H. Choi, H. K. Yang, and S. Kitano.
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113 T. Kubota, N. Hiki, S. Nunobe, K. Kumagai, S. Aikou, R. Watanabe, T. Sano, and T.
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114 S. Nunobe, N. Hiki, S. Tanimura, K. Nohara, T. Sano, and T. Yamaguchi. The clinical safety
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115 S. Mine, T. Sano, N. Hiki, K. Yamada, S. Nunobe, and T. Yamaguchi. Lymphadenectomy
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116 M. Tokunaga, T. Sano, S. Ohyama, N. Hiki, T. Fukunaga, K. Yamada, and T. Yamaguchi.
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117 N. Hiki, S. Nunobe, T. Kubota, and X. Jiang. Function-preserving gastrectomy for early
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118 T. Fukunaga, N. Hiki, T. Kubota, S. Nunobe, M. Tokunaga, K. Nohara, T. Sano, and T.
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119 S. Mine, T. Sano, N. Hiki, K. Yamada, T. Kosuga, S. Nunobe, and T. Yamaguchi. Proximal
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120 M. Fujishiro, M. Kaminishi, N. Hiki, I. Oda, J. Fujisaki, N. Uedo, M. Kaise, S. Tanabe, M.
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122 K. Kumagai, N. Hiki, S. Nunobe, X. Jiang, T. Kubota, S. Aikou, S. Tanimura, T. Sano, and T.
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123 T. Kubota, N. Hiki, T. Sano, S. Nomura, S. Nunobe, K. Kumagai, S. Aikou, R. Watanabe, T.
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124 K. Kumagai, N. Hiki, S. Nunobe, S. Sekikawa, T. Chiba, T. Kiyokawa, X. Jiang, S. Tanimura,
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125 S. Mine, T. Sano, N. Hiki, K. Yamada, T. Kosuga, S. Nunobe, H. Shigaki, and T. Yamaguchi.
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126 T. Kosuga, N. Hiki, S. Nunobe, H. Noma, M. Honda, S. Tanimura, T. Sano, and T.
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127 M. Honda, N. Hiki, S. Nunobe, M. Ohashi, T. Kiyokawa, T. Sano, and T. Yamaguchi. Long-
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128 T. Irino, N. Hiki, S. Nunobe, M. Ohashi, S. Tanimura, T. Sano, and T. Yamaguchi. Subtotal
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132 T. Irino, S. Nunobe, N. Hiki, Y. Yamamoto, T. Hirasawa, M. Ohashi, J. Fujisaki, T. Sano, and
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135 T. Yoshikawa, H. Takeuchi, S. Hasegawa, I. Nozaki, K. Kishi, S. Ito, M. Ohi, S. Mine, J.
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136 T. Irino, S. Nunobe, N. Hiki, Y. Yamamoto, T. Hirasawa, M. Ohashi, J. Fujisaki, T. Sano, and
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137 Y. Kurokawa, N. Hiki, T. Yoshikawa, K. Kishi, Y. Ito, M. Ohi, N. Wada, S. Takiguchi, S. Mine,
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141 T. Kiyokawa, N. Hiki, S. Nunobe, M. Honda, M. Ohashi, T. Sano, and T. Yamaguchi.
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144 M. Honda, N. Hiki, S. Nunobe, M. Ohashi, K. Kumagai, Y. Hashimoto, S. Mine, S. Kamiya, T.
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145 M. Honda, N. Hiki, S. Nunobe, M. Ohashi, S. Mine, M. Watanabe, S. Kamiya, T. Irino, T.
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150 K. Kumagai, N. Hiki, S. Nunobe, T. Irino, S. Ida, M. Ohashi, T. Yamaguchi, and T. Sano.
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152 Y. Inoue, A. Saiura, T. Sato, T. Ishizawa, J. Arita, Y. Takahashi, N. Hiki, T. Sano, and T.
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153 J. Zhou, N. Hiki, S. Mine, K. Kumagai, S. Ida, X. Jiang, S. Nunobe, M. Ohashi, T. Sano, and
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154 M. Aizawa, M. Honda, N. Hiki, T. Kinoshita, H. Yabusaki, S. Nunobe, H. Shibasaki, A.
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155 T. Kiyokawa, N. Hiki, S. Nunobe, M. Honda, M. Ohashi, and T. Sano. Preserving infrapyloric
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156