DATA SHEET HyPerforma G3Lab Controller

HyPerforma G3Lab ControllerReliable process control

The Thermo Scientifi c™ HyPerforma™ G3Lab™ Controller can control most brands of single-use or autoclavable bioreactors or fermentors that are ≤50 L, including stirred-tank and rocking models. The controller operates using Thermo Scientifi c™ TruBio™ software, which provides easy process scale-up or scale-down and the confi gurability to modify your control strategy along with your process. The enclosure contains state-of-the-art transmitters along with power supplies, pumps, input/output (I/O) modules, and the hardware required to connect to the control network, providing maximum control capability.

HyPerforma G3Lab Controller key features• Open-architecture capabilities to integrate with vessels

from other suppliers (Sartorius, Eppendorf, Millipore, and Applikon)

• Optional* redundant controller for improved reliability

• A common control platform throughout a product’s life cycle

• Flexible upstream TruBio software powered by the Emerson™ DeltaV™ system

• Nonproprietary, industry-standard, cGMP-validated (requires validation package) DCS that provides networked multiple-vessel control capability

• Built-in calibration

• The ability to build and manage complex, multifeed dosing strategies that provide for third-party peripheral integration as needed

HyPerforma G3Lab Controller accessories

TruBio upstream softwareTruBio confi gurable upstream software provides easy-to-use process control. It can be confi gured by the user through its visual interface, eliminating the need to learn automation control programming. TruBio software is powered by the Emerson DeltaV system, has been developed according to GAMP™ 5 methods, and conforms to regulatory requirements for use in cGMP-compliant processes. Developed for use with HyPerforma controllers, TruBio software is designed to support easy scaling and technology transfer and allow the ability to build sophisticated process control strategies. It also provides the fl exibility to incorporate a wide range of cell culture, fermentor, or mixing vessels, and manage multiple data streams from several unit operations.

TruDO and TrupH sterilizable sensorsWe provide reusable sensors with high reliability and superior performance for cell culture and fermentation process monitoring. Thermo Scientifi c™ TruDO™ and TrupH™ sensors have been specifi cally designed to minimize drift in bioprocess environments, undergo sterilization cycles, and help ensure measurement consistency from batch to batch. We also provide material certifi cates and lot traceability for cGMP applications.

pH+dO2 single-use sensor and readerThe Thermo Scientifi c™ pH+dO2 Sensor contains single-use sensors for dissolved oxygen (DO), pH, and temperature, in a compact assembly that is welded securely into a Thermo Scientifi c™ HyPerforma™ Single-Use Benchtop Bioreactor and Rocker Bioreactor.

• USP Class 6 compliant, free of animal-derived components

• Leverages TruFluor™ pH and DO sensor technology in a compact, precalibrated assembly

• Incorporates TruFluor 316L stainless steel thermal window for highly accurate readings

TruFlow gas mass fl ow controller (MFC)The Thermo Scientifi c™ TruFlow™ gas MFC is designed to work with all of the HyPerforma control systems. Its compact assembly provides up to six standard mass fl ow controllers and three associated solenoid valves. When connected, the TruFlow gas MFC is instantly recognized by TruBio software to provide precise control of gas fl ow, without requiring any confi guration, even at extremely low fl ow rates.

• Variety of fl ow rate options*

• Flow range confi gurability

• Plug-and-play connectivity

Note: MFCs with fl ow rates higher than 50 L/min are mounted as individual units and are not part of the main MFC block.* May require additional confi guration for specifi c fl ow rate. Please consult with your local Thermo Fisher Scientifi c sales representative for more information.

TruFlow gas mass fl ow controller (MFC)The Thermo Scientifi c™ TruFlow™ gas MFC is designed

HyPerforma G3Lab Controller specifications

Cover description

Top cover material Aluminum

Physical

Utility tower dimensions (H x W x D) 438.4 x 240 x 482.6 mm (17 1/4 x 9 3/8 x 19 in.)

Weight/shipping weight 16.4 kg/21.4 kg (36.5 lb/47 lb)

Enclosure rating Standard: NEMA 2 (NEMA 12 available as an made-to-order option)

Operating conditions

Operating temperature 5°C to 40°C (41°F to 104°F)

Storage temperature 5°C to 40°C (41°F to 104°F)

Relative humidity 5% to 95% (noncondensing)

Certifications Tested and verified as meeting CE standards EN-60101 and EN-61326

Utility Connection

Liquid controlFour variable-speed Watson-Marlow™ series 114 peristaltic pumps

Tubing ID: 0.8 mm (wall thickness 1.6 mm) Tubing ID: 4.8 mm (wall thickness 1.6 mm)

Flow range 0.16 mL/min to 5.5 mL/min 3 mL/min to 104 mL/min

Gas control (TruFlow controller) Up to four mass flow controllers with three output connectors

Watson-Marlow series 114 peristaltic pump specifications

Power supply 24 V DCMax current (@25°C) 0.25 A

Average current (@25°C) 0.2 A

Operating temperature 5°C to 50°C (41°F to 122°F)

Storage temperature –10°C to 70°C (14°F to 158°F)

Humidity 10% to 90% (noncondensing)

Speed 5 to 160 rpm

Accuracy ±2 rpm or ±2% of setpoint

Certifications CE: EN-60101 and EN-61326

Tubing (thickness, ID) 0.8 mm, 4.8 mm

Watson-Marlow series 114 peristaltic pump speeds

Speed Minimum/maximum flow rate (mL/min)

1 0.16/3

10 0.3/6

50 1.7/30

100 3.4/57.5

160 5.5/104

250 NA

300 NA

TruLogic DCS controller specifications

Dimensions (H x W x D) 610 x 203 x 610 mm (24 x 8 x 24 in.)

Enclosure rating NEMA 12

Operating temperature 0°C to 40°C (32°F to 104°F)

Storage temperature 0°C to 50°C (32°F to 122°F)

Weight/shipping weight 36 kg/77 kg (80 lb/170 lb)

Relative humidity 5% to 95% (noncondensing)

Certifications CE: EN-60101 and EN-61326

Connection Up to 8 G3Lab Controllers

Power110–240 VAC, 50/60 Hz Includes uninterruptible power supply (UPS)

Logic controller Emerson DeltaV MQ or MX controller

Ethernet Primary and secondary Ethernet switches, six spare port connectors each

Standard communication cards Modbus, DeviceNet, Profibus DP, traditional I/O module

Range of operating parameters

Volume 50 L 100 L 250 L 500 L 1,000 L 2,000 L

Recommended maximum gas flow rates (slpm) D

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Air 5 5 5 10 9 9 25 13 13 50 25 25 100 40 40 200 60 60

O2 5 – – 10 – – 25 – – 50 – – 100 – – 200 – –

CO2 1 – – 2 – – 2 – – 2 – – 5 – – 5 – –

N2 1 – – 2 – – 5 – – 5 – – 10 – – 10 – –

Total 5 5 5 10 9 9 25 13 13 50 25 25 100 40 40 200 60 60

Exhaust load 20 20 90 90 180 360

TruFlow gas MFC flow rate (L/min)

Glass Rocker

Volume 1 L 3 L 7 L 15 L 10 L 20 L 50 L

Air-sparge 0.25 0.5 2 5 NA NA NA

Air-overlay 0.5 2 5 10 20

O2 0.25 0.5 2 5 NA NA NA

CO2 0.1 0.25 0.5 2 10

N2-optical 0.1 0.25 0.5 2 NA NA NA

TruFlow gas MFC specifications

Enclosure dimensions (H x W x D) Six mass flow controllers: 9.1 x 7.4 x 6.2 in.

Rating NEMA 5, IP 51 (liquid wipedown)

Maximum gas flow rate Configurable up to 30 slpm*

Weight/shipping weight 5.8 kg/9.1 kg (12.8 lb/20 lb)

Operating temperature 5ºC to 40ºC (41ºF to 104ºF)

Storage temperature –25ºC to 70ºC (–15ºF to 158ºF)

Relative humidity 5% to 95% (noncondensing)

Certification CE: EN-61326 and EN-61010

Inlet pressure 1.6 to 2.3 bar/25 to 35 psig

Outlet pressure 0 to 1.38 bar/0 to 20 psig

Accuracy ±0.8% of flow rate and ±0.3% full scale (Burkert)

Repeatability ±0.1% full scale (Burkert)

Mass flow controllers Up to six per vessel (standard)

Solenoid valves Three per gas

Outlet headers/spargers Three total

Cable assembly 2 m (6 ft) standard

Note: MFCs greater than 50 L/min are mounted as individual units and are not part of the main MFC block. * May require additional configuration for specific flow rate. Please consult with your local sales representative for more information.

Automation packages 1 2 3 4

Cat. No. F100-2679-001 F100-2679-003 F100-2679-004 F100-2679-005

Number of G3Lab Controller systems* 1–2 3 4 8

TruLogic Base Cabinet (NEMA 12/IP54, stainless steel cabinet) 1 1 1 1

DeltaV MQ Controller, M-Series, VE3008 1 1

DeltaV MX Controller 1 1

Serial card 1 2 2 4

TruBio Media Version 13, Release 5.0.X 1 1 1 1

DeltaV Software Media Pack 1 1 1 1

ProPlus 25 Device Signal Tag (DST) 1 1 1

Analog Control Output 25 DST 1 1 1

PlantWeb Experience 100 DST, v12.3 or newer software—one operator station; 250 pt OPC-DA on ProPlus; 1-year Guardian Support included

1

Guardian Support, 1 year, 100 DST 1 1 1

Remote Services, system service by remote access (requires customer approval in advance) from off-site (daily rate without service contract)

1 1 1 1

Microsoft™ Excel™ software, one license 1 1 1 1

ProPlus Workstation, Precision Minitower, No Monitor, DeltaV Dual and Quad Monitor, English or Non-English Microsoft™ Windows™ 10 Enterprise IoT 2016, RAID 1

1

ProPlus Workstation (PowerEdge tower server, RAID 1, Windows Server 2016)

1 1 1

Application Station (PowerEdge tower server, RAID 10, Windows Server 2016)

1 1 1

Operator Station: Small Form Factor Tower, Single Monitor, Windows 10 Enterprise loT 2016; Quad-Core CPU, 1 x 500 GB SATA Drive (monitor not included)

1

22 in. Wide-Screen Monitor (required for TB 5.0 batch)

1 2 2 3

Cable Assembly, Cat5e, Yellow Boot, TruLogic, PRI Network, 20 ft (6 m)

1 2 2 3

Cable Assembly, Cat5e, Black Boot, TruLogic, SEC Network, 20 ft (6 m)

1 2 2 3

Application/base station license (250 DeltaV for OPC-DA plus 250 DeltaV Historian Parameters) (required for Application Station use)

1 1 1

Application Station/Historian license scale-up (1000 DeltaV Historian Parameters)

1 1 1

DeltaV equipment crating/packaging 1 1 1 1

Audit trail 1 1 1 1

* One G3Lab Controller per bioreactor. For more information on the automation package, please contact your sales representative.

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals. © 2019 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. DeltaV is a trademark of DeltaV Emerson Process Management. Microsoft, Excel, and Windows are trademarks of Microsoft Corporation. GAMP is a trademark of the International Society for Pharmaceutical Engineering, Inc. Watson-Marlow is a trademark of Watson-Marlow Fluid Technology Group. COL09091 0419

Find out more at thermofisher.com/sut

Ordering information

HyPerforma G3Lab Controller* Cat. No.

HyPerforma G3Lab Controller with DeltaV license, TruBio license, with 4 MFCs, 4 Watson-Marlow series 114 pumps, transmitter for pH+dO2 Sensor (optical pH and DO), TruSens transmitter for RTD, and all necessary cables; for HyPerforma Rocker Bioreactor only; GMP

F100-2694-001

HyPerforma G3Lab Controller with DeltaV license, TruBio license, with 4 MFCs, 4 Watson-Marlow series 114 pumps, transmitter for pH+dO2 Sensor (optical pH and DO), TruSens transmitter for RTD, and all necessary cables; for HyPerforma Rocker Bioreactor and HyPerforma Single-Use Benchtop Bioreactor; non-GMP

F100-2694-002

HyPerforma G3Lab Controller with DeltaV license, TruBio license, with 4 MFCs, 4 Watson-Marlow series 114 pumps, TruSens transmitter for RTD, and all necessary cables; for HyPerforma Glass Bioreactor only; GMP

F100-2695-001

HyPerforma G3Lab Controller with DeltaV license, TruBio license, with 4 MFCs, 4 Watson-Marlow series 114 pumps, TruSens transmitter for RTD, and all necessary cables; for HyPerforma Glass Bioreactor only; non-GMP

F100-2695-002

Note: All bioreactors listed are GMP-compliant.

* Each lab-scale bioreactor needs to be operated using a HyPerforma G3Lab Controller and appropriate automation platform.  Please contact your Thermo Fisher Scientific sales representative for more information on standard package options suitable for your requirements.