Generic Name Lasix

7/31/2019 Generic Name Lasix

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Generic Name:Furosemide Brand Name:Fumide,Furomide,Lasix,Luramide

Classifications:electrolytic and water balance agent; loop diuretic

Pregnancy Category:C

Availability

20 mg, 40 mg, 80 mg tablets; 10 mg/mL, 40 mg/5 mL oral solution; 10 mg/mL injection

Actions

Rapid-acting potent sulfonamide “loop” diuretic and antihypertensive with pharmacologiceffects and uses almost identical to those of ethacrynic acid. Exact mode of action not clearly

defined; decreases renal vascular resistance and may increase renal blood flow.

Therapeutic effectsInhibits reabsorption of sodium and chloride primarily in loop of Henle and also in proximal and

distal renal tubules; an antihypertensive that decreases edema and intravascular volume.Reportedly less ototoxic than ethacrynic acid.

UsesTreatment of edema associated with CHF, cirrhosis of liver, and kidney disease, including

nephrotic syndrome. May be used for management of hypertension, alone or in combination with

other antihypertensive agents, and for treatment of hypercalcemia. Has been used concomitantly

with mannitol for treatment of severe cerebral edema, particularly in meningitis.

Contraindications

History of hypersensitivity to furosemide or sulfonamides; increasing oliguria, anuria, fluid and

electrolyte depletion states; hepatic coma; pregnancy (category C), lactation.

Cautious useInfants, older adults; hepatic cirrhosis, nephrotic syndrome; cardiogenic shock associated with

acute MI; history of SLE, history of gout; patients receiving digitalis glycosides or potassium-

depleting steroids.

http://rnspeak.com/drug-study/furosemidelasix-drug-study/attachment/furosemide/



Route & dosage

Edema adult:PO 20 – 80 mg in 1 or more divided doses up to 600 mg/d if needed

IV/IM 20 – 40 mg in 1 or more divided doses up to 600 mg/d

child:PO 2 mg/kg, may be increased by 1 – 2 mg/kg q6 – 8h (max: 6 mg/kg/dose)

IV/IM 1 mg/kg, may be increased by 1 mg/kg q2h if needed (max: mg/kg/dose)neonate:PO 1 – 4 mg/kg q12 – 24h

IV/IM 1 – 2 mg/kg q12 – 24h

Hypertension adult:PO 10 – 40 mg b.i.d. (max: 480 mg/d)

Administration

Oral

Give with food or milk to reduce possibility of gastric irritation.

Schedule doses to avoid sleep disturbance (e.g., a single dose is generally given in themorning; twice-a-day doses at 8 a.m. and 2 p.m.).

Note: Slight discoloration of tablets reportedly does not alter potency.

Store tablets at controlled room temperature, preferably at 15° – 30° C (59° – 86° F) unless

otherwise directed. Protect from light.

Store oral solution in refrigerator, preferably at 2° – 8°C (36° – 46 F). Protect from light and

freezing.

Intramuscular

Protect syringes from light once they are removed from package.

Discard yellow or otherwise discolored injection solutions.

Intravenous

Note: Verify correct IV concentration and rate of infusion/injection with physician beforeadministration to infants or children.

PREPARE direct: Give undiluted.

ADMINISTER direct: Give undiluted at a rate of 20 mg or a fraction thereof over 1 min. With

high doses a rate of 4 mg/min is recommended to decrease risk of ototoxicity.

Incompatibilities Solution / Additive:Buprenorphine, chlorpromazine, ciprofloxacin, diazepam,diphenhydramine, dobutamine, doxapram, doxorubicin, droperidol, erythromycin, gentamicin,

isoproterenol, labetalol, meperidine, metoclopramide, milrinone, netilmicin, pancuronium,

prochlorperazine, promethazine, quinidine, thiamine vinblastine, vincristine. Y-site: Amrinone,amsacrine, ciprofloxacin, diazepam, diltiazem, dobutamine, diphenhydramine, dopamine,

doxorubicin, droperidol, esmolol, filgrastim, fluconazole, gemcitabine, gentamicin, hydralazine,



idarubicin, methocarbamol, metoclopramide, midazolam, milrinone, morphine, netilmicin,

nicardipine, ondansetron, quinidine, thiopental, tobramycin, vecuronium, vinblastine, vincristine,vinorelbine, TPN.

Use infusion solutions within 24 h. • Store parenteral solution at controlled room

temperature, preferably at 15° – 30° C (59° – 86° F) unless otherwise directed. Protect fromlight.

Adverse effects CV:Postural hypotension, dizziness with excessive diuresis, acute hypotensive episodes,

circulatory collapse.

Metabolic:Hypovolemia, dehydration, hyponatremia, hypokalemia, hypochloremia metabolic

alkalosis, hypomagnesemia, hypocalcemia (tetany), hyperglycemia, glycosuria, elevated BUN,

hyperuricemia;.

GI:Nausea, vomiting, oral and gastric burning, anorexia, diarrhea, constipation, abdominalcramping, acute pancreatitis, jaundice.

Urogenital:Allergic interstitial nephritis, irreversible renal failure, urinary frequency.Hematologic:Anemia, leukopenia, thrombocytopenic purpura; aplastic anemia, agranulocytosis(rare).

SpecSenses:Tinnitus, vertigo, feeling of fullness in ears, hearing loss (rarely permanent), blurred

vision.

Skin:Pruritus, urticaria, exfoliative dermatitis, purpura, photosensitivity, porphyria cutanea tarde,

necrotizing angiitis (vasculitis).

BodyWhole:Increased perspiration; paresthesias; activation of SLE, muscle spasms, weakness;

thrombophlebitis, pain at IM injection site.

Nursing implications

Assessment & Drug Effects

Observe patients receiving parenteral drug carefully; closely monitor BP and vital signs.

Sudden death from cardiac arrest has been reported.

Monitor BP during periods of diuresis and through period of dosage adjustment.

Observe older adults closely during period of brisk diuresis. Sudden alteration in fluid

and electrolyte balance may precipitate significant adverse reactions. Report symptoms tophysician.

Lab tests: Obtain frequent blood count, serum and urine electrolytes, CO2, BUN, blood

sugar, and uric acid values during first few months of therapy and periodically thereafter.

Monitor for S&S of hypokalemia .

Monitor I&O ratio and pattern. Report decrease or unusual increase in output. Excessive

diuresis can result in dehydration and hypovolemia, circulatory collapse, and

hypotension. Weigh patient daily under standard conditions.

Monitor urine and blood glucose & HbA1C closely in diabetics and patients with

decompensated hepatic cirrhosis. Drug may cause hyperglycemia.

Note: Excessive dehydration is most likely to occur in older adults, those with chroniccardiac disease on prolonged salt restriction, or those receiving sympatholytic agents.



Patient & Family Education

Consult physician regarding allowable salt and fluid intake.

Ingestion potassium-rich foods daily (e.g., bananas, oranges, peaches, dried dates) to

reduce or prevent potassium depletion.

Learn S&S of hypokalemia . Report muscle cramps or weakness to physician.

Make position changes slowly because high doses of antihypertensive drugs taken

concurrently may produce episodes of dizziness or imbalance.

Avoid replacing fluid losses with large amounts of water.

Avoid prolonged exposure to direct sun.

Do not breast feed while taking this drug

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Generic Name Lasix