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Genetics evolution
1
10,000 BC 2016
Genetic evolution
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MU announces PRRS resistant pig
Selective breeding Directed recombination? Domestication
1900 AD 2000 2010 2015 10,000 BC
Relationship Based Genomics
Efficiency & sustainability prolificacy, feed efficiency, health & robustness
Meat quality taste, leanness, yield
Gene editing ‘invented’
Darwin develops evolution theory
First transgenic Crop introduced
Shull describes heterosis
Cost to sequence drops factor 1000 in 3 years
Mendel ‘invents’ genetic science
Watson & Crick describe DNA molecule
Human Genome Project completed
Selective breeding
3
Genetic Improvement (ΔG)
Parents Children
Selective breeding works
Prolificacy
1960s 2010s
14 pigs Per year
28 pigs Per year
+100%
4
900 lbs of feed each pig
550 lbs of feed each pig
-40%
Selective breeding works
Feed conversion
1960s 2010s
6
Manure per lbs of lean meat reduced by more than 60%
350 lbs of feed x 1 bln hogs = …
Meat quality
75 lbs of lean each pig
120 lbs of lean each pig
+60%
Selective breeding works
1960s 2010s
Selective breeding works
Prolificacy
Feed conversion
Meat quality
1960s 2010s
14 pigs Per year
28 pigs Per year
900 lbs of feed each pig
550 lbs of feed each pig
75 lbs of lean each pig
120 lbs of lean each pig
+100%
-40%
+60%
Manure reduced per lb of lean meat by more than 60%
Accelerating genetic gain: what’s next?
Gene Editing
The next frontier…
The blight of PRRS
PRRSv has challenged the swine industry for ~30 years There is no cure, existing treatment has limited effect PRRSv cost global pork over $4bln each year
Waste of animal well-being, feed, and human emotion
Delivering unique value
PRRS resistance A high level overview
• Pigs were created with minor nucleotide edits within their existing DNA
• No new or foreign DNA was inserted into the pigs
Genetics revolution
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10,000 BC 2016 2020
Evolution Revolution?
Realizing the future
• We don’t have the perfect pig but that simple possibility excites and drives us
• Genetic improvement is accelerating at a faster pace than ever before
• Breakthrough technologies will further accelerate this pace of change
• Continued investment in service and support creates the greatest focus on opportunities and probability of success
PIC is dedicated to the responsible exploration of innovations that benefit the well-being of animals, farmers, and society
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