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CALIFORNIA TUMOR TISSUE REGISTRY

Genitourinary and Prostatic Tumors Study Cases, Subscription B

May,2007

California Tumor Tissue Registry c/o: Department of Pathology and Huma n Anatomy

Loma Linda University School of Medicine 11021 C11mpus Avenue, Afl 335 Lom11 Linda, Ca.llfornia 92350

(909) 558-4788 FAX: (909) 558-el88

E-mail: c!tr@linkline.com Web site & Case of the Month: www.cttr.org

/33€

2

Target audience; Practicing pathologists and pathology residents.

Goal: To acquaint the participant with the histologic features of a variety of benign and

malignant neoplasms and tumor-like conditions.

Objectives: The participant will be able to recognize morphologic features of a variety of benign

and malignant neoplasms and rumor-like conditions and relate those processes to pertinent references in the medical literature.

Educational methods and media: Review of representative glass stides with associated histories. Feedback on consensus diagnoses from participating pathologists. Listing of selected references from the medical literature.

PTincinal faculty: Donald R. Chase, MD

CMECredit; Loma Linda University School of Medicine designates this continuing medical

education activity for up to 2 hours of Category I of the Physician's Recognition Award of the American Medical Association.

CI\<IE credit is offered for the subscription year only.

Accreditation: Lorna Linda University School ofMedicine is accredited by the Accreditation

Council for Continuing Medical Education (ACCME) tO sponsor continuing medical education for physicians.

Study Cases, May, 2007 Subscription B

Contributor: Lorna Linda Pathology Group (rc) Lorna Linda. CA

Tissue from: Epididymis

Clinical Abstract:

Case No. 1 - May, 2007 B

Accession #30447

A 44-year-old man presented with a slowly growing right scrotal mass, and a several year history of suprapubic pain. On ultrasound, an epididymal mass was identified. Past medical history included one episode of gonorrhea. A right radical orchiectomy was performed.

Gross Pathology: The 92 gram, 3.5 x 3.5 x 2.0 em testicle with an attached 8.0 x 3.0 x 2.0 em spermatic cord

included 30 cc of clear yellow hydrocele fluid. A 2.5 x 2.0 x 2 .0 em firm nodule was within the superior part of the epididymis, not involving the testis but extending up into the spermatic cord.

Cont.ributor: Dharam Rahmani, M.D. Case No. 2 - May, 2007 B Richmond, VA

Tissue from: Foreskin Accession #30528

Clinical Abstract: A 43-year-old diabetic man presented with severe balanitis which did not respond to

pharmacotherapy. On examination, the foreskin was edematous, inflamed and had ulcerations. Circumcision was done.

Gross Pathology: The specimen consisted of two fragments of wrinkled skin measuring 3.8 x 3.0 x 1.8 em and

3.0 x 2.5 x 1.0 em. The fragments showed areas of geographic necrosis.

3

Contributor: Dharam Ramnani, M.D. Case No. 3 - May, 2007 B Richmond, VA

Tissue from: Foreskin Accession #30530

Clinical Abstract: An 87-year-old man underwent circumcision for phimosis. He had a history of prostatic

adenocarcinoma (Gleason 3+3=6) detected four years previously presented

Gross Pathology: The specimen consisted of a 5.0 x 3.5 x 1.5 em fragment of dark wrinkled skin.

Snecial Studies: Positive: CEA (strongly), P504s (racemase), PAS (weak.ly) Negative: HMB-45, S-1 00 protein, Prostate specific antigen, Prostatic acid phosphatase

Contributor: Kenneth Frankel, M.D. Case No. 4 - May, 2007 B Glendale, CA

Tissue from: Scrotum, spermatic cord Accession #30392

Clinical Abstract: A 57-year-old man sought treatment for a scrotal mass.

Gross Pathology: The 15.0 x 11.0 x 11.0 em specimen consisted of circumscribed pink-gray tissue with dense

yellow-tan internal parenchyma. There was no evidence of cystic degeneration or hemorrbage.

Special Studies: Positive: Negative:

Ki-67 (30% nuclear positivity), Desmin (strongly), NSE & CD68 (diffuse/weak) S-100, CAM 5.2

Contri.butor: Marc Keen, M.D. Case No. s - May, 2007 B Ludington, Ml

Tissue from: Right testicle Accession #30420

Clinical Abstract: A 69-year-old man developed a right testicular mass for which an orchiectomy was perfonned.

Skin biopsies perfonned two years earlier on the abdomen and chest were positive for a high grade malignant neoplasm with a similar appearance on microscopic examillation. Immunoperoxidase stains on the skin biopsies were positive for lysozyme and CD43, and negative for SIOO, HMB45, Pankeratin, PSA, CD79a and myeloperoxidase.

Gross Pathology: The mass was solid, 3.5 em, firm, tan and homogeneous without hemorrhage or necrosis.

Special Studies (testicular mass): Positive: CD45, Lysozyme, CD43 Negative: CD79A, Myeloperoxidase, PLAP

Contributor: Lester Thompson, M.D. Case No. 6 - May, 2007 B Woodland Hills, CA

Tissue from: Testis Accession #30372

Clinical Abstract: A 45-year-old man presented with an enlarging testicle. There was pain associated wi th

palpation. Ultrasound demonstrated a solid testicular mass.

Gross Pathology: At resection, a 4.2 em, light tan-pink, tleshy mass was identified within the testis, confined by

the tunica albuginea.

Study Cases, May, 2007 Subscription B 5

Contributor: Jouf Kollin, M.D. Case No. 7 - May, 2007 B Lakewood, CA

Tissue from: Rigbt scrotal mass Accession #30225

Clinical Abstract: Approximately I week after being involved in a motor vehicle accident, an 18-year-old man

noted an enlarging scrotal mass. Scrotal ultrasound confirmed a complex, solid mass. AFP was greater than 1000 and beta HCG was 6. A right radical orchiectomy was performed.

Gross Pathology: The 405 gram, 12.0 x 10.0 x 7.0 em partially necrotic mass completely replaced the testis. The

cut surface was variegated, with solid, gray-tan and fish-flesh areas, while other areas were cystic, the cysts measuring up to 1.5 em in diameter. ·

Contributor: Jin Mci, M.D. Case No. 8 - May, 2007 B Hangzhou, China

Tissue from: Kidney Accession #30431

Clinical Abstract: After experiencing one year of hematuria, this 43-year-old man presented with pain in the right

lumbar area of three days duration. A right nephrectomy was performed.

Gross Pathology: The 17.0 x 14.0 x 11.0 em specimen included a 12 x 9 em well-circumscribed mass with a

gray-yellow and tan cut surface. 1t was focally both hard and soft in texture.

6 Srudy Cases, May, 2007 Subscription B

Contributor: Xuedong Wang, M.D. Case No. 9 - May, 2007 B Pasadena, CA

Tissue from : Right kidney Accession #30538

Clinical Abstract: A nephrectomy was performed on a 28-year-old woman after a renal mass was identified on

workup.

Gross Pathology: The 382 gram, 12 x 8 x 6.8 em specimen had multiple weU-circumscribed, 0.2 to 2. 7 em

coalescing cysts in the outer cortex of the inferior pole. The bivalved specimen showed a well­circumscribed, 7.5 x 8.4 x 6.4 em multilocular variegated cyst. The cut surface ranged from white-tan and fibrous to red-brown-yellow and hemorrhagic. Cysts grossly abutted the hilar stn1ctures. A small amount of uninvolved renal parenchyma was noted at the superior pole, compromising less than 25% of the specimen.

Contributor : Douglas Hank.~, M.D. Case No. 10 - May, 2007 B San Francisco, CA

Tissue from: Left kidney Accession #30484

Clinical Abstract: A left inferior pole renal mass was identified in a 54-year-old woman. A left radical

nephrectomy was performed.

Gross Pathology: The 5.8 x 6.5 x 11.8 em kidney with attached perirenal fat had a 5.4 x 5.1 em fum, white-tan,

nodular mass replacing most of the inferior pole, just inferior to the hilum. The mass grossly bulged into the hilar fat and abutted the inferior capsule.

Study Cases, May, 2007 Subscription B 7

CALIFORNIA TUMOR TISSUE REGISTRY

"Genitourinary & Prostatic Neoplasms"

Minutes - Subscription B

May, 2007

SUGGESTED READING (General Topics from Recent Literature):

Utility of ALK-1 Protein Expression and ALK Rearrangements in Distinguishing InOammatory Myofibroblastic Tumor From Malignant Spindle Cell Lesions of lhe Urinary Bladder. Sukov WR, CheVJlle JC, et al. Mod Patllo/2007; 20:592-603.

The Pathology ofGastic Cardia. A Prospective, Endoscopic and Morphologic Study. Cestari R, Yillanacci V, et at. Am J Srtrg Patlro/2007; 31:706-710.

Late-Onset Wilson's Disease. Ferenci P and Czlonkowska A. Gastroenterology 2007; 132:1294-1298. Diagnosis of Chronic Endometritis in Biopsies with Stromal Breakdown. Gilmore H, Fleischhacker D and Hecht JL.

Hum Pathol 2007; 38:581-584. lmmunostaining for SYT Protein Discriminates Synovial Sarcoma from Other Soft Tissue Tumors. Analysis of 146

Cases. He R, Patel RM, et al. Mod Patlro/ 2001; 20:522-528.

Califomia Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University School of Medicine 11021 Campus Avenue, AH 335 Lorna Linda, Califomia 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: cttr@linkline.com Web site & Case of the Month: www.cttr.org

FILE DIAGNOSES

(Preferably submitted on website at www.cttr.org. Click "subscriptions", then "submit answcl'll.")

Case 1:

Case 2:

Case 3:

Case 4:

Case 5:

Case 6:

Case 7:

Case 8:

Case 9:

CTfR Subscription B May 2007

Smooth muscle hyperplasia/hamartoma, testicular adnexa T-78000, M-75500

Herpes simplex viral infection of foreskin T -02540, 0..{)404

Paget's disease, foreskin T-76330, M-85423

Low grade myosarcoma (''leiomyosarcoma"), scrotum T-79400, M-88903

Extramedullary myeloid tumor, testis T-78000, M-73500

Classic seminoma with intratubular germ cell neoplasia (ITGCN), testis T-78000, M-90613

Mixed germ cell rumor with teratoma and yolk sac components, testis T-78000, M-8631 0

Oncocytoma, kidney T-71000, M-82900

Multilocular renal cell carcinoma, clear cell type, kidney T-71000, M-83123

Case 10: Papillary ronal cell carcinoma, kidney

T-7 1000, M-83123

Case No. 1 - Accession No. 30447

C&noga Park .. Leiomyoma Escondido - Idiopathic smooth muscle hyperplasia Glendale • Leiomyoma (,qma llnda • Vasitis nodosa Mountain Vjsw lEI Camino Hospilall - Leiomyoma. Ornnge <UCI Medical Center) .. Leiomyoma Palo Al!o - Leiomyoma vs. smooth muscle hl'J)<:rplosio San Diego CNoyu! Medical Center San Diegol · LA:iomyoma Sao Diego IUCSp Medical CeoJot) - Leiomyoma San Francisco <San Frnncisco Oeuml HO$Ditall · Leiomyoma Ark,... IUnjymirv of Ark!IM!IS Medioal Center> - Leiomyoma, cpidid}mus Connecticut ('.Yst Hartford) - Fibrous psudotumor Florida (Munroe Regional Medjeal C<."'terl - fibrous psudotumor

May, 2007

Illinois (Hcartlond Regional Medjcal Center) • LoCllliz.cd smooth muscle hl'J)<:rplnsio (lciomyomo-likc) of epididymis Illinois (lovola Unjversitv Medjcol Cen[er) - Nodular and diffuse Hbrous proliferation Kansas <Coffevvj!lc Regjona) Msslical Center) - Leiomyoma Kansas fPctC!JOO Laborntorv Services) - Leiomyoma · Knnsa.1 CPhvsjcjgns Reference Lnborntorvl .. Leiomyoma Louisiana ILSUHSC PaJhnlogyl - Leiomyoma Marvland CIJlc John's Hopkin's Hospital> - Leiomyoma Marvland !Unjvqsjty ofMarxland Medical Center> - Leiomyoma M.....,huwu CUM ASS Memorial Meclical Ccn!ctl - Leiomyoma Michie:an ilimrv Ford Hosoj!a!l • Leiomyomo Missouri <Trumgn Medical Ccms;r> - Smooth muscle hamanomn New York (Nussuu Unjyersity Modicnl Center) - Leiomyoma New York <Stony Brook Unjyersitv Hospital> .. Leiomyoma New York <SUNY Downstate Medical Center> .. Sperm granuloma vs. smooth muscle lesion North C!lrolina IWinS!Qn-Saleml - Pan>testicular leiomyoma with S«::ndary testicular atrophy Nonh Coroljno !Womack Army Medic:! I Cen!erl - leiomyoma Ohjo. Columbus - Epididymis. smooth muscle proliferation Oklahoma COk!uhoma Univerfjty Medical Center) - Leiomyomn JJennsylvanjn (Conemaugh Memorial Mcdicql Ccptcrl - Leiomyoma Pcnnsvlvania (Drexel Univcrsjty College of Medicine) .. Leiomyoma Pcnnsvlvaoia !Wilkes-Barre General Hospi~all - Smooth muscle hyperplasia of •~icular adnexa Pueno Rico Nojven;iry ofPueno Rico) - Nodular and diffuse fibrous proliferodon Sou!h Dakota CLCM PathologjJ!s, P,C.) - Leiomyoma Texas. Lubhock ~ ldomyomn Texas CScon & White Mcmorjnl tlospitall - Smooth muscle hYJ>trplasia oftestlculur udnexa Texas Sugarland - Adenomatoid tumor WC$1 Virginia C\Vw.el Counrv Homitall - Spcnna1ocele Brnzill!.ahora<orio Arn!!omi• Potho!ogisa Eci<ologial - Leiomyoma, epididymis Cnnada (pasqun Hos-pital) .. leiomyoma China <Sir Run Run Shaw Hosnitnll - Leiomyonm Jrcland CGalwny Residents) - Leiomyoma with maturation arrest/fibromatosis Jaoan (Asahi Generol Hosoital\ • Leiomyosarcoma Japan <Gunma Vni\'ersjOO - Leiomyofll3 Japan <Hamemat5U Univmjly School of Medidnel - Leiomyoma Oatar IHamnd Medical ComorQtjonl • Epididymal leiomyoma (3); Proliferative funiculi<is (2) Saudi Arabia <Kin• Fahad Natjonnj Guard Hosojmll - Smooth musole hypcfRiasin of!esticular adnexa Soain CPovjsa HpspitnD - Leiomyoma United Kingdom CRadcliffc: liPFpjtall - Epididymis/Jciomyoma

Case 1 - Diagnosis: Smooth muscle hyperplasia/hamartoma, testicular adnexa

T-78000, M-75500

Case I - References: Fish<:r WC and Helwig EB. lciomyomas of the Skin Arcll Dmnatology 1963; 88:510-520.

CTTR. May, 2007: "Minutes" (Subscription B) 3

Friclman E, Skarda J, Ofelc-Moravslcy E. et al. Complex Multilocullll' Cystic Lesion of Re<e Te$tiS, Accompanied by Smooth MUS<:Ic Hypcrplasio, Mimicking lntratesticular l<:ydig Cell Neoplasm. Virclwws Arch 2005; 447(4):768· 771.

van Kooten EO, Hage JJ, Meinhardt W, et al. Acquired Smooth-Muscle Hamartoma of the Scrotum. A Histological Simulator? J Cullm Patlro/2004; 3 1 (5):388-392.

fine SW, Davis NJ, Lykins LE, et al. Solitary Testicular Myofibroma. A Case Report and Review of the Literature. Arch Pathol l.IJbMed2005; 129(10):1322·1325.

Schrecengost .IE, Tabbara S, Panerson J, et al. Cutaneous Mesenchymal Hamartoma with Mixed Myogenous Differentiation. J Cutan Patho/ 2006; 33(4):327-330.

Holst VA, Junkins-Hopkins JM and Elenitsas R. Cutaneous Smooth Muscle Neoplasms. Clinical Features, Histologic Findings, and Treatment Options. JAm Acad Dermato/ 2002; 46(4}:477-490.

Case No. 2 - Accession No. 30528

Canoga. Park • BataniLis with necrosis and ulceration Emodido • Syphilis Qlendale - Chronic balanitis Lorna Linda • Ulcer, foreskin Mountain View lEI Camino Hosnj!all • BaJanills, r/o syphilis Omnae (UCI Ms;sljcpJ Center> - Vasculiri:;, Polo Alto - Necrotizing balanitis Sao Diego <Naval Medical Center San Diego) • HSV balanitis Sao Diego <UCSD Medical Cguql • loon's balanilislplasma cell SM francisco CSqn Fnmcisco General Hospitall - Chronic ulc4.!rotive balanitis Arkansas fUnjyrnjtv of Arkansus Medical Centstr> .. Primary chuncre, penis Coooecticu1 (West Hartford! . T-ccll lymphoma Florida (M\mrps Regional M~djcgl Center> - Chronic endartaiti.Vsyphilis llljnois <Heanlan4 Regional Medje! Center) • Herpes simplex dermatitis with ulceration Olinois fLoypla Univcrsirv Mcsfjel Center) - HSV balanitis

May, 2007

KMsac: <Coffc:yyj!!e Regional Modi cal Center> - Epithelial hyperplasia with ulcer and cl1ronic and acute inflammation Kp.nsas <Pe-terson J,ttboratoa Services) .. Hcrpatic ulcers Kansas <Physicinns Reference Laboratory) - Ulcer nnd necrosis L.ouisiana ILSUHSC Pathology) • Suspe<:t malignant lymphoproliforntivc process Mnrylaod CThe!ohn's Hopkin's Hosoitall • Oangr<:noos balanitis Marvland <Uojvcui!y of Maryland Medjca! Center> · Oangr<:nous balanitis (Corbus disease) Massachusetts IUMASS Memorjpl Medical Center> - Balanitis Michigan /Henry ford Hosnjta!\ • Gangrenous bulnoitis Misso\Jri (Jounuq Medical Center) - Herpes New York <Nmuqu University Mesfjcal Center) - Ulcerating acute and chronic inflammation Nsw York fStO!ly Brook Univrnjtv Horoi<all • Syphilic chanae New Yorls ISVNY DownS!ate Mc<ljcat Center) • HC!pis Noah Carolina CWjnston-Saleml - Gangrenous balanitis Nonh Carolina !Womack Army Medical Center) • Posthilis, NOS (4) Ohio Columbus · Foreskin, ulcerarion .. acute/chronic inflammation, prob herp.;s Oklahoma !Oklahoma Univ=ity Mes!jcal Center> • Bahcct's disease Pmnsylvania lConcmaue:h Memorial Medical CgJter) • BaJaniti,s xa-otica obliterans Pcoosvlvanja !Drexel UoiveajN College of Mcdjciocl · Ulcerated balanitis with herpes simplex virus infection J,ennsylvania <Wilkes-Bam: General Hospital) - Balanitis xcrotica obliterans, ulcerated Pyti:rto Rico (Unjycrsitv of Puerto Rico) .. Herpetic ulcer South Dakoto ILCM Patholoaisl•· !'.C.) . Balnnitis circumscripta plosmacellulnris Texas Lubbock • Malignant lymphoma Tent <Scott & Wbjtc Memorial Hospjtall · Balanitis of Zoon Texas Sugacland - Ouooie ulcct~~tive prosthesis We~t Vjrg!nia CWet7.el County Hosnjton - Gangrenous balanitis Brozj! <Laborntorjo Anntomio Puthol()gica Ecitoloaio) - SyphiliH/mucosal neuromn CAnada (pasgun Hosoitall - Zoon•s balanitis Canada fSher!lrookc University tlospiml) . Lue; China <Sir Run Bun Shaw Hosnjaoll - Syphilis Ireland fOotway Residents) • Syphilic cbancre/aogioocuroma Jqpnn CAsal1j Qencral Hospital) - Herpes simplex virus infection of foreskin Jnpon (Gunmn \Jniversirv) - Herpes virus ihfcction

4 CTTR. May, 2007; "Minutes" (SUbsctiptoon B)

Japan CHnmamottu Universirv School ofMedicjncl - Superf"tcial tprcading melanoma Oatar (Hamad Medical Corponujonl • Balanitis cin:umscripta (Zoon's balanitis) Snudi Arabia (Kjng fahad National Guard Hospitn!l - Fournier's gengrene Spain (Povisa tlospits!) - Hepatic ulcers (vs. syphilis) United Kjngdprn <Radcliffe Hosphal} • Plasma cell balanitis, foreskin

Case 2 · Diagnosis: Hepes simplex viral infection of foreskin

T-02540, 0 ·0404

ea~ 2 - Refqsnccs: Mcnz GJ, Jourdcn J and Remington M, c:t al. Risk of Transmission of Genital lierpcs. Pn:sented a1 Fifth lmcmalional Meeting.

International Society for STD Research, Scaute, August 1·3 1983. Nahmias AJ and Roizman B. Infection with Herpes Simplex I and 2. N cngiJ Mtd 1973; 289(15):667; 781-789. Vurdi A, Dogan Rand Engelhard D. Neonatal Genital Herpes Simplex Virus TYJ>O 1 Infection After Jewish Ritual Circumcision.

Modem Medicine and Religious Tradilio,. P•dlatrics2004; 11 4(2):259·263. Rocst RW, Macrti.dorf J, Kant M, van der Mcijden WI, et of. High Incidence of Genotypic Variance Between Sequcmial Herpes

Simplex Virus Type 2 Isolates from H1V·I·Scropositi"" Patienu with R«:urm~t Genital Heq>es. J Infect Dis 2006; 194(8):111S·III8. •

Cunningham AL, Diefenbach RJ, Miranda-Sakscnn M, et al. The Cycle of Human Herpes Simplex Virus Infection. Virus Transport and Immune Control. J Infect Dis 2006; 194 Suppl l pS I I-8.

Kimberlin OW. Diagnosis of Herpes Simplex Virus in the Em of Polymerase Chain Reaction. Petllatr Infect Dis l 20()(); 23(9):841 · 842.

Xu, F, Sternberg MR, Kottiri BJ, ct al. Trends in Herpes Simplex Virus Type I and Type 2 Sc:roprevaleocc in the United States. JAMA 2006; 296(8):964·973.

Case No. 3 - Accession No. 30530

Canoga Park • Paget's disease ~scondido • Pa~ct's disease Glendale - 1•1\Q,c:I~S disease secondary to prosuue carcinomA Lorna Linda • Hxtra mammary Paget's (crythrop1osia ofqueda) Mountain View CEI Camino Hospjcall - Paget's disease Orange (lJCI Medical CC!!Jcrl • Paget's disease Palo Alto · Metastatic prostate corcinoma Son Diego CN111i!!l Medieal Center San Diego) . EKiramammary Paget's disease San Djegn fUCSD Medical Center) . Paget's disease San Francisco CSrm francisco General Hospitall - Paget's disease Arkansas CUnjymitv of Arlcansas Medical Cenu;r) . Extra-mammary Paget's disease, penis Connecticut OYC51 Hartford) • MctaSt11tic prost01ie adenocarcinoma Florida CMunroe Regional Medjsnl Center) · Paacl's disease of roreskin Jllinois CHcartlund Regional Mcdjcpl Center) - llnger•s diseDSc !ll jnois <Loyola University Medjcnl Centerl · Paget's disease Kansas (CQ[evvil!c Regional Medical Centorl • l'agct's disease of foreskin Kansss IPctcnoo laboratory Savices) • Extramammary Pagel's Kansas {Phvsjcjans Rcfqenes Loboratorvl - Pugct's disease Louisiana CLSUHSC Pathology) • Adenocarcinoma, metastatic to foreskin (?prostate I degree) Man·land <The John's Hookjn's Hosnitan - l'nacl's disease Mgryland <Unjycrnity of Maryland Mcdiel Center) .. Extra·mommury Paget~s diseASe Massaehusens <UMASS Memorial Medical Cenlorl • Pa!(et's disca.o;e Michigan <Hcmy Ford HOS!lita!l • l'aget's disease Missouri CTruman Medical Center> - Extra-mamrnnry Paget's New York CNWfsau University Medical Center) - Paget's disease New York CSJony Brook Universjly Hospital) - Extnl·mammary Pogc~·s disease New Yorlt CSVNX Downstate Medical Center) • Paget's disease Noah Carolina (Winston-Salem> - Paget's disease Nonh Ctroljna !Womack Anny Medical Ccmcrl • Paget' s disease (4) Ohio Columbus - Page1"s disease. roreskin Oklahoma COklqhoma Universjty Medical Center) - Pagel's disease Pcnnsylyaoju (Conemaugh Memorial MedicAl Center) - Extra~mnmmary Paget's dist..-use

CITR. May. 2007; "Minutes" (Subscription B)

May,2007

5

Penn;sylwnia !Drcxc1 Uniyersjty Co1tege of Medicine> · Paget's disease Pennsylyanja fWHkes-Barrc Gcncrol Hospital> - Extra-mammary Pagec's disease Puerto Rico CUniversjty ofPuctJo Rico) - Paget's disense of the penis South Q>kom !LCM Patbologisl$ P.C.) - Extra-mammary Paget's disease Texas, Lybbock • Paget's distllS< Texas !Scott & Wbjte Memorigl Hosoitq!l - Paget's diseuse Texus. Sugarlaod · Paget's diseuse West Vjrginia <Wetr.cl County llosoitall • Paget's dlsease Brazjl !kabor.uorio Anatomia Pl!holoeica Eeitologial - EJ<na-mammary Paget's disease (prostate primary) Gane.da (Pasaua Hospita1l - Page['$ disease Canacln <Shcrbrookc University 11ospitall • l,oget's disease Ching (Sir Run Run Shaw Hospjtoll - Paget's disease Irs! and !Galway Residents> - Extra-mammary Paget's disease Japan !ASahi General Hosoital} • Paget's disease Japan CGunma Unjycrsityl - Extra-mammary Paget's disease Japan (Homamotsu Unj versitv Schoo) ofMcdjcinel · Poget's disease Oatar !Hamad Mcdjeal Comomtjon) - Paget's disease of the penis (carcino= of colon should be excluded) Saudi Alnhia <Kina Fahad Natj!lAAI Guard Hospital) - Pillet's disease: Sot1in (povjsa HospjJa1l - Paget's disease United Kingdom <Rndcliffe Hospjtall - Pogct's disease, foreskin

Case 3 - Diagnosis: Pagel's disease, foreskin

T-76330, M-85423

Case 3 - References: Oionyssopoulos A, Mandckou-L.efaki I, Vakirlis E, et al. Exmunammlll)' Paget's Disease Isolated Localization on the Groin-Wide

Local Excision with hnmedicate Reconstntction. Ann Surg Onco/2006; 13(9): 1235-1240. Henning JS. Extramammary Paget's Disease of the Penis and Scrotum. J Dntgs Dermaro/2006; 5(7):652-654. Donoval BA, Landay AL, Moses S, ct al. HI V-I Target Cells in foreskins of African Men with Val)'ing liiscoriesofStxually

Transmitted Infections. Am J Clln Potlto/2006; 125(3):386-391. Yang WJ, Kim DS, lm YJ, et nl. Extramnrntnary )>agel's Disease of Penis and Scrotum. Uro/2005; 65(5):972-975. Quinn AM, Sienko A, Basrnwala z. el aJ. Extmmammnry Paget 0i.SC3..~e olthc: Scrocum with F'eanm::s of Bowen Disease. Arch

Potho/Lob M•d 2004; 128( 1):84-86.

Case No. 4 - Accession No. 30392

Canogn Park · Fibromamsi!l V$. proliferative funiculitis Essondjdo - Myxoid leiomyosarcoma Lorna Lin<la - Fibromatosis, spermatic eord Mountain View <r;J Camino 11omhall - Leiomyosarcoma, low grade Orange CUCI Mcdjcal Center) • Malignant myolibroblastic tumor Palo Al!o · Leiomyosarcoma San Djcgo CNavgl Medical Cen1g San Diego) - Fibrous pscudolumor San Djego IUCSQ M<dica! Cenu;r} - ln6ammatory myofibroblasric rumor San Fmncjseo <San Francisco General Hosnitan · Leiomyoma Connecticut CWest Hartford> - Lciomyosorcomn Florida <Munroe Rs.'giona1 Mcdjcal Centq) · Rhabdomyosarcoma lllinoj• <Heanland R<J!ional MgliCJ!I Centql - Myofibromatous !Unlor nlinois <Loyola Uojyersiry Medical Center) ~ Rhabdomyossrcom3 Kansns (Coffeyville Regional Medical Center) - Leiomyoma Kansas <Peterson Lqbonuorv Scryjcesl - Leiomyosarcoma Kansas <PhysiciOJ)s Reference L1boratorvl - Paratesticular rhabdomyoma Loujsjana !lSUHSC Pathology\ • Proliferati¥C funieitis Marvlond CThc John's Honkin·s I:Jospitall - Low gn~dc leiomyosarcoma Ma1ylnnd (University ofMarvlnnd Medical Center) - Low grnde leiomyosarcoma

May,2007

Mas~qcbusetlS <UMASS Memgripl Medicql Center) - Myofibroblastie tumor with unknown malignant potential Mjcbjgan !Henry fon! Hospj[oll - Angiomyofibroblastoma Missouri O)uman Medical Center> • Myofibroblastoma

6 CTIR, May, 2007: "'Minutes" (Subscription B)

New York INQI!sau Uniymjty Medical Csntql - Steroid ec!! !lnT10r

New York (Stony Brook Uniyersirv Hospjtu!) .. Pscudoinnrunmatory tumor New York (SUNY Downstate Medical Cenccrl - Myoflbrublastic lesion North Caro!ino (Winston-Salem) - Angiomyofibrob!astomo North Caroling (Womack Anny Medical Cguei) - Nodular and diffuse fibrous proliferation (4) Ohio. Columbus - Spindle ec!! proliferation, sm><um Oklahoma (Oklahoma Unjymity Mcdicnl C(.."fltcrl ~ Neurofibroma Pcnnsylvanja (Conemaugh Mc!Dorial Mcdjcnl Center) - Pcritesticular fibrosis Pcnnsvlvanio CDrcxeJ Uniyeaity Col! eRe of Medicine> - Desmoplastic tlbroblastornalfibromatosis Pennsvlvanjo (Wilkes· Bam; General Hmiu!l) • Angiomyofibroblastoma Puerto Rico N njversirv of Pysrto Rico) - Fibromatosis/smooth muscle: hyperplasia South Dakota CLCM Pmho!ocists. P.C.) - Malignant hem•topoetic neoplasm Texas Lubbock • Embryonal rhabdomyosorcoma Texas <Scott & White Memorial HosoitaJ> - Myofibroblustoma Texas. Sue!lfland - Ltiomyoma West Virginjn CWe<zel CooniV HQSDi!liJ) - Myofibrob!astoma Brazil CLaborptgrio Anatomjo PnthoJogicg Ecirologial - Spindle cell rhabdomyosarcoma Canada CPMgun HospitaD .. Neurofibroma Canada CShgbrooke Universjtv Hospital) • RJ1abdomyt>sorooma China !Sir Rug Run Sbaw Hospjll!ll - Myofibroblastomo Ireland CGa!wy Residents) • Sclerosing well-diffcreotioted li~ with ? dedifferentiation Jpnan CAst1hj Qeneral HospitoJl - Angiomyofibroblastomn Japnn CGUJtma Uniyer~ityl - Fibrosarcoma Japan CHamamotsu University Schoo) oC Mqdicincl - Cellular angiofibroma Oa•ar !Hamad Medical Corporotionl • Leiomyoma (3); Angiomyofibrob!astoma (2) Sgudi Arabia (King Fahad Nptjonal Guard Hospital) - Leiomyoma Spain (Povisn Hosoitall - Cellular angiofibroma (vs. low grade leiomyosarcoma) United Kingdom <Radc1iflb Hospital) - Genital rhabdomyoma, spermatic cord

Case 4 ·Diagnosis: Low grade myosarcoma ("leiomyosarcoma"), scrorum

1' • 79400, M-88903

Case 4 - References: Co!licr DS, Pain JA and Hamilton-Dutoit SJ. Leiomyosarcoma of the Scrotum. J Suf'8 Onco/1987(3); 34:176-178 Johnson H. Jr. Lciomyosnrcomn ofScrorum. Uro/1987(4); 29:436-438. Ray B, Huvos AG and Whitmore \'IF Jr. Unusual Malignant Tumors oftht Scrotum. Review ofS Cascs J Urol19n; 108(5):760·

766. Wa!liDabi K,Og•wa 0 , Kom•tasu H, ct at. Malignant Fibrous Histiocytoma of Scrotal Wall. A Case Report. J Uro/ 1988;

140(1):151·152.

Case No. 5 - Accession No. 30420

Canoga Pork • Anaplastic Jorge eel! lymphoma Escondido - Granulocytic sarc-oma Glendalo · High grade lymphoma Lorna Lindo • Lymphoma Mountain Vjew IE! Camino Hospital! • Qranulocyric sarcoma (Amol-MS) Orange CUC! Medical Center! - Granulocytic sarcoma Polo Alto - Lymphoma

May, 2007

Snn Diego (Nnyal Medical Cen1er San DjCQQl • Hcm•to!ymphoid neoplasm; fuvor T-coll (8); AM L (3);NKIT cell ( I) Sag Die•o IUCSD Medical CsnJerl - Myeloid sarcoma San .Fmncim <San Francisco General HQS!j!ll!l - Chloroma Arkansas fVojyersitv of Arkansas Medico! Center) - Hematolymphoid neoplasm, favor acute monocycic leukemia, testis Connecticut <Ws;t Hottfordl - Chloromaflcukemia m)•eloid, acute Florida CMynroo Rcgjonol Msx!ical Ccn1crl - Diffuse large cell lymphoma Illinois CHeanland Rcgionpl Medical CCJltcr) - Acute myelogenous leukemia (chl01'0ma) Kansas (Coffeyville Regional Medical Cquer) - Granulocytic sarcoma Kansa.~ CPetmpn Lahomtorv Scryjeesl - Extramedullary myeloid rumor Kansas fPbysjcians Reference Laboratory) . Granulocytic sarcoma

C'rrR. May, 2007; "Minutes" (Subscription B) 7

Louisiana ILSUHSC Pathology) - Large cell lymphoma Maryland IThc John's tlonkjn 's Hospital) - Granulocytic $3rtomo Marvland CUnjyersjJy of Maryland Medical Center! - Myeloid san:omn involving the testis Mosmhusc!!siYMASS Memorial Medical Center! - Myeloid sarcoma Mjchjgan CHcnrv ford Hosoilll1l - Blastic Nl< cell lymphoma Missouri CTrumnn Medical Center) - Gnmuloc;yti<: sarcoma New York fNwau UniV<Ri!V Me<lis;al Center) - T -cell lymphoma N~ York CStooy Brpok Unjversitv Hospitall - Systemic mast cell disease New York !SUNY Downslllte Medical Genter) - Anaplastic Iorge cell lymphoma Nonh Carpljna CWjnston-Seleml - Granulocytic sarcoma North Carolina {Wpmack Anny Medical Center) - Malignant h•matopoietic neoplasm (4) Ohio. Columbus - Neoplastic hematopoietic· infilU'Ute, te..'itis Oklahoma !Oklahoma Uojver.<jty Medical Center) - NK-cclllymphoma Pennsylvania <Consrmnugh Memorial Medical Center) - Large grtululor cell T-ccll lymphoma Pennsylynnjo <Drexel University College of Medicine) • Myeloid snrcomn (monocytic type) Pcnnsylynnjp CWilkes-Bnqe General Hosoitan - Anaplustic lymphoma, T-ccll Puerto Rico CUniversity of Puerto Rico) - Granulocytic: sarcoma/'f-ccll lymphoma South Oako(!J !LCM Pathologists P.C.) - Malignant hematopoctic neoplasm Tcxa.~ Lubbock - Oranulocy1ie sarcoma Tcxa.' !Sco!t & WbjJe Mgnorial Hospital) - Large cell lymphoma Texas Su•ar!gnd • Malignant lymphoma West VjQ!jnjn (Wc!2el County Hosoi!lll} - Diffuse large B-cclllymphomo Brazil O..bom!orio Ana!omia Pathologica Ecitologjal - Histoeytic sam>ma (I); Peripheral T-celllymphomo, unspcciflcd (I) Cana4a !P!!!!Qut Ho.mitall - CD4/C056 positive hematodennic neoplasm canada !Shqbrooke Unjymjrt Hosoital) - T -<>ell malignant lymphoma, tJ<tro nodal China !Sir Run Run Shaw Hosnitall - Malignant lymphoma Ireland !GalwaY Residents) · OLBCL Jaoan !Asabj Oeoem! Hosnilllll - Peripheral T -eelllymphoma, unspocilied Japan CGunmB UnjvmiM - Malignant lymphoma Japan (!famama(<u Unjversirt School of Medicine) - Mulign•nt lymphoma, diffuse large Oatar!li!lmad Medjcol Comorntionl - Non-Hodgkin's lymphoma, 1'-ccll type Saudi Arabjo IKjna fnhnd National Guard Hospital) - Extm-nod:ol NKIT-cclllymphoma Spain CPoyjsn HospjtnJ> .. Granulocytic sarcoma 'United Kingdom CRodcliffe Hpspitall - Histocytio lymphomu, testis

Case 5- l>lqgnosls: Ex!raDiedullnry myeloid tumor, testis

T-78000, M-73500

Out$lde Con•ultation: Gary Keeney, M.D. (Mayo Clinic; Rochester, MN): "Extramedullary myeloid tumor with monocytic differentiation, testis."

Case 5 - References: Konoplev S and Bueso-Rrunos CE. Advanocs in the Pad1ologic Diagnosis and Biology of Acute Myeloid Leukemia .. Am Dlogn

Pa1hol 2006; 10{1):39-65. Hu SlY, Huang SP. Yang SF, etal. Chloroma of the Testis after Allo£cncic Peripheral Blood Stem Cell Transplantarion. A Case

Repon. Kaohsiung J Med Sci 2004; 20(1 0):506-51 1. Valbucna JR, Admirand JH, Lin P, et al, Myeloid Sarcoma Involving tho Tcs!is. Am J Clin Pmho/2005; 124(3):445-'152. Rawal A, Keeler TC nod Milano MA. Testicular Extmmedullary Myeloid Cell Tumor. R•1>oO of a Case with Unique

ClinicoJ)athologic Feal\lres and a Brief Review oft he Litcrnturo. Arch Pt11ho/ Lab Med 2004; 128(3):332-334. Lane JE, Wolkcr AN , Kulharya A, ct al. Cutaneous Sclerosing Extmmcdullary Hematopoietic Tu1flor in Chronic Myelogenous

Leukemia . .I C111t111 Pnrho/2002; 29( I 0):608·612.

Case No. 6 - Accession No. 30372

Canoga Park · Seminoma Escondido - Seminoma Glendale - Seminoma Lorna Undo - Seminoma

s

May, 2007

CITl\, May, 2007: "Minutes" (Subscription 0)

Mountain Vjcw <EI Camino Hosnitall - Seminoma Orange CUC[ Modica! Center) - Seminoma Palo Alto - Seminoma San Diego <Naval Medical Centq San Diego> - Seminoma Sao Diego IUCSD Medical Center) - Seminoma San Francisco <San Frnnci§CO Genera) Hosgjtnll . Seminoma Arkansa.~ <Uojvcp;jty of Arkansas Medical Ccntq) - Seminoma, classic type, testis Connecticuc CWcst Hartford) - Seminoma f lorida (Munroe Recrional Medical Centq) - Seminoma l!ljnois IHean!ond Regional Modica! Cemql - Seminoma Kansas ICoffevvjllc Regjonal Medical C<nter\ - Seminoma Knnsas £Peterson laboratory Services> - Classic seminoma Kansas (Physjcjnns Reference Laboratorvl · Seminoma !,ouisiana ILSUHSC Pathology) - Seminoma Marylaod Obc John's Hookjn' s Hosoitall - Seminoma, classical type Marvtand <Unjvmity of Maryland Medical Center) - C1assic seminoma Massachusem; <UMASS Memorial Medico! Cenrerl - Seminoma Mjchignn CHcnrv Ford Ho:mjHlll - Classic seminoma Mjssouri O'ruman MedJcal Ccnt<.Tl - Seminoma New York CNa.~u Uniymjw Medical Csnterl . Seminoma New York <Srony Brook Unjysniry Hosnjtoll - SpennOIOC)1i~: seminoma New York <SUNY Downstq!c Mcdjcal Center) - Seminoma North Curo!ino <Winston· SAlem) · Seminoma with intnuubu1ar g<."Iltl cell neoplasia North Carolina <Womack Army Medical Ccptql - Seminoma. classic (4) Ohjo. Columbus - Seminoma, testis Oklahoma <Oklahoma Unjymity Modiea! Cemerl - S"""""tocytic seminoma Pennsylvania (Conemaugh Memorial Mcdjcal Center) - Anaplastic seminoma Pennsvlvania <Drexel Uniyrnity CoJ!egeof'Modicjne) - St:minoma, c lassical type Pcnnsvlvaniq /Wilkes-Bam; General Ho~pjlol) · Spcnnalocytic seminoma Puerto Rioo CUniversirv of Puerto Riool - Classic sarcoma/T -eel! !ymphoiDJI South Dak01a C!.CM Parho!ogj$15. P.C-j - Seminoma Texas. lubbSlCk - Seminoma Texas <Scott & White Mcmodnl Hospital) .. Seminomu Texas Suaa[!and - Semino1na West Viraini!l CWW;C:I Counw Hospital) - Seminoma B]'ll2il Clt!bomlario Anatomjn Palhologig El:ito!o!!ial • Classic seminoma Canada (Pasguq Hospirall - Seminoma Canada (Sbcrbrookc Unjyersity Hospitall .. Seminoma China ISir Run Run Shaw 1-!osnitall • Seminoma Ireland CGalwoy Residents> . Classic seminoma Jnpan CAsahj G,pncral Ho.tniyll · Seminoma J;man CGunmn University) · Seminoma Jnnan <Hamumotsu Univcrsjw School of Medic-ine) · Seminoma Oatar CHamsd Mcsljcol Comorationl - Seminoma Saudi Anlbja (King Fah!!!l National Guard Hospital! - Seminoma and intr8tubular gcnn cell neoplasm (ITGCN) Soain £Poviy Homitall - Owic seminoma with intnuubular nc::oplasia United Kinedom CRadc:ljffc Hospitall - Clwica1 seminoma. testis

Case 6 - Diagnosis: Classic seminoma with intra!ubular germ cell neoplasia (ITGCN), testis

T-78000, M-906!3

Case 6 - References: Burl<e AP and Mostofl FK. lntrutubu!ar Malignant Genn Cells in Testicular Biopsies. Clinical Course and Identification by Staining

For Placental Alkaline Phosphatase. Mod Paiho/!988; 1(6):475-479. Klein FA, Mclumod MR and Whtimore WF Jr. lntratubular Malignant Omn O;!!s (Carcinoma In-Situ) Aooompanying Invasive

Testicuhu 0 <'Tftl Cell Tumors. J Urol 1985; 133(3):413-41 5. Coffin CM, EwingS, Dohner LP. Frc(]uency of !ntcr!obulnr Germ Cell Neoplasio with lnvusive 1'e•ricular Gcnn Cell Tumors.

Histologic and hnmunocy!ochemical Features. Arch Pmhoi!Ab Med 1985; 109(6):555-559-Fiynn MJ, Chi!derbouse A. Mead GM, eta!. Unusual Cystic Change in Classic Seminoma of the Testis. Am J Surg Patlto/2006;

30(1): 137-139-Bemey DM , Lee A, Shama.sh J, et al. The Association Bctwec11 Jntratubulnr Seminoma and Invasive Ocrm Cell Tumors. Hum

Pm!Jo/ 2006; 37(4):458-461.

CITR, May, 2007_ "Minutes" (Subscription 0)

Case No. 7 - Accession No. 30225

Canoga Park • lmmnturc teratoma with embryonal and yolk sac cancer Escondido • Tcnuoma and yolk sac nnnor Glendale - Mixed gcnn cell tumor, yolk sac and teratomo Lorna Linda • Teratoma) testicle Mountain View CEI Camino Hospitall • Mixed genn cell tumor (immature teratoma and yolk soc) Orange NCI Medical Center) - Mixed germ cell tumo< {teratoma and yolk sac tumor) Palo Alto • Terntoma San Diego (Nnypl Medical Center Sao pjego> · Mixed gcnn cell rumor San Diego CUCSQ Medical Center) - Malignant mixod gem1 cell tumor, yolk sue and immature tcrotoma Stm Francisco (San Francisco Gcncrul Hospjtall • Mixed genn cell tumQr Arkansa.~ <University of Arkansas McsHea I Center) - Jmmoture teratoma. testis Connecticut CWes) Hnnfordl - Yolk soc rumor Florida !Munroe Regional Medical Cenu;r) - Mixed germ cell rumor with tc:rotoma and yolk sac tumor

May,2007

Illinois (HcaRIPJld Regional Medical Center) - Malignant mi•ed gc::nn cell neoplasm (teratoma, cndodennal sinus tumor) Kansas CCoffevvi!Je Regional Mcsfjcal Center) - Teratoma Kansas CPetmon Lpborarorv Services:) - Mixed germ cell tumor, immature tcratom~t ond yolk sue K.ansa, IPhysicinns Reference Laboa1too1 • Mixed gcnn cclrtumor with terotomn and yolk sac tumor Loujsiana CLSUtiSC Pathology\ - Malignant gcnn cell t•mor with tcr.uoma and PNET Marv!and l'['be John's Hopkin's Hosphall - Mixed genn cell tumor with t<mtoma. yolk sac and focal seminoma clements Marvtand IUnjymjrv ofM!!!)'Iand Mcclical Centerl - Mixed germ cell tumor with yolk sac and mature teratoma oomponcnts Massachuselts CUM ASS Memorial Mcclical Center) - Non·scntinomacous mixed germ <ell tumor Michi•M IHcnrv ford Hospicall - Mi•ed gcnn cell tumor with tennomatous and yolk sac components Missouri <Trum;m Mesfjcal Center) • Jmmarure terntomn New York (Stony Brook University Hg~phaJ} - Mixed gcnn cell tumor with mnturc teratoma and yolk sue component New York CSVNY Downsl!lje Mcdicnl Cen!orl - Mixed gcnn cell rumor (tcrotolnn nnd yolk sac tumor) Nonh Caroling Oyinston·Salcrnl - Malignant mixed gcnn cell rumor (YST nnd immarure teratoma) NO!!h CarolinaCW9mack Anny Mccljql Centql - Mixed genn cell tumo< (4) Ohio. Columbus - Germ eel! tumor, testis Oklahoma <Okfahomt\ Unjversity Mcdjca! Center\ ~ hnrnuture teratoma Pennsylvania CConemnugh Memorial Medical Center) • Mixed gemt cell tumor Pcnnsvlvanin <Drexel Univernjtv Collgg.eofMedicine) • Mixed germ cell tumor Pcnnsvlvanjq <Wilkes-Barre General tlosuita!) • Non-scminomatousgcnn cell tumor, (PNET) immoture tenuoma wtth yolk sac

tumor Pumo Riro CUnjyersirv ofPueno Rjcol - Mixed genn cclllumor, immature teratoma and yolk soc tumor Soud! Dakoca CLCM Pathologist<, P.C.) - Non-seminornatous germ cell rumor with teratoma and yolk sac component$ Tel! as. Lubbock - Mixed non-s<:minomo<ous germ cell tumor Texas <Scott & White Memorial Hosni.Uill - Mixed germ cell tumor with tcrutomatous and yolk soc components J'exnj:;. Sugarlnnd • Non-scminomatous gcnn cell tumor (immoture teratoma, yolk sac rumor) West Virginia (Wctr.cl Countv HospitaJl - Mix.e<l gcnn cell tumor with embryonal yolk sac and cenuomatous elemtt~ts Bmzil fl aboratodo Anaromia Patholog!q Ecjtolooial • Mixed genn cell tumor (immature teratoma and embryonal corciooma) Canada {Pasqua Hospital! - Teratoma and yolk sac rumo< Can$ IShcrbrool!e Univeniry Homjtal) - Mixed germ cell tumor, teratoma and embryana! <:areinomo and yolk sac tumor China (Sir Run Run Shaw Hospita!l - Mixed germ cell tumor Ireland !Galway Rc:;jdentt•l • Marure cystic teratoma Janag (Asahi Gcncml Hospital\ - Mixed teratoma and yolk sac tumor Jupnn <Gunma Un!yersitvl - Yolk sue tumor and im1nature teratoma Japan (Hamam:mv Uojversity School ofModicinel . Mixed genn cell tumor eomposed of yolk 53C rumor, embryonal Oatar (Hamad Mcclical Corporoliwl . Malignant mixed genn cell rumor Saudi Arabia (!(jnR fnhad National Gu;w! Hospital) - Malignant mixed germ cell tumor Snain (Poyjsa Ho,pjlall - Mixed genn cell rumor. immarure Md mature teraJoma and yolk sac: tumor United Kingdom !Radcliffe Hospjtnll - lnunaiUJ'e teratoma, testis

Ca~e 7 - Dlagnnds: Mixed genn ceU rumor with teratoma and yolk sac components, testis

T-78000,~-86310

Case 7 - References: Schrader AJ, Ohln~nnn CH and Rossmnnith S, ct ol. Impact of Evidence-Based !ntcrdiscip!inaJy Guidelines on Testis Cancer

Managen~ent. Cancer 2006; I 06(2):3 13·3 19.

tO CTTR. May, 2007: "Minutes" (Sib>alfliiOO 0)

Muller J, and Skakkebaek NE. Abnormal Cells in Mal descended Tesccs. A Srudy of Cell Oensicy, Nuclear Size and Ocoxyrinuclcic Acid Concenc in Tescicular Biopsies lrom 50 Boys. J Uro/ 1984; 131(4)::730-733.

Moscati FK. Palhology of Germ Cell l'umors of Testis. A Progress Report. Cmrcer 1980; (7 Suppl) 45:1735-1754 Dixon FJ and Moor<: RA. Tumors ofche Male Sex Organs. Alias of Tumor Paihology. Sec VIII, Fasc 316 and 32. Armed Forcts

l11Stit of Pat/sol, Washing1on DC 1953. Oliver RTO, Hope-Scone HF and Blandy JP. Justificacion ofche Usc of Surveillance in Managemcnc ofScage I Germ Cell Tumors

of !he Testis 1983;. Dr J Uro/ 55(6):760-763.

Case No. 8 • Accession No. 30431

Canoga park • Renal oncocytoma Escondido • Oncocytoma Glendale - OncocytOma Lorna Linda • Oncocytic renal cell carcinoma_ Mountain Vjew l EI Camjno Hosnital) . Oncocytoma Oronge <UC! Mt"djcaJ Center) - Oncocytoma Palo Alco - Oncocytoma

May, 2007

San Diego CNnval Medical Center San Ojego) - ConYCnrional renal cx-11 coscinoma, cosjnophilic variant (6); Oncocytoma (5); Carcinoid (2)

San Dieoo CUCSD Mcdjcpl Center\ • Oncocytoma San f rancisco <San Francjsco Genera) Hospitnll - ParugungJiomo Arkansas CUpivcr.;ity ofArtansas Medical Ccnccr\ - Oncocytoma, kidney Conn<:c~icut (West Hanford\ - Oncocytoma Florida/Munroe Re..ionol Medical Cen•er> - OncQ<:ytoma Hlinois CHcart!and Regjonol Medical Ct1Her) ~ Oncocytoma Kansas (Coffeyville Rcgjoonl Medical Centc.r) - Oncocytoma· Kansas <Petcrson LahomtON Sgyices> - Carcinoid tumor Kansas (Physicians ReCerencc Labora!ClO!I • Chromophobe rmaJ cell carcinoma LouisiMa CLSUHSC Pa!holosv> • Oneocycoma Maryland CTbe John's Honkjn's HosnitgU - Oncocytoma Maryland CUn\vctjjty of Maryland Mcd!cg! Ccntcrl · Oncocytoma Massachur;cus CUMASS Memorial Mtdjcal Center) .. Oncocyroma Michigan !Henry Ford Homisal) . Oncocytoma Mj$Souri !Tryman MediCAl Ccncq} - Chromophobe renal cell carcinoma New Yprk <Srony Brook Unjversirv Ho,llnital) .. Gmnulnr cell variant or rena! cell carcinoma New York {SUNY Downstate Medical Comer) - Oncob!astic oncocytoma \'S. oncoeytic carcinod rumor Nor!h C!lJ'91ina (WinS!on-Solcml - Oncocytoma North Q!mlina fWomacls Anny Medical Ccncer\ • Oncocytoma (4) Ohio. Columbys - Epiihelial neoplasm, kidney Oklahoma (Oklahoma Unjycrsjty Medical Ccntt-Tl - Onccx:ytoma Pcnnsylvnnla <Conemaugh Memorial Modjcal Center> • Oncocytomo Pennsvlvanjg !OrexeJ Unjversity College o(Medichtcl · Oncocytoma Penn.wiYMja (Wjlkes-Barre General Hosphall · Chromophobe renal cell carcinomn Puerto Rjco CUni\'Cf'Sity oCPucno Rico> • Renal oncocytoma Souih Dakocn CLCM Pa!hologi<!s P.C.) - Oncocytomn I exa.l:l Lubbru:k - Renul cell io:arcinomo, oncocytic type Tcxa<; <Scou & White Memorial Hospitol) - Oncocytoma Texas. SugAdand . Oncocytoma West Vi!l!jnja Qlle<zel Coupty Hospi!all • Chromophobe renal cell carcinoma Brnzi! CLaborptorio Annttunia Pathologjca Ecito1ogial - Oncocytomn, kidney Canada (Pasqua Hosoit~,n • Oncocytomu Canada CShcrbrpoke Uniymjty Hospirall - Oncocytoma China !Sir Run Run Shaw Hospimll - Oncocytoma Ireland CGolwav Residcn!S) - Onoocytomn ~mal cell carcinoma Japan CAsabi Oenetal Hospjtall - Oncocytoma Japan £Gumma UnjversiJVl .. Oncocytoma Japan CHrunpmotsu UnjyerJjtv Schoo, of Modicinel · Oncocytoma Oatar <Hamad Medical Cotpon11ion\ • Rc:nal oncocyto•nu Saudi Arabia lKjng Fnhbd Natjonal Guml Hosoitall - Oncoq1oma Spain CPoyita; HospitaD - Ontocytomn United Kjngdom <Radcljffc Hospital> .. Oncytoma, kidney

CTTR, May, 2007; "Minutes" (Subsmpcion B) II

Case 8 -Diagnosis: Oncocytoma, kidney

T-71000.~·82900

Case 8 - References: Slorl:el S. Eblt IN and Adlakha, ct al. Classification of Renal Cell C4n:inomas. Wcxkgroup No I UniO< lntemationale Contn: Je

Canc:cr (UJCC) and American Joint CO<nmitteeon Cancer (NCC). Canctr 1997; 80(5):987-989. Amin MB, Crotty TB, Tickoo SK and Farrow GM. Renal Oneoeytoma. A Reappraisal of Morphologic Features with

Clinic:opathologic Findings in 80 Cases. Am J Surg Patho/ 1991; 21 (I): 1·1 2. Fuzesi L, Cunowon B, BraunS, ct al. Renal Oneoeytoma with a Translocation (9: I 1Xp23; q13) 1994; J Uro/152: 471-472. van den IJc'fg E, Oijkuizen T, Storkel S, et al. Chromownol Otan&C$ in Renal Oneocytomos. Evidence That (5: 11) (q3S;q 13) May

Characterize a Second Subqroup on Oncocytomas. Cancer Gtntt Cytog•lltt 1995; 79(2): I 64-168.

C ase No. 9 - Accession No. 30538

Canoga Park .. Mulcilocular renal '-"Yst with clear cell renal cell cnrcinom:~ Escondjdo · Multilocular clear cell renal cell caroinomn Glendale .. Multilocular cystic renal cell carcinoma L9ma Linda • Cystic n:nnl cell can:inoma MouoJajo View CEI Camino Hosnitall - Multicystic renal cell carcinoma OrangeiUC! MediCA! Csnterl - Multilocular cystic n:nal cell can:inoma Palo Allo - Multilocular cystic rmal ccU carcinoma San Diego CNayAl Me<!ieal Center San Diego) - Multilocular cystic n:nol cell carcinoma San Diego CUCSp Me!lical Cquru - Multilocular renal cell con:inomo San Francisco CSan Francisco General Hospita1) . Multiloculated cyS1ic clear cell renal carcinoma Arkansas CUnjyqsjty of Arkonsas Medical Center) - Clear cell carcinoma, mullicystic, kidney Connecticut CWe,~t Hanford) · Multilocular cystic renal cell carcinoma florida (Munroe:; Regjonal Medical Center) • tvtulticystic renal cel l cnrcinomn

May,2007

!llinojs Ctlconluod Regjonal Medical Center) - Renal celleoroinomn, elcarcell l)']lC(grade 1), with cystic ch•ngc Kansas CCoffcwllle Reg joan! Medict!l Center> - lntra cystic renal (clear) cell carcinoma Knnsqs <Peterson Loboraton Services) - Multilocular cystic rcnul celt ct1rcinoma Kunsos CPhysjcipos Reference Lahoratorvl - Cystic reno I cell carcinoma Louisjaon (!,S\Jt!SC Pmhologyl • Cystic (clcarcell) renal cell can:inoma Mnrvland <The John's Hopkin's Hospital) - Multilocular cy$tic renal cell carcinoma Marvland CUniycrsi'Y of Maryland Mes!ical Center) • Multilocular cystic rC1lal cell carcinoma of clear cell type (FuhmM II) Massachu!et!A CUM ASS Memorial Medical Center) • Multilocular cystic renal cell carcinoma, clear cell type Michison <Hcnrv ford HospitaD · Multiocular cystic renal cell carcinoma Mipoyri O:nnnM Medical Center> - Clear cell renal cell carcinoma New Yods CS!opy Broo!s Upjvmjtv Hospital) - Mulrilocular cystic renal cell cam noma New Yods CSVNY Downstate Medical Center) - Multilocular cystic n:nal eellear<:inoma North Carolina QVjnston-Saleml - Multilocular eystie renal cell can:inoma North Camlipa CWoJDqck Annv Medie-•1 Center) • Cystic renal cell carcinoma (4) Ohio Columbu3 .. Cystic renal cell carcinoma, kidney Oklahpmp {Qklpbomg Universirv Medical Center> . Multilocular cystic renal cell carcinoma Pcnnsylynnjp <Conemaugh Memorial Medico I Center) · Multilocular cystic renal cell carcinoma Pennsylvnnja <Drexel Univs.'Tsity ColJcgc ofMcdicine) . Renal cystic clc"r cell carcinoma Pcnosylynnitt CWilkcs. Bnrre General Hospital) . Cystie rcnul cell ourcinomo, clear cell type F, Grade 2 Puerto Rico CUn!yerslrv of Puerto Rico) - Multilocular cystic renal cc11 carcinornn South DakOJil CLCM Pothologjs!S, P.C.) - Multilocular cystic rcnol cell carcinoma 1'exas Lubbock • Mesoblastic nephroma T~xas (Scolt & Wbjte Memorial HospjtaD · Cystic renal cell cnrcinomn Texas Sugp£1ond · Multilocular cystic renal cell carcinomn West Vjrgjnja f\Vctzcl Counrv Hosoitall • Multicystic renal cell carcinoma Bmjl <Laboratorio Anatnmia Pathologica Ecitologial - RcnaJ cell carcinoma, clear cell type cystic multilocular Canada CPa.<0\!3 Ho!!pjtp!l - Multilocular cystic renal cello carcinoma Canada CSherbrpoke University HosoitaD • Clear cell can:inoma (multicysric pattern} Cbin• ISjr Rug Sun Shaw H"'Pitnl\ - Clear cell renal cell eareinO<na Ireland CGalwav Retidentil - Renal cell camnoma (mulrilocular cystic variant) Janan IAs.&;hj Genmal Hosnitall .. Multilocular cystic renal cell carcinoma

12 CTTR. May, 2007: .. Minutes .. {SubscnptiOn ll)

Japan CGumna Uniycg;jtyl . Cystic renol cell carcinoma Japan CHamamntsu Univmity School of Medicine) . PapiUary renal cell Cllrtinoma Oator <Hamad Medical Corpo!Jtion) • Renal cell carcinoma Saudi Ambia <King Fahad Nllional Gua!d Hosoitall • Multilobular cystic renalccllcaranoma Spajn CPovis.a Hq,~pitall ~ Cystic renal cell carcinoma United Kingdom (Radcliffe Hospital) - Cystic renal ocllcarcil\oma, kidney

Case 9 - Diagnosis: Multilocular renal cell carcinoma, clear cell type, kidney

T-71000, M-831 23

Case 9 - References: Bonsib SM. T2 Clear Cell Renal Cell Curci noma is 11 Rare Entity. A Study of 120 Clear Cell Reno I Cell Carcinomas, J Uro/2005;

174:1199-1202. Grignon OJ and Chc M. Clear Cell Renal Cell Carcinoma. Clin lAb Med 2005; 25(2):305-316. Yao M, Tabuchi H, Nagashima Y, claL Gene Expression Analysis of Renal Carcinoma. Adipose Differentiation­

Related Protein as a Potential Diagnostic and Prognostic Biomarker for Clear-Cell Renal Carcinoma. J Patho/2005; 205(3):317-387.

Shen Rand Wen P. Clear Cell Renal Cell Carcinoma with Syncytial Giant Cells. A Case Report and Review of the Literature. Arch Path of Lab Med 2004; 128(12):1435-1438.

Singh H, Florcs-Sandovnl N and Adams J. Renal-Type Clear Cell Carcinoma occurrin& in the Prostate. Am J Surg Patllo/2003; 27(3):407-41 0.

Case No. 10 - Accession No. 30484

Canoga l'ark • Papillary renal cell carcinoma Escondido - Collecting duCl carcinoma Glen dole - Collecting duct carcinoma Lomn Linda - Popillary rcnul cell carcinoma Mountajn View fEI Camino Hosqjtal> - Collecting due( carcinoma Otani!C <UCJ Medical Cgncrl - Collecting duct tumO< Palo Aho • Papillruy renal cell carcinoma San Djpgo <Naval Medical Center San Diego) - Collecting duet carcinomo San Diego <UCSQ Medical Center) - Papillary rcn•l cell carcinoma San fmncisco <Son FranciSC!) Oeneral Howitall - Papillary renal careinomo Conncctjcut CWest Hprtford> . Papillary R:nal c:ell cardnomu Florida (Munroe Regional Modica( Center) .. Reno! cell carcinoma. chromophil nJjnois <Heartland Regional Medical Center> · Collecting duet carcinoma Kansns <Coffeyville Regional Mc!lical Ccn1ql - P.pillary ~al cell carcinoma Kans!M <Pstmon Laboratorv Services) .. Collecting duct renal cell carcinoma KnnRM CPhysicjnns Referc.."TICC Laboratorv) . Papillary renal coli carcinon1a Louisiana CLSYHSC Pathology} - Papillary renal cell carcinoma

May,2007

Marylll!ld !Tbe John's Honkip's HOSQiUIIl • Collce1ing duct carcinoma vs. high-grade papillary renal cell carcinoma Mary!ond CUniversitv ofMurylMd Medical Center) • tligh gflldt papillary renal cell carcinoma (vs. collecting duct carcinoma) Massachusetts fUM ASS Mcmorjal Medical Center) · Collecting ducc carcinoma Michigug IH..,rv fgrd Hospholl - Renal cell carcinomo, collecting duct type Mimuri <Truman Medical Center) - Renal cell carcinoma, papillary type New York <Stonv Brook Unjyqsjry Hospjtgll - Papillary rene I cell carcinoma, rypc 11 New York <SUNY Dov.mstntc Medical Ccnt{,.Tl - Collecting duct carcinoma North Carolina (Wjnston-Sa!em) - Papillary ronal cell carcinoma NO!!h Carolina <Womack ArmY Medig! Cooter) • Collecting duct carcinoma (4) Ohio Columbus · Papillary can:inomo. kidney Oklahoma (Oklahoma Unjycrsjty Mcs:ljcnl Center) • Papillary n:nal cell earcinorna Pennsylyania <Conemaugh Memorial Medical Ccntql . Connecting doer carcinoma PcnMYivnnia fl>reel University College of Medicine) - Renal papillary carcinoma Pennsylyania IWilkg-Barre Gcncrnt Hospital) · Papillary rcnal cell carcinoma. high·arode Puerto Rico ClJniys;rsity of Puerto Rico) • Collecting duct carcinoma South Pakota fLCM PathologisL< P.C.) - Papillary renal cell carcinoma Texas, Lubbock - Papillary renal cell carcinoma

CT1'R, May, 2001i "Minutts" (Subscription B) !3

I$11as !Seon & White Mqnorjal H9spha!\ - Medullary carcinoma Texas SugarJand - Papillary renal cell carcinoma, rype 2 West Vjrginia <Wetzel County Hospj!al> - Papillary renal cell carcinoma Brazil (Loborntorio Anptomja Patholoaiea Ecitologjul - Renal cell carcinoma, pupillary type: 2 Canadn !Pmua Hosoi!l!O - Papillary carcinoma, metastatic thyroid Canada !Shert!rookc Unjvm~ity HosojtoO - Renal cell carcinoma, papillary variant, rypc 2 China CSjr Run Run Shaw Hospital) · Collecting duel carcinoma Ireland (Galway- Resjdgnts) - Collecting duct carcinoma Jaoan (Asahi General Hosnjta!l - Papillary renal cell carcinoma Japan CGunma Universjtyl - Collccling duct carcinoma Janan IHnm81DlllSU Unjlll:!Sirv School of Medicine! - Bellini duct carcinoma Oatar (Hpmad Medical Cornoration) - Collecting duer c:arcinomu Saudi Ambia {King l'nhod Notional Guqrd Hospital\ - Papillary renal cell carcinoma Spajn (povisa Hosnitnn • Collecting duct carcinomn United Kjn•dom !1\adcliffe Hospital} - Papillary r<:nnl cell carcinoma, rypc II

Case 1.0 - Diagnosis: Papillary reno! cell carcinoma, kidney

T-7 I 000, M·83123

Case 10- References: Mancillo·Jimenez R, Stanley RJ, et ol. Papillary Renal Cell Carcinoma. A Clinicol, Radiologic and Pothologic Study of 34 Coses.

Cancer 1976; 38(6):2460-2480. Sidhar SK, Clark J, Gill S, ct al. The 1 {X; I} (p 11 .2; g21.2} Translocation in Papillary Renal Cell Cnrcinoma Fuses a Novel Gene

PRCC to TFE3 Trnnscription Factor Gene. Hum Mol Gtnel 1996; 5(9):1333-1338. Urn JC and Wojcik EM. Fine Needle ASpiration Cytology of Papillary Renal Cell Carcinoma. the A$$0Ciation with concomitant

Sccondory Malignancies. Dlagn Cytopatho/ 2006; 34(12):797·800. Yamanaka K, Miyake H, Hara I, cl ul. l'upillnry Renal Cell Carcinoma. A Clinicnpaihologicol Study of 35 Cuscs. In/ J Urol 3006;

I 3(8): 1049·1052. Au WY, Ho KM and Shck l W. Papillary Renal Cell Carcinoma and Gastrointestinal Stromal Tumor. A Unique A$$0Ciation. Ann

Onco/2004; 15(5):843·844. Sweeney P, EI-Naggor AK, l in SH, Cl al. Biologi041 Significance ofC-Met Over Expression in P•J>illary Rcnol Cell Carcinoma. J

Uro/2002; 168(1):51-55.

14 CTTR, M•y. 2007: "Minu1cs" (Subscription 0)

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