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G E O R G E T H E R A P O N D O S , M B C H B , F R C P C , M P H
T R A N S P L A N T H E P A T O L O G Y
O C H S N E R M U L T I O R G A N T R A N S P L A N T I N S T I T U T E
N E W O R L E A N S
Hepatocellular carcinomaNew developments
Disclosures
Advisory boards:
Boston Scientific
Mallinckrodt Pharma
Rebiotix Inc
Speaker’s bureau
Intercept Pharma
Eisai Co.= maker of Lenvatinib
Pembrolizumab
APPROVED!
Currently approved therapies
Only approved first line agents
Sorafenib
Lenvatinib
Regorafenib
Cabozantinib
Ramucirumab
Nivolumab
Multiple combination trials are ongooing
Durvalumab+ Tremelimumab
Nivolumab+ Ipilimumab/Cabozantinib
Lenvatinib+Pembrolizumab
Atezolizumab+ Bevacizumab
Nivolumab+ Sorafenib
Take home points
1) Rapidly evolving field
2) Choice of treatment for advanced HCC
TKIs
Immunotherapy
3)
First line= Sorafenib/Lenvatinib
Second line= multiple agents
Oncology involvement essential