GNIPST Bulletin 46.2

12-06-2015

GGGNNNIIIPPPSSSTTT BBBUUULLLLLLEEETTTIIINNN 22200011155512th June, 2015 Volume No.: 46 Issue No.: 02

Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE

BASED LEARNING AND PRACTICE

Contents Message from PRINCIPAL Editorial board Historical article News Update Knowledge based Article Disease Related Breaking

News Upcoming Events Drugs Update Campus News Students Section Editors Note Archive

GNIPST Photo Gallery For your comments/contribution OR For Back-Issues, mailto:[email protected]

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

W e bs i t e : ht t p: / / gni ps t. a c. i n

12-06-2015

MESSAGE FROM PRINCIPAL

"It can happen. It does happen. But it can't happen if you quit." Lauren Dane.

We are what we repeatedly do. Excellence then is not an act, but a habit. Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the last years editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academic excellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners are supported in maximizing their potential and talents. Education needs to focus on personalized learning and instruction, while promoting an education system that is impartial, universally accessible, and meeting the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order to achieve their aims. We are all very proud of you, our students, and your accomplishments and look forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looking forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in this direction and fruits of these efforts will be received by our students in the near future. Our Teachers are committed and dedicated for the development of the institution by imparting their knowledge and play the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on this path.

My best wishes to all.

Dr. A. Sengupta

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTA EDITOR MS. JEENATARA BEGUM ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE Pharmacy Today and Tomorrow: Pharmacy, with its heritage of 50 centuries of service to mankind, has come to be recognized as of the great professions. Like Medicine, it has come through many revolutions, has learned many things, has had to discard many of its older ways. Pharmacists are among the community's finest educated people. When today's retail pharmacist fills a prescription written by a physician, he provides a professional service incorporating the benefits of the work of pharmacists in all branches of the profession - education, research, development, standards, production, and distribution. Pharmacy's professional stature will continue to grow in the future as this great heritage and tradition of service is passed on from preceptor to apprentice, from teacher to student, from father to son.NEWS UPDATE Software tracks source of fecal pollution in

water: 12th June, 2015 Scientists have developed a new piece of software to predict the source of fecal pollution in seas, reservoirs and rivers. The system, called Ichnaea, uses the automatic learning and analysis of various biological indicators to make highly reliable predictions of this type of pollution, which poses a serious health risk. Fecal pollution is increasingly more common in rivers and water reserves.


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New powerful drug candidate can improve a failing hearts function: 12th June, 2015 An experimental drug improves the ability of heart muscle cells damaged by heart failure to pump blood, according to the results of a new study.

Severely impaired stroke survivors regain arm function after intensive physical therapy: 12th June, 2015 Time may heal all wounds, but in the case of stroke survivors, the key to better recovery is to spend more time in an intensive physical therapy program, according to a new study.

Mechanism regulating gene expression linked to bone and joint damage in ankylosing spondylitis: 12th June, 2015 A new study reveals that DNA methylation -- a mechanism that regulates gene expression -- could influence the progression of structural damage to the joints and spine in ankylosing spondylitis. Study findings showed significant associations between a low methylation score and more radiographic progression of the disease, and implicated smoking in worsening of disease outcome.

Viral protein helps Epstein-Barr virus-infected B cells escape human killer T cells: 11th June, 2015 About 90 percent of adults worldwide are infected with Epstein-Barr virus, or EBV. The virus infects B cells (the white blood cells that make antibodies) and can contribute to B-cell-derived cancers, but in most people it remains dormant -- a state scientists refer to as 'latent infection' -- for the rest of their lives. A new study sheds new light on why the infected person's immune system cannot eliminate EBV, or the associated cancer risk.


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Lactobacillus reuteri may have multiple benefits as a probiotic in premature infants: 09th June, 2015 A new study finds that supplementing enteral nutrition with Lactobacillus reuteri (L. reuteri) DSM 17938 as a probiotic may reduce the risk of necrotizing enterocolitis (NEC) in premature infants. NEC is a condition where portions of the bowel undergo tissue death. It is the second most common cause of death among premature infants.

Molecular imaging reveals marker of neurodegenerative disease: 08th June, 2015 Brain researchers have been working for years on targeting a cellular process involved in neurodegeneration and cognitive dysfunction. A specialized molecular imaging agent does the job by binding to a transporter of the neurotransmitter acetylcholine, a major mediator of the central nervous system, say researchers.

Amyloid scan of the heart predicts major cardiac events: 08th June, 2015 Amyloid build-up is commonly talked about in relation to Alzheimer's disease, but amyloidosis can be found throughout the body. An excessive accumulation of these insoluble proteins could cause a heart attack or even death. A new molecular imaging scan of amyloid in the heart could help diagnose the problem, say researchers.

PET/CT captures hidden source of neuroendocrine cancer: 08th June, 2015 The origin of cancer is often obscured by metastases -- tumors that have already spread to other tissues. This is especially the case for neuroendocrine tumors, a malignancy of nerve cells scattered throughout various organ systems that are sensitive to the signaling of neurotransmitters and hormones. An investigational


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molecular imaging technique could be the key to finding the elusive primary tumor.

Cloud-based neuroimaging analysis could aid Alzheimer's diagnosis: 08th June, 2015

Alzheimer's disease remains a chronic, incurable neurodegenerative disease and a worldwide health concern. Equally as important as developing comprehensive diagnostic tests is finding a means of normalizing all the ensuing data -- and that technology has arrived.

For detail mail to editor

KNOWLEDGE BASED ARTICLE Measles

After an incubation period of 812 days, measles begins with increasing fever (to 39C-40.5C) and cough, coryza, and conjunctivitis. Symptoms intensify over the 24 days before the onset of rash and peak on the first day of rash. The rash is usually first noted on the face and neck, appearing as discrete erythematous patches 38 mm in diameter. The lesions increase in number for 2 or 3 days, especially on the trunk and the face, where they frequently become confluent. Discrete lesions are usually seen on the distal extremities, and with careful observation, small numbers of lesions can be found on the palms of 25%50% of those infected. The rash lasts for 37 days and then fades in the same manner as it appeared, sometimes ending with a fine desquamation that may go unnoticed in children who are bathed daily. An exaggerated desquamation is commonly seen in malnourished children. Fever usually persists for 2 or 3 days after the onset of the rash, and the cough may persist for as many as 10 days. Measles is transmitted by the respiratory route and is highly infectious. Infectivity is greatest in the 3 days before the onset of rash, and 75%90% of susceptible household contacts develop the


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disease. The early prerash symptoms are similar to those of other common respiratory illnesses, and affected persons often participate in routine social activities, facilitating transmission. Numerous outbreaks of disease in highly vaccinated populations occur when children in the first few days of illness attend sporting events as participants or spectators, especially indoor events such as basketball and wrestling tournaments. Outbreaks also occur when ill children are brought to a doctor's office or emergency room for evaluation for fever, irritability, or rash. Mild, Modified and Atypical Measles: Milder forms of measles occur in children and adults with preexisting partial immunity. Infants who have low levels of passively acquired maternal antibody and persons who receive blood products that contain antibody often have subclinical infections or minimal symptoms that may not be diagnosed as measles. Vaccination protects >90% of recipients against disease, but after exposure to natural measles, some vaccinees develop boosts in antibody associated with mild symptoms and may have rash with little or no fever or nonspecific respiratory symptoms. People with inapparent subclinical measles virus infections are not known to transmit measles virus to household contacts. Atypical measles occurred in children who received formalin-inactivated (killed) measles vaccine that was in use in the United States from 1963 to 1968. These children developed high fever, a rash that was most prominent on the extremities and often included petechiae, and a high rate of pneumonitis. Recent studies in monkeys indicate that this illness was caused by antigen-antibody immune complexes resulting from incomplete maturation of the antibody response to the vaccine. Complications: Measles virus infects multiple organ systems and targets epithelial, reticuloendothelial, and white blood cells, including monocytes, macrophages, and T lymphocytes. Pathological studies of children dying during acute measles have found multinucleated giant cells


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typical of measles virus infection throughout the respiratory and gastrointestinal tracts and in most lymphoid tissues. Measles virus infection leads to a decline in CD4 lymphocytes, starting before the onset of rash and lasting for up to 1 month, and resulting in suppression of delayed-type hypersensitivity as measured by anergy to skin test antigens, including tuberculosis antigen. Whether measles predisposes to reactivation of latent Mycobacterium tuberculosis infections has been a subject of debate. Complications from measles have been reported in every organ system. Many of these complications are caused by disruption of epithelial surfaces and immunosuppression. Rates of complications from measles vary by age and underlying conditions. Impact of Measles Vaccine: Measles vaccination is one of the most cost-effective health interventions ever developed. Without the vaccine, 5 million children would die each year from measles-assuming an estimated case-fatality rate of 2%3%. Without measles vaccination, the costs of caring for those with measles in the United States would be ~$2.2 billion annually, and the indirect costs would be an additional $1.6 billion. Each dollar spent on measles vaccine saves $12$ 17 in direct and indirect costs. Measles vaccination was associated with a 36% decline in overall death rate and a 57% reduction in the rate of death directly attributable to measles or diarrhea, respiratory illness, or malnutrition in Bangladesh. Koenig et al. found that unvaccinated children of low socioeconomic status were 2.5 times more likely than children of high socioeconomic status to die of measles. In vaccinated populations, children of low socioeconomic status had a risk of death only 50% higher than that of children of high socioeconomic status. Holt et al. found that vaccinated children in households of lower socioeconomic status had a markedly higher chance of surviving to age 39 months than did unvaccinated children in households of lower socioeconomic status. Measles


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vaccination had a lesser effect on overall child survival in households of higher socioeconomic status. In Haiti, Bangladesh, and sub-Saharan Africa, measles vaccination was associated with an overall reduction in mortality of 30%86%. Aaby and colleagues have hypothesized that measles vaccination is associated with a reduction in mortality resulting from nonspecific beneficial effects on the immune system; however, the data are not conclusive.

Jeenatara Begum Assistant Professor

GNIPST

DISEASE RELATED BREAKING NEWS Middle East respiratory syndrome coronavirus

(MERS-CoV) Republic of Korea: (12th June, 2015) Situation in Korea Between 8 and 12 June 2015, the National IHR Focal Point of the Republic of Korea notified WHO of 62 additional confirmed cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), including 6 deaths. Read more

UPCOMING EVENTS 61st IPSF World Congress sponsored by Indian Pharmaceutical

Association (IPA) at Marriott Hotel, Hyderabad, India is going to on 30th July to 9th August, 2015.


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DRUGS UPDATES FDA Advisory Committee Recommends Approval

of Praluent (Alirocumab) Injection for Patients with Hypercholesterolemia: (09th June, 2015) Sanofi and Regeneron Pharmaceuticals, Inc. today announced that the Endocrinologic and Metabolic Drugs Advisory Committee (EMDAC) of the U.S. Food and Drug Administration (FDA) recommended the approval of the investigational therapy Praluent (alirocumab) Injection. The Committee voted 13 to 3 (with no abstentions) that Sanofi and Regeneron had sufficiently established that the low-density lipoprotein cholesterol (LDL-C, or bad cholesterol) lowering benefit of Praluent exceeds its risks to support approval in one or more patient populations. Read more

CAMPUS NEWSFAREWELL PROGRAMME:

On 15th May 2015 GNIPST clebrated the farewell programme Sesh Chithi for the final year students of M.Pharm, M.Sc, B.Pharm, B.Sc and BHM.

JIS SAMMAN 2015 On 11th May, 2015 GNIPST attended the JIS SAMMAN 2015.

JIS SAMMAN Awards: Best College (Non Engineering):

GNIPST Best Principal:

Dr (Prof.) Avijit Sengupta Best HOD:

Mr. Jaydip Ray Best Faculty:

Mr. Debabrata Ghoshdastidar (Pharmacy)


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Dr. Swati Chakraborty (Life Sciences) Best faculty since inception:

Mr. Jaydip Ray Best Office Staff:

Ms. Jaya Banerjee Best technical Assistant:

Mr. Somnath Majhi College Blue:

Avik Paul Highest DGPA of 2014:

B.Pharm:Purbali Chakraborty (4th year) Diksha Kumari (3rd year) Aishika Dutta (2nd year) Sampita Paul (1st year) M.Pharm: Aritra Mukherjee (Pharmaceutical Chemistry) Mounomukhar Bhattacharya (Pharmacology) B.Sc (Biotechnology): Papiya Saha (3rd year) Shomasree Das (2nd year) Ayanita Basak (1st year) B.Sc (Microbiology): Bonhisikha Chatterjee (3rd year) Riaz Hossain (2nd year) Soumi Chowdhury (1st year) BHM: Bishal Roy (3rd year) Shreyabhanja Chowdhury (2nd year) Recitation:

Udita Majumder Debate:

Srijita Roy Poushali Ganguly


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Quiz: Arani ray Dipayan Nath Band:

Syantan Ghoswami Anurag Ghosh Atanu Mondal Arka Khamaru Ritobroto Paul Abhirup Dasgupta

Fashion: Md. Nadeem Shah Koustav Sarkar Shaksar Saha Avirup Dasgupta Ranit Kundu Namrata Ganguly Shreyasee Mitra Chandrika Saha Debopriya Chatterjee Riya Taran

Innovative Modeling: Ankit Chowdhury Kartik Koley Mudasar Manna Dipan Chaterjee Abhishek Singh Kaustav Pal Manojit Dutta

SPIRIT JIS 2015 On 03th to 05th April, 2015 JIS organised SPIRIT JIS 2015. GPAT 2015 Result:

The following B.Pharm. final year students have qualified, GPAT-2015. We congratulate them all.


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Diksha Kumari Rupanjay Bhattacharya Avik Paul Xtasy 2015: GNIPST is going to organize the Tech Fest Xtasy 2015 from 30th March, 2015 to 1st April, 2015.

FINISHING SCHOOL TRAINING PROGRAMME: The FINISHING SCHOOL TRAINING PROGRAMME is going to organize by the Entrepreneurship Development Cell and Training & Placement Cell, GNIPST in collaboration with Indian Pharmacy Graduates Association (IPGA), Bengal Branch from 21st February to 11th April, 2015 at GNIPST Auditorium. On 21

st February, 2015 the Finishing School Training Programme of

GNIPST was inaugurated by Sri Soumen Mukhopadhyay, Deputy Director, Drug Control Office, Goutam Kr. Sen, President, IPGA, Mr. Subroto Saha, Asst. Directorate, Drug Control Office, Mr. Ranendra Chakraborty, Sales Manager and Associate Director Dr. Reddys Laboratory. On 28th February, 2015 Dr. D. Roy, Former Deputy Drug Controller, Mr. Sujoy Chakraborty, divisional Therapy Manager, Cipla and Mr. Vikranjit Biswas, Senior Manager, Learning & Development, Cipla delivered their valuable lectures in the 2nd day FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 14th March, 2015 Mr. Milindra Bhattacharya, Senior Manager, QA & QC, Emami Ltd. and Mr. Joydev Bhoumik, Manager, Operation, Ranbaxy Laboratory Limited delivered their valuable lectures in the 3rd day FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 21st March, 2015 Mr. Tridib Neogi, Associate Vice-President (Quality Assurance), Albert David Ltd. delivered his valuable lectures in the 4th FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 28th March, 2015 Dr. Gautam Chaterjee, an Alumni of Jadavpur University and presently associated with NIPER delivered his


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valuable lectures in the 5th FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 11th April, 2015 the closing ceremony of the FINISHING SCHOOL TRAINING PROGRAMME was held in GNIPST Auditorium. JOBS:

All the students of Final Year B. Pharm and M. Pharm are hereby informed that an interview will be conducted on 23rd May, 2015 by Standard Pharmaceuticals Ltd. GSK for post: Production, QA, QC. All the students of Final Year B. Pharm and M. Pharm are hereby informed that an interview will be conducted by GSK for sales and marketing job. Details given below:

Date: 27.03.2015Time: 09:45 amVenue : GSK Consumer Healthcare Limited, Unit No. 208,

2nd Floor, Ecospace Campus B (3 B), New Town, Rajarhat, 24 Pgs (N). Kolkata-700156.

THYROCARE provisionally selected 15 students from JIS Group. Amongst these, 3 students of B. Sc (H) Biotechnology and M. Sc Biotechnology have been selected. Ipsita Mondal (M. Sc Biotechnology)Debriti Paul (M. Sc Biotechnology)Debopriya Chatterjee {B. Sc (H) Biotechnology}

The final year students of B.Pharm (31 students) and B.Sc (11 students) attended the pooled campus drive of Abbott India Ltd. on 10th March, 2015 at Jadavpur University. Among them 17 students have gone through to the final round of this pooled campus drive and short listed for final selection.

ACHIEVEMENT: Congratulations to Anurag Chanda, student of B.Pharm final year

who have got the 1st prize in poster presentation event in Prakriti 2015 at Department of Agricultural and Food engineering, IIT, Kharagpur.


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OTHERS: On 24th and 25th February, 2015 Swamiji of Gourio Mathwasdelivered some motivational lectuers in GNIPST.

The students of GNIPST participated in the 4th Sardar JodhSinghTrophy organised by NIT on 20th February, 2015. On 8th February, 2015 Gnipst celebrated the ReunionprogrammeReminiscence Reloaded 2015.

STUDENTS SECTION WHO CAN ANSWER FIRST????

The scientific name of which animalmeans"black and white cat foot"?

Answer of Previous Issues Questions: A) Magnetic ink character recognition

Identify the person

Answer of Previous Issues Image: Philip Kotler

Send your thoughts/Quiz/Puzzles/games/write-ups or any other


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contributions for Students Section& answers of this Section at [email protected] NOTE

It is a great pleasure for me to publish the 2nd issue of 46th Volume of GNIPST BULLETIN. All the followers of GNIPST BULLETIN are able to avail the bulletin through facebook account GNIPST bulletin I am very much thankful to all the GNIPST members and readers who are giving their valuable comments, encouragements and supports. I am also thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar and Mr. Soumya Bhattacharya for their kind co-operation and technical supports. Thank you Mr. Soumya Bhattacharya for the questionnaires of the student section. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

ARCHIVE The general body meeting of APTI, Bengal Branch has been

conducted at GNIPST on 15th June, 2012. The program started witha nice presentation by Dr. Pulok Kr. Mukherjee, School of NaturalProducts, JU on the skill to write a good manuscript forpublication in impact journals. It was followed by nearly two hourlong discussion among more than thirty participants on differentaspects of pharmacy education. Five nonmember participantsapplied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT forconducting the two years post graduate course (M.Pharm)in PHARMACOLOGY. The approved number of seat is 18.


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The number of seats in B.Pharm. has been increased from 60 to120.

AICTE has sanctioned a release of grant under ResearchPromotion Scheme (RPS) during the financial year 2012-13toGNIPST as per the details below:a. Beneficiary Institution: Guru Nanak Institution of PharmaceuticalScience & Technology.

b. Principal Investigator: Dr. LopamudraDutta.c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d. Approved duration: 3 yearse. Title of the project: Screening and identification of potential

medicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

Activity Clubs of GNIPST: Name of Club Member Faculty SPORTS Mr. Debabrata GhoshDastidar LITERARY AND PAINTING Ms. Jeenatara Begum SCIENCE AND INNOVATIVE MODELLING

Mr. Samrat Bose

ECO Ms. Sumana Roy SOCIAL SERVICES Dr. Asis Bala PHOTOGRAPHY Ms. Sanchari Bhattacharya CULTURAL Ms. Priyanka Ray DEBATE AND EXTEMPORE Mr. Soumya Bhattacharya


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Software tracks source of fecal pollution in water: 12th June, 2015 New powerful drug candidate can improve a failing hearts function: 12th June, 2015 Severely impaired stroke survivors regain arm function after intensive physical therapy: 12th June, 2015 Mechanism regulating gene expression linked to bone and joint damage in ankylosing spondylitis: 12th June, 2015 Viral protein helps Epstein-Barr virus-infected B cells escape human killer T cells: 11th June, 2015 Lactobacillus reuteri may have multiple benefits as a probiotic in premature infants: 09th June, 2015A new study finds that supplementing enteral nutrition with Lactobacillus reuteri (L. reuteri) DSM 17938 as a probiotic may reduce the risk of necrotizing enterocolitis (NEC) in premature infants. NEC is a condition where portions of the bowel undergo... Molecular imaging reveals marker of neurodegenerative disease: 08th June, 2015 Amyloid scan of the heart predicts major cardiac events: 08th June, 2015 PET/CT captures hidden source of neuroendocrine cancer: 08th June, 2015 Cloud-based neuroimaging analysis could aid Alzheimer's diagnosis: 08th June, 2015For detail mail to editor

KNOWLEDGE BASED ARTICLEMeaslesMeasles is transmitted by the respiratory route and is highly infectious. Infectivity is greatest in the 3 days before the onset of rash, and 75%90% of susceptible household contacts develop the disease. The early prerash symptoms are similar to thos...Mild, Modified and Atypical Measles: Middle East respiratory syndrome coronavirus (MERS-CoV) Republic of Korea: (12th June, 2015)Situation in KoreaRead more FDA Advisory Committee Recommends Approval of Praluent (Alirocumab) Injection for Patients with Hypercholesterolemia: (09th June, 2015)Read more CAMPUS NEWS STUDENTS SECTION

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GNIPST Bulletin 46.2