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Graduation Project I
Device for controllable administration of drug dosage
Prepared By: - Mona Ibrahim 200002091 - Azza Al Hassani 200002019 - Asma Ahmed 200002020 - Hamda Al Ketbi 199902209 - Moza Al Shamsi 199903856
Adviser’s name : - Dr. Yousef Haik
Presentation Layout
Motivation Objectives Design Process Testing Device Dispensing Device Communication Device Conclusion
Motivation
Dispensing Device
Testing Device
Physician
Patient
Project DescriptionProject Description
Blood Clotting
A natural process in which blood cells and fibrin strands clump together to stop bleeding
Blood Coagulation Mechanism
Prothrombin Time (PT)
• The time it takes plasma to clot. • PT is reported in seconds
International Normalization Ratio (inr)
• The ratio of the patient's clotting time to the mean reference value.
)(normal
test
PT
PTINR
Anticoagulants
Medications that delay
the coagulation of blood Some of these are:
Heparin Argatroban
Hirudin Warfarin
Warfarin
the most widely used oral
anticoagulant.
It is a non-habit forming medication.
to prevent formation of new blood
clots in high-risk patients
Motivation
Frequent Monitoring
Dose adjustment
Reduce patient error
Time saving
Availability of a patient medical history
Reduce visitation to clinic.
Objectives
Design a blood testing mechanism
Design a drug dispensing mechanism
Design and construct a working prototype of the system Dispensing
DeviceTesting Device
Physician
Patient
Design Process
Gantt Chart
The ProTime System-PT-
INR Testing
Market Analysis
Coaguchek System
INRatio®PT Monitoring
System
The Harmony INR
Monitoring System
Function Structure
Drug dose
Blood sample
System
Global device function
Overall function structure
Blood Sample Testing
DeviceDispenser
Communicator
INR value Dose
Drug Dosage Hold
Sample
Specifications
Dispensing DeviceMeasuring Device
Touch button operation
Portable and easy to use
Large, easy to read reporting screen
Durable
Repeatable
Cost effective meter and test strip
Dimension 5"×3"
Touch button operation
Portable and easy to use
Large, easy to read reporting screen
Durable
Repeatable
Cost effective meter and test strip
Dimension 5"×3"
Small sample volume: 20 µL
Perform measurement automatically as soon as the sample is applied
Measuring time is less than one minute
Sensitive: can measure less than 1 mg/mL of Prothrombin
Small sample volume: 20 µL
Perform measurement automatically as soon as the sample is applied
Measuring time is less than one minute
Sensitive: can measure less than 1 mg/mL of Prothrombin
Measuring Device
Made of biocompatible materials
Disposable sample holder
Meet the International Biomedical Instrumentation standards
Made of biocompatible materials
Disposable sample holder
Meet the International Biomedical Instrumentation standards
Store medicine
Dispense one tablet at the time Time for dispensing to be less than 2 minutes
Patient interference to the device is negligible
Store medicine
Dispense one tablet at the time Time for dispensing to be less than 2 minutes
Patient interference to the device is negligible
Cost effective
Durable
Dimension 5”×2.5”
Safe, no sharp corner
Cost effective
Durable
Dimension 5”×2.5”
Safe, no sharp corner
Dispensing Device
Cost effective
Dimension 5”×3”
Communication between the medical doctor and the device within one day
Cost effective
Dimension 5”×3”
Communication between the medical doctor and the device within one day
Communication Device
The whole device dimension should not exceed 26.5"×12"
The whole device dimension should not exceed 26.5"×12"
Developing concepts
Testing Morphological Chart
Hold Sample
Testing methods
1.RLC1.RLC
2. Protein 2. Protein separationseparation
3. Contact 3. Contact angleangle
4. Plasma 4. Plasma profileprofile
5. 5. ViscosityViscosity
6. Light 6. Light intensity intensity
7. Shear 7. Shear stressstress
88.Charged.Charged
ParticleParticle
9.Elisa9.Elisa
10.Cantilever 10.Cantilever beam beam
11.Piezoelect11.Piezoelectricric
1212. Blood . Blood layer layer thicknessthickness
Display INR
Digital display
PrinterLED
monitorLCD
Testing Methods
1 .RLC Testing Method
Experiments
Measuring the capacitance across the copper plates with time
Capacitance vrs Time
2
2.1
2.2
2.3
2.4
0 5 10 15 20 25
Time (sec)
C (
Mic
ro F
arad
)
Series1
experiments
Measuring the capacitance across the copper plates with time for different INR values (adding tissue factor)
Capacitance vs time
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5
Time (min)
Cap
acit
ance
(µ
F)
INR=1.7
INR=1
INR=2.4
Contact angle Method
Contact angle measurements
camera
sample stage
light source
Syringe
Captive Bubble Contact Angle apparatus
ResultResult
θ is too small to measure
Measure surface area
Surface Area method
Protein Separation Method
viscosity Method
Charged particle Method
Resistance measurements
Measuring the distance moved
Shear stress
Light intensity Blood layer thickness
Cantilever beam Method Plasma profile Method
More
Drug dispensing device
dispenser Morphological Chart
Tablet Holder
Mover
Belt
Shaft
Gear
Pulleys
Manual
Rollers
Piston
dispenser Morphological Chart
ActuatorDc motor
pneumatic
hydraulic
Step motor
countIR sensor
Laser Sensor
Distance Sensor
Lock
solenoidWorm gearSpring damping
Spring solenoid
arm locking)hook(
dispenser Morphological Chart
Cuttercutter
Scissors)Sharp (
Paper cutterUtility
Knife
Ejector
Dispensing concept 1
Dispensing concept 2
Dispensing concept 3
Dispensing concept 4
Dispensing concept 5
Communication device
communication Morphological Chart
Sending signals
Wire
modem
Sound
Fiber optic
Laser
transmitter
Cost estimation
The budget
CONCLUSION
FUTURE WORK
Resuming investigating the testing methods
Evaluating testing methods to select the proper one
Analyzing the design of testing, dispensing, and communication
Building a prototype for the whole device
Experiments